Article
Biochemistry & Molecular Biology
Jae Sang Han, Jun Gu Kim, Thi Phuong Linh Le, Yong Beom Cho, Mi Kyeong Lee, Bang Yeon Hwang
Summary: Three new ursane-type triterpenes and twenty-one known triterpenoids were isolated from the methanolic extract of Potentilla chinensis. Some of these compounds showed inhibitory effects on nitric oxide production in LPS-induced RAW264.7 macrophages.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mamta P. Sumi, Blair Tupta, Sanjoy Roychowdhury, Suzy Comhair, Kewal Asosingh, Dennis J. Stuehr, Serpil C. Erzurum, Arnab Ghosh
Summary: This study discovered that hemoglobin in lung epithelial cells can protect soluble guanylyl cyclase in smooth muscles from excessive nitric oxide. However, in patients with asthma or chronic obstructive pulmonary disease, lung epithelial hemoglobin may be unable to scavenge nitric oxide due to a lack of heme.
Article
Plant Sciences
Kai-Nan Song, You-Jia Lu, Cheng-Jiao Chu, Yan-Ni Wu, Hui-Lian Huang, Bo-Yi Fan, Guang-Tong Chen
Summary: Biotransformation of betulonic acid by Rhizopus arrhizus CGMCC 3.868 led to the production of 16 new compounds with antineuroinflammatory activities. Among these compounds, 3, 8, 9, 14, and 21 showed improved inhibitory effects, with IC50 values lower than the positive control.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Andrology
Monica G. Ferrini, Andrea Abraham, Leslie Graciano, Sabine Nguyen, Jesse N. Mills, Jacob Rajfer
Summary: Revactin (R) can up-regulate nitrite formation and cGMP expression in human CSMC by activating the iNOS-NO-cGMP pathway, without affecting the expression of eNOS or nNOS.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jose Britto-Junior, Rafael Campos, Matheus Peixoto, Antonio Tiago Lima, Felipe Fernandes Jacintho, Fabiola Z. Monica, Ronilson Agnaldo Moreno, Edson Antunes, Gilberto De Nucci
Summary: The release of dopamine, noradrenaline, adrenaline, and 6-nitrodopamine (6-ND) from Chelonoidis carbonaria aortic rings is coupled to nitric oxide (NO) synthesis. 6-ND acts as a selective dopamine D-2-like receptor antagonist and affects the vascular smooth muscle reactivity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Cell Biology
Stepan Gambaryan
Summary: Circulating blood platelets are regulated by stimulatory and inhibitory factors, and maintaining a balance between these processes is crucial for normal platelet and vascular function. The NO/cGMP/PKG signaling pathway plays a significant role in platelet inhibition, but its regulation is still not well understood.
Article
Chemistry, Medicinal
Xing Yang, Shi-Li Wu, Bao-Jing Li, Yan-Ping Li, Hong-Ping He, Fa-Wu Dong
Summary: Nineteen triterpenoids, including five new compounds, were isolated from the fruits of Aphanamixis polystachya. These compounds exhibited anti-inflammatory activity by inhibiting nitric oxide production in macrophages.
Article
Multidisciplinary Sciences
Monica Zocchi, Marco Bartolini, Jeanette A. Maier, Sara Castiglioni
Summary: Magnesium plays a pivotal role in maintaining skeletal muscle health and optimizing performance. Deficiency in magnesium can decrease muscle strength and affect muscle behavior and metabolism. Nitric oxide appears to be a key player in these effects. Understanding these mechanisms can help improve muscle conditions associated with magnesium deficiency.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Jianing Gao, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S. Lu, Lemin Zheng
Summary: Aortic aneurysm is a chronic aortic disease with a high risk of rupture, but it is difficult to diagnose in the early stage due to its concealment. Surgical intervention and endovascular treatment are currently the only effective therapies. The exact mechanisms of aortic aneurysm remain unclear, and researchers are investigating new targets for diagnosis and treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Loic Louvet, Gaelle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frederic Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne-Laure Bonnet, Caroline Andrique, Celine Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre-Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six
Summary: In this study, we investigated the role of Vasn expression in vascular function. Vasn knockout mice showed decreases in blood pressure, angiotensin II levels, and vessel contractibility. In vitro experiments revealed that Vasn deficiency resulted in SMC contractile phenotype switching, changes in intracellular calcium levels, and impaired NO signaling. These findings highlight the importance of Vasn SMC expression in maintaining vascular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Physiology
Charles E. Norton, Rebecca L. Shaw, Ron Mittler, Steven S. Segal
Summary: This study found that endothelial cells (ECs) are more resistant to oxidative stress than smooth muscle cells (SMCs) in cerebral arteries. The endothelium protects SMCs by reducing calcium ion entry through TRPC3 channels. These findings provide insights into the cellular response to acute oxidative stress in the cerebral vascular supply.
