Article
Behavioral Sciences
Paloma Molina Hernandes, Matheus Fitipaldi Batistela, Heloisa Helena Vilela-Costa, Ana Beatriz Sant 'Ana, Vinicius Dias Kumpel, Mariane Cariati Tirapelle, Ariela de Oliveira Pedro Bom, Telma Goncalves Carneiro Spera de Andrade, Helio Zangrossi Jr
Summary: Changes in 5-HT1A receptor-mediated neurotransmission in the hippocampus are associated with anxiety, depression, and the action of antidepressant drugs. Studies have shown that 5-HT1ARs in the ventral pole play a tonic inhibitory role in anxiety processing, while not being involved in regulating panic-related escape behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
William H. Powell, Lucy E. Annett, Ronan Depoortere, Adrian Newman-Tancredi, Mahmoud M. Iravani
Summary: Anxiety is a common neuropsychiatric disorder with abnormalities in serotonergic function playing a role in its pathogenesis. NLX-112, a highly selective 5-HT1A receptor full agonist, has been shown to alleviate anxiety-like behaviors in mice, potentially possessing anxiolytic properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara A. Bricker, Chandrashekhar Voshavar, Edem K. Onyameh, Uma M. Gonela, Xinsong Lin, Tracy L. Swanson, Laura B. Kozell, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: In this study, we synthesized and separated the enantiomers of SYA0340, identified their absolute configurations, and evaluated their binding affinities and functional characteristics at the 5-HT1A and 5-HT7A receptors. The results showed that both enantiomers have similar agonist properties at the 5-HT1A receptor and antagonist properties at the 5-HT7A receptor, with SYA0340-P1 displaying higher potency as a 5-HT1A receptor antagonist. Therefore, SYA0340-P1 is considered the eutomer and these enantiomers may serve as new pharmacological probes for the 5-HT1A and 5-HT7A receptors.
Article
Neurosciences
Esther Silk, Mustansir Diwan, Thallita Rabelo, Hailey Katzman, Ana Carolina P. Campos, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Hamani
Summary: The results of the study suggest that chronic DBS in rodents can alleviate feeding delay and immobility in stressed mice. Although no significant changes were observed, there was an increased expression of 5-HT1B receptors in some brain regions and a reduction in the raphe nucleus in the animals treated with DBS. Additionally, the behavioral effects of DBS were mitigated by using the 5-HT1B antagonist GR-127935.
PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong
Summary: This study found that activation of AMPA receptors in the lateral habenula can reduce anxiety-like behaviors and increase dopamine and serotonin levels in the basolateral amygdala. Conversely, blocking AMPA receptors in the LHb may induce anxiety-like effects and decrease dopamine and serotonin levels in the BLA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study examined whether the prosocial effects induced by MDMA are mediated by 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA). The results showed that selective inhibition of 5-HT transporters before MDMA administration did not suppress the prosocial effects. However, the 5-HT1A receptor antagonist WAY100635 significantly suppressed the prosocial effects of MDMA. Furthermore, local administration of WAY100635 into the BLA, but not the mPFC, suppressed the MDMA-induced prosocial effects. These findings suggest that MDMA induces prosocial effects through the stimulation of 5-HT1A receptors in the BLA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Matthieu Colom, Benjamin Vidal, Sylvain Fieux, Jerome Redoute, Nicolas Costes, Franck Lavenne, Ines Merida, Zacharie Irace, Thibaud Iecker, Caroline Bouillot, Thierry Billard, Adrian Newman-Tancredi, Luc Zimmer
Summary: The study evaluated the sensitivity of the radiopharmaceutical [F-18]F13640 to endogenous serotonin release, demonstrating its effectiveness in measuring neurotransmitter fluctuations but highlighting the importance of longer PET scans for accurate displacement measurements.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Keren Nitzan, Dekel David, Motty Franko, Roni Toledano, Sharon Fidelman, Yaarit Simchon Tenenbaum, Maya Blonder, Shir Armoza-Eilat, Alon Shamir, Moshe Rehavi, Yair Ben-chaim, Ravid Doron
Summary: Depression and anxiety disorders are common, and traditional Chinese medicine can be a safe and effective alternative to conventional drugs. Shan Zha, a herb that is sold as a nutritional supplement, has been found to have similar anxiolytic and antidepressant effects as conventional drugs by activating 5-HT1A receptors and increasing BDNF levels. Its transition to clinical trials may be easier due to its availability as a nutritional supplement.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Hu-Jiang Shi, Dan-Lian Wu, Rong Chen, Na Li, Li-Juan Zhu
Summary: The study found that fluoxetine modifies mood behaviors and hippocampal neuroplasticity by disrupting the nNOS-CAPON interaction, which is associated with postsynaptic 5-HT1AR activation.
Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chen Li, Fantao Meng, Jacob C. Garza, Jing Liu, Yun Lei, Sergei A. Kirov, Ming Guo, Xin-Yun Lu
Summary: The adipokine adiponectin is found to act on 5-HT neurons through AdipoR1 receptors to regulate depression-related behaviors in a sex-dependent manner, possibly by influencing 5-HT synthesis and reuptake.
