Article
Neurosciences
Hao-Lun Sun, Xiu-Qing Yao, Li Lei, Wang-Sheng Jin, Yu-Di Bai, Gui-Hua Zeng, An-Yu Shi, Jun Liang, Li Zhu, Yu-Hui Liu, Yan-Jiang Wang, Xian-Le Bu
Summary: This study found that renal failure is associated with abnormal AD biomarkers and cognitive decline, suggesting that renal function may be involved in the pathogenesis of AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Elnaz Poorgolizadeh, Farshad Homayouni Moghadam, Kianoush Dormiani, Naeimeh Rezaei, Mohammad Hossein Nasr-Esfahani
Summary: Sacubitril/valsartan is the first angiotensin receptor-neprilysin inhibitor drug approved for heart failure by the US and EU, especially recommended for hypertensive heart failure. However, it may cause memory and cognitive dysfunction, and could even exacerbate Alzheimer's disease. More studies are needed to evaluate the safety of Sacubitril/valsartan, particularly its effects on cognitive function long-term.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Zunshu Du, Yizhi Song, Xinyue Chen, Wanning Zhang, Guitao Zhang, Hui Li, Lirong Chang, Yan Wu
Summary: The study reveals that astrocytic GluN2A plays a critical role in exerting protective effects on synapses by regulating NGF against A beta synaptotoxicity, through modulating pNF-kappa B, Furin, and VAMP3 to control NGF synthesis, maturation, and secretion. This discovery may contribute to establishing new targets for Alzheimer's disease prevention and early therapy.
Article
Biochemistry & Molecular Biology
Minhui Ye, Xiaoju Lin, Qiuhong Wang, Bingyou Yang, Changfu Wang
Summary: In this study, six new compounds were isolated from a medicinal plant and investigated for their neuroprotective effects. It was found that two iridoids and three lignans could significantly maintain the viability of PC12 cells.
Review
Biochemistry & Molecular Biology
Victoria Campos-Pena, Pavel Pichardo-Rojas, Talia Sanchez-Barbosa, Emma Ortiz-Islas, Citlali Ekaterina Rodriguez-Perez, Pedro Montes, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Rafael Valencia-Quintana, Jorge Francisco Cerna-Cortes, Danira Toral-Rios
Summary: The presence of insoluble aggregates of amyloid beta (A beta) in the brain is a hallmark of Alzheimer's disease, and it has been shown to contribute to extensive neuronal loss. The distribution and content of cholesterol in the membrane play an important role in the production and accumulation of A beta peptides, leading to dysfunction and neuronal death. The monomeric forms of A beta peptides can trigger changes in Tau phosphorylation and cognitive function through their internalization by specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Haiyang Du, Xiaoyu Meng, Yu Yao, Jun Xu
Summary: GLP-1R agonists, a type of drug used to treat type 2 diabetes, have the potential to reduce inflammation and oxidative stress, provide neurotrophic effects, and decrease the progression of Alzheimer's disease. Further clinical trials are needed to validate their effectiveness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Simon W. So, Kendra M. Fleming, Joshua P. Nixon, Tammy A. Butterick
Summary: Obesity, a known risk factor for Alzheimer's disease, increases microglial activation and inflammation. In this study, we found that a high fat diet led to neuroinflammation and cognitive decline in mice. The activation of brain microglia in obesity exacerbated AD pathology and increased the accumulation of amyloid beta plaques. Our results showed that a high fat diet decreased locomotor activity and increased anxiety-like behavior and behavioral despair. It also led to memory deficits and increased microgliosis and Aβ deposition in a young adult AD mouse model.
Article
Chemistry, Medicinal
Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernan Geronimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein accumulation, oxidative stress, and neurotransmitter alterations. A comparative study of valerian extracts from endemic Argentinian species showed that V. carnosa had the most promising results against AD-related biological targets.
