Article
Agriculture, Multidisciplinary
Duo Yun, Yajie Wang, Yuyu Zhang, Mengzhen Jia, Tianzhi Xie, Yihang Zhao, Cong Yang, Weixuan Chen, Rui Guo, Xuebo Liu, Xiaoshuang Dai, Zhigang Liu, Tian Yuan
Summary: The findings of the study suggest that sesamol attenuates scopolamine-induced cognitive dysfunction by balancing the cholinergic system, reducing neuroinflammation, and oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Clinical Neurology
O. A. Nedogreeva, N. A. Evtushenko, A. O. Manolova, D. Peregud, A. A. Yakovlev, N. A. Lazareva, N. Gulyaeva, M. Y. Stepanichev
Summary: The development of cholinergic deficit is considered an early sign of pathological conditions including Alzheimer's disease. In the olfactory bulbectomy model, oxidative damage of proteins may cause cholinergic dysfunction rather than irreversible neuronal damage, indicