Article
Plant Sciences
Majid Rasool Kamli, Abeer Abdullah M. Sharaf, Jamal S. M. Sabir, Irfan A. Rather
Summary: The ethyl-acetate extract showed the strongest inhibitory effect against AChE and had the highest antioxidant potential. It also contained the highest total phenolic content, suggesting it may serve as a potential pharmacological lead for treating cognitive disorders.
Article
Anatomy & Morphology
Hector De La Luz Torres, Paola Rojas Perez, Adriana Berenice Silva Gomez
Summary: Olfactory bulbectomy (OBX) is an experimental strategy widely used to study depression. This study investigated the effect of neonatal OBX on learning and memory, as well as dendritic spine density in the dorsal hippocampus, in male and female rats. Results showed that male rats with OBX exhibited more pronounced spatial learning deficit, while female rats showed a significant decrease in basilar dendritic spine density. These findings suggest sexual dimorphism in the effect of OBX on the dorsal hippocampus and its relation to spatial learning and memory processes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biotechnology & Applied Microbiology
Meryem Topal, Ilhami Gulcin
Summary: This study evaluated and compared the antidiabetic, anticholinergic, and antioxidant abilities of rosmarinic acid with standards. The results showed that rosmarinic acid exhibited strong antioxidant activity and inhibition towards acetylcholinesterase and alpha-glycosidase enzymes.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Samia Khnissi, Giovanni Bomboi, Ikram Khemiri, Imen Ben Salem, Maria Dattena, Salma Sai, Souha Ben Mustapha, Andrea Cabiddu, Narjess Lassoued
Summary: The supplementation of wormwood and rosemary in the diet of Barbarine rams positively affects reproductive traits such as body weight, scrotal circumference, sperm concentration, and sperm motility. It also leads to a decrease in blood glucose and insulin levels and an increase in plasma cortisol concentration. Therefore, the addition of wormwood and rosemary can enhance the reproductive function of rams.
FOOD SCIENCE & NUTRITION
(2023)
Article
Endocrinology & Metabolism
Shaymaa Rezk, Samah Lashen, Mohamed EL-Adl, Gehad E. Elshopakey, Mona M. Elghareeb, Basma M. Hendam, Thomas Caceci, Carlo Cenciarelli, Hany E. Marei
Summary: Rosemary oil can enhance cognitive function in rat models of cognitive deficit after transplantation of human olfactory bulb neuronal stem cells (hOBNSCs). Pre-administration of rosemary oil before cell transplantation can further improve multiple biochemical indicators and neuroprotective effects. This study reveals the potential application of rosemary oil in the field of neurosciences.
METABOLIC BRAIN DISEASE
(2022)
Article
Behavioral Sciences
M. B. Yossen, M. Buteler, M. Lozada
Summary: The use of odours during carrion exploitation by V. germanica wasps depends on whether they are locating or relocating the resource. Experienced wasps are influenced by olfactory stimuli when food is moved from the learnt location, but ignore odours when returning to the foraging site. This suggests a cue hierarchy where local landmarks are more reliable for relocating carrion.
Article
Mathematics, Applied
Ji Quan, Xu Dong, Xianjia Wang
Summary: This study examines the impact of conformity behavior on social learning and cooperation. Through simulation experiments, it is found that cooperation can be constantly induced when there is rational conformity behavior in social learning. The study also reveals that independent strategies among agents promote reciprocity among cooperative groups, an extended imitation range helps distinguish cooperative groups, and an appropriate payoff threshold facilitates a more reasonable distribution of payoffs and strategies.
APPLIED MATHEMATICS AND COMPUTATION
(2022)
Review
Biochemistry & Molecular Biology
Seyyed Mohammad Amin Alemohammad, Seyed Mohammad Reza Noori, Ehsan Samarbafzadeh, Seyyed Mohammad Ali Noori
Summary: This paper discusses the influence of gut microbiota and nutrition on spatial memory and learning. Research has shown that diet and changes in gut microbiota can affect cognitive abilities, such as high-fat diet and reduction of Akkermansia muciniphila leading to impaired spatial learning and memory.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Psychology, Multidisciplinary
Yingying Yang, Sonia Conde Santiago, Daria Lasc, Arielle Hershkovich, Lauren Grove
Summary: This study developed a questionnaire to assess children's everyday spatial behaviors and found that these behaviors were associated with broader child development outcomes and individual differences. The results showed that everyday spatial behaviors were positively correlated with age and predicted sense of direction, even after controlling for age and parent reports. This questionnaire can be a valuable tool to promote interest in and competence in spatial skills in everyday settings and support STEM learning.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Behavioral Sciences
Thomas Doublet, Mona Nosrati, Clifford G. Kentros
Summary: Interactions between conspecifics are crucial for memory formation, and observational learning can help rodents acquire tasks. Rats can learn the location of a hidden reward by observing a conspecific, without physically exploring the environment.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Computer Science, Information Systems
Shuxiang Fa, Xiaohui Yang, Shiyuan Han, Zhiquan Feng, Yuehui Chen
Summary: With the development of deep learning, fatigue detection technology for drivers has made remarkable progress. The proposed lightweight MS-STAGCN effectively utilizes skeleton data to identify driver states, achieving good performance even for lightweight design. The method achieves an accuracy of 92.4% on the NTHU-DDD dataset, showing potential for real-world fatigue detection tasks.
JOURNAL OF VISUAL COMMUNICATION AND IMAGE REPRESENTATION
(2023)
Article
Computer Science, Artificial Intelligence
Rui Liu, Zhi-An Huang, Yao Hu, Zexuan Zhu, Ka-Chun Wong, Kay Chen Tan
Summary: In this study, a spatial-temporal co-attention learning (STCAL) model is proposed for diagnosing autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) from functional magnetic resonance imaging (fMRI) data. The model achieves competitive accuracies on the ABIDE I, ABIDE II, and ADHD-200 datasets, and the potential for feature pruning based on the co-attention scores is validated. The clinical interpretation analysis of STCAL allows medical professionals to focus on discriminative regions of interest and key time frames from fMRI data.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Automation & Control Systems
Yu Xie, Guanjun Liu, MengChu Zhou, Lifei Wei, Honghao Zhu, Rigui Zhou, Lei Cao
Summary: In this study, a spatial-temporal gated network (STGN) is proposed to automatically learn new transactional representations for credit card fraud detection. The model outperforms existing methods and advances the field of CCFD. Features integrating the behavioral characteristics of fraudsters and considering the time and location intervals of historical transactions are found to enhance the model's ability to identify frauds.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Liming Gu, Yanlin Zhou, Gefei Wang, Huixiong Deng, Xinli Song, Xuanting He, Tingting Wang, Xiaoxuan Chen, Jianping Dai, Rui Li
Summary: This study examined the long-term effects of non-neurotropic influenza virus infection on mice, with results showing that emotional and spatial memory abilities were impacted during the recovery period.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Cesar Hernandez-Reyes, Shunsuke Shigaki, Mayu Yamada, Takeshi Kondo, Daisuke Kurabayashi
Summary: This study investigates the olfactory search behavior of male silk moths in a virtual reality environment using inverse reinforcement learning. The results suggest that inverse reinforcement learning can effectively learn adaptive olfactory search strategies in different environments.
IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS
(2022)
Review
Neurosciences
Luana M. Manosso, Anderson Camargo, Alcir L. Dafre, Ana Lucia S. Rodrigues
Summary: Vitamin E has been found to play a role in the prevention and/or treatment of major depressive disorder (MDD) by modulating oxidative stress and neuroinflammation. This narrative review presents evidence from clinical and preclinical studies showing the relationship between low vitamin E status and MDD symptoms. More research is needed to determine the efficacy of vitamin E for alleviating depressive symptoms.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Neurosciences
Morgana Moretti, Ana Lucia S. Rodrigues
Summary: Ascorbic acid is a crucial neuroprotective compound that can prevent and treat neurodegenerative diseases and psychiatric disorders, with mechanisms involving neurogenesis and synaptic plasticity.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Angela Patricia Franca, Marissa Giovanna Schamne, Bruna Soares de Souza, Thiago Correa, Jose E. Da Silva-Santos, Geison Souza Izidio, Rui Daniel Prediger
Summary: The study provides evidence that agmatine treatment can improve olfactory and cognitive impairments observed in an animal model of ADHD, particularly in olfactory discrimination, object recognition, and social recognition memory tasks. Additionally, agmatine enhances cognitive flexibility in SHR in the water maze test.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ana Belen Ramos-Hryb, Francis L. Pazini, Ana Paula Costa, Mauricio P. Cunha, Manuella P. Kaster, Ana Lucia S. Rodrigues
Summary: The study discovered the crucial role of HO-1 in mediating the antidepressant-like effects of UA, and revealed a synergistic antidepressant effect when UA was combined with CoPP. Interestingly, fluoxetine did not show a significant correlation with the activity of HO-1.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Correction
Neurosciences
D. Rial, F. S. Duarte, J. C. Xikota, A. E. Schmitz, A. L. Dafre, C. P. Figueiredo, R. Walz, R. D. S. Prediger
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Review
Biochemistry & Molecular Biology
Anna L. M. Parsons, Eboni M. V. Bucknor, Enrico Castroflorio, Tania R. Soares, Peter L. Oliver, Daniel Rial
Summary: One of the most important characteristics of the brain is its high metabolic demand, resulting in the generation of reactive oxygen species (ROS) that can cause oxidative stress (OS). OS is associated with many neurological disorders, including epilepsy. Neuroinflammation and excessive production of ROS are likely key features of seizure initiation and propagation. This review explores the role of OS in epilepsy, its connection to neuroinflammation, and its impact on synaptic function. It also discusses the latest advances in anti-epileptic drugs (AEDs) and their interaction with OS.
