Article
Multidisciplinary Sciences
Michael Moret, Irene Pachon Angona, Leandro Cotos, Shen Yan, Kenneth Atz, Cyrill Brunner, Martin Baumgartner, Francesca Grisoni, Gisbert Schneider
Summary: Generative chemical language models (CLMs) can be used to generate new molecular structures from a textual representation. Hybrid CLMs can leverage bioactivity information for training compounds. In this study, a virtual compound library was created using a generative CLM and refined using a CLM-based classifier for bioactivity prediction. A new PI3K gamma ligand with sub-micromolar activity was identified, highlighting the potential of hybrid CLMs for molecular design.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Pierre-Alain Chaumeil, Aaron J. Mussig, Philip Hugenholtz, Donovan H. Parks
Summary: This study presents an updated version of GTDB-Tk that uses a divide-and-conquer approach to reduce memory requirements while minimizing classification impact.
Article
Multidisciplinary Sciences
Maria Dolores Ramos-Barbero, Clara Gomez-Gomez, Laura Sala-Comorera, Lorena Rodriguez-Rubio, Sara Morales-Cortes, Elena Mendoza-Barbera, Gloria Vique, Daniel Toribio-Avedillo, Anicet R. Blanch, Elisenda Balleste, Cristina Garcia-Aljaro, Maite Muniesa
Summary: In this study, 25 new crAss-like phages (termed crAssBcn) infecting Bacteroides intestinalis were isolated and genetically characterized, showing their wide distribution in fecal samples from people around the globe.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Breno Martins de Deus, Conceicao Fernandes, Adriana K. Molina, Virginie Xavier, Tania C. S. P. Pires, Filipa Mandim, Sandrina A. Heleno, Tiane C. Finimundy, Lillian Barros
Summary: Consumer demand for natural and healthier products has increased interest in the bioactive and therapeutic properties of plant extracts. This study evaluates the phenolic compounds profile, bioactivities, and toxicities of plant extracts from eight European flora species. The results suggest that these extracts have potential as natural preservatives due to their richness in bioactive compounds.
Article
Chemistry, Analytical
Zhanpeng Shang, Yungang Tian, Yang Yi, Kai Li, Xue Qiao, Min Ye
Summary: This study compared the biological activities and chemical components of different parts of Glycyrrhiza uralensis, a popular medicinal plant. The results showed distinct biological activities and identified 1301 compounds. Further analysis of differential chemicals can promote the utilization of medicinal resources from G. uralensis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Microbiology
Yin-Feng Wang, Si-Ren Hu, Li Fu, Yan Xiao, Xin-Ke Tang, Jian Gao
Summary: In this study, a novel species of actinobacterium was isolated and characterized from healthy leaves of Xanthium sibiricum in China. Based on various characteristics and gene analysis, it was named Streptomyces spinosirectus sp. nov. This finding is of great significance for the study of Streptomyces species.
CURRENT MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xu Hong, Jinfang Zheng, Juan Xie, Xiaoxue Tong, Xudong Liu, Qi Song, Sen Liu, Shiyong Liu
Summary: The three-dimensional structure of RNA is important in its recognition with RNA-binding proteins. RR3DD is an RNA classification database based on RNA fold and global 3D structural similarity, containing a large number of RNA chains classified and clustered. Through structural alignment, some unannotated RNAs can be annotated in RR3DD.
