Review
Oncology
Yang Liu, Xiao Li, Tianyu Zhang, Guoyan Liu
Summary: Ovarian cancer has a high fatality rate and poor survival due to nonspecific symptoms in early stages and chemotherapy resistance. Exosomes, nano-sized vesicles secreted by cells, play a significant role in tumor microenvironment remodeling, angiogenesis and metastasis, and immune metastasis and chemotherapy resistance in ovarian cancer. They transfer chemotherapy resistance by delivering proteins and miRNAs, and participate in resistance mechanisms such as multidrug-resistance transporters, apoptosis inhibition, epithelial-to-mesenchymal transition, and signal transduction pathway alteration. Exosomes are also important in early detection, chemotherapy efficacy evaluation, and treatment of ovarian cancer. They can be utilized as chemotherapeutic delivery vehicles and therapeutic targets, as well as for cancer immunotherapy. This article reviews the latest research progress of exosomes in ovarian cancer, elucidating the mechanisms of exosome-mediated chemotherapy resistance and discussing their therapeutic potential in improving chemotherapy sensitivity.
Article
Oncology
Hsiao-Yun Lu, Yi-Jou Tai, Yu-Li Chen, Ying-Cheng Chiang, Heng-Cheng Hsu, Wen-Fang Cheng
Summary: The study developed an ovarian cancer risk score (OVRS) based on the expression of 10 ovarian-cancer-related genes to predict chemoresistance and outcomes in EOC patients. Results showed that patients with OVRS >= 10 had significantly shorter disease-free survival (DFS) and overall survival (OS), and were more likely to be chemoresistant. The high OVRS group also had shorter median OS in patients from the TCGA database.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shrabanti Chowdhury, Jacob J. Kennedy, Richard G. Ivey, Oscar D. Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R. Savage, Anna B. Berry, Boris Reva, Umut Ozbek, Azra Krek, Weiping Ma, Felipe da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J. Voytovich, Yajue Huang, Sun-Hee Lee, Lindsay Bergan, Travis D. Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N. Hoofnagle, Zachary T. Herbert, Alexey I. Nesvizhskii, Bing Zhang, Jeffrey R. Whiteaker, David Fenyo, Wilson McKerrow, Joshua Wang, Stephan C. Schuer, Vasileios Stathias, X. Steven Chen, Mary Helen Barcellos-Hoff, Timothy K. Starr, Boris J. Winterhoff, Andrew C. Nelson, Samuel C. Mok, Scott H. Kaufmann, Charles Drescher, Marcin Cieslik, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Summary: To enhance our understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we analyzed the proteogenomic landscape of 242 HGSOCs and identified a 64-protein signature that accurately predicts a subgroup of HGSOCs refractory to initial platinum-based therapy. We also found a significant association between the lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness, and identified 5 clusters of HGSOC based on pathway protein expression, which may represent different mechanisms of refractoriness and potential therapeutic vulnerabilities.
Article
Biotechnology & Applied Microbiology
Suiying Liang, Yueyang Liu, Jianhui He, Tian Gao, Lanying Li, Shanyang He
Summary: The overexpression of FAM46A in ovarian cancer patients is associated with aggressive phenotype and poor prognosis. Additionally, FAM46A overexpression leads to increased resistance to cisplatin in ovarian cancer cells. However, inhibition of FAM46A sensitizes ovarian cancer cells to cisplatin cytotoxicity. Mechanistically, upregulation of FAM46A activates TGF-beta/Smad signaling and upregulates nuclear Smad2 levels.
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Maria del Mar Munoz-Gallardo, Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Francisco Jose Martinez-Amaro, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: This review analyzes the impact of LncRNA H19 on chemotherapy and radiotherapy in breast cancer, lung adenocarcinoma, glioma, and colorectal carcinoma, as well as its oncogenic and protective roles in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Stella Paffenholz, Camilla Salvagno, Yu-Jui Ho, Matthew Limjoco, Timour Baslan, Sha Tian, Amanda Kulick, Elisa de Stanchina, John E. Wilkinson, Francisco M. Barriga, Dmitriy Zamarin, Juan R. Cubillos-Ruiz, Josef Leibold, Scott W. Lowe
Summary: This study developed a fast and flexible mouse model to mimic the metastatic patterns and treatment response features of high-grade serous ovarian carcinoma. The research found that senescence propensity is a predictor of therapy response and a limited senescence-associated secretory phenotype could enhance the vulnerability of tumors to both chemotherapy and immune checkpoint blockade.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhiyuan Feng, Mohan Chen, Jiayin Zhan, Rong Wu, Yang Shi, Yunsheng Xue, Ran Liu, Jun-Jie Zhu, Jingjing Zhang
Summary: A nanoprodrug based on CRISPR-Cas13d was designed for the optical modulation of gene editing and prodrug release, effectively improving cancer therapy. The experiment showed that the nanoprodrug could control gene editing and drug release through light activation, and successfully eliminated primary tumors and prevented liver metastasis. This study expands the research in gene editing and nanomedicine, accelerating the discovery of new therapeutic approaches.
