Article
Agricultural Engineering
Boworn Kunakhonnuruk, Phithak Inthima, Anupan Kongbangkerd
Summary: This study was conducted to examine the in vitro mass propagation of B. monnieri using the temporary immersion system (TIS). The results showed that TIS had significant effects on the growth and biomass accumulation of the plant compared to continuous immersion and semi-solid systems. The production of four types of bacosides in B. monnieri obtained from microcontainer cultivation was significantly higher than that in TIS, while the total yield of bacosides obtained from different culture systems showed no significant differences.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Vijayanna Tirumalapura Shalini, Sajjanar Jambappa Neelakanta, Jaideep Sitaram Sriranjini
Summary: Brahmi, or Bacopa monnieri, is a popular herb in Ayurveda used for the management of neurological psychiatric disorders with active principles belonging to alkaloids, glycosides, flavonoids, and saponins categories. Research worldwide has shown its neuroprotective potential in various disorders such as Alzheimer's disease, epilepsy, Parkinson's disease, and cerebral ischemia.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Chemistry, Medicinal
James D. Kean, Luke A. Downey, Jerome Sarris, Jordy Kaufman, Andrea Zangara, Con Stough
Summary: This study investigated the effectiveness of Bacopa monnieri extract in reducing inattention and hyperactivity in young children. The findings suggest that the extract may have cognitive, mood, and sleep benefits in children aged 6 to 14 years, although it did not improve behavioral outcomes. Further research is needed to confirm these findings.
PHYTOTHERAPY RESEARCH
(2022)
Review
Geriatrics & Gerontology
Ayush Agarwal, Biswamohan Mishra, Anu Gupta, M. Vasantha Padma Srivastava, Aneesh Basheer, Jyoti Sharma, Venugopalan Y. Y. Vishnu
Summary: This article provides a narrative review of the challenges in designing clinical trials of Bacopa monnieri (BM) in treating dementia and offers evidence-based recommendations. The trials of BM need to improve in terms of sample size estimation and assessment of effect size. Current measures for diagnosis and outcomes should adopt a more comprehensive approach, and new scales should be developed for prodromal Alzheimer's Disease (AD). Adherence to clinical trial guidelines will enhance the quality of evidence and aid in evaluating the efficacy of BM in treating AD/prodromal AD and other neurodegenerative dementias. Future studies should implement more randomized controlled trials with accurately diagnosed AD/prodromal AD patients, recommended dosages of BM, and a pre-specified study duration to achieve adequate power.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Grace M. McPhee, Luke A. Downey, Keith A. Wesnes, Con Stough
Summary: Results from a randomized controlled trial showed that older adults who consumed Bacopa monnieri (BM) had slower reaction times in an image discrimination task compared to the placebo group, while the placebo group had faster reaction times in a spatial working memory task. This suggests that BM may affect the speed-accuracy trade-off in cognitive processes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Rupa Sanyal, Saheli Nandi, Sharmila Pandey, Ujani Chatterjee, Tulika Mishra, Sutapa Datta, Dorairaj Arvind Prasanth, Uttpal Anand, Abhijit Bhagwan Mane, Nishi Kant, Niraj Kumar Jha, Saurabh Kumar Jha, Mahipal S. Shekhawat, Devendra Kumar Pandey, Abhijit Dey
Summary: Bacopa monnieri, also known as water hyssop or Brahmi, is a small herb commonly used in Ayurvedic medicine for its memory-enhancing and cognition-improving effects. Recent research has focused on the pharmacologically active compounds in this plant, such as brahmine, alkaloids, herpestine, and saponins, including bacoside A, bacoside B, and betulic acid. Studies have shown its neuroprotective and memory-supporting properties, as well as other therapeutic activities like antimicrobial and antioxidant effects. However, overexploitation and habitat destruction have put this plant at risk of extinction, necessitating conservation efforts. In vitro studies have explored methods like organogenesis and cell suspension cultures to produce and enhance bacosides, as well as genetic transformation techniques. Molecular marker-based studies have also demonstrated clonal fidelity among natural and in vitro-generated plantlets. The review highlights the recent advancements in in vitro studies of B. monnieri, including root and shoot organogenesis, callus induction, secondary metabolite production, acclimatization of plantlets, genetic transformation, and clonal fidelity.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biology
Martha Martinez-Garcia, Gloria Garduno-Solorzano, Graciliana Lopes, Begona Astrain Sanchez, Ralph Urbatzka, Guilherme Scotta Hentschke, Jorge E. Campos, Vitor Manuel Oliveira Vasconcelos
Summary: Using molecular markers, we confirmed the taxonomic status of Bacopa monnieri from Mexico and analyzed its chemical content and potential bioactivity. The results show that B. monnieri has great potential as a natural source of compounds with antioxidant, anti-inflammatory, and anti-obesity properties. This plant's raw material can be effectively used as a nutritional and medicinal supplement.