Article
Multidisciplinary Sciences
Judit Sonkoly, Edina Toth, Nora Balogh, Lajos Balogh, Denes Bartha, Kinga Csendesne Bata, Zoltan Batori, Nora Bekefi, Zoltan Botta-Dukat, Janos Boloni, Aniko Csecserits, Janos Csiky, Peter Csontos, Istvan Dancza, Balazs Deak, Zoltan Konstantin Dobolyi, Anna E-Vojtko, Ferenc Gyulai, Alida Anna Habenczyus, Tamas Henn, Ferenc Horvath, Maria Hohn, Gusztav Jakab, Andras Kelemen, Gergely Kiraly, Szabolcs Kis, Gergely Kovacsics-Vari, Andras Kun, Eva Lehoczky, Attila Lengyel, Barbara Lhotsky, Viktor Loki, Balazs Andras Lukacs, Gabor Matus, Andrea McIntosh-Buday, Attila Mesterhazy, Tamas Miglecz, V. Attila Molnar, Zsolt Molnar, Tamas Morschhauser, Laszlo Papp, Patricia Posa, Tamas Redei, David Schmidt, Ferenc Szmorad, Attila Takacs, Julia Tamas, Viktor Tiborcz, Csaba Tolgyesi, Katalin Toth, Bela Tothmeresz, Orsolya Valko, Viktor Virok, Tamas Wirth, Peter Torok
Summary: The existing plant trait databases have limited applicability for studying the flora and vegetation of Eastern and Central Europe due to their limited geographical data coverage and incorporation of records from regions with different climatic conditions. To address this issue, PADAPT, a regional dataset of plant traits for the Pannonian region, has been compiled, providing data on 54 traits and attributes of plant species in the region.
Review
Biochemistry & Molecular Biology
Sweta Bhambhani, Kirtikumar R. Kondhare, Ashok P. Giri
Summary: Alkaloids, a class of plant specialized metabolites with diverse biological activities, have been utilized in traditional and modern healthcare systems for the treatment of various ailments. Research on alkaloids is crucial for enhancing biological properties and productivity, with alternative methods like heterologous and homologous systems being explored. Chemical modifications during alkaloidal conversions play a key role in conferring biological activities, with potential commercial applications in the marketplace.
Review
Biochemistry & Molecular Biology
Maria Celeste Dias, Diana C. G. A. Pinto, Artur M. S. Silva
Summary: Flavonoids are natural antioxidants synthesized in plants, playing a crucial role in plant stress tolerance and human health with anti-inflammatory and antimicrobial properties. They also have various applications in the food industry, cosmetics, and pharmaceuticals. Developing extraction methods for flavonoids with high purity and yield is essential for their industrial use.
Article
Ecology
Vitalii Zemlianskii, Ksenia Ermokhina, Gabriela Schaepman-Strub, Nadezhda Matveyeva, Elena Troeva, Igor Lavrinenko, Mikhail Telyatnikov, Igor Pospelov, Natalia Koroleva, Nadezhda Leonova, Olga Khitun, Donald Walker, Amy Breen, Nikita Kadetov, Olga Lavrinenko, Tatiana Ivleva, Sergey Kholod, Nataliia Petrzhik, Yakov Gunin, Maria Kurysheva, Anna Lapina, Denis Korolev, Ekaterina Kudr, Elena Plekhanova
Summary: The goal of the Russian Arctic Vegetation Archive (AVA-RU) is to unify and harmonize data of plot-based plant species and their abundance, vegetation structure, and environmental variables from the Russian Arctic. This database can be used to assess the status of the Russian Arctic vegetation and document biodiversity changes in the future. It can also support scientific studies and inform nature protection and restoration efforts.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Article
Chemistry, Multidisciplinary
Srijit Seal, Hongbin Yang, Maria-Anna Trapotsi, Satvik Singh, Jordi Carreras-Puigvert, Ola Spjuth, Andreas Bender
Summary: In this study, similarity-based merger models were developed to combine outputs of individual models trained on cell morphology and chemical structure, as well as the structural and morphological similarities of compounds in the test dataset. Logistic regression models were used to apply these similarity-based merger models on predictions and similarities from 177 assays, achieving better performance compared to using structural or cell painting models alone. These results demonstrate that similarity-based merger models combining structure and cell morphology can accurately predict a wide range of biological assay outcomes and expand the applicability domain.
JOURNAL OF CHEMINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Cretin, Tatiana Galochkina, Yann Vander Meersche, Alexandre G. de Brevern, Guillaume Postic, Jean-Christophe Gelly
Summary: Understanding the functions and origins of proteins requires dissecting them into independent fragments, with structural domains being the typical level of analysis. SWORD2 is a web server that helps to explore protein structures by decomposing them into hierarchical protein units. It provides relevant substructures and can be useful for both biologists and bioinformaticians studying proteins.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Agronomy
Abdulrhman Almadiy, Gomah Nenaah
Summary: Essential oils and terpenes extracted from Juniperus procera and Thymus vulgaris have shown promising insecticidal activity against khapra beetle, especially Thymus vulgaris oil. Further research is needed to confirm their safety for use as grain protectants.