Article
Oncology
Katia A. Mesquita, Reem Ali, Rachel Doherty, Michael S. Toss, Islam Miligy, Adel Alblihy, Dorjbal Dorjsuren, Anton Simeonov, Ajit Jadhav, David M. Wilson, Ian Hickson, Natalie J. Tatum, Emad A. Rakha, Srinivasan Madhusudan
Summary: Increased expression of FEN1 in ovarian cancer is associated with poor survival outcomes, while inhibition of FEN1 can enhance platinum sensitivity and exhibit synthetic lethality in BRCA2 and POL beta deficient cells. These findings suggest that FEN1 is a promising target for ovarian cancer therapy.
Article
Chemistry, Multidisciplinary
Chao Peng, Yu Liang, Ning Su, Siwen Chen, Zhen Yuan, Yanqun Chen, Dong Wu, Bin Wu, Yang Zhang, ZiTing Xu, Si Zheng, Yingjia Li, Bingxia Zhao
Summary: Chemo-radiotherapy has significant advantages in treatment and prognosis. This study constructed biodegradable nanoagents that can deliver chemotherapeutics and alleviate hypoxia to enhance chemo-radiotherapy. The nanoagents demonstrated self-activation and on-demand release of the chemotherapeutic drug through stimulation by glutathione (GSH). Moreover, the nanoagents triggered cascade catalytic reactions to alleviate hypoxia and enhanced the chemo-radiotherapy effect. The results suggest that these nanoagents have promising potential for boosting chemo-radiotherapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Bo Wang, Jing Chen, Julia S. Caserto, Xi Wang, Minglin Ma
Summary: The study introduces a local chemo-immunometabolic therapy using a hydrogel loaded with doxorubicin and a Kyn-degrading enzyme to alleviate immunosuppression, resulting in anti-tumor responses in preclinical models.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Sajid Ali, Muhammad Umair Amin, Imran Tariq, Muhammad Farhan Sohail, Muhammad Yasir Ali, Eduard Preis, Ghazala Annbreen, Shashank Reddy Pinnapireddy, Jarnnila Jedelska, Jens Schaefer, Udo Bakowsky
Summary: The study aimed to develop an integrated system combining photodynamic and chemotherapeutic approaches for the treatment of multidrug-resistant cancers. The nanoformulations showed good biocompatibility and cytotoxicity against cancer cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Oncology
Jiayu Zhao, Mei Li, Jiao Xu, Wei Cheng
Summary: Ion channels play a crucial role in regulating ion balance, generating electrical and chemical signals, and their dysfunction is associated with cancer and cancer chemo-resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vruti Patel, Chitra Rajani, Vishakha Tambe, Dnyaneshwar Kalyane, Neelima Anup, Pran Kishore Deb, Kiran Kalia, Rakesh K. Tekade
Summary: This review highlights the important role and application of photothermal therapy combined chemotherapy in overcoming chemoresistance in cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Guochuang Chen, Leli Zeng, Bo Bi, Xiuyu Huang, Miaojuan Qiu, Ping Chen, Zhi-Ying Chen, Yulong He, Yihang Pan, Yu Chen, Jing Zhao
Summary: Ovarian cancer, often diagnosed at an advanced stage, is highly lethal. While BiTEs have shown promise in hematological malignancies, their efficacy in solid tumors has been limited by short half-life, intravenous infusion requirement, and toxicity. To overcome these challenges, a gene-delivery system based on alendronate calcium (CaALN) is designed to express therapeutic levels of BiTE (HER2xCD3) for effective ovarian cancer immunotherapy.
Article
Oncology
Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg, Viji Shridhar
Summary: The study demonstrates that downregulation of PLA2G3 inhibits lipid droplet biogenesis, reduces cell growth, and increases sensitivity to platinum drugs in ovarian cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Engineering, Biomedical
Shingo Semba, Nobuto Kitamura, Masumi Tsuda, Keiko Goto, Sadamu Kurono, Yoshihiro Ohmiya, Takayuki Kurokawa, Jian Ping Gong, Kazunori Yasuda, Shinya Tanaka
Summary: Through gene expression profiling and proteomic analysis, we found that the treated PAMPS gel adsorbed various proteins secreted from ATDC5 cells, with THBS playing a significant role in the induction of chondrogenic differentiation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Letter
Cardiac & Cardiovascular Systems
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Daisuke Hotta, Shinya Tanaka, Toshihisa Anzai
KARDIOLOGIA POLSKA
(2021)
Article
Engineering, Biomedical
Takayuki Nonoyama, Lei Wang, Masumi Tsuda, Yuki Suzuki, Ryuji Kiyama, Kazunori Yasuda, Shinya Tanaka, Kousuke Nagata, Ryosuke Fujita, Naoya Sakamoto, Noriyuki Kawasaki, Hisayoshi Yurimoto, Jian Ping Gong
Summary: The tough double network (DN) hydrogels have successfully bonded to defected bones of rabbits in vivo, thanks to the low crystalline hydroxyapatite (HAp) of calcium-phosphate-hydroxide salt coated on the surface layer inducing spontaneous osteogenesis. Analyzing the dynamic osteogenesis process at the gel/bone interface reveals that synthetic HAp can be reutilized for bone formation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Clinical Neurology
Ran Tomomasa, Yasuhito Arai, Reika Kawabata-Iwakawa, Kohei Fukuoka, Yoshiko Nakano, Natsuko Hama, Satoshi Nakata, Nozomi Suzuki, Yukitomo Ishi, Shinya Tanaka, Jun A. Takahashi, Yoshiaki Yuba, Mitsutaka Shiota, Atsushi Natsume, Michihiro Kurimoto, Yoshiki Shiba, Mikiko Aoki, Kazuki Nabeshima, Toshiyuki Enomoto, Tooru Inoue, Junya Fujimura, Akihide Kondo, Takashi Yao, Naoki Okura, Takanori Hirose, Atsushi Sasaki, Masahiko Nishiyama, Koichi Ichimura, Tatsuhiro Shibata, Junko Hirato, Hideaki Yokoo, Sumihito Nobusawa
Summary: ELTMDs are high-grade tumors with mesenchymal differentiation, harboring fusion genes involving C11orf95. Although they show genetic and morphological associations with supratentorial ependymomas, they cannot be classified as ependymomas. Further analysis of more cases is needed to clarify their characteristics.
Article
Pathology
Yukitomo Ishi, Ai Shimizu, Emi Takakuwa, Minako Sugiyama, Michinari Okamoto, Hiroaki Motegi, Shinsuke Hirabayashi, Yuko Cho, Akihiro Iguchi, Atsushi Manabe, Sumihito Nobusawa, Shinya Tanaka, Shigeru Yamaguchi
Summary: A 5-year-old girl presented with headache and vomiting, and was found to have a right frontal lobe tumor with marked calcification. Surgical resection was performed successfully, and pathological examination confirmed a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration. Negative staining for specific markers was observed during immunohistochemistry.
PATHOLOGY INTERNATIONAL
(2021)
Article
Biology
Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Summary: The study revealed the downregulation of a cardiac-specific mitochondrial component in aged mice, leading to heart failure. Mice with cardiac-specific deletion of CISD1 showed cardiac dysfunction after 12 months and developed HF after 16 months. These findings suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Masaaki Nagano, Shinji Kohsaka, Takuo Hayashi, Toshihide Ueno, Shinya Kojima, Aya Shinozaki-Ushiku, Shigeki Morita, Masumi Tsuda, Shinya Tanaka, Toshiya Shinohara, Yuko Omori, Fumiko Sugaya, Hiroaki Kato, Yoshiaki Narita, Jun Nakajima, Kenji Suzuki, Kazuya Takamochi, Hiroyuki Mano
Summary: Information on the molecular features of PPC remains limited. Next-generation sequencing was used to determine genomic and transcriptomic profiles, revealing differences among patients and potential treatment options targeting driver mutations and immune checkpoint inhibitors.