MOLECULAR PSYCHIATRY
(2021)
Article
Developmental Biology
Delaney R. Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H. Roossien
Summary: Serotonin receptor 5-HT1A plays an important role in regulating the axon outgrowth and branching of serotonergic neurons.
DEVELOPMENTAL NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chayma El Khamlichi, Flora Reverchon, Nadege Hervouet-Coste, Elodie Robin, Nicolas Chopin, Emmanuel Deau, Fahima Madouri, Cyril Guimpied, Cyril Colas, Arnaud Menuet, Asuka Inoue, Andrzej J. Bojarski, Gerald Guillaumet, Franck Suzenet, Eric Reiter, Severine Morisset-Lopez
Summary: This study demonstrates that Serodolin is a unique agonist/antagonist that modulates the biological functions of GPCRs through specific signaling pathways. Additionally, Serodolin has a significant analgesic effect on pain sensation and acts specifically through 5-HT7R. This research provides new insights into the molecular mechanism of 5-HT7R and the modulation of pain response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Yu Ohmura, Iku Tsutsui-Kimura, Hitomi Sasamori, Mao Nebuka, Naoya Nishitani, Kenji F. Tanaka, Akihiro Yamanaka, Mitsuhiro Yoshioka
Article
Behavioral Sciences
Mao Nebuka, Yu Ohmura, Shuntaro Izawa, Youcef Bouchekioua, Naoya Nishitani, Takayuki Yoshida, Mitsuhiro Yoshioka
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Urology & Nephrology
Hiroki Chiba, Takeya Kitta, Yu Ohmura, Madoka Higuchi, Masafumi Kon, Michiko Nakamura, Mitsuhiro Yoshioka, Nobuo Shinohara
INTERNATIONAL JOURNAL OF UROLOGY
(2020)
Article
Pathology
Utano Tomaru, Tomoki Ito, Yu Ohmura, Kei Higashikawa, Syota Miyajima, Ruka Tomatsu, Tsunehito Higashi, Akihiro Ishizu, Yuji Kuge, Mitsuhiro Yoshioka, Masanori Kasahara
Summary: Proteasomal dysfunction in mice leads to memory impairment, neuronal loss, accumulation of phosphorylated tau, and activation of ER stress-related apoptosis pathways. The decline in proteasomal function with aging may be involved in the development and progression of AD in elderly patients.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai
Article
Biology
Lucas R. Glover, Kerry M. McFadden, Max Bjorni, Sawyer R. Smith, Natalie G. Rovero, Sarvar Oreizi-Esfahani, Takayuki Yoshida, Abagail F. Postle, Mio Nonaka, Lindsay R. Halladay, Andrew Holmes
Article
Biochemistry & Molecular Biology
Yu Ohmura, Kentaro Iwami, Srikanta Chowdhury, Hitomi Sasamori, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Akihiro Yamanaka, Mitsuhiro Yoshioka
Summary: The article explores the strategy changes in decision making under different environmental conditions and the role of the central serotonergic system in model-based decision making. Through manipulation of serotonin neurons, it is demonstrated that their impact on model-based decision making has been confirmed.
Article
Biochemistry & Molecular Biology
Naoya Nishitani, Yu Ohmura, Keita Kobayashi, Taichi Murashita, Takayuki Yoshida, Mitsuhiro Yoshioka
Summary: Chronic smokers may experience nicotine withdrawal symptoms during tobacco cessation, leading to a risk of smoking relapse. Studies have shown that the central serotonergic system plays a crucial role in regulating nicotine withdrawal symptoms, with specific serotonergic raphe nuclei being important for these symptoms' modulation. Optogenetic manipulation of serotonergic neurons in the median raphe nucleus (MRN) was found to mimic nicotine withdrawal symptoms, while activation of these neurons could potentially serve as a therapeutic strategy for preventing these manifestations.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Psychiatry
Youcef Bouchekioua, Mao Nebuka, Hitomi Sasamori, Naoya Nishitani, Chiaki Sugiura, Masaaki Sato, Mitsuhiro Yoshioka, Yu Ohmura
Summary: This study highlights the significant role of 5-HT2C receptors in conditioned fear responses and emphasizes caution in assessing molecular targets and candidate therapies for trauma- and stress-related disorders.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Morioka
Summary: Clinical evidence suggests that cognitive impairment is a common comorbidity of chronic pain such as neuropathic pain, but the mechanism behind this impairment remains unclear. This study investigated the role of the proinflammatory molecule HMGB1 and microglial activation in cognitive impairment in mice with neuropathic pain. The findings suggest that blocking HMGB1 or microglial activation could be a novel approach to reducing cognitive impairment associated with neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Summary: This study examined the role of dopamine D-5 receptors in impulse control and found that they are not necessary for impulse control. The results highlight the importance of time series analysis and detailed analysis of the learning process in understanding the behavioral functions of D-5 receptors.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Katsuhiro Aikawa, Takayuki Yoshida, Yu Ohmura, Kerise Lyttle, Mitsuhiro Yoshioka, Yuji Morimoto
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)