Article
Biochemistry & Molecular Biology
Bartlomiej Piasecki, Anna Biernasiuk, Adrianna Skiba, Krystyna Skalicka-Wozniak, Agnieszka Ludwiczuk
Summary: The study conducted chemical analysis on 19 essential oils from seven different Cymbopogon species and found that they exhibit moderate to high antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), with C. flexuosus-lemongrass essential oil showing the best performance.
Article
Infectious Diseases
Amanda Mara Teles, Joao Victor Silva-Silva, Juan Matheus Pereira Fernandes, Katia da Silva Calabrese, Ana Lucia Abreu-Silva, Silvio Carvalho Marinho, Adenilde Nascimento Mouchrek, Victor Elias Mouchrek Filho, Fernando Almeida-Souza
Summary: Aniba rosaeodora essential oil and linalool showed antibacterial, antioxidant, and antitrypanosomal activities. They did not exhibit cytotoxic effects and could potentially reduce nitric oxide production in macrophages, indicating their pharmacological potential for further studies.
Article
Food Science & Technology
Maria Francesca Bozzini, Ylenia Pieracci, Roberta Ascrizzi, Basma Najar, Marco D'Antraccoli, Luca Ciampi, Lorenzo Peruzzi, Barbara Turchi, Francesca Pedonese, Alice Alleva, Guido Flamini, Filippo Fratini
Summary: This study aimed to investigate the antibacterial effectiveness and chemical composition of Salvia essential oils (EOs) on Listeria monocytogenes. The results showed that S. chamaedryoides EO exhibited the best inhibitory activity and may be used as a natural preservative in the food industry.
Article
Biochemistry & Molecular Biology
Tatiane Cristina Silva Maiolini, Welton Rosa, Daniel Oliveira Miranda, Thais A. Costa-Silva, Andre G. Tempone, Paula Carolina Pires Bueno, Danielle Ferreira Dias, Daniela Aparecida Chagas de Paula, Patricia Sartorelli, Joao Henrique G. Lago, Marisi Gomes Soares
Summary: This study extracted and evaluated the essential oils from 18 Myrtaceae species for their anti-T. cruzi activity. The results suggested that eight essential oils showed potential as sources of bioactive compounds against T. cruzi. Several active components were also identified.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Pedro Silvino Pereira, Carlos Vinicius Barros Oliveira, Ana Josicleide Maia, Maria Celeste Vega-Gomez, Miriam Rolon, Cathia Coronel, Antonia Eliene Duarte, Henrique Douglas Melo Coutinho, Abolghasem Siyadatpanah, Roghayeh Norouzi, Seyed Jafar Adnani Sadati, Polrat Wilairatana, Teresinha Goncalves Silva
Summary: This study identified the components of the essential oil of C. winterianus and tested its potential against parasitic protozoa. The essential oil showed significant cytotoxicity at high concentrations in mammalian cells and exhibited clinically relevant activities against the parasites.
Article
Entomology
Paula Tatiana Lopes Seixas, Antonio Jacinto Demuner, Luiz Claudio Almeida Barbosa, Cristiane Isaac Cerceau, Daiane Einhardt Blank, Marcelo Henrique Dos Santos, Elizeu de Sa Farias, Marcelo Coutinho Picanco
Summary: The larvicidal effect of essential oils from the leaves of three Artemisia species against A. aegypti was evaluated. The EO of Artemisia camphorata was found to be the most effective, with germacrene D-4-ol as the main active constituent. It can be promising for developing natural larvicides against A. aegypti.
JOURNAL OF APPLIED ENTOMOLOGY
(2023)
Article
Agronomy
Neha Sharma, Zahid Nabi Sheikh, Saud Alamri, Bikarma Singh, Mahipal Singh Kesawat, Sanjay Guleria
Summary: This study aimed to evaluate the chemical composition and antibacterial activity of the essential oils of Cymbopogon citratus, Cymbopogon khasianus, and Mentha arvensis. The results showed that the essential oils exhibited strong antibacterial activity, with the combination of Mentha arvensis essential oil and chloramphenicol showing the best synergistic effect against Escherichia coli.
