Article
Biology
Peter R. Strege, Luke M. Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A. Ahern, Lorin S. Milescu, Gianrico Farrugia, Arthur Beyder
Summary: Shear stress and patch suction can reversibly alter the kinetic properties and maximum current of NaChBac, suggesting it is mechanosensitive. Structural analysis reveals a large displacement of the intracellular gate, supporting the proposed mechanosensitive mechanism.
Article
Environmental Sciences
Lorenzo Cozzolino, Katy R. Nicastro, Peter C. Hubbard, Laurent Seuront, Christopher D. Mcquaid, Gerardo I. Zardi
Summary: Microplastic pollution has negative impacts on marine biota and different species may respond differently. In this study, researchers found intraspecific diversity in the behavioral responses of a marine mussel to plastic pollution, with individuals from different lineages showing varied responses to beached microplastics.
ENVIRONMENTAL POLLUTION
(2024)
Article
Microbiology
Atef Omar, Jeong Hyeon Yeo, Jae-Ho Jung
Summary: The morphology, ontogenesis, and molecular phylogeny of a new ciliate, Pseudostylonychia obliquocaudata n. gen., n. sp., were investigated. The new species is characterized by specific body shape, infraciliature, macronuclear pattern, and undulating membranes. It is phylogenetically related to various ciliate species and subspecies.
EUROPEAN JOURNAL OF PROTISTOLOGY
(2022)
Article
Biology
E. Tamayo, J. W. Mouland, R. J. Lucas, T. M. Brown
Summary: Animal survival depends on the ability to adjust behavior according to environmental conditions, including the perception of light. The circadian system plays a key role in regulating rest and activity based on diel changes in light quantity and spectral content. This study reveals that the acute effects of light on behavior in mice are influenced by both melanopsin-dependent irradiance signals and the spectral content of the light.
Article
Biochemistry & Molecular Biology
Magali Rey-Campos, Raquel Rios-Castro, Cristian Gallardo-Escarate, Beatriz Novoa, Antonio Figueras
Summary: Metatranscriptomics is a useful approach for studying microbiomes, providing information on both microbial diversity and the host-microbiome relationship. Despite differences in microbiome composition among tissues and species, common taxa can be identified using both metatranscriptomic analysis and 16S rRNA sequencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Xiong Liu, Rui Zhang, Mohammad Fatehi, Yifang Wang, Wentong Long, Rui Tian, Xiaoling Deng, Ziyi Weng, Qinyi Xu, Peter E. Light, Jingfeng Tang, Xing-Zhen Chen
Summary: This study reveals that TACAN acts as an inhibitor of PKD2 and mediates the mechanosensitivity of the PKD2-TACAN channel complex. This finding is important for understanding the pathogenesis of autosomal dominant polycystic kidney disease.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Article
Chemistry, Multidisciplinary
Jiaru Fang, Dongxin Xu, Hao Wang, Jin Wu, Ying Li, Tao Yang, Chuan Liu, Ning Hu
Summary: Electrophysiology is a unique biomarker for disease investigation or drug assessment in electrogenic cells. Vertical nanoelectrode arrays have been successful in achieving high-quality intracellular electrophysiological study in electrogenic cells. However, achieving high success rate and high-quality, long-term intracellular recording using inexpensive nanostructures remains a challenge. In this study, a scalable and robust hollow nanopillar electrode was developed to enhance intracellular recording of cardiomyocytes. Regulation of the nanostructure geometry proved to be a powerful strategy in enhancing intracellular recording.
Article
Psychology, Multidisciplinary
Vanessa Harwood, Daniel Kleinman, Gavino Puggioni, Alisa Baron
Summary: In this study, the predictive role of P300 event-related potential (ERP) in phonological working memory (PWM) skills was investigated. The results showed that the P300 ERP in response to native phoneme contrasts can predict nonword repetition ability. However, the response to non-native contrasts was not significant and was unrelated to English nonword repetition performance.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Endocrinology & Metabolism
Joseph D. Gardinier
Summary: Adaptation to mechanical loading is crucial for bone mass maintenance and prevention of age-related bone loss. However, prolonged loading can lead to diminishing returns as the anabolic response saturates quickly. Osteocytes play a key role in responding to skeletal loading and facilitating anabolic response, but their sensitivity can be limited by underlying mechanisms.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Biodiversity Conservation
Chi-Yun Chen, Tien-Hsuan Lu, Ying-Fei Yang, Chung-Min Liao
Summary: The overall impact potential of MPs on marine mussels in the South Pacific Ocean, Mediterranean Sea, and South Atlantic Ocean was found to be low, while MPs from the North Pacific Ocean were likely to pose a potential threat. This highlights important implications for understanding the relationships between environmental MPs and the exposure risk for marine organisms in different oceanic regions worldwide.
ECOLOGICAL INDICATORS
(2021)
Article
Chemistry, Multidisciplinary
Tailise Carolina de Souza-Guerreiro, Gaia Bondelli, Iago Grobas, Stefano Donini, Valentina Sesti, Chiara Bertarelli, Guglielmo Lanzani, Munehiro Asally, Giuseppe Maria Paterno
Summary: Recent studies have shown that optical modulation of bacterial membrane potential, using a membrane-targeted azobenzene, can induce hyperpolarization of the potential in cells of Bacillus subtilis. The isomerization of the azobenzene was found to induce ion channel opening in the bacterial membrane. This new approach has the potential to contribute to the study and control of bacterial electrical signaling and better understanding of microbial phenomena.
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Article
Biochemistry & Molecular Biology
Isis J. Amaye, Patrice L. Jackson-Ayotunde, Miguel Martin-Caraballo
Summary: Trifluoromethylated N-benzamide enaminones have shown potential as anticonvulsants for drug-resistant epilepsy. They target T-type Ca2+ channels, with two meta-trifluoromethyl N-benzamide enaminones inhibiting these channels. The lead analogs of these compounds affect the gating mechanism of Cav3.3 T-type Ca2+ channels, while altering the steady-state inactivation of Cav3.2. This research provides insights for the development of specific blockers for T-type Ca2+ channels in the treatment of epileptic seizures.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Gulzar Ahmed Rather, Anima Nanda, Manzoor Ahmad Pandit, Showket Yahya, Mohmmad Ashaq Sofi, Hamed Barabadi, Muthupandian Saravanan
Summary: The study successfully synthesized ZnONPs using Bergenia ciliate leaf extract as reducing and capping agents, and characterized their properties through various analysis methods, demonstrating good optical, morphological, and degradation performance.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)