Article
Biochemistry & Molecular Biology
Tushar Dubey, Preeti Kushwaha, H. V. Thulasiram, Madhura Chandrashekar, Subashchandrabose Chinnathambi
Summary: In this study, the ethanolic extract of Bacopa monnieri was found to inhibit Tau aggregation and rescue the viability of Tau-stressed cells. Bacopa monnieri reduced Tau aggregation in vitro and decreased ROS and caspase-3 activity in cells. It acted as an antioxidant and restored Nrf2 levels, reduced phospho-Tau load, and phosphorylation of GSK-3 beta in formaldehyde-stressed cells. Furthermore, it restored the NUP358 arrangement in cells, suggesting that Bacopa monnieri could be considered a promising formulation for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Ahsas Goyal, Sainu Gopika, Abhishek Kumar, Debapriya Garabadu
Summary: Parkinson's disease is a chronic and progressive neurodegenerative disorder with limited treatment options. However, Brahmi, a herbal medicine, has been found to exert neuroprotective effects in Parkinson's disease by reducing oxidative stress and inflammation, and enhancing dopamine levels.
CURRENT DRUG TARGETS
(2022)
Review
Biotechnology & Applied Microbiology
Hosakatte Niranjana Murthy
Summary: Bacopa monnieri, a traditional Indian herb, has various medicinal functions such as memory enhancement, antidepressant, and anticonvulsant. Bacosides extracted from Bacopa monnieri are important pharmaceutical compounds, and cell and tissue cultures can be used as alternatives for their production.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Urooj Fatima, Sonam Roy, Shahnawaz Ahmad, Lamya Ahmed Al-Keridis, Nawaf Alshammari, Mohd Adnan, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Bacopa monnieri, a traditional herb in Ayurveda, has been found to have neuroprotective properties and potential effects on cognitive enhancement. Its active phytochemical constituents and molecular mechanisms have been investigated to better understand its therapeutic applications in neurological disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Mahima Sharma, Pankaj Kumar Gupta, Pankaj Gupta, Debapriya Garabadu
Summary: Bacopa monnieri, also known as Brahmi, has shown significant therapeutic activity against neuropathic pain in animal models. This study aimed to evaluate the anti-nociceptive potential of methanolic extract of Bacopa monnieri in adult zebrafish model of pain. The results demonstrated that the standardized methanolic extract of Bacopa monnieri exhibited antioxidant effects and antinociceptive activity in adult zebrafish.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Urooj Fatima, Sonam Roy, Shahnawaz Ahmad, Sabeeha Ali, Wafaa M. M. Elkady, Ilyas Khan, Rana M. Alsaffar, Mohd Adnan, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Bacopa monnieri extracts have health benefits in terms of anti-cancer and neuroprotection, making them suitable for treating neurological disorders and improving cognitive function.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Asmaa M. Zaazaa, Nadia N. Daoud, Ola A. El-Gendy, Ahmad Al-Shafei
Summary: This study suggests that Bacopa monnieri can improve reserpine-induced depression comparable to citalopram. In the experiment, the groups receiving Bacopa monnieri and citalopram showed lower immobility time compared to the group receiving only reserpine, and the levels of serotonin, dopamine, and norepinephrine were also restored.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Chemistry, Medicinal
Samarpita Banerjee, Uttpal Anand, Suchhanda Ghosh, Durga Ray, Puja Ray, Samapika Nandy, Ganpat Dewaji Deshmukh, Vijay Tripathi, Abhijit Dey
Summary: Brahmi, or Bacopa monnieri, is a widely used herb for treating neurological disorders, known for enhancing memory and containing potential bioactive compounds. This review highlights the use of Brahmi and its active principles in managing neurological disorders, while also discussing the signaling pathways modulated by these compounds. Additionally, it critically summarizes the current knowledge on this herb based on literature from various scientific sources.
PHYTOTHERAPY RESEARCH
(2021)
Review
Integrative & Complementary Medicine
Witoo Dilokthornsakul, Atcharapan Rinta, Teerapon Dhippayom, Piyameth Dilokthornsakul
Summary: Ginger can enhance human milk volume in mothers with vaginal births, but not in mothers with C-section. Combined ginger products may also improve human milk volume.
COMPLEMENTARY MEDICINE RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Jumpol Singhirunnusorn, Siwaporn Niyomsri, Piyameth Dilokthornsakul
Summary: Laparoscopic liver resection is not cost-effective in the early stage of HCC.
Review
Hematology
Teerapon Dhippayom, Kansak Boonpattharatthiti, Treeluck Thammathuros, Piyameth Dilokthornsakul, Itsarawan Sakunrag, Beth Devine
Summary: This study compared the effects of different strategies for warfarin self-care and found that patient self-care with INR measurement at least once weekly was more effective. This finding has important implications for the management of warfarin therapy.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Allergy
Teerapon Dhippayom, Apinya Wateemongkollert, Kanchana Mueangfa, Haerin Im, Piyameth Dilokthornsakul, Beth Devine
Summary: This study compares the efficacy of different strategies to support self-management in patients with asthma based on a newly developed framework. The results indicate that different features of self-management support strategies have varying effects on asthma control and the risk of hospitalization and emergency department visits.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Economics
Piyameth Dilokthornsakul, Ratree Sawangjit, Pisit Tangkijvanich, Maneerat Chayanupatkul, Tawesak Tanwandee, Wattana Sukeepaisarnjaroen, Pajaree Sriuttha, Unchalee Permsuwan
Summary: This study evaluated the cost-effectiveness of nucleos(t)ide analogues (NAs) for chronic hepatitis B (CHB) treatment in Thailand. The results showed that TAF, TDF, LAM/TAF, and LAM/TDF were dominant options, while ETV/TAF or ETV/TDF were cost-effective options.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Article
Integrative & Complementary Medicine
Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul
Summary: This study systematically reviews the mechanisms and evidence for the use of propolis and honey in COVID-19 prevention and treatment. In silico studies showed that compounds from propolis could interact with target proteins of SARS-CoV-2, interfering with viral entry and replication. Clinical studies indicated that propolis and honey could improve clinical symptoms and decrease viral clearance time. However, the limited number of studies and small sample sizes highlight the need for future clinical research.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Endocrinology & Metabolism
Arintaya Phrommintikul, Piyameth Dilokthornsakul, Unchalee Permsuwan
Summary: This study estimated the real-world financial burden of type 2 diabetes treatment, complications, and cardiovascular death. The findings indicate that diabetes and its complications incur a substantial financial burden, necessitating a multi-sectoral effort from government, providers, patients, and private sector for effective management of diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Suchiwa Pan-On, Piyameth Dilokthornsakul, Waree Tiyaboonchai
Summary: Although curcumin has health benefits, its clinical application is limited by its poor solubility and stability. Nanocarrier-based drug delivery systems (NDS) are effective in improving curcumin's physicochemical and pharmacological effects. This study reviewed evidence of lipid and polymer-based NDS for oral delivery of curcumin. Most studies found that NDS increased curcumin absorption compared to free curcumin.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Health Care Sciences & Services
