Article
Neurosciences
Zhimin Sun, Qiyao Li, Xiaopeng Li, Yunpeng Shi, Chengrui Nan, Qianxu Jin, Xiaoyan Wang, Yayu Zhuo, Zongmao Zhao
Summary: This study demonstrates that CK2 phosphorylates NR2B, down-regulates the expression of NR2B, and interferes with the interaction between NR2B and PSD95, thus alleviating inflammatory reactions, inhibiting neuronal apoptosis, and reducing oxidative stress after ICH. CK2 and NR2B may be new potential therapeutic targets for the treatment of ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Reng Ren, Yuanjian Fang, Prativa Sherchan, Qin Lu, Cameron Lenahan, John H. Zhang, Jianmin Zhang, Jiping Tang
Summary: The study demonstrates that kynurenine/AHR is involved in the pathological processes of mitochondria-mediated cell death and free radical accumulation after intracerebral hemorrhage. Inhibition of AHR can alleviate oxidative stress and neuronal apoptosis, providing neuroprotective effects.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Neurosciences
Fei Wang, Wu-lin Li, Li-juan Shen, Ting-ting Jiang, Jian-jun Xia, Da-li You, Shan-you Hu, Li Wang, Xiao Wu
Summary: This study investigated the protective role of crocin in brain injury caused by intracerebral hemorrhage (ICH) and identified its mechanism. The results showed that crocin can alleviate ICH-induced brain edema and neurological deficits and exert its effect by inhibiting ferroptosis.
NEUROTOXICITY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Siying Ren, Yue Chen, Likun Wang, Guofeng Wu
Summary: Intracerebral hemorrhage is a devastating form of stroke that induces cell death responsible for secondary brain injury. Iron-dependent cell death, known as ferroptosis, plays a crucial role in the occurrence and progression of intracerebral hemorrhage. Understanding and targeting the regulators and signaling pathways of ferroptosis could lead to potential treatments for intracerebral hemorrhage.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Julia Masomi-Bornwasser, Elena Kurz, Christina Frenz, Jan Schmitt, Dominik M. A. Wesp, Jochem Koenig, Johannes Lotz, Florian Ringel, Thomas Kerz, Harald Krenzlin, Naureen Keric
Summary: This study found that higher levels of SOD and GSH-Px in plasma were associated with better clinical outcomes in patients with ICH, while higher plasma TAS and CSF MDA were linked to unfavorable outcomes. Larger ICH volume was positively correlated with a worse outcome at week six.
Review
Immunology
Yan Zhang, Suliman Khan, Yang Liu, Guofeng Wu, V. Wee Yong, Mengzhou Xue
Summary: This article discusses the sources and possible molecular mechanisms of oxidative stress in causing brain injury in intracerebral hemorrhage (ICH), as well as anti-oxidative stress strategies to alleviate the devastation of ICH.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Yuan Cao, Wenbiao Xiao, Shuzhen Liu, Yi Zeng
Summary: Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with unclear underlying mechanisms. Ferroptosis, a newly identified form of cell death, has been implicated in ICH-induced neuronal death. This review summarizes the current evidence on the mechanism of ferroptosis after ICH and discusses its interaction with other forms of cell death, such as apoptosis and autophagy. The therapeutic application of targeting ferroptosis in ICH is also explored.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Zhanyi Xu, Baoshuai Zhao, Jianhui Mao, Zhaosheng Sun
Summary: This study demonstrated that downregulation of MALAT1 protected against intracerebral hemorrhage by suppressing inflammation and oxidative stress through upregulating miR-146a in rats.
Article
Behavioral Sciences
Jianjiang Wang, Jie Yin, Xi Zheng
Summary: This study investigates the effects of artemisinin (ART) on neurological recovery in a mouse model of intracerebral hemorrhage (ICH) induced by collagenase. The results show that ART can upregulate L1 expression to alleviate brain edema, reduce oxidative stress, and inhibit inflammation, thus improving the neurological outcome in mice with ICH.
BRAIN AND BEHAVIOR
(2022)
Article
Endocrinology & Metabolism
Xiong Deng, Jinmei Yang, Ruqi Qing, Heying Yuan, Pinhua Yue, Song Tian
Summary: Lovastatin plays a suppressive role in brain damage caused by intracerebral hemorrhage (ICH). It improves cognitive function, learning and memory abilities, reduces nervous system damage, and inhibits oxidative stress and inflammatory response.