Article
Biochemistry & Molecular Biology
Fotis A. Baltoumas, Evangelos Karatzas, Sirui Liu, Sergey Ovchinnikov, Yorgos Sofianatos, I-Min Chen, Nikos C. Kyrpides, Georgios A. Pavlopoulos
Summary: NMPFamsDB is a database of metagenome- and metatranscriptome-derived protein families that do not have hits to proteins of reference genomes or Pfam domains. It provides useful information such as sequence alignments, taxonomic information, structure predictions, and 3D structure models, and significantly expands the understanding of known protein sequence clusters.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Geriatrics & Gerontology
Anton De Spiegeleer, Jordi Van Migerode, Antoon Bronselaer, Evelien Wynendaele, Milan Peelman, Filip Vandaele, Geert Byttebier, Guy De Tre, Luc Belmans, Christophe Van de Wiele, Mike Sathekge, Diemer Van Dijck, Bo Saxberg, Myriam Alexander, David Fedson, Dirk Elewaut, Nele Van den Noortgate, Bart De Spiegeleer
Summary: This study suggests that the use of statins in nursing home residents can reduce all-cause mortality, indicating the potential geroprotector effect of statins in this population. More research is needed to further investigate this effect.
Article
Chemistry, Analytical
Frederick Verbeke, Kevin Van der Borght, Anton De Spiegeleer, Nathan Debunne, Yorick Janssens, Evelien Wynendaele, Bart De Spiegeleer
Summary: A method for detecting Streptococcal competence stimulating quorum sensing peptides in human saliva at the nanomolar level was developed using an anti-adsorption diluent. The study found that a small number of saliva samples contained these peptides, indicating the production of quorum sensing peptides by Streptococcus species in the human oral cavity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Sultan Suleman, Sileshi Belew, Dereje Kebebe, Markos Duguma, Henok Teshome, Gemmechu Hasen, Evelien Wynendaele, Luc Duchateau, Bart De Spiegeleer
Summary: Quality-by-design (QbD) is a systematic approach based on science and quality risk management to design and develop products/services. It has been widely applied in the pharmaceutical industry but not well established in facilities like quality control laboratories. This study introduces the concept of laboratory QbD (lQbD) using the example of a water purification system in a drug quality laboratory. The established water purification system's capability was evaluated through routine monitoring of quality parameters and the quality of different grade water used in the laboratory.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Remote Sensing
Amna Qayyum, Bernard De Baets, Laure De Cock, Frank Witlox, Guy De Tre, Nico Van de Weghe
Summary: This paper explores the micro-scale traffic interactions at intersections and presents a novel approach to detect and represent the micro-scale traffic movement interactions at a non-signalized T-junction. The study shows that this approach allows for more detailed tracking of vehicle movements and plays an important role in traffic safety assessment.
GEO-SPATIAL INFORMATION SCIENCE
(2023)
Article
Biology
Evelien Wynendaele, Nathan Debunne, Yorick Janssens, Anton De Spiegeleer, Frederick Verbeke, Liesa Tack, Sophie Van Welden, Evy Goossens, Daniel Knappe, Ralf Hoffmann, Christophe Van De Wiele, Debby Laukens, Peter Van Eenoo, Lars Vereecke, Filip Van Immerseel, Olivier De Wever, Bart De Spiegeleer
Summary: This study identifies quorum sensing peptides as potential regulators of host-microbe interactions and demonstrates that a metabolite of an EntF peptide promotes colorectal cancer metastasis in vivo. These findings provide a starting point for further investigation into the role of the microbiome in colorectal cancer metastasis and the development of novel biotherapeutics in other disease areas.
