Article
Oncology
Catherine Powers-James, Aimee J. Christie, Santhosshi Narayanan, Wenli Liu, Telma Gomez, Lorenzo Cohen, Gabriel Lopez
Summary: This study examined the characteristics of referral to health psychology in the context of integrative oncology. Female, black, younger, and obese patients were more likely to be referred to health psychology. Referred patients reported worse fatigue, sleep, depression, and anxiety. The most common reasons for referral were diet/nutrition, overall health, and stress/anxiety.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Health Care Sciences & Services
Masahiro Shiihara, Toru Furukawa
Summary: Cell models play a crucial role in the research and development of cancer therapies. Recent advances in patient-derived cancer organoids have provided a valuable platform for studying cancer biology and personalized medicine, particularly in the field of pancreatobiliary cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Miriam Ratliff, Hichul Kim, Hao Qi, Minsung Kim, Bosung Ku, Daniel Dominguez Azorin, David Hausmann, Rajiv K. Khajuria, Areeba Patel, Elena Maier, Loic Cousin, Arnaud Ogier, Felix Sahm, Nima Etminan, Lukas Bunse, Frank Winkler, Victoria El-Khoury, Michael Platten, Yong-Jun Kwon
Summary: The genetic and cellular heterogeneity of glioblastoma poses challenges for effective uniform treatment, especially at recurrence. To address this, personalized strategies and stratification of potential targeted therapies within a clinically relevant timeframe are necessary. Functional profiling of drug candidates against patient-derived glioblastoma organoids (PD-GBO) holds promise in preclinically discovering effective personalized treatments. A PD-GBO-based profiling platform was established and successfully identified potential treatment options for three out of four patients in a turnaround time of 13-15 days. This approach proves to be a complement and potentially an alternative to current molecular profiling efforts, providing a clinically relevant time period for personalized treatment discovery. The use of PD-GBO platforms is also warranted for preclinical identification of new drugs against morphological glioblastoma features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Chemical
Alexandra Elena Lazar, Leonard Azamfirei
Summary: Personalized Medicine (PM) is rapidly advancing in everyday medical practice, particularly in the treatment of critically ill patients. The integration of basic research and complex mathematical models allows for the processing of biodata and the extraction of specific information for individualized treatment. However, there are challenges associated with PM in intensive care, such as economic, approval, and ethical issues.
Article
Health Care Sciences & Services
Nicolo Bizzarri, Camilla Nero, Francesca Sillano, Francesca Ciccarone, Marika D'Oria, Alfredo Cesario, Simona Maria Fragomeni, Antonia Carla Testa, Francesco Fanfani, Gabriella Ferrandina, Domenica Lorusso, Anna Fagotti, Giovanni Scambia
Summary: Gynecological cancers require complex interventions due to specific patient needs. Centralization to high-volume centers improves patients' outcomes. Advances in modern technologies have led to increased research in gynecological oncology, with a focus on personalizing therapies. Personalized care should also address each patient's unmet needs, requiring a multidisciplinary effort.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Zhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang
Summary: This research established an effective three-dimensional culture system for generating kidney cancer organoids and successfully generated 33 organoid lines from different subtypes of kidney cancer. These organoids preserved the histological architecture, mutational landscape, and transcriptional profile of the parental tumor tissues, and revealed inter- and intra-tumoral heterogeneity. Additionally, the organoids can be used for drug screening and evaluating the efficacy of immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Gwendolyn Mayer, Svenja Hummel, Neele Oetjen, Nadine Gronewold, Stefan Bubolz, Kim Blankenhagel, Mathias Slawik, Rudiger Zarnekow, Thomas Hilbel, Jobst-Hendrik Schultz
Summary: The study aimed to investigate the user experience and acceptance of the self-management app Self-administered Psycho Therapy SystemS among patients with depression and healthy adults. Results showed that patients with depression accepted the app more and gave higher ratings in quality compared to healthy adults.
Review
Oncology
Yuenan Wang, Ye Li, Zonghai Sheng, Weiwei Deng, Hongyan Yuan, Shubin Wang, Yajie Liu
Summary: Patient-derived organoids (PDO) technology provides more relevant cancer models for developing and optimizing therapeutic strategies, especially in combining radiotherapy with other treatments and studying radiation dose escalation. This review introduces the recent advances in PDO technology and personalized radiotherapy, and examines its applications in radiation therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Timothee Olivier, Vinay Prasad
Summary: The article highlights the potential risks of molecular test-based strategies in cancer treatment, including overtreatment and undertreatment. It emphasizes the importance of testing novel strategies in addition to standard of care and focusing on settings with widespread agreement. It also reminds healthcare professionals to be aware of scientific pitfalls when considering running trials or implementing new strategies.
Review
Oncology
Dominika Skwierawska, Jose Antonio Lopez-Valverde, Marcin Balcerzyk, Antonio Leal
Summary: Boron Neutron Capture Therapy (BNCT) is a promising targeted radiation treatment that provides precise and personalized therapy for cancer. However, there are still critical issues to be resolved and further research is needed. Functional imaging technologies and biological information play important roles in developing individualized treatment plans.
Article
Health Care Sciences & Services
Michael Kenn, Rudolf Karch, Dan Cacsire Castillo-Tong, Christian F. Singer, Heinz Koelbl, Wolfgang Schreiner
Summary: The presence or absence of estrogen and progesterone receptors is an important biomarker for therapy selection in breast cancer patients. Conventional immunohistochemistry measurement has errors, and there have been attempts to increase precision by incorporating gene expression information. Dempster-Shafer decision theory (DST) is a suitable approach for dealing with contradicting evidence obtained through different techniques. This study compares DST with classical statistics in the context of breast cancer patient data, aiming to demonstrate the potential applications of DST in medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Cynthia Aristei, Elisabetta Perrucci, Emanuele Ali, Fabio Marazzi, Valeria Masiello, Simonetta Saldi, Gianluca Ingrosso
Summary: Breast cancer, as the most common malignancy in women, requires personalized treatment approaches in radiation oncology. While systemic therapies based on molecular subtypes are personalized, personalized radiation therapy is still in development to better tailor treatment and improve outcomes. Efforts are being made to identify prognostic factors and biomarkers for personalized radiation therapy selection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Simona Di Giambenedetto, Alberto Borghetti, Lorena Quagliozzi, Valeria Gallucci, Francesca Lombardi, Arturo Ciccullo, Anna Fagotti, Enrica Tamburrini, Giovanni Scambia
Summary: Healthcare-associated infections (HCAIs) in gynecologic cancer patients can be effectively managed through personalized treatment and multidisciplinary antimicrobial stewardship programs. This retrospective study evaluated 27 patients and found that all patients achieved clinical cure, with low mortality rates, and outpatient antimicrobial therapy reduced hospital stays.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Agurne Sampedro, Javier Pena, Pedro Sanchez, Naroa Ibarretxe-Bilbao, Nagore Iriarte-Yoller, Cristobal Pavon, Natalia Ojeda
Summary: Cognitive remediation is an effective intervention for improving functional outcomes in schizophrenia. This study found that older age, fewer years in education, lower scores in baseline cognition and functional outcome, and more negative symptoms were associated with greater improvement in functional outcomes after cognitive remediation.
PSYCHIATRY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Kaushik Chakravarty, Victor Antontsev, Yogesh Bundey, Jyotika Varshney
Summary: The development of successful drugs is costly and time-consuming, but artificial intelligence plays a crucial role in accelerating the process by leveraging data and bridging the gap between drugs and diseases.
DRUG DISCOVERY TODAY
(2021)
Article
Biochemistry & Molecular Biology
Serena Oliveri, Clizia Cincidda, Giulia Ongaro, Ilaria Cutica, Alessandra Gorini, Francesca Spinella, Francesco Fiorentino, Marina Baldi, Gabriella Pravettoni
Summary: The study investigated long-term changes in health-related choices, individual tendencies, and risk attitudes among Italian GT users. Results showed that participants who intended to modify their behavior after learning their GT results did so over time, with a healthier diet being the most common long-term behavioral change observed. Psychological variables like risk-taking attitude and risk tolerance did not seem to affect the decision to change lifestyle. Overall, there was a reduction in anxiety and worry over health, but also a decrease in motivation for health promotion and prevention, health esteem, and positive expectations for future health.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Oncology
Giulia Corrao, Luca Bergamaschi, Mattia Zaffaroni, Iacopo Cavallo, Giulia Marvaso, Daniela Alterio, Fabrizio Mastrilli, Silvio Capizzi, Isacco Desideri, Gabriella Pravettoni, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: The study evaluated the work and psychological impact of COVID-19 on radiation therapy residents in Lombardy during the first 3 months of the outbreak. Results showed that most residents experienced increased workload and stress, with difficulties in sleep quality and concentration. Despite the availability of psychological support, none of the residents requested it. The majority of residents adapted to the new workplace scenario, highlighting some health risks and well-being challenges.
Article
Public, Environmental & Occupational Health
Davide Mazzoni, Dario Monzani, Paolo Riva, Gabriella Pravettoni
Summary: The study found that patient involvement by healthcare providers can impact patients' psychological well-being by satisfying their fundamental psychological needs, especially beneficial for those living with chronic conditions.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Dario Monzani, Luca Pancani, Patrice Rusconi, Gabriella Pravettoni
Summary: Engaging in unhealthy behaviors and not engaging in healthy ones are common, despite available information on health risks. People's perception of disease onset time is influenced by their likelihood of the disease and fear of developing it.
PSYCHOLOGICAL REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jose P. Werba, Monica G. Giroli, Niccolo Simonelli, Lorenzo Vigo, Alessandra Gorini, Alice Bonomi, Fabrizio Veglia, Elena Tremoli
Summary: This study assessed the uptake and effectiveness of a primary cardiovascular prevention program for disadvantaged and ethnic minority communities. The program achieved positive outcomes in terms of cardiovascular risk improvement, smoking cessation, and favorable changes in diet quality, anxiety, depression, and physical activity. However, increasing global uptake requires further sensitization and awareness actions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Health Care Sciences & Services
Alessandra Gorini, Federica Galli, Mattia Giuliani, Antonia Pierobon, Jose Pablo Werba, Edvige Palazzo Adriano, Daniela Trabattoni
Summary: During an acute cardiac event, Takotsubo Syndrome (TTS) and Acute Coronary Syndrome (ACS) exhibit similar clinical characteristics. This exploratory research found that post-recovery TTS patients differ from ACS patients in their level of concern about their health and their need for reassurance and information. Additionally, only TTS patients reported the presence of a significant emotional trigger preceding the acute cardiac event.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Giulia Marton, Dario Monzani, Laura Vergani, Silvia Francesca Maria Pizzoli, Gabriella Pravettoni
Summary: In this study, the psychometric characteristics of the Risk Propensity Scale (RPS) were explored for the first time in an Italian sample. The Italian version of the RPS showed high internal consistency and satisfactory convergent and discriminant validity.
PSYCHOLOGICAL REPORTS
(2023)
Article
Genetics & Heredity
Giulia Ongaro, Eleonora Brivio, Clizia Cincidda, Serena Oliveri, Francesca Spinella, Daniela Steinberger, Ilaria Cutica, Alessandra Gorini, Gabriella Pravettoni
Summary: There are differences between Italian and German genetic testing users in terms of health-related behaviors, psychological characteristics, and attitudes toward genetic information. Germans have more unhealthy behaviors but feel more confident about their physical well-being, while Italians prioritize medical control and sharing results with doctors.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Paola Gabanelli, Dario Monzani, Elena Fiabane, Erica Quaquarini, Mara Frascaroli, Emanuela Balletti, Antonio Bernardo, Cristina Maria Teragni, Federica Grossi, Gabriella Pravettoni, Alessandra Gorini
Summary: This study explored risk estimations related to COVID-19 perception and distress in oncologic outpatients undergoing active hospital treatments compared to the general population. The results showed that cancer patients have a lower risk perception and a more positive illness representation related to COVID-19 compared to control subjects. The level of distress is not associated with the clinical status, but it is moderated by illness perception.
PSYCHOLOGY & HEALTH
(2022)
Article
Environmental Sciences
Alessandra Gorini, Mattia Giuliani, Elena Fiabane, Alice Bonomi, Paola Gabanelli, Antonia Pierobon, Pasquale Moretta, Giovanna Pagliarulo, Simona Spaccavento, Gaetano Vaudo, Matteo Pirro, Massimo R. Mannarino, Laura Milani, Maria Paola Caruso, Paola Baiardi, Laura Adelaide Dalla Vecchia, Maria Teresa La Rovere, Caterina Pistarini, Damiano Baldassarre
Summary: This study analyzed the prevalence of psychological symptoms and their determinants in different categories of healthcare workers during the COVID-19 pandemic. The results showed that anxiety and depressive symptoms did not reach the pathological threshold, but post-traumatic and burnout symptoms tended toward the critical threshold, especially in physicians. Perceived stress was found to be the main determinant of psychological distress.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Alessandra Gorini, Beatrice De Maria, Patrycja Krasinska, Maurizio Bussotti, Francesca Perego, Laura Adelaide Dalla Vecchia
Summary: Little is known about physiological and psychological responses to mental stress in stable patients affected by pulmonary arterial hypertension (PAH). The current explorative controlled pilot study found that there were no significant differences in heart rate and perceived stress between PAH patients and healthy subjects during standardized mental stress testing. However, there was a significant correlation between heart rate and perceived stress.
Article
Health Care Sciences & Services
Martina Vigore, Andrea Steccanella, Marina Maffoni, Valeria Torlaschi, Alessandra Gorini, Maria Teresa La Rovere, Roberto Maestri, Maurizio Bussotti, Sergio Masnaghetti, Francesco Fanfulla, Antonia Pierobon
Summary: This study demonstrates how psychophysical symptoms may vary during different waves of the COVID-19 pandemic and emphasizes the importance of protective factors in balancing subjective distress.
Article
Psychology, Multidisciplinary
Valeria Sebri, Stefano Triberti, Gabriella Pravettoni
Summary: Previous research suggests that focusing on self-representations enhances the ability to evaluate internal sensations. This study analyzed the decision-making process under various conditions of stimulated self-representations and found that participants tended to choose losses more frequently when primed with bodily self-representations. This could be due to the distractive nature of bodily self-focus, diminishing participants' long-term outcome commitment, or the enhanced interoception leading to aversion to losses.
CURRENT PSYCHOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Lucrezia Savioni, Stefano Triberti, Ilaria Durosini, Valeria Sebri, Gabriella Pravettoni
Summary: This research found that future psychological interventions may utilize specific tools to consider patients' reasons for adhering to the interventions. Additionally, non-participation/dropout is often associated with factors related to intervention commitment and its interference with daily life. On the other hand, patients' reasons for participation are often linked to the value they find in the intervention according to their personal needs and experience of illness.
PSYCHOLOGY & HEALTH
(2022)
Article
Psychology, Multidisciplinary
S. Petrocchi, P. Iannello, G. Ongaro, A. Antonietti, G. Pravettoni
Summary: The study found that COVID-19 exposure increased anxiety and health-related information seeking, while risk aversion affected health information seeking and perceived lockdown usability, thus impacting distress levels.
CURRENT PSYCHOLOGY
(2022)