Article
Clinical Neurology
Anderson Camargo, Ana Paula Dalmagro, Eslen Delanogare, Daiane B. Fraga, Ingrid A. Wolin, Ana Lucia B. Zeni, Patricia S. Brocardo, Ana Lucia S. Rodrigues
Summary: The mTORC1 signaling pathway plays a key role in the antidepressant effects of ketamine and guanosine combination therapy, promoting fast and sustained antidepressant responses and dendritic spine formation.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Vivian B. Neis, Isabel Werle, Morgana Moretti, Priscila B. Rosa, Anderson Camargo, Yasmim de O. Dalsenter, Nicolle Platt, Axel F. Rosado, William D. Engel, Gudrian Ricardo L. de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lucia S. Rodrigues
Summary: Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. However, this study found that cholecalciferol has an antidepressant-like effect in female mice and may exert its effects through modulation of the serotonergic system.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Clinical Neurology
German Josuet Lapo-Talledo, Jorge Andres Talledo-Delgado, Diego Portalanza, Ana Lucia S. Rodrigues, Aline Siteneski
Summary: Suicide rates and choice of suicide method have increased in Ecuador after natural disasters such as earthquakes and the COVID-19 confinement. Hanging accounted for the majority of suicide cases in the country. The province most severely affected by the 2016 earthquake saw an increased suicide rate.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Bruna R. Kouba, Ana Clara N. C. Torra, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Vitamin D-3 has shown antidepressant-like responses in mice, possibly through increasing BDNF levels and synaptic protein synthesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Clinical Neurology
Gudrian R. L. de Almeida, Jozimar C. Szczepanik, Ingrid Selhorst, Mauricio P. Cunha, Alcir L. Dafre
Summary: This article presents the activity and role of methylglyoxal (MGO) in the central nervous system, as well as the relationship between MGO metabolism and pain, psychiatric, and cognitive-related diseases. Through reviewing preclinical studies and the impact on neurotransmitter systems, the article explores the modulating effects of MGO on behavior and diseases.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Ana P. Dalmagro, Glorister A. Alte, Ana Lucia B. Zeni, Carla I. Tasca, Ana Lucia S. Rodrigues
Summary: This study investigated the antidepressant-like and neuroprotective effects of guanosine and ketamine in mice and found that both substances showed protective effects against glutamate-induced damage. The combination of guanosine and ketamine exhibited enhanced antidepressant-like effects and increased glutamine synthetase activity and GLT-1 levels. The findings suggest that guanosine has potential as a treatment for depression and should be further studied.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Endocrinology & Metabolism
Bruna R. Kouba, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Alzheimer's disease is primarily caused by neuroinflammation, as evidenced by the co-localization of amyloid-beta plaques with activated glial cells and increased levels of inflammatory cytokines. Current pharmacological treatments are challenging, hence compounds with anti-inflammatory and antioxidant properties are being explored as potential therapies. Vitamin D, due to its neuroprotective effects and high prevalence of deficiency, has emerged as a promising candidate. This review highlights the antioxidant and anti-inflammatory properties of vitamin D, and its potential effects on the neuroinflammatory process in Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)