Article
Neurosciences
Colin A. Lee, Jeffrey W. Brown, Rhanor Gillette
Summary: A study found that the sea slug, an unsegmented creature, uses a neuronal network to control its crawling. This network is similar to those found in complex animals with segmented bodies and jointed appendages, suggesting that it existed in the common ancestor of soft-bodied animals and has been conserved throughout evolution.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Zhifeng Zhong, Simin Zhou, Bin Xiang, Yu Wu, Jiaxin Xie, Peng Li
Summary: Living at high altitude can impair cognitive function, with significant associations found between peripheral plasma neurotransmitters and cognitive performance. Exposure to chronic hypobaric hypoxia can alter brain neurotransmitter levels, emphasizing a possible causal effect on cognitive performance.
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kishore K. Joshi, Tarmie L. Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel, Christopher Rongo
Summary: Metazoans utilize protein homeostasis pathways to respond to adverse conditions, with the nervous system playing a role in regulating proteostasis in different tissues. This study reveals that Caenorhabditis elegans uses biogenic amine neurotransmitters to modulate UPS proteostasis in epithelia by promoting eicosanoid production through P450 monooxygenases, ultimately maintaining protein turnover.
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Edenia C. Menezes, Relish Shah, Lindsay Laughlin, K. Yaragudri Vinod, John F. Smiley, Catarina Cunha, Andrea Balla, Henry Sershen, Francisco X. Castellanos, Andre Corvelo, Catia M. Teixeira
Summary: Early life is a critical period where enhanced neural plasticity allows the developing brain to adapt to its environment. Exposure to fluoxetine in early postnatal period can lead to reduced effort-related motivation and blunted dopaminergic activation in reward tasks in adulthood. Administering bupropion in adulthood can rescue the reduction in motivation, highlighting the involvement of the dopaminergic system in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Saheed E. Elugoke, Omolola E. Fayemi, Abolanle S. Adekunle, Thabo T. Nkambule, Bhekie B. Mamba, Eno E. Ebenso
Summary: Nanodiamond is a type of carbon nanomaterial that can be used to detect neurotransmitters that provoke physiological responses, but there are limited electrochemical ND-based NT sensors available. The study focused on the performance of existing sensors, interactions between NTs and NDs, and the lack of data on the subject.
Article
Biochemical Research Methods
Rajasree G. Krishnan, Beena Saraswathyamma
Summary: This study presents a protocol for the simultaneous electroanalysis of tryptamine, serotonin, and dopamine using a conducting poly-murexide-based electrode, the first report of its kind. The analytes underwent irreversible electro-oxidation at the modified electrode surface under optimized conditions, with linear ranges for dopamine, serotonin, and tryptamine. The specificity of the developed electrode was satisfactory in the presence of other biomolecules, and electroanalysis was demonstrated in human serum for these targets.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jaume Lillo, Iu Raich, Laura Silva, David A. Zafra, Alejandro Lillo, Carlos Ferreiro-Vera, Veronica Sanchez de Medina, Jose Martinez-Orgado, Rafael Franco, Gemma Navarro
Summary: The study found that CBD acts on CB2-5HT(1A)-Hets and reduces the abnormal expression of the receptor-receptor complex under hypoxic and ischemic conditions, thereby exerting a therapeutic effect on neonatal hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Itaru Miura, Sho Horikoshi, Mizue Ichinose, Yuhei Suzuki, Kenya Watanabe
Summary: This review provides a comprehensive overview of the drug design, development, and therapy of lurasidone for schizophrenia treatment. Lurasidone has specific effects on different receptors and has been found to be effective in improving symptoms and preventing relapse in patients with schizophrenia. It also has minimal metabolic side effects and improves cognitive and functional performance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Behavioral Sciences
Salar Vaseghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Summary: Cannabinoids interact with multiple neurotransmitters in learning and memory, yielding unpredictable effects, with mechanisms that require further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Paul J. Fletcher, Zhaoxia Li, Xiaodong Ji, Guy A. Higgins, Douglas Funk
Summary: This study examined the effects of manipulating serotonin receptors on alcohol self-administration and alcohol-seeking behavior in rats. The results showed that blocking 5-HT2A receptors had limited effects on reducing alcohol-seeking, while activating 5-HT2C receptors had a broader range of effects on reducing alcohol self-administration, alcohol drinking, and alcohol-seeking behavior.
