Review
Immunology
Qin Hu, Gujie Wu, Runtian Wang, Huiyun Ma, Zhouwei Zhang, Qun Xue
Summary: This article provides a systematic review on the mechanism of tumor-associated macrophages (TAM) polarization, therapeutic strategies, and the biological functions of Tim-3 positive macrophages, aiming to provide new insights into the pathogenesis and treatment of lung cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Xintong Zhou, Xiaomin Wang, Qi Sun, Wenfeng Zhang, Cun Liu, Wenzhe Ma, Changgang Sun
Summary: This paper discusses the infiltration and polarization effects of natural compounds on lung cancer tumor-associated macrophages (TAMs), provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Lianlian Tian, Jun-Long Zhao, Jian-Qin Kang, Shi-bo Guo, Nini Zhang, Lei Shang, Ya-Long Zhang, Jian Zhang, Xun Jiang, Yan Lin
Summary: Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation, with a lack of safe and effective medicine. Studies have shown that Astragaloside IV (AS-IV) extracted from traditional Chinese medicine can alleviate experimental colitis symptoms by modulating macrophage phenotype transition, potentially offering a new approach for IBD treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zicong He, Shuixing Zhang
Summary: TAMs are crucial immune cells in tumors, and their functional transformation from M1 to M2 as tumors progress plays a key role in immunosuppression and tumor promotion processes. Understanding the mechanism of TAM functional transformation in the hypoxic environment is essential for developing novel tumor immunotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Jun-Jie Li, Ya-Ling Li, Wei Chu, Gao-Qin Li, Min Zhang, Juan-Juan Dong, Ling Li, Cheng-Hao Li, Jin-Bao Zhang, Jia-Wei Li, Xiao-Jie Jin, Yong-Qi Liu
Summary: In this study, the protective effect of Astragalus membranaceus extract (AS-IV) and its potential molecular mechanism on intestinal mucositis induced by Cytarabine (Ara-C) were investigated. The results showed that AS-IV improved intestinal damage, decreased inflammation, and inhibited macrophage polarization to M1. The mechanism may be associated with the regulation of the AKT signaling pathway. AS-IV may serve as a novel AKT inhibitor to counteract the intestinal adverse effects of chemotherapy.
Article
Nanoscience & Nanotechnology
Wen-Pin Su, Li-Chan Chang, Wei-How Song, Li-Xing Yang, Liu-Chun Wang, Zi-Chun Chia, Yu-Cheng Chin, Yan-Shen Shan, Chih-Chia Huang, Chen-Sheng Yeh
Summary: Au PG nanoparticles have promising potential in lung cancer immunotherapy by promoting macrophage polarization and improving tumor inhibition and immunosuppression.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Jia Liu, Ze-Xian Liu, Jia-Jun Li, Zhao-Lei Zeng, Jin-Hong Wang, Xiao-Jing Luo, Chau-Wei Wong, Jia-Bo Zheng, Heng-Ying Pu, Hui Sheng, Qi-Nian Wu, Hao Li, Gang Wan, Bo Li, De-shen Wang, Rui-Hua Xu, Huai-Qiang Ju
Summary: Tumor-associated macrophages (TAM) are important for tumor development and progression. This study found that the long noncoding RNA MALR promoted aerobic glycolysis and angiogenesis in tumor cells by activating the HIF1a signaling pathway. It also identified the MALR-ILF3-HIF1a axis as a potential target for cancer therapy.
Article
Medicine, Research & Experimental
Jing Xun, Lingfang Du, Ruifang Gao, Long Shen, Dekun Wang, Lichun Kang, Chuan'ai Chen, Zhujun Zhang, Yuying Zhang, Shijing Yue, Shuxin Feng, Rong Xiang, Xue Mi, Xiaoyue Tan
Summary: This study demonstrates that miR-138-5p delivered from breast cancer cells to tumor-associated macrophages via exosomes can downregulate KDM6B expression, inhibit M1 polarization, and stimulate M2 polarization, ultimately promoting tumor metastasis. Additionally, exosomal miR-138-5p levels positively correlate with the progression of breast cancer, suggesting it as a potential prognostic marker and therapeutic target.
Review
Oncology
Nisha Kumari, Seung Hong Choi
Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lu Shi, Hongchen Gu
Summary: Despite the great progress in immunotherapy, the efficacy in treating solid tumors has not met expectations, largely due to the immune-suppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play crucial roles in this environment, and research focuses on repolarizing them from pro-tumor to anti-tumor phenotypes. Nanotechnology offers significant opportunities for targeting and modulating TAM polarization to improve cancer immunotherapy outcomes.