METABOLIC BRAIN DISEASE
(2023)
Article
Immunology
Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li
Summary: CCR2 expression is upregulated in both mouse models and clinical patients with subarachnoid hemorrhage. Inhibition of CCR2 can alleviate neuroinflammation and neuronal apoptosis. CCR2 levels in cerebrospinal fluid are associated with a 6-month prognosis in patients.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Integrative & Complementary Medicine
Yongpan Huang, Bin He, Chong Song, Xian Long, Jianbin He, Yansong Huang, Lijing Liu
Summary: This study evaluated the protective effects of oxymatrine (OMT) in myocardial injury caused by type 2 diabetes mellitus. Diabetic rats were treated with OMT orally for 8 weeks, and the results showed that OMT alleviated myocardial injury by reducing blood glucose and oxidative stress and promoting the expression of antioxidative enzymes and the Nrf2/HO-1 pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Biology
Yan Zhang, Suliman Khan, Yang Liu, Rabeea Siddique, Ruiyi Zhang, Voon Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a devastating disease that affects approximately 2 million patients worldwide annually. This review focuses on understanding the pathological roles of gap junctions and hemichannels in secondary brain injury following ICH, with the aim of identifying effective therapeutic strategies for ICH.
Review
Biochemistry & Molecular Biology
Yingyi Zheng, Ruoqi Li, Xiang Fan
Summary: This review explores the potential of natural products therapy to target oxidative stress (OS) in intracerebral hemorrhage (ICH). Numerous studies have demonstrated the potent antioxidant properties of natural products, including polyphenols, phenolic compounds, terpenoids, alkaloids, etc. These natural products offer the possibility of treatment of OS after ICH, but further research is needed for their wider application in the clinic.
Article
Cell Biology
Bing Li, Yan Zhang, Haiying Li, Haitao Shen, Yang Wang, Xiang Li, Gang Cui, Gang Chen
Summary: The study demonstrated that upregulation of Miro1 significantly alleviated secondary brain injury (SBI) induced by intracerebral hemorrhage (ICH) in vivo and in vitro, by improving neuronal damage through facilitation of mitochondrial transport and distribution.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Microbiology
Saif Ullah, Kai Ji, Jun Li, Yongchang Xu, Chengjian Jiang, Huimin Zhang, Man Huang, Youjun Feng
Summary: MCR-4 and MCR-8 are new members of the ongoing MCR family of colistin resistance, while NMCR-2 is identified as a possible progenitor of MCR-8 with similar actions and mechanisms.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Neurosciences
Juan Chen, Xiao-Lin Ma, Hui Zhao, Xiao-Yu Wang, Min-Xin Xu, Hua Wang, Tian-Qi Yang, Cheng Peng, Shuang-Shuang Liu, Man Huang, Yu-Dong Zhou, Yi Shen
Summary: Autism spectrum disorder (ASD) is characterized by impaired social communication and rigid behaviors, and abnormal synapse development and E/I imbalance may contribute to its pathogenesis. Astrocytes play a crucial role in synaptic formation and function, and targeting altered GABAergic neurotransmission represents a promising therapeutic strategy for ASD.
Article
Infectious Diseases
Kang Chang, Haibo Wang, Jianping Zhao, Xianghong Yang, Bo Wu, Wenkui S. Sun, Man Huang, Zhenshun Cheng, Hong Chen, Yuanlin Song, Ping Chen, Xiangqi Chen, Xin Gan, Wanli Ma, Lihua Xing, Yimin Wang, Bin Cao
Summary: This study found that the loading dose of polymyxin B and the combined use of multiple nephrotoxic drugs are independent risk factors for polymyxin B-associated acute kidney injury (AKI). Additionally, the estimated glomerular filtration rate has a protective effect on the occurrence of AKI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Jin Zhao, ShuGao Ye, Feng Liu, Man Huang, Yongshan Xu, Yuan Chen, JingYu Chen
Summary: This study reviewed 4 cases of heterotopic lung transplant (HLTx) and found that it can be a feasible alternative to conventional lung transplant in emergency cases, with good outcomes observed in the short and long term.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Infectious Diseases
Qiqiang Liang, Qinyu Zhao, Xin Xu, Yu Zhou, Man Huang
Summary: In this study, a prediction model for carbapenem-resistant Gram-negative bacteria (CR-GNB) carriage was constructed, which can predict the incidence of CR-GNB within a week. The results showed that machine learning models performed well in terms of accuracy and the area under the receiver operating characteristic curve, and can help medical staff identify high-risk groups more accurately in real-time.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Juan Chen, Qiqiang Liang, Xinyi Chen, Jing Wu, Yanchao Wu, Gaoqin Teng, Man Huang