Article
Cell Biology
Julia R. Naso, Gang Wang, Alexandra Pender, Selina K. Wong, Jingyao Zhu, Cheryl Ho, Diana N. Ionescu, Chen Zhou
Article
Oncology
Julia Naso, James Bras, Carlos Villamil, Diana N. Ionescu, Gang Wang, Tawimas Shaipanich, Eve-Lea Beaudoin, Renelle Myers, Stephen Lam, Chen Zhou
CANCER CYTOPATHOLOGY
(2020)
Letter
Pathology
He Zhen Ren, Basile Tessier-Cloutier, Julia R. Naso, Martin Koebel, Cheng-Han Lee, Andrew Churg
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medical Laboratory Technology
Julia R. Naso, Hui-Min Yang, David F. Schaeffer
Summary: Real-world reporting of pT4a category and lymphovascular invasion shows substantial variability at both local and regional levels. Interobserver agreement regarding T4a staging and lymphovascular invasion is only moderate, highlighting the need for quality improvement initiatives in addressing these features.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Pathology
Julia R. Naso, Gang Wang, Norbert Banyi, Fatemeh Derakhshan, Aria Shokoohi, Cheryl Ho, Chen Zhou, Diana N. Ionescu
Summary: Various PD-L1 expression assays in NSCLC show potential interchangeability, providing more testing options and reducing logistical barriers.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Menchus Quan, Shihuan Kuang
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Daisy Unsihuay, Pei Su, Hang Hu, Jiamin Qiu, Shihuan Kuang, Yingju Li, Xiaofei Sun, Sudhansu K. Dey, Julia Laskin
Summary: The development of a novel online photochemical approach for lipid isomer identification utilizing selective derivatization of double bonds with singlet oxygen provides a new strategy for exploring the complexity of the lipidome. Fragmentation of lipid hydroperoxide products in a mass spectrometer allows for rapid identification of C=C bond locations in lipids. This cost-effective method can be easily integrated into lipidomics workflows.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
Julia R. Naso, James T. Topham, Joanna M. Karasinska, Michael K. C. Lee, Steve E. Kalloger, Hui-li Wong, Jessica Nelson, Richard A. Moore, Andrew J. Mungall, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Daniel J. Renouf, David F. Schaeffer
Summary: This study assessed whether histomorphological features can be used as surrogate markers for predicting molecular subgroups and overall survival in PDAC. The combination of low gland formation and low neutrophil infiltration was significantly associated with poor prognosis PDAC subgroups and independently predicted shorter overall survival.
Article
Biochemistry & Molecular Biology
Nanjian Luo, Feng Yue, Zhihao Jia, Jingjuan Chen, Qing Deng, Yongju Zhao, Shihuan Kuang
Summary: The study reveals a novel role of Mfn2 in regulating mitochondrial complex I protein abundance and respiratory functions in myogenic progenitors and myofibers, without obvious effects on myoblast differentiation, muscle development and function, and muscle regeneration.
Article
Engineering, Biomedical
Naagarajan Narayanan, Zhihao Jia, Kun Ho Kim, Liangju Kuang, Paul Lengemann, Gabrielle Shafer, Victor Bernal-Crespo, Shihuan Kuang, Meng Deng
Summary: Optimizing the biophysical properties of HA-CS hydrogels can promote skeletal muscle regeneration in VML injuries in mice, supporting implant integration with host tissue and facilitating satellite cell migration, myofiber formation, angiogenesis, and innervation with reduced scar tissue formation in vivo. Hydrogel-treated mice showed functional improvements comparable to autograft-treated mice as early as 1 week post-implantation.
BIOACTIVE MATERIALS
(2021)
Article
Pathology
Julia R. Naso, Adrian B. Levine, Hossein Farahani, Lucian R. Chirieac, Sanja Dacic, Joanne L. Wright, Chi Lai, Hui-Min Yang, Steven J. M. Jones, Ali Bashashati, Stephen Yip, Andrew Churg
Summary: SpindleMesoNET, a deep learning classifier, accurately distinguishes sarcomatoid mesothelioma from benign spindle cell mesothelial proliferations with high predictive performance, showing potential as an ancillary tool in diagnostic pathology.
Article
Pathology
Julia R. Naso, Basile Tessier-Cloutier, Janine Senz, David G. Huntsman, Andrew Churg
Summary: p53 immunohistochemistry is crucial in distinguishing between benign and malignant mesothelial proliferations, with absent or overexpression p53 staining patterns serving as markers of malignancy. Combining p53 staining with BAP1/MTAP staining increases sensitivity, improving diagnostic accuracy for epithelioid and sarcomatoid mesotheliomas.
Article
Cell Biology
Feng Yue, Stephanie N. Oprescu, Jiamin Qiu, Lijie Gu, Lijia Zhang, Jingjuan Chen, Naagarajan Narayanan, Meng Deng, Shihuan Kuang
Summary: In skeletal muscle satellite cells, the dynamic distribution of lipid droplets determines cell fate, with LDLow cells outperforming LDHigh cells in regeneration and self-renewal. Interventions in LD biogenesis and catabolism disrupt cell fate balance and impair the regenerative capacity of SCs.
Article
Medical Laboratory Technology
Julia R. Naso, Jackie Chan, Janani Reisenauer, Eric S. Edell, Katherine Stackhouse, Aaron O. Bungum, Robert A. Vierkant, Karlyn Pierson, Andrew Seidl, Charles D. Sturgis, Chady Meroueh, Yajue Huang, Christopher P. Hartley
Summary: The use of a remote-controlled robotic microscope improved the ease of adequacy assessment compared to non-robotic telecytology and enabled expediently rendered strongly concordant diagnoses. This study provides evidence that modern robotic telecytology is a feasible and user-friendly method for remotely and potentially intraoperatively rendering adequacy assessments and diagnoses on bronchoscopic cytology specimens.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Biochemical Research Methods
Jingjuan Chen, Feng Yue, Shihuan Kuang
Summary: This study provides a comprehensive protocol to visualize and quantify lipid droplets in mouse muscle satellite cells, which can be adapted for other cell types of interest.