Review
Immunology
Jiashu Han, Luochu Dong, Mengwei Wu, Fei Ma
Summary: Immunotherapy has revolutionized tumor treatment, but many patients still do not respond due to the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play a crucial role in shaping this microenvironment and interacting with intratumoral T cells. However, the heterogeneity and plasticity of TAMs make it challenging to target specific factors and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jing Gao, Yuanzheng Liang, Liang Wang
Summary: This review focuses on the role of tumor-associated macrophages (TAMs) in the tumor microenvironment (TME). It summarizes macrophage polarization, the effects on the TME, and emphasizes the importance of M2-like TAMs in immune checkpoint blockade and CAR-T cell therapy. It also discusses signaling pathways associated with TAM polarization and potential strategies for targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yihan Sun, Genyi Jiang, Qianhua Wu, Lei Ye, Bilan Li
Summary: Tumor-associated macrophages (TAMs) in endometrial cancer (EC) play a significant role in promoting tumor development and metastasis through interactions with the tumor microenvironment, and may serve as a potential target for EC immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Rosaria Galdiero, Ilaria Mormile, Francescopaolo Granata, Stefania Loffredo, Aikaterini Detoraki, Francesca Della Casa, Maria Luisa Trocchia, Annagioia Ventrici, Amato de Paulis, Francesca Wanda Rossi
Summary: Cancer-related inflammation plays an important role in tumor initiation and progression. Tumor-associated macrophages (TAMs) have plasticity and can contribute in different ways to carcinogenesis. Secreted phospholipase A(2) enzymes (sPLA(2)s) have multiple biological effects on cancer-related inflammation.
Article
Biochemistry & Molecular Biology
Xianjun Sun, Yubao Lv, Junjun Wang, HuiQin Cheng, Jianhua Huang, Yijie Du, Jingcheng Dong
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Oncology
Wenqian Wang, Ming Dong, Jie Cui, Fei Xu, Chen Yan, Cheng Ma, La Yi, Weifeng Tang, Jingcheng Dong, Ying Wei
MOLECULAR MEDICINE REPORTS
(2019)
Article
Pharmacology & Pharmacy
Shan Jiang, Jing Sun, Nabijan Mohammadtursun, Zhang Hu, Qiuping Li, Zhengxiao Zhao, Hongying Zhang, Jingcheng Dong
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Chemistry, Medicinal
Linwei Lu, Mingfei Zhang, Xiaoyi Wang, Yanyu Zhang, Zhilan Chai, Man Ying, Juan Guan, Weiyi Gong, Zhengxiao Zhao, Lumei Liu, Yang Hu, Weiyue Lu, Jingcheng Dong
PHYTOTHERAPY RESEARCH
(2020)
Article
Medicine, Research & Experimental
Qiuping Li, Jing Sun, Yuxue Cao, Baojun Liu, Lulu Li, Nabijan Mohammadtursun, Hu Zhang, Jingcheng Dong, Jinfeng Wu
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Pharmacology & Pharmacy
Jiaqi Liu, Lumei Liu, Jing Sun, Qingli Luo, Chen Yan, Hongying Zhang, Feng Liu, Ying Wei, Jingcheng Dong
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Cell & Tissue Engineering
Yu-Hao Cheng, Jing-Cheng Dong, Qin Bian
WORLD JOURNAL OF STEM CELLS
(2019)
Article
Medicine, Research & Experimental
Lingli Hu, Feng Liu, Lulu Li, Li Zhang, Chen Yan, Qiuping Li, Jian Qiu, Jingcheng Dong, Jing Sun, Hongying Zhang
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Xianjun Sun, HuiQin Cheng, BaoJun Liu, Yijie Du, Jingcheng Dong, Jianhua Huang
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Integrative & Complementary Medicine
Jie Cui, Ming Dong, La Yi, Ying Wei, Weifeng Tang, Xueyi Zhu, Jingcheng Dong, Wenqian Wang
Summary: The study demonstrates that acupuncture treatment can significantly suppress allergic airway inflammation and mucus secretion, decrease airway resistance while increasing lung dynamic compliance, and reduce the levels of inflammatory cytokines in the airways. Acupuncture also inhibits the influx of pulmonary ILC2s and production of IL-5, IL-9, and IL-13, providing protection against respiratory inflammation associated with asthma.
ACUPUNCTURE IN MEDICINE
(2021)
Article
Plant Sciences
Qiuping Li, Guifang Wang, Shi Hang Xiong, Yuxue Cao, Baojun Liu, Jing Sun, Lulu Li, Nabijan Mohammadtursun, Hua Yu, Jingcheng Dong, Jinfeng Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Jingjing Liu, Xiaohong Deng, Xianjun Sun, Jingcheng Dong, Jianhua Huang
Review
Biochemistry & Molecular Biology
Cong Xie, Mai Maititusun Ya Likun, Qing-li Luo, Jing-cheng Dong
Summary: Cellular senescence, characterized by permanent cell proliferation arrest, plays a crucial role in the development of cancer and age-related illnesses. This study reviews the recent progress on cellular senescence and its impact on lung inflammation, providing insights into the underlying mechanisms and clinical relevance. The study also proposes the importance of controlling cellular senescence and pro-inflammatory response activation in order to attenuate inflammatory lung conditions and improve disease outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Integrative & Complementary Medicine
Gao Zhen, Liu Yingying, Xu Yizhe, Dong Jingcheng
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Xiaohong Deng, Jingjing Liu, Lantao Liu, Xianjun Sun, Jianhua Huang, Jingcheng Dong
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)