Article
Chemistry, Multidisciplinary
Alvaro Martinez-Camarena, Marian Merino, Ana Virginia Sanchez-Sanchez, Salvador Blasco, Jose M. Llinares, Jose L. Mullor, Enrique Garcia-Espana
Summary: A novel amino-nanozyme based on boehmite nanoparticles has been designed to address important issues in Huntington disease. The amino-nanozyme exhibits SOD activity, mitoROS scavenging properties, and the ability to disaggregate mutant huntingtin deposits in cells.
CHEMICAL COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Karen A. Sap, Karlijne W. Geijtenbeek, Sabine Schipper-Krom, Arzu Tugce Guler, Eric A. Reits
Summary: Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene, resulting in the accumulation and toxicity of mutant HTT (mHTT) protein. The ubiquitin-proteasome system (UPS) is involved in clearing mHTT proteins, but the polyQ expansion in mHTT affects its interaction with ubiquitinating enzymes and targeting for degradation. Various ubiquitin-modifying enzymes have been identified that can improve mHTT turnover and overall homeostasis, providing potential targets for therapeutic intervention in HD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Weijian Tan, Qinhua Zheng, Kexin Feng, Xiaolin Feng, Wenting Zhong, Caiyu Liao, Shangjian Li, Yuntong Liu, Wenzhong Hu
Summary: Oxidative stress plays a role in aging and neurodegenerative disorders, and foods containing phenolic compounds may have preventive effects against Alzheimer's disease. Gastrodia elata, a traditional Chinese medicinal and food plant, has shown potential for the prevention and treatment of Alzheimer's disease. The study suggests that Gastrodia elata polyphenols have neuroprotective benefits that can prevent or treat Alzheimer's disease and could be used as a reference for the development of functional foods or drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agronomy
Xingwei Duan, Lixia Li, Yuhao Lin, Fujie Zhang, Shanshan Li, Yuxin Liao
Summary: This paper proposes an I-YOLOX object detection algorithm based on deep learning and computer vision to improve the efficiency and accuracy of identifying the grade of Gastrodia elata in the market. The improved model outperforms other target detection algorithms in terms of mean average precision, model size, computation amount, and frames per second, providing a theoretical basis for the development of online identification systems of different grades of Gastrodia elata in practical production.
Article
Clinical Neurology
Carolina Bianchi, Beatriz Alvarez-Castelao, Alvaro Sebastian-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Diaz-Hernandez
Summary: Recent evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation and UPS dysfunction in tauopathies, including Alzheimer's disease (AD). This study investigates the impact of ATP, a danger-associated molecule pattern (DAMP) associated with neuroinflammation, on AD-associated UPS dysfunction.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Agronomy
Cheng Li, Manman Zhang, Jinshao Li, Mingjin Huang, Xianqiang Shao, Zaifu Yang
Summary: In this study, the pathogenic fungi Fusarium redolens causing black rot disease in Gastrodia elata were identified using morphological and molecular methods.
Article
Biology
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Summary: The water extracts of Gastrodia elata Blume (GE) show neuroprotective effects in G2019S-induced Parkinson's disease fruit flies and transgenic mice by improving motor abilities and protecting dopaminergic neurons. The mechanism involves the activation of the Nrf2 protein in glial cells, which inhibits degenerative signaling pathways in neurons, ultimately preventing neuronal loss and maintaining coordination.