Watcharaporn Taburee, Teerapon Dhippayom, Kittiphon Nagaviroj, Piyameth Dilokthornsakul
Summary: This study aimed to systematically review and quantitatively synthesize the effect of anticholinergics on death rattle (DR) treatment and prophylaxis. The results showed no strong evidence for the regular use of anticholinergics in DR treatment, but hyoscine butyl bromide appeared to have a high potential in DR prophylaxis.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sunee Lertsinudom, Somsak Tiamkao, Sineenard Mungmanitmongkol, Piyameth Dilokthornsakul
Summary: This study assessed the feasibility and impact of telepharmacy services on clinical and economic outcomes among patients with epilepsy in Thailand. The results showed that telepharmacy services improved clinical symptoms, detected drug-related problems, and effectively reduced medical costs. However, further studies are needed to assess the impacts of telepharmacy services.
Article
Health Care Sciences & Services
Piyameth Dilokthornsakul, Ratree Sawangjit, Manathip Osiri, Praveena Chiowchanwisawakit, Worawit Louthrenoo, Unchalee Permsuwan
Summary: This study aimed to assess the cost-effectiveness of biologic disease-modifying antirheumatic drugs (bDMARDs) for treating patients with psoriatic arthritis who failed conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). The results showed that secukinumab 150 mg was cost-effective in the Thai context while price negotiation was important for other bDMARDs.
VALUE IN HEALTH REGIONAL ISSUES
(2023)
Article
Pharmacology & Pharmacy
Porapong Petch-in, Surasak Saokaew, Pochamana Phisalprapa, Piyameth Dilokthornsakul
Summary: This study examined the association between pre-operative severe hypoalbuminemia and in-hospital death and length of hospital stay in patients undergoing gastrointestinal surgery. The study found that severe pre-operative hypoalbuminemia was associated with an increased risk of in-hospital mortality. The risk of death for patients with severe hypoalbuminemia was relatively similar when using different cut-offs.
DRUGS-REAL WORLD OUTCOMES
(2023)
Review
Pharmacology & Pharmacy
C. N. Scholfield, Neti Waranuch, Chuenjid Kongkaew
Summary: This systematic review aimed to evaluate the efficacy and safety of skin-applied formulations containing CBD. Eight articles were selected, including placebo-controlled trials and single-arm trials. The results showed that CBD had positive effects on dermatopathologies, pain, and behavior. However, the studies had high risk of bias and reporting deficiencies, which compromised the reliability of the data. The diversity in methodologies and formulations also hindered the synthesis of CBD dose, efficacy, and safety. Further clinical trials are needed to provide reliable and unbiased evidence on the outcomes of CBD preparations.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Meeting Abstract
Economics
S. Niyomsri, M. Nimworapan, W. Wongcharoen, P. Dilokthornsakul
Article
Psychology, Developmental
Kenneth K. C. Man, Shih-Chieh Shao, Nathorn Chaiyakunapruk, Piyameth Dilokthornsakul, Kiyoshi Kubota, Junqing Li, Nobuhiro Ooba, Nicole Pratt, Anton Pottegard, Lotte Rasmussen, Elizabeth E. Roughead, Ju-Young Shin, Chien-Chou Su, Ian C. K. Wong, Yea-Huei Kao Yang, Edward Chia-Cheng Lai
Summary: Younger patients treated with antipsychotics face an increased risk of metabolic events. This study investigated how this risk varies according to ethnicity, the class of antipsychotic, and age group, and found that the risk is similar between Asian and non-Asian populations regardless of differences in drug utilization patterns.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)