Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Jianyuan Fu, Zhong-teng Lu, Guang Wu, Zhe-cheng Yang, Xiaoqi Wu, Dan Wang, Zuo-ming Nie, Qing Sheng
Summary: Based on the experiments, it was found that Gas-miR2-3p from Gastrodia elata can attenuate neuroinflammation by regulating inflammatory factors and suppressing the activation of the NF-kappa B signaling pathway. This suggests that G. elata miRNAs have a modulatory role in neuroinflammation across different species.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ping Sun, Weiling Li, Jiazheng Guo, Qian Peng, Xiansheng Ye, Song Hu, Yuchen Liu, Wei Liu, Haifeng Chen, Jialu Qiao, Binlian Sun
Summary: In this study, we identified Ergosterol as an effective anti-neuroinflammatory agent that inhibits the NF-kappa B pathway induced by LPS in microglia cells. We found that Ergosterol can significantly decrease the pro-inflammatory cytokines induced by LPS, possibly by inhibiting the NF-kappa B, AKT, and MAPK signaling pathways. Moreover, Ergosterol treatment in mice reduced microglial activation and pro-inflammatory cytokine levels, and restored synaptic protein expression, thereby reducing neuron damage.
Article
Engineering, Chemical
Ji-Woong Park, Woong Kim, Chul Yung Choi, Seok-Jun Kim
Summary: The study found that RLE effectively suppressed the inflammatory response induced by LPS in BV-2 cells, suggesting its potential use as a preventive agent against diseases triggered by microglial inflammatory responses.
Article
Neurosciences
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Oyinkansola D. Adegbola, Alaa A. Al-Hindawi
Summary: The study found that the spike protein S1 of SARS-CoV-2 can induce neuroinflammation in BV-2 microglia through activation of NF-kappa B and p38 MAPK. These findings contribute to our understanding of the mechanisms underlying CNS pathologies of SARS-CoV-2.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Plant Sciences
Han Zhu, Gaorui Wang, Yuyan Bai, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: Bear bile powder (BBP) has been used to treat neuroinflammation, and its mechanism of action may involve the TGR5/AKT/NF-κB signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Ao Guo, Jingfan Li, Lan Luo, Chunyi Chen, Qing Lu, Jianjuan Ke, Xiaobo Feng
Summary: This study shows that VPA alleviates neuropathic pain by suppressing proinflammatory cytokines, promoting M2 microglial polarization, reducing spinal cell apoptosis, and regulating the STAT1/NF-kappa B and JAK2/STAT3 signaling pathways to modulate microglial function and suppress spinal neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Summary: The study found that hydroxychloroquine (HCQ) can improve neurological recovery in mice post-TBI by inhibiting the inflammatory response through the TLR4/NF-kappa B signaling pathway. HCQ reduces the expression of proinflammatory cytokines, attenuates blood-brain barrier (BBB) disruption and brain edema, and upregulates tight junction expression. This suggests that HCQ could be a potential therapeutic agent for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Chen Sun, Yuqing Shen, Piaopiao Liu, Yi Shen, Yue Hu, Ping Li, Ying Zhang, Fengqin Miao, Jianqiong Zhang
Summary: NLRC5 plays a critical role in microglial activation and is associated with LPS or CUMS-induced depressive mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ting Li, Yun Xin Zhai, Tianyi Zheng, Bing Xu
Summary: In this study, neferine was found to suppress the activation of microglia and attenuate neuroinflammation, providing potential therapeutic options for Parkinson's disease.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Chemistry, Medicinal
Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang
Summary: This study investigates the potential therapeutic use of stigmasterol for treating neuropathic pain. It finds that stigmasterol can regulate microglial M1/M2 polarization to alleviate neuropathic pain. The research demonstrates the modulatory effects of stigmasterol on pain-related markers and inflammatory factors in animal and cell experiments.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Taisuke Murata, Sho Ishiwa, Xin Lin, Yosuke Nakazawa, Kenji Tago, Megumi Funakoshi-Tago
Summary: Nobiletin, a flavonoid found in shikuwasa, has been shown to have anti-inflammatory effects by inhibiting the production of inflammatory substances and reducing neuroinflammation in mice. These findings suggest that nobiletin could be a potential drug for preventing neuroinflammation.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Alejandro Villarreal, Camila Vidos, Matias Monteverde Busso, Maria Belen Cieri, Alberto Javier Ramos
Summary: The study reveals that microglial cells play a crucial role in initiating the pathological conversion of astrocytes, leading to chromatin remodeling. These findings provide new insights for studying and modifying the pathological remodeling of astrocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Young-Jin Jang, Adithan Aravinthan, Mohammad Amjad Hossain, Spandana Rajendra Kopalli, Bumseok Kim, Nam Soo Kim, Chang-Won Kang, Jong-Hoon Kim
Summary: The study suggests that Korean Red Ginseng may help normalize cardiac gene expressions in diabetic mice, alleviate cardiovascular dysfunction by regulating the expression of associated genes.
JOURNAL OF GINSENG RESEARCH
(2021)
Review
Medicine, Research & Experimental
Md. Ezazul Haque, Md. Jakaria, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi
Summary: GCN5 is a highly studied histone acetyltransferase that plays essential roles in epigenetic regulation and chromatin modification. It is involved in diverse biological processes such as gene regulation, cellular proliferation, metabolism, and inflammation, and its dysregulation has been linked to various disorders. Understanding the role of GCN5 in disease progression and developing novel therapeutic agents targeting GCN5 are important areas of research.