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Gulmira Ozek, Temel Ozek, Liliya N. Kirpotina, Andrei Khlebnikov, Mark T. Quinn
Summary: Rhododendron extracts contain various compounds and essential oils from flowers and leaves have different chemical compositions, affecting intracellular Ca2+ mobilization in human neutrophils and microglial cells. The essential oils may have immunotherapeutic properties and modulate innate immune responses, possibly through inhibition of neutrophil migration.
Article
Chemistry, Applied
Diep Trinh Thi, Dung Luong Van, Trung Phung Van, Hoai Nguyen Thi, Thao Do Thi, Uyen Nguyen Thi To, Linh Tran Thi Hoai, Khai Dang Vinh, Thanh Truc Huynh, Tran Le Thi Thanh
Summary: New essential oils (EOs) extracted from different parts of two Luvunga species (L. scandens and L. hongiaoensis) from Vietnam were examined for their chemical composition, anti-inflammatory and cytotoxic activity. The EOs contained various compounds, with beta-caryophyllene being the major constituent in L. scandens, and beta-elemene and caryophyllene oxide being dominant in L. hongiaoensis. The EOs showed anti-inflammatory and cytotoxic effects against certain cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Infectious Diseases
Cecilia Baldassarri, Giulia Falappa, Eugenia Mazzara, Laura Acquaticci, Elena Ossoli, Diego Romano Perinelli, Giulia Bonacucina, Stefano Dall'Acqua, Loredana Cappellacci, Filippo Maggi, Farahnaz Ranjbarian, Anders Hofer, Riccardo Petrelli
Summary: This study investigated the susceptibility of Trypanosoma brucei to Anthriscus nemorosa essential oils and their isolated compounds, shedding light on their potential as antiparasitic agents. The research also revealed a disrupted energy metabolism in trypanosomes exposed to the essential oils, indicating the efficacy of Anthriscus nemorosa EO in developing effective antiparasitic formulations, including nanoemulsions.
Review
Plant Sciences
Mohamed El Yaagoubi, Hicham Mechqoq, Abdellah El Hamdaoui, Venugopal Jrv Mukku, Abdelhamid El Mousadik, Fouad Msanda, Noureddine El Aouad
Summary: Thymus species from Morocco are traditionally used for treating various diseases, and their essential oils have diverse biological activities such as antibacterial, antioxidant, and anti-inflammatory effects, primarily composed of monoterpenes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Alina Kluga, Margarita Terentjeva, Nenad L. Vukovic, Miroslava Kacaniova
Summary: The study revealed the antimicrobial activity of essential oils against freshwater fish pathogens, suggesting potential applications in aquaculture.
Article
Biochemistry & Molecular Biology
Oberdan Oliveira Ferreira, Silvia Helena Marques da Silva, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
Summary: The chemical compositions of essential oils from Myrcia multiflora and Eugenia florida were analyzed using gas chromatography and flame ionization detection, and their fungicidal potential against five yeast fungicide species was evaluated. Myrcia multiflora (B) essential oil showed significant inhibitory effect against the fungal species.
Article
Biochemistry & Molecular Biology
Azize Demirpolat
Summary: This study analyzed the chemical composition of essential oils of seven Polygonum species and found qualitative and quantitative differences among them. Additionally, the study revealed the essential oil components of these Polygonum species for the first time through a literature review.
Article
Plant Sciences
Milena D. D. Vukic, Nenad L. L. Vukovic, Ana D. D. Obradovic, Lucia Galovicova, Natalia Cmikova, Miroslava Kacaniova, Milos M. M. Matic
Summary: This study evaluates the chemical composition and biological properties of Tanacetum balsamita L. essential oils obtained from different plant organs. The essential oils showed better antimicrobial activity compared to commercially available antibiotics and exhibited potential antitumor effects. The oils exerted antioxidative potential and decreased migratory capacity in tested cancer cells.
Article
Chemistry, Medicinal
Gilles Degotte, Bernard Pirotte, Michel Frederich, Pierre Francotte
Summary: Malaria, caused by Plasmodium falciparum, is one of the deadliest infectious diseases globally, especially in Africa. Despite the availability of effective drugs, the number of cases has been increasing since 2015, possibly due to parasite and mosquito resistance. Therefore, there is a need to search for new alternative treatments. Polyphenols, specifically small phenolic acids, could serve as a promising starting point for developing new antimalarials.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Hafiz Abdul Khaliq, Sergio Ortiz, Mireille Alhouayek, Giulio G. Muccioli, Joelle Quetin-Leclercq
Summary: The anti-inflammatory potential of Convolvulus arvensis was evaluated and the results showed that the extracts and major constituents of the plant can significantly inhibit the expression of pro-inflammatory mediators, supporting its use in the treatment of inflammatory diseases.