NPJ PRECISION ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Rigel Suzuki, Daichi Yamasoba, Izumi Kimura, Lei Wang, Mai Kishimoto, Jumpei Ito, Yuhei Morioka, Naganori Nao, Hesham Nasser, Keiya Uriu, Yusuke Kosugi, Masumi Tsuda, Yasuko Orba, Michihito Sasaki, Ryo Shimizu, Ryoko Kawabata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Hirofumi Sawa, Terumasa Ikeda, Takashi Irie, Keita Matsuno, Shinya Tanaka, Takasuke Fukuhara, Kei Sato
Summary: The Omicron variant of SARS-CoV-2 has spread rapidly in several countries and has shown lower fusogenicity and attenuated pathogenicity compared to the Delta variant.
Article
Multidisciplinary Sciences
Akatsuki Saito, Takashi Irie, Rigel Suzuki, Tadashi Maemura, Hesham Nasser, Keiya Uriu, Yusuke Kosugi, Kotaro Shirakawa, Kenji Sadamasu, Izumi Kimura, Jumpei Ito, Jiaqi Wu, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Samantha Loeber, Masumi Tsuda, Lei Wang, Seiya Ozono, Erika P. Butlertanaka, Yuri L. Tanaka, Ryo Shimizu, Kenta Shimizu, Kumiko Yoshimatsu, Ryoko Kawabata, Takemasa Sakaguchi, Kenzo Tokunaga, Isao Yoshida, Hiroyuki Asakura, Mami Nagashima, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kazuhisa Yoshimura, Akifumi Takaori-Kondo, Masaki Imai, Shinya Tanaka, So Nakagawa, Terumasa Ikeda, Takasuke Fukuhara, Yoshihiro Kawaoka, Kei Sato
Summary: During the COVID-19 pandemic, the B.1.617.2/Delta variant has been found to be highly fusogenic and more pathogenic in infected hamsters compared to prototypic SARS-CoV-2. The P681R mutation in the spike protein of this variant enhances viral fusogenicity and pathogenicity.
Article
Oncology
Akira Hirota, Jean-Emmanuel Clement, Satoshi Tanikawa, Takayuki Nonoyama, Tamiki Komatsuzaki, Jian Ping Gong, Shinya Tanaka, Masamichi Imajo
Summary: This study revealed that activation of ERK MAP kinase signaling is a novel mechanism for retinoid resistance in breast cancer cells. It also demonstrated that suppression of RAR signaling and activation of ERK signaling are associated with specific subtypes of breast cancers and poor patient prognosis.
Article
Orthopedics
Yuki Suzuki, Eiji Kondo, Takuma Kaibara, Masatake Matsuoka, Ryosuke Hishimura, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Shinya Tanaka, Norimasa Iwasaki
Summary: This article presents a rare case of bilateral complete discoid medial menisci, a congenital anatomical variant of the knee. The effectiveness of arthroscopic partial meniscectomy with or without peripheral suture on symptomatic complete discoid medial menisci is highlighted, based on 60-month excellent clinical and functional results.
JOINT DISEASES AND RELATED SURGERY
(2023)
Meeting Abstract
Oncology
Michio Tani, Masumi Tsuda, Jun Suzuka, Lei Wang, Akinobu Taketomi, Shinya Tanaka
Meeting Abstract
Oncology
Masumi Tsuda, Jun Suzuka, Lei Wang, Shinji Kohsaka, Hiroyuki Mano, Shinya Tanaka
Meeting Abstract
Oncology
Ayaka Hachiro, Jun Suzuka, Lei Wang, Masumi Tsuda, Shinya Tanaka
Article
Clinical Neurology
Zen-ichi Tanei, Yuko Saito, Shinji Ito, Tomoyasu Matsubara, Atsuko Motoda, Mikihiro Yamazaki, Yasuhiro Sakashita, Ito Kawakami, Masako Ikemura, Shinya Tanaka, Renpei Sengoku, Tomio Arai, Shigeo Murayama
Summary: Lewy body disease is a progressive neurodegenerative disorder with various clinical diagnoses, such as Parkinson's disease and dementia with Lewy bodies, often accompanied by non-motor symptoms like constipation. The presence of Lewy pathology in the esophagus is significantly associated with autonomic failures and correlates closely with the progression of LBD in the peripheral nervous system.
ACTA NEUROPATHOLOGICA
(2021)