Review
Cell Biology
Shofiul Azam, Md. Ezazul Haque, In-Su Kim, Dong-Kug Choi
Summary: Microglia are important brain macrophages involved in brain development, homeostasis, and repair. Dysregulation of their functions can lead to the development and exacerbation of neurodegenerative diseases.
Review
Pharmacology & Pharmacy
Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, In-Su Kim, Yuxi Lin, Young-Ho Lee, Dong-Kug Choi
Summary: In Parkinson's disease, the aggregated alpha-synuclein in Lewy bodies and mitochondrial dysfunction play crucial roles in neurodegeneration, with interactions between aggregated alpha-synuclein and mitochondria potentially leading to neuronal loss, making it an emerging drug target for Parkinson's disease treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Summary: The study found that Cordycepin from Cordyceps militaris has protective effects against ageing and oxidative stress-induced male infertility.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Agronomy
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Summary: This study investigated the beneficial effects of cordycepin on aging-associated testicular inflammation and serum biochemical changes in naturally aged rats. The results showed that cordycepin treatment significantly improved the altered biochemical parameters and attenuated the increased expression of inflammatory mediators in aged rats.
Review
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Duk-Yeon Cho, In-Su Kim, Sang-Ho Seol, Dong-Kug Choi
Summary: Neurological disorders are an important global health issue, and there is a lack of effective treatment options. Alpha- and beta-asarone, secondary metabolites found in plants, show potential neuroprotective effects. They act through multiple mechanisms, including antioxidant, anti-inflammatory, and antiapoptotic effects, making them a promising therapeutic approach for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Ju-Young Park, In-Su Kim, Dong-Kug Choi
Summary: Piperine (PIP) has shown potential therapeutic effects in various diseases, including inflammation, cardiac and hepatic diseases, neurodegenerative diseases, and cancer. Although PIP has poor pharmacokinetic properties, its interaction with metabolic enzymes and the Monoamine oxide B (MAO-B) active site make it a xenobiotics bioenhancer and a potential MAO-B inhibitor. Advancements in pharmaceutical technology have improved PIP's limitations. However, the structure activity relationship (SAR) study suggests that some of PIP's metabolites may be toxic or have pharmacological potential.
Article
Biochemistry & Molecular Biology
Spandana Rajendra Kopalli, Sung-Kwang Yoo, Bokyung Kim, Si-Kwan Kim, Sushruta Koppula
Summary: This study demonstrated that apigenin isolated from Carduus crispus can protect the testes from oxidative damage. Apigenin can inhibit H2O2-induced cellular damage and increase ROS levels, and it can also restore the expression levels of antioxidants and spermatogenesis-associated molecules.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Md. Ezazul Haque, Duk-Yeon Cho, Joon-Soo Kim, Md. Jakaria, In-Su Kim, Dong-Kug Choi
Summary: Dioscin treatment can protect neuronal cells by inducing autophagy and suppressing the mitochondrial apoptosis pathway, reducing apoptosis and autophagic flux impairment caused by MPP+.
Review
Biochemistry & Molecular Biology
Shofiul Azam, Md. Jakaria, JoonSoo Kim, Jaeyong Ahn, In-Su Kim, Dong-Kug Choi
Summary: Metabotropic glutamate receptors (mGluRs), especially mGluR5, play important roles in neurodegenerative diseases and neuropsychiatric disorders. Recent research suggests that mGluR5 radioligands could be used to assess disease progression and track drug properties.
Review
Biochemistry & Molecular Biology
Spandana Rajendra Kopalli, Venkata Prakash Annamneedi, Sushruta Koppula
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by dysregulation of cytokines and other immune mediators. The JAK/STAT pathway plays a crucial role in AD pathogenesis, and its dysregulation can lead to inflammation and pruritus. SOCS proteins negatively regulate the immune-related inflammatory responses mediated by the JAK/STAT pathway. Natural product-derived biomolecules targeting JAK/STAT/SOCS signaling have shown potential in treating AD and other inflammatory disorders.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi
Summary: The study shows that Dioscorea nipponica Makino ethanol extract and its active compound dioscin can protect against neurotoxicity by inhibiting NF-kappa B phosphorylation and upregulating neurotrophic factor BDNF expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Dominic J. Acri, Yanwen You, Mason D. Tate, Hande Karahan, Pablo Martinez, Brianne Mccord, A. Daniel Sharify, Sutha John, Byungwook Kim, Luke C. Dabin, Stephanie Philtjens, H. R. Sagara Wijeratne, Tyler J. Mccray, Daniel C. Smith, Stephanie J. Bissel, Bruce T. Lamb, Cristian A. Lasagna-Reeves, Jungsu Kim
Summary: Previous research has shown that genetic heterogeneity plays a crucial role in modeling amyloid accumulation and other phenotypes seen in Alzheimer's disease. However, the mechanisms behind the impact of genetic background on the pathogenicity of tau aggregates remain unknown. This study induced tau aggregation in mice with different genetic backgrounds and conducted RNA sequencing to identify key genes associated with tau seeding and amyloid response. The findings suggest that the genetic context of mice affects the alteration of transcriptome and tau seeding, providing valuable resources for better modeling tauopathy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Monu Kumar Kashyap, Shubhada V. Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B. Kale, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Cardiotoxicity is a well-known adverse effect of cancer-related therapy, and it significantly affects patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) can result in cardiac complications. The mechanisms underlying cardiotoxicity associated with CRC treatment are complex and involve the modulation of various signaling pathways, ultimately damaging cardiac tissue. Therefore, the identification and management of cardiotoxicity associated with CRC drug therapy have become increasingly important.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)