Article
Plant Sciences
Ramona Paltinean, Irina Ielciu, Daniela Hanganu, Mihaela Niculae, Emoke Pall, Luc Angenot, Monique Tits, Andrei Mocan, Mihai Babota, Oleg Frumuzachi, Mircea Tamas, Gianina Crisan, Michel Frederich
Summary: This study evaluated the alkaloid content of F. schleicheri and assessed its antioxidant, anti-cholinesterase, and cytotoxic potential. The results showed that F. schleicheri has significant medicinal potential and selective cytotoxicity towards tumor cells.
Review
Pharmacology & Pharmacy
Espoir K. Kambale, Joelle Quetin-Leclercq, Patrick B. Memvanga, Ana Beloqui
Summary: Diabetes is a chronic condition with high blood glucose levels that cannot be cured. Managing diabetes involves a healthy lifestyle, exercise, and medication. Nanoparticulate delivery systems have shown promise in enhancing the effectiveness of herbal treatments for diabetes, but further clinical trials are needed.
Article
Agriculture, Dairy & Animal Science
Esaie Tchetan, Pascal Abiodoun Olounlade, Erick Virgile Bertrand Azando, Hafiz Abdul Khaliq, Sergio Ortiz, Alban Houngbeme, Georcelin Goue Alowanou, Bossima Ivan Koura, Guenole Coovi Akouedegni, Marcel Romuald Benjamin Houinato, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: In this study, the anthelmintic activity, cytotoxicity, and chemical composition of plants used in Benin to treat digestive parasitosis in small ruminants were explored. The results are important for the rational use of these plants and for the identification of new anthelmintic molecules.
Article
Biochemistry & Molecular Biology
Loic Martinet, Aymeric Naome, Lucas C. D. Rezende, Deborah Tellatin, Bernard Pignon, Jean-Denis Docquier, Filomena Sannio, Dominique Baiwir, Gabriel Mazzucchelli, Michel Frederich, Sebastien Rigali
Summary: Streptomyces lunaelactis strains isolated from moonmilk deposits exhibit significant heterogeneity in the content of biosynthetic gene clusters (BGCs) for specialized metabolite production. Specifically, the cryptic BGC 28a is carried only by a subgroup of S. lunaelactis strains and is predicted to produce nonribosomal peptide antibiotics containing piperazic acid (Piz). Through metabolomics and peptidogenomics analysis, the cyclic hexapeptide lunaemycin A, with a unique amino acid sequence, was identified as the main compound synthesized by BGC 28a. Lunaemycins demonstrated potent bactericidal activity against Gram-positive bacteria, including multi-drug resistant clinical isolates. This study highlights the importance of accurate in silico analysis in elucidating the structure and bioactivity of cryptic BGCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anais Pannequin, Joelle Quetin-Leclercq, Jean Costa, Aura Tintaru, Alain Muselli
Summary: Chromatographic and spectroscopic methods were used to investigate the volatile metabolites of the liverwort Plagiochila porelloides harvested in Corsica. Three new compounds were isolated and their structures were determined. The essential oil and extract of P. porelloides showed moderate antiprotozoal and anticancer activities.
Article
Biochemistry & Molecular Biology
Allison Ledoux, Carla Hamann, Olivier Bonnet, Kateline Jullien, Joelle Quetin-Leclercq, Alembert Tchinda, Jacqueline Smadja, Anne Gauvin-Bialecki, Erik Maquoi, Michel Frederich
Summary: Casearia coriacea Vent., a plant endemic to the Mascarene Islands, exhibited potent antiplasmodial activity through the presence of three identified compounds, caseamembrin T (1), corybulosin I (2), and isocaseamembrin E (3), with IC50 values ranging from 0.25 to 0.51 μg/mL. While these compounds also showed antileishmanial and antitrypanosomal properties, they exhibited selectivity towards the malaria parasite with selectivity indices ranging from 6 to 12 and 25 to 100, respectively. Additionally, compounds 1-3 demonstrated promising activity against pancreatic carcinoma cells (IC50 < 1 μg/mL). However, the main compound, caseamembrin T (1), displayed significant toxicity when evaluated on zebrafish embryos.