Article
Multidisciplinary Sciences
Xiao Yang, Meihui Song, Ying Wang, Taicong Tan, Zhongyu Tian, Binyuan Zhai, Xuan Yang, Yingjin Tan, Yanding Cao, Shaojun Dai, Shunxin Wang, Liangran Zhang
Summary: This study identifies a molecular pathway for axis length regulation in meiotic cells. It shows that the cohesin regulator Pds5 interacts with proteasomes to regulate the ubiquitination level of chromosome proteins, which affects chromosome axis length. Two ubiquitin E3 ligases, SCF and Ufd4, are involved in this pathway. These findings contribute to our understanding of how Pds5 regulates meiotic chromosome organization and suggest a conserved regulatory mechanism in higher eukaryotes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Plant Sciences
Dania P. Lobaina, Roberto Tarazi, Tamara Castorino, Maite F. S. Vaslin
Summary: The ubiquitin-proteasome system (UPS) is crucial for maintaining cellular balance and plays a key role in DNA repair, gene transcription, and protein activation. Viruses often manipulate the UPS to maintain viral protein levels and evade host defenses. Understanding the mechanisms used by plant viruses to subvert host defenses is important for developing biotechnological approaches for viral resistance.
Article
Biotechnology & Applied Microbiology
Jiaotong Yang, Pengfei Li, Yuping Li, Qiaoqiao Xiao
Summary: This article introduces an improved gene functional analysis platform (GelFAP v2.0) for G.elata, which integrates new genome data, transcriptome resources, and analysis tools. The platform helps researchers carry out gene functional research by constructing co-expression networks and annotating genes with functional information.
Article
Biochemistry & Molecular Biology
Paul J. Kamitsuka, Marwan M. Ghanem, Rania Ziar, Sarah E. McDonald, Morgan G. Thomas, Gunnar F. Kwakye
Summary: Exposure to cadmium (Cd), a heavy metal, can induce neurotoxicity and cell death. In this study, the researchers found that mutant huntingtin protein (mHTT) cells are more susceptible to acute Cd-induced cell death compared to wild-type (WT) cells. They also discovered that mHTT and acute Cd exposure synergistically impair mitochondrial bioenergetics and protein degradation mechanisms, leading to cell death. Furthermore, Cd exposure promotes neurodegeneration in Huntington's disease (HD) striatal cells by impairing autophagy and altering protein degradation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zane Svikle, Beate Peterfelde, Nikolajs Sjakste, Kristine Baumane, Rasa Verkauskiene, Chi-Juei Jeng, Jelizaveta Sokolovska
Summary: Diabetic retinopathy is the most common complication of diabetes, causing blindness in the working-age population. This review summarizes the literature data on modifications of the ubiquitin-proteasome system (UPS) in diabetes and diabetic retinopathy, explores the role of UPS in the development and progression of diabetes and DR, and discusses the association of UPS modifications with other mechanisms of DR.
Article
Biotechnology & Applied Microbiology
Jinlong Cai, Ikram Muhammad, Bilian Chen, Peng Xu, Yiguo Li, Huini Xu, Kunzhi Li
Summary: This study focuses on the genomic analysis of the symbiotic relationship between Armillaria species and Gastrodia elata, a Chinese herbal medicine. The results provide important genomic information for further understanding the molecular mechanism of symbiosis.
Review
Pharmacology & Pharmacy
Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang, Cheong-Meng Chong