Article
Pharmacology & Pharmacy
Kotomi Maeda, Yuji Hotta, Naoya Ieda, Tomoya Kataoka, Hidehiko Nakagawa, Kazunori Kimura
Summary: Controlled relaxation of rat bladder neck specimens was achieved by using NORD-1 and light irradiation. NORD-1 permeated into the urothelium of specimens in the NORD-1 group, while no response to irradiation was observed in the vehicle and NORD-1+ODQ groups.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Arash Y. Tehrani, Marco A. Ciufolini, Pascal Bernatchez
Summary: Marfan syndrome is a connective tissue disorder caused by mutations in the FBN1 gene, with progressive aortic root widening being a serious manifestation. Our understanding of MFS-associated aortic remodeling remains fragmented, with nitric oxide synthase-related changes potentially playing a significant role in the pathogenesis.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Shpetim Thaci, Berat Krasniqi, Miribane Dermaku-Sopjani, Arleta Rifati-Nixha, Sokol Abazi, Mentor Sopjani
Summary: This study describes the relaxing effects of Vitex agnus-castus extract on isolated rabbit arterial rings. The extract demonstrated calcium channel blocking activities and its vasodilator effect was mainly endothelium-dependent and mediated by NO/cGMP and prostaglandins synthesis. These findings suggest that Vitex agnus-castus extract may have potential therapeutic benefits for cardiovascular disorders.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Chemistry, Applied
Jean-Bosco Jouda, Emmanuel Mfotie Njoya, Ruland Tchuinkeu Nguengang, Virginie Flaure Tsague Tankeu, Hans-Georg Stammler, Yoshihito Shiono, Norbert Sewald, Alain Meli Lannang
Summary: A new compound, asperpyrone (1), and two known compounds, stigmasterol (2) and 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-isobenzofuranone (3), were isolated from the solid rice culture of the endophytic fungus Aspergillus sp. The structure of asperpyrone (1) was determined through extensive spectral analysis. However, asperpyrone (1) did not show significant amoebicidal activity against Entamoeba moshkovskii in axenic culture.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Rostan Mangoua Talla, Jean-Bosco Jouda, Isabelle Kamga Mawabo, Catherine Tegasne, Gervais Mouthe Happi, Gilbert Deccaux Wabo Fotso Kapche, Bruno Ndjakou Lenta, Norbert Sewald, Jean Wandji
Summary: The methanol extract of Chrysophyllum lacourtianum stem bark yielded a new secondary metabolite, lacourtianal (1), and eight known compounds. The structures of these compounds were determined by NMR spectroscopic and mass spectrometric analysis. The antibacterial activity of the methanol extract and compounds 1-9 were tested, and lacourtianal (1) and ursolic acid (5) showed strong antibacterial activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Paul Etoga Mbarga, Hugues Fouotsa, Brigite Ndemangou, Julio Issah Mawouma Pagna, Ines Michele Kanko Mbekou, Pierre Mkounga, Hans-Georg Stammler, Marcel Frese, Fabrice Boyom Fekam, Bruno Ndjakou Lenta, Norbert Sewald, Ephrem Augustin Nkengfack
Summary: The bio guided fractionation of the crude extract of the air-dried whole plant of C. aegyptiaca led to the isolation of two new compounds, conyflavone and conyclerodane, along with five known compounds. These compounds demonstrated moderate antibacterial activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Guy Raphael Sado Nouemsi, Jean-Bosco Jouda, Peron Bosco Leutcha, Valaire Yemene Matieta, Virginie Flaure Tsague Tankeu, Jenifer Reine Ngnouzouba Kuete, Ilhami celik, Victor Kuete, Norbert Sewald, Alain Meli Lannang
Summary: A new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether, was isolated and identified from the leaves of Thonningii Bauhinia. It exhibited antibacterial activity against Gram-negative multidrug-resistant bacteria and MRSA, especially in combination with EPI PassN.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fanny-Aimee Essombe Malolo, Ariane Dolly Kenmogne Kouam, Judith Caroline Ngo Nyobe, Lidwine Ngah, Marcel Frese, Jean Claude Ndom, Moses K. K. Langat, Bruno Ndjakou Lenta, Dulcie A. A. Mulholland, Norbert Sewald, Jean Duplex Wansi
Summary: A phytochemical investigation of the roots of Citrus x paradisi Macfad. led to the identification of two new compounds along with ten known compounds. Compound 3 and 4 from the genus Citrus were reported for the first time. The MeOH extract of the roots and compounds 1-7 showed significant activity against cancer cells.