Article
Biochemistry & Molecular Biology
Esaie Tchetan, Sergio Ortiz, Pascal Abiodoun Olounlade, Kristelle Hughes, Patrick Laurent, Erick Virgile Bertrand Azando, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: By performing LC-MS/MS analysis and molecular networking, the main compounds in Terminalia leiocarpa were identified as ellagic acid and derivatives, gallic acid, astragalin, rutin, quinic acid, and fructose. Among them, ellagic acid and gallic acid showed good anthelmintic activity against C. elegans. Other unidentified compounds may also contribute to the observed activity.
Article
Biochemistry & Molecular Biology
Andrzej Bak, Jiri Kos, Gilles Degotte, Aleksandra Swietlicka, Tomas Strharsky, Dominika Pindjakova, Tomas Gonec, Adam Smolinski, Pierre Francotte, Michel Frederich, Violetta Kozik, Josef Jampilek
Summary: A series of 4-chlorocinnamanilides and 3,4-dichlorocinnamanilides were investigated for their antiplasmodial activity, and 23 compounds showed IC50 < 30 μM. The 3,4-dichlorocinnamanilides exhibited a broader range of activity compared to the 4-chlorocinnamanilides. The most effective agent was (2E)-N-[3,5-bis(trifluoromethyl)phenyl]-3-(3,4-dichlorophenyl)prop-2-en-amide with IC50 = 1.6 μM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joelle Quetin-Leclercq
Summary: Leishmaniasis, a neglected tropical disease, still infects thousands of people per year worldwide. Resistance to major treatments has become a healthcare burden, especially in low-income countries. Eugenol, a phenylpropanoid, has shown antileishmanial activity against Leishmania mexicana mexicana (Lmm), but its mechanism of action is still unclear.
Article
Biochemistry & Molecular Biology
Gilles Degotte, Michel Frederich, Pierre Francotte, Thierry Franck, Thomas Colson, Didier Serteyn, Ange Mouithys-Mickalad
Summary: Malaria, caused by a Plasmodium genus parasite, is a widespread infectious disease that poses a serious public health problem, especially in underdeveloped countries due to increased resistance to antimalarial drugs. The study aims to explore new therapeutic approaches, including the redox process in the parasite's development. Ellagic acid and its analogues, known for their antioxidant and parasite-inhibiting properties, show potential as drug candidates. However, their low oral bioavailability has led to the development of new polyphenolic compounds. The research investigates their modulatory effect on the redox activity of neutrophils and myeloperoxidase involved in malaria.
Article
Microbiology
Alexandre Le Loarer, Remy Marcellin-Gros, Laurent Dufosse, Jerome Bignon, Michel Frederich, Allison Ledoux, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Anne Gauvin-Bialecki, Mireille Fouillaud
Summary: Despite advances in medicine and technology, deadly diseases are still a threat to humanity. To find effective treatments, research is focusing on unexplored habitats with unique biodiversity, such as the marine environment. Studies have shown the potential of bioactive compounds from marine organisms in treating diseases.
Article
Biochemistry & Molecular Biology
Elise Gerometta, Gaetan Herbette, Elnur Garayev, Arnaud Marvilliers, Jean-Valere Naubron, Carole Di Giorgio, Pierre-Eric Campos, Patricia Clerc, Allison Ledoux, Michel Frederich, Beatrice Baghdikian, Isabelle Grondin, Anne Gauvin-Bialecki
Summary: A new chromanone compound (1) was isolated from the leaf extract of Calophyllum tacamahaca Willd, a medicinal plant, together with 13 known metabolites belonging to different families. The structure of compound (1) was characterized using various spectroscopic techniques. Compound (1) showed moderate cytotoxicity against HepG2 and HT29 cell lines, while compounds 7, 8, and 10-13 exhibited potent cytotoxic activity. A feature-based molecular networking approach led to the discovery of many xanthones, including analogues of the cytotoxic xanthone pyranojacareubin (10), in the leaf extract.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)