Article
Neurosciences
Fardin Nabizadeh, Parya Valizadeh, Mohammad Balabandian
Summary: This study found that the use of statin drugs may help slow down or stabilize Aβ deposition in subjects without cognitive impairment. However, once clinical symptoms of cognitive impairment appear, statins fail to slow down Aβ deposition. Overall, statin users may have slower Aβ aggregation compared to non-users.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Eugenie Nepovimova, Lucie Svobodova, Rafael Dolezal, Vendula Hepnarova, Lucie Junova, Daniel Jun, Jan Korabecny, Tomas Kucera, Zuzana Gazova, Katarina Motykova, Jana Kubackova, Zuzana Bednarikova, Jana Janockova, Catarina Jesus, Luisa Cortes, Joao Pina, Danijela Rostohar, Carlos Serpa, Ondrej Soukup, Laura Aitken, Rebecca E. Hughes, Kamil Musilek, Lubica Muckova, Petr Jost, Marketa Chvojkova, Karel Vales, Martin Valis, Zofia Chrienova, Katarina Chalupova, Kamil Kuca
Summary: The series of tacrine-benzothiazole hybrids show promising anti-AChE properties and capability to block Aβ aggregation, with the most potent derivative being 10w that exhibits highly selective inhibition of AChE. Moreover, 10w also demonstrates strong inhibitory effects against ABAD activity.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang, Tianhui Wang
Summary: Moderate exercise promotes the clearance of beta-amyloid and hyperphosphorylated Tau protein in AD mice by activating the PI3K/Akt signaling pathway, leading to improved cognitive ability and reduced pathological changes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Neurosciences
Leslie C. Norins
Summary: Substantial evidence supports the clinical testing of FDA-approved drugs for repurposing to treat Alzheimer's disease, including drug mechanisms of action, in vivo testing, and epidemiological data. Investigating already-approved compounds can be faster and more cost-effective than un-approved compounds in the drug pipeline. With the increasing prevalence of AD due to longer life expectancy, the lack of an effective drug for treatment is a pressing public health concern.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Food Science & Technology
Huan-Huan Zhou, Guiping Wang, Lan Luo, Wei Ding, Jia-Ying Xu, Zengli Yu, Li-Qiang Qin, Zhongxiao Wan
Summary: This study found that lactoferrin had no effects on cognitive function in Alzheimer's disease mice, but may help maintain gut microbiota homeostasis.
FOOD & NUTRITION RESEARCH
(2021)
Article
Neurosciences
Tomoko Tanaka, Shinobu Hirai, Masato Hosokawa, Takashi Saito, Hiroshi Sakuma, Takaomi Saido, Masato Hasegawa, Haruo Okado
Summary: The study found that maternal separation can induce early AD-related pathology by affecting microglial activation and the vascular system.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Azadeh Karami, Taher Darreh-Shori, Marianne Schultzberg, Maria Eriksdotter
Summary: This study investigated the soluble levels of the key cholinergic enzyme, ChAT, in both plasma and CSF of individuals at different clinical stages of dementia. The results suggest an inverse U-shape dynamic of changes in cholinergic signaling in the brain in the continuum of AD, which greatly differs from the changes observed in the plasma compartment. Further validation is needed to confirm these findings.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yan Li, Bo Zhang, Xue-Wei Liu, Ming Liu, Shu-Ming Huang
JOURNAL OF CHEMICAL NEUROANATOMY
(2016)
Article
Cell Biology
Na Wang, Yong-ming Jia, Bo Zhang, Di Xue, Maharjan Reeju, Yan Li, Shu-ming Huang, Xue-wei Liu
NEURAL REGENERATION RESEARCH
(2017)
Article
Biochemical Research Methods
Yan Li, Bo Zhang, Wei Wen, Shuang Liu, Di Hao, Ming Liu, Hai-Xue Kuang, Shu-Ming Huang
JOURNAL OF NEUROSCIENCE METHODS
(2012)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)