Article
Computer Science, Artificial Intelligence
Antoon Bronselaer, Toon Boeckling, Filip Pattyn
Summary: This paper explores a dynamic setting for improving data quality, using association analysis and set cover method for discovering and fixing violations. Empirical results show that repeated search and repair can enhance recall while mitigating the drop in precision.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Computer Science, Information Systems
Yoram Timmerman, Antoon Bronselaer
Summary: This study proposes a new automated procedure for monitoring online news accuracy by observing changes made to online articles and detecting errors that are corrected. Classification models are built to detect objective, subjective, and linguistic errors in online news updates. The models are evaluated using a large dataset collected from six Flemish online newspapers. Results show that different learning algorithms and language models have slight performance differences, with F2-scores of 0.45, 0.25, and 0.80 obtained for objective, subjective, and linguistic error classification respectively.
INFORMATION PROCESSING & MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
Anton De Spiegeleer, Amelie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin van der Borght, Hannah Hirmz, Nele van den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele
Summary: This study discovered the potential of quorum-sensing peptides to modulate the immune system in microbiome-host interactions. Through screening 89 peptides, four of them were found to activate immune cells in vitro, and one of them was detected in human plasma. These findings are biologically significant and reveal the immunomodulatory potential of quorum-sensing peptides.
Article
Chemistry, Analytical
Iro Konstantina Ventouri, Wayne Chang, Florian Meier, Roland Drexel, Govert W. Somsen, Peter J. Schoenmakers, Bart de Spiegeleer, Rob Haselberg, Alina Astefanei
Summary: We developed an online analytical platform combining asymmetrical flow field-flow fractionation (AF4) with native mass spectrometry (nMS) for studying labile higher-order structures (HOS) of protein biotherapeutics. The platform also utilizes UV absorbance, multi-angle light scattering (MALS), and differential refractive-index (UV-MALS-dRI) detectors. We studied the stability and dissociation pathways of the tetrameric biotherapeutic enzyme L-asparaginase (ASNase) and found the presence of intact octamers and degradation products using AF4-MALS/nMS. Exposure of ASNase to high pH disrupted the equilibrium between non-covalent species and led to HOS dissociation. The developed platform provides valuable insights for aggregation and stability studies of protein biopharmaceuticals.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Amelie Descamps, Kevin Van der Borght, Anton De Spiegeleer, Evelien Wynendaelea, Bart De Spiegeleer
Summary: To improve the translation of peptidomic research, it is crucial to detect peptides at low levels in biofluids. This study investigates often neglected parts of the analytical process and proposes novel approaches for sample collection, preparation, chromatography, and MS detection. The recommendations provided will enhance the reliability of peptidomics bio-analytics.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Hannah Hirmz, Frederick Verbeke, Bartosz Wielgomas, Christophe Furman, Emmanuelle Lipka, Bart De Spiegeleer, Evelien Wynendaele
Summary: Green chemistry initially focused on organic synthetic approaches, and now green analytics is also seeking ways to reduce volumes, cost, and ecotoxicity of analytically used chemicals and lower energy usage. The current emphasis is on techniques like miniaturization, on-line spectroscopy, and chemicals used in the analytical process. However, little attention has been given to the production and use of analytical reagents in greening analytics.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Communication
Yoram Timmerman, Sarah Van Leuven, Antoon Bronselaer
Summary: Online news updates are commonly applied across news outlets and topics. Approximately 35% of articles are updated at least once, with an average of 1.94 updates per updated article. Around 4.2% of textual changes are made to correct errors, typically without any communication with the readers. Hence, transparency regarding news updates should be enhanced.
JOURNALISM PRACTICE
(2023)
Article
Computer Science, Artificial Intelligence
Antoon Bronselaer, Maribel Acosta
Summary: Data integration is the process of consolidating information from multiple sources, and in this work, the problem is treated as a data cleaning problem. The methodology uses edit rules and a partial key to model consistency within and between sources. By adapting the set cover method, an efficient algorithm is developed to find minimal-cost repairs, which provide solutions for the initial data fusion problem. The implemented repair engine, Parker, is significantly faster and produces repairs with comparable or better quality than existing tools.
INFORMATION FUSION
(2023)
Article
Computer Science, Information Systems
Toon Boeckling, Guy De Tre, Antoon Bronselaer
Summary: This paper proposes and studies a type of tuple-level constraint called selection rules, explores their concepts and properties, and investigates rule implication with selection rules. Compared to HoloClean, repair strategies with selection rules show better performance and accuracy in terms of error detection and correction.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)