Article
Biochemistry & Molecular Biology
Tomoaki Aoki, Vanessa Wong, Yusuke Endo, Kei Hayashida, Ryosuke Takegawa, Muhammad Shoaib, Santiago J. Miyara, Rishabh C. Choudhary, Tai Yin, Kota Saeki, Simon C. Robson, Lance B. Becker, Koichiro Shinozaki
Summary: Insufficient oxygen supplementation during resuscitation may prolong ischemia and lead to unfavorable biological responses 2 hours after cardiac arrest.
Article
Cardiac & Cardiovascular Systems
Yu Okuma, Lance B. Becker, Kei Hayashida, Tomoaki Aoki, Kota Saeki, Mitsuaki Nishikimi, Muhammad Shoaib, Santiago J. Miyara, Tai Yin, Koichiro Shinozaki
Summary: The study shows that post-resuscitation normoxic therapy can alleviate oxidative stress in multiple organs and improve oxygen metabolism and survival rates. On the other hand, hyperoxic therapy post-cardiac arrest can increase mitochondrial oxidative stress.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Critical Care Medicine
Hugues de Courson, Thomas Julien-Laferriere, Delphine Georges, Philippe Boyer, Eric Verchere, Matthieu Biais
Summary: The study aimed to evaluate the diagnostic accuracy of ORI in detecting arterial oxygen tension (PaO2) > 100mmHg. The results showed that ORI had relatively low ability in diagnosing hyperoxia, while SpO(2) provided better detection.
ANNALS OF INTENSIVE CARE
(2022)
Article
Biophysics
Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Pablo Tomas-Carus, Rafael Timon, Guillermo Olcina, Martin Burtscher
Summary: This study aimed to explore the differences in cardiorespiratory responses to normobaric hypoxia between men and women. The results showed that men had a more pronounced ventilatory response to hypoxia compared to women, while women experienced a faster decrease in peripheral oxygen saturation during the first few hours in hypoxia.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2022)
Article
Endocrinology & Metabolism
Pieter T. Deckers, Alex A. Bhogal, Mathijs Bj Dijsselhof, Carlos C. Faraco, Peiying Liu, Hanzhang Lu, Manus J. Donahue, Jeroen C. W. Siero
Summary: The study found that 'CO2 in air' is not iso-metabolic compared to carbogen, and the reduction in CMRO2 during hypercapnia is mitigated when hyperoxia is included. These findings have implications for interpreting measurements using hypercapnic or hypercapnic-hyperoxic stimuli.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Medicine, General & Internal
Laurent Reydellet, Audrey Le Saux, Valery Blasco, Cyril Nafati, Karim Harti-Souab, Romain Armand, Ariane Lannelongue, Emilie Gregoire, Jean Hardwigsen, Jacques Albanese, Sophie Chopinet
Summary: Hyperoxia is common during liver transplantation, but no guidelines support its use. Recent studies have shown the potential harm of hyperoxia in similar ischemia-reperfusion models. Hyperoxia after orthotopic liver transplantation can increase lactate levels and worsen patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Irina A. Mandel, Yuriy K. Podoksenov, Sergey L. Mikheev, Irina V. Suhodolo, Yulia S. Svirko, Vladimir M. Shipulin, Anastasia V. Ivanova, Andrey G. Yavorovskiy, Andrey I. Yaroshetskiy
Summary: Hypoxic-hyperoxic preconditioning (HHP) may reduce endothelial damage and improve postoperative outcome in cardiac surgery with cardiopulmonary bypass. The HHP group had a lower frequency of postoperative complications compared to the control group. Endothelial damage markers were predictive of postoperative complications.
Article
Multidisciplinary Sciences
Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel R. Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose
Summary: The sensitivity of the brain to hypoxia is inversely related to the levels of sulfide:quinone oxidoreductase (SQOR) and its capacity to catabolize sulfide in mice, rats, and naturally hypoxia-tolerant ground squirrels. Silencing SQOR increased brain sensitivity to hypoxia, while neuron-specific SQOR expression prevented hypoxia-induced sulfide accumulation and ischemic brain injury. Pharmacological scavenging of sulfide maintained mitochondrial respiration in hypoxic neurons and made mice resistant to hypoxia, indicating a potential therapeutic target for ischemic brain injury.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Sabine A. Eming, Peter J. Murray, Edward J. Pearce
Summary: Macrophages play a central role in wound healing, with inflammatory macrophages responding to initial wound stimuli and alternatively activated macrophages essential for wound closure. Metabolic changes in macrophages have significant effects on their functional states, and the metabolic interplay between macrophages and fibroblasts is crucial for wound healing.
Article
Cell Biology
Song Li, Lihua Luo, Yan He, Ruohan Li, Yangfan Xiang, Zhenjie Xing, Yejian Li, Abdullkhaleg Ali Albashari, Xiangyan Liao, Keke Zhang, Liang Gao, Qingsong Ye
Summary: This study aimed to investigate the protective effects of dental pulp stem cell-derived exosomes (DPSC-Exos) against cerebral ischaemia-reperfusion (I/R) injury and explore the underlying mechanism. DPSC-Exos were found to alleviate brain oedema, cerebral infarction, and neurological impairment in I/R mice, potentially through the inhibition of the HMGB1/TLR4/MyD88/NF-κB pathway. Additionally, DPSC-Exos also showed anti-inflammatory effects by reducing the expression of IL-6, IL-1 beta, and TNF-alpha both in vitro and in vivo.
CELL PROLIFERATION
(2021)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Review
Immunology
Yalda Rahbar Saadat, Seyed Mahdi Hosseiniyan Khatibi, Anis Sani, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: The kidneys, which consume large amounts of oxygen, are highly susceptible to ischemic insults and can be a major cause of acute kidney injury (AKI). However, kidneys also have the ability to sense and respond to changes in oxygen levels to prevent harm from inadequate oxygen. The hypoxia-inducible factor (HIF) plays a crucial role in maintaining homeostasis under hypoxic conditions by regulating genes involved in metabolic adaptation, angiogenesis, and energy conservation. This review focuses on the oxygen-sensing mechanisms in kidneys, particularly in proximal tubular cells (PTCs), and discusses the molecules and non-coding RNAs involved in ischemic response and metabolic reprogramming.
INFLAMMOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hao Lyu, Dong Ming Sun, Chi Ping Ng, Jun Fan Chen, Yu Zhong He, Sin Yu Lam, Zhi Yuan Zheng, Hadi Askarifirouzjaei, Chi Chiu Wang, Wise Young, Wai Sang Poon
Summary: HIE is a condition where a baby's brain is damaged due to lack of blood and oxygen supply, with current treatment involving supportive care and hypothermia. Researchers have modified the Vannucci model to establish an experimental model closer to human neonatal HIE, which shows mild brain damage and a surgical mortality rate of 30%.
Review
Biochemistry & Molecular Biology
Hsiao-Chin Wang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: Oxygen therapy is important for newborns, but excessive oxygen levels can lead to intestinal inflammation and damage due to oxidative stress. Multiple molecular factors, including nitric oxide, NF-kappa B pathway, reactive oxygen species, toll-like receptor-4, etc., contribute to hyperoxia-induced intestinal injuries. The Nrf2 pathway and antioxidant cytokines or molecules play a role in preventing cell apoptosis and tissue inflammation. NF-kappa B and Nrf2 pathways are essential for maintaining oxidative stress balance and preventing cell apoptosis and tissue inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)