Article
Biochemistry & Molecular Biology
Brice Maxime Nkouayeb Nangmou, Hermine Laure Maza Djomkam, Georges Bellier Tabekoueng, Willifred Dongmo Tekapi Tsopgni, Gabin Thierry Mbahbou Bitchagno, Michel Arnaud Mbock, Raceline Gounoue Kamkumo, Marcel Frese, Bruno Ndjakou Lenta, Silvere Augustin Ngouela, Nobert Sewald, Anatole Guy Blaise Azebaze
Summary: The root extract of Nauclea xanthoxylon showed significant inhibition activity against chloroquine resistant and sensitive Plasmodium falciparum strains. Bio-guided fractionation led to the discovery of the new compound xanthoxyloside, which exhibited strong anti-malarial activity. Other compounds with anti-malarial properties were also identified. These findings support the traditional use of Nauclea xanthoxylon in treating malaria.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Armelle Tafouo Tsakou, Blanche Laure Ndontsa, Eric Carly Nono Nono, Nadine Tseme Wandji, Gabin Thierry Mbahbou Bitchagno, Jean Jules Kezetas Bankeu, Leon Azefack Tapondjou, Norbert Sewald, Bruno Ndjakou Lenta
Summary: Chemical investigation of Gymnanthemum theophrastifolium led to the isolation of a new sesquiterpene (1), a new polyacetylene (2), and a naturally occurring compound (3), along with sixteen known compounds (4-19). Their structures were determined by NMR and MS analysis. This is the first report on the chemical constituents of G. theophrastifolium. The results also provide insights into the chemophenetic knowledge of G. theophrastifolium.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Hermine Wete Nono, Arno Rusel Donfack Nanfack, Billy Toussie Tchegnitegni, Cyrille Armel Njanpa Ngansop, Faustine Leonie Mafodong Dongmo, Maurice Ducret Awouafack, Fabrice Fekam Boyom, Bruno Lenta Ndjakou, Hans-Georg Stammler, Beate Neumann, Norbert Sewald, Silvere Augustin Ngouela
Summary: The phytochemical investigation of Helichrysum foetidum led to the isolation of four undescribed compounds, including two ent-beyer-15-ene-type diterpenoids, foetidumins A and B, one flavonoid, foetidumin C, and one chalcopyrone, foetidumin D. In addition, fourteen known compounds were also isolated. Foetidumin C, erythroxylol A, and kaempferol showed the highest antileishmanial potency. The extracts of flowers and twigs also exhibited high activity against Plasmodium falciparum.
Article
Chemistry, Multidisciplinary
Gaelle Talle Juidzou, Elodie Gisele Mouafo Anoumedem, Denis Kehdinga Sema, Virginie Flaure Tsague Tankeu, Peron Bosco Leutcha, Larissa Yetendje Chimi, Jean Paul Dzoyem, Simeon Kouam Fogue, Norbert Sewald, M. Iqbal Choudhary, Alain Meli Lannang
Summary: A new unsaturated aliphatic anhydride derivative and ten known compounds were isolated from a fungus inhabiting Pittosporum mannii. The p-terphenyls are suggested as the chemophenetic marker for the genus Aspergillus. The tested sample showed good antibiofilm activity, low anti-inflammatory activity, and moderate cytotoxicity.
JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Arnauld Kenfack Djoumessi, Raymond Ngansop Nono, Beate Neumann, Hans-Georg Stammler, Gabin Thierry Mbahbou Bitchagno, Noella Molisa Efange, Celine Nguefeu Nkenfou, Lawrence Ayong, Bruno Ndjakou Lenta, Norbert Sewald, Pepin Nkeng-Efouet-Alango, Jean Rodolphe Chouna
Summary: Two new limonoids (1 and 2) and eleven known compounds (3-13) were isolated and identified from the stem bark of Trichilia monadelpha. The antibacterial and antiplasmodial activities of the extracts and isolated compounds were evaluated. The fraction E showed significant activity against Staphylococcus aureus, while certain compounds exhibited high activity against Plasmodium falciparum 3D7 strain.
Article
Integrative & Complementary Medicine
Laetitia M. Youmbi, Yves S. D. Makong, Armelle T. Mbaveng, Simplice B. Tankeo, Ghislain W. Fotso, Bruno L. Ndjakou, Jean D. Wansi, Veronique P. Beng, Norbert Sewald, Bonaventure T. Ngadjui, Thomas Efferth, Victor Kuete
Summary: This study aimed to identify the cytotoxic constituents of Brucea antidysenterica and demonstrate their mode of induction of apoptosis on cancer cell lines. The results showed that Brucea antidysenterica and its constituents have potential antiproliferative effects and can induce apoptosis through caspase activation, alteration of mitochondrial membrane potential, and increased reactive oxygen species levels.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Tobias Heinks, Simon Koopmeiners, Nicolai Montua, Norbert Sewald, Matthias Hoehne, Uwe T. Bornscheuer, Gabriele Fischer von Mollard
Summary: An enzyme cascade consisting of l-amino acid oxidase (hcLAAO4) and catalase (hCAT) was immobilized together with the (S)-selective amine transaminase (ATA-Vfl) to achieve higher reaction rates and more efficient H2O2-removal. The co-immobilized enzyme cascade showed good stability and high enantiomeric purity in preparative kinetic resolutions. However, further recycling was limited due to the instability of ATA-Vfl. The use of an engineered ATA-Vfl-8M in the immobilized enzyme cascade allowed a significant reduction in the amount of co-substrate required.
Article
Biochemistry & Molecular Biology
Caroline Besse, Hartmut H. Niemann, Norbert Sewald
Summary: This study demonstrates that covalent homodimerization by disulfide engineering can significantly improve the thermostability of halogenases Thal and PyrH while retaining their activity. This method is of great importance for improving the stability and application potential of halogenases.
Article
Biochemistry & Molecular Biology
Nicolai Montua, Norbert Sewald
Summary: In this study, a bifunctional regeneration enzyme for two-step catalytic flavin regeneration was introduced, using phosphite as an inexpensive sacrificial substrate. This fusion protein showed good performance when co-expressed with various flavin-dependent Trp-halogenases, enabling carrier-free immobilization for protein production and the preparative synthesis of halotryptophan. The scalability of this system was demonstrated in bench-top bioreactors on a 2.5 L scale. Furthermore, the inclusion of a 6-halotryptophan-specific dioxygenase into the co-expression strain allowed for the conversion of the halogenation product to the kynurenine derivative, enabling the one-pot synthesis of L-4-Cl-kynurenine and its brominated analogue on a preparative scale.
Article
Integrative & Complementary Medicine
Rostan Mangoua Talla, Alfred Ngenge Tamfu, Brussine Nadege Kweka Wakeu, Ozgur Ceylan, Celine Djama Mbazoa, Gilbert Deccaux Wabo Fotso Kapche, Bruno Ndjakou Lenta, Norbert Sewald, Jean Wandji
Summary: Due to the increasing antibiotic resistance, there is an urgent need to search for antimicrobial substances that can disrupt bacterial biofilms and quorum sensing. In this study, twenty compounds isolated from the medicinal plant Gambeya lacourtiana were evaluated for their antibiofilm and anti-quorum sensing effects against selected pathogenic bacteria. The results showed that most of the compounds inhibited violacein production and disrupted signal molecule reception.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)