Summary: This study compared the effectiveness of CAZ/AVI and polymyxin B in treating CRPA infection and analyzed the predictors of 30-day mortality or survival. The results showed that CAZ/AVI therapy was superior to polymyxin B therapy in terms of 14-day and 30-day mortality, in-hospital mortality, and bacterial clearance rate. Multivariate analysis also identified age, CAZ/AVI therapy, and central venous catheterization as independent predictors of 30-day mortality or survival.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Cell Biology
Yun Ge, Man Huang, Yong-ming Yao
Summary: This article summarizes recent research advances on efferocytosis and discusses its relationship with immune cell populations, as well as its role in resolving inflammatory response and modulating immune balance. Efferocytosis is considered a potential therapeutic target for various inflammatory diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Qiwei Chen, Lizhang Liu, Xiaofang Hu, Xu Jia, Xiaowei Gong, Youjun Feng, Man Huang
Summary: The study focuses on the diversity of KPC-2-producing plasmids in highly transmissible ST11 clones of carbapenem-resistant K. pneumoniae (CRKP). The researchers report a clinical case of a rare ST437 CRKP isolate, K186, which produces KPC-2. Whole-genome sequencing revealed three distinct resistance plasmids, one of which, pK186_KPC, is a small IncN-type plasmid of 26,012bp. The study further suggests that the carbapenem-resistant pK186_KPC might have arisen from the integration of ancestral IncN and IncFII plasmids.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cardiac & Cardiovascular Systems
Zhenjie Liu, Jinyi Chen, Xin Xu, Fen Lan, Minzhi He, Changming Shao, Yongshan Xu, Pan Han, Yibing Chen, Yongbin Zhu, Man Huang
Summary: This study investigated the short-term outcomes of using VA-ECMO with or without PMT to treat acute life-threatening massive or submassive PE. The results showed that an ECMO-first strategy complemented with PMT can effectively stabilize hemodynamics and improve survival rates in these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Qiqiang Liang, Juan Chen, Yongshan Xu, Yibing Chen, Man Huang
Summary: Carbapenem-resistant gram-negative bacteria (CRGNB) infections have become a global public health concern. This study identified high-risk factors for infection in CRGNB carriers, including colonization with CRKP and CRPA, immunocompromise, and prior use of carbapenems. Early use of effective antibiotics may be associated with reduced mortality in CRGNB-infected patients.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Medicine, General & Internal
Kang Chang, Haibo Wang, Jianping Zhao, Xianghong Yang, Bo Wu, Wenkui Sun, Man Huang, Zhenshun Cheng, Hong Chen, Yuanlin Song, Ping Chen, Xiangqi Chen, Xin Gan, Wanli Ma, Lihua Xing, Yimin Wang, Xiaoying Gu, Xiaohui Zou, Bin Cao
Summary: This study suggests that the appropriate polymyxin B/tigecycline combination therapy is not superior to appropriate polymyxin B therapy in terms of 28-day mortality in the treatment of hospital-acquired pneumonia caused by carbapenem-resistant organisms.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Lun Tian, Libin Zhang, Naiding Zhang, Xin Xu, Yongshan Xu, Zhenjie Liu, Man Huang
Summary: This case study examines a severe multiple trauma patient who experienced sudden massive pulmonary embolism and unstable hemodynamic status. After undergoing AngioJet catheter embolectomy and ECMO treatment, the patient's condition improved with the clearance of pulmonary embolism.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Lun Tian, Libin Zhang, Naiding Zhang, Xin Xu, Yongshan Xu, Zhenjie Liu, Man Huang
Summary: The use of perclose Proglide for total percutaneous closure of femoral arterial puncture site following VA-ECMO has become widespread due to its benefits in enhancing patient comfort and reducing complications. However, it also adds extra time to the procedure and increases the risk of infection. This study describes a modified technique for percutaneous post-closure that is simple and rapidly applied, suitable for weaning off VA-ECMO.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Yangyanqiu Wang, Yin Jin, Xiaowei Ji, Man Huang, Bo Xie
Summary: In this study, the metabolites of the most common sepsis-related pathogen were analyzed, and their correlation with clinical indicators was investigated. The results revealed that differential metabolites may be associated with sepsis.
INFECTION AND DRUG RESISTANCE
(2022)
Letter
Emergency Medicine
Man Huang, Yong-Shan Xu, Sheng Yan, Yan-Jun Shi, Sai-Bo Pan, Yi-Bing Chen, Chen-Yang Gao, Jing-Yu Chen, Wei-Lin Wang
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