Summary: Parkinson's disease is an age-related neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the midbrain. Current drugs mainly aim to increase dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. Gastrodia elata Blume, a traditional medicinal herb, has shown potential as an add-on therapy for Parkinson's disease by reducing dopaminergic neuron death and pathological changes in various models.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Zenghu Su, Yuangui Yang, Shizhong Chen, Zhishu Tang, Hongbo Xu
Summary: This review comprehensively summarizes the processing methods, chemical composition, pharmacological activities, and molecular mechanisms of Gastrodia elata over the past 66 years, providing a valuable reference for researchers to understand its research status and applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-Chin Tsai, Wei-Yu Chen, Wassim Abou-Kheir, Tao Zeng, Juan Juan Yin, Hisham Bahmad, Yi-Chao Lee, Yen-Nien Liu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Anatomy & Morphology
Chih-Ju Chang, Ming-Yuan Chang, Yi-Chao Lee, Kai-Yun Chen, Tsung-I Hsu, Yi-Hsin Wu, Jian-Ying Chuang, Tzu-Jen Kao
DEVELOPMENTAL DYNAMICS
(2018)
Article
Neurosciences
Yi-Chao Lee, Ying-Chao Chang, Chia-Ching Wu, Chao-Ching Huang
MOLECULAR NEUROBIOLOGY
(2018)
Article
Plant Sciences
Chu-Jen Kuo, Chi-Chen Huang, Szu-Yi Chou, Yu-Chun Lo, Tzu-Jen Kao, Nai-Kuei Huang, Connie Lin, Hsin-Chuan Lin, Hui-Ching Lin, Yi-Chao Lee
Article
Medicine, Research & Experimental
Ta-Chung Liu, Yi-Chao Lee, Chiung-Yuan Ko, Ren-Shyan Liu, Chien-Chih Ke, Yu-Chun Lo, Pei-Sung Hong, Chao-Yi Chu, Ching-Wen Chang, Pu-Wei Wu, You-Yin Chen, San-Yuan Chen
Article
Biochemistry & Molecular Biology
Chung-Che Wu, Pin-Tse Lee, Tzu-Jen Kao, Szu-Yi Chou, Ruei-Yuan Su, Yi-Chao Lee, Shiu-Hwa Yeh, Jing-Ping Liou, Tsung-I Hsu, Tsung-Ping Su, Cheng-Keng Chuang, Wen-Chang Chang, Jian-Ying Chuang
Article
Plant Sciences
Nai-Kuei Huang, Chung-Chih Lin, Yun-Lian Lin, Chuen-Lin Huang, Chun-Tang Chiou, Yi-Chao Lee, Shu-Yi Lee, Hung-Tse Huang, Ying-Chen Yang
Article
Nanoscience & Nanotechnology
Wei-Chen Huang, Hui-Shang Chi, Yi-Chao Lee, Yu-Chun Lo, Ta-Chung Liu, Min-Yu Chiang, Hsu-Yan Chen, Ssu-Ju Li, You-Yin Chen, San-Yuan Chen
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Hsin-Chuan Lin, Chiung-Yuan Ko, Kuen-Haur Lee, I-Han Chen, Tzu-Jen Kao, Wen-Chang Chang, Tsung-I Hsu, Yi-Chao Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Oncology
Yen-Nien Liu, Shaoxi Niu, Wei-Yu Chen, Qingfu Zhang, Yulei Tao, Wei-Hao Chen, Kuo-Ching Jiang, Xufeng Chen, Huaiyin Shi, Aijun Liu, Jinhang Li, Yanjing Li, Yi-Chao Lee, Xu Zhang, Jiaoti Huang
CLINICAL CANCER RESEARCH
(2019)
Article
Clinical Neurology
Chi-Wei Lee, Yi-Ju Chen, Han-Fang Wu, Yueh-Jung Chung, Yi-Chao Lee, Cheng-Ta Li, Hui-Ching Lin
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Christine Chin-jung Hsieh, Yu-Chun Lo, Ssu-Ju Li, Ting-Chun Lin, Ching-Wen Chang, Ting-Chieh Chen, Shih-Hung Yang, Yi-Chao Lee, You-Yin Chen
Summary: Tuberous sclerosis complex is a rare hereditary disease characterized by neuropsychiatric symptoms, with limited effectiveness of current pharmacological treatments. Curcumin may help improve learning and memory deficits, while DTI is a sensitive tool for monitoring neuropathological changes.
Article
Biochemistry & Molecular Biology
Chu-Jen Kuo, Kuen-Haur Lee, Chi-Chen Huang, I-Fang Wang, Christine Chin-jung Hsieh, Hsin-Chuan Lin, Yi-Chao Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Hsin-Chuan Lin, Yung-Hao Ching, Chi-Chen Huang, Ping-Chieh Pao, Yi-Hua Lee, Wen-Chang Chang, Tzu-Jen Kao, Yi-Chao Lee
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
Article
Cell Biology
Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang, Chi-Chen Huang
JOURNAL OF BIOMEDICAL SCIENCE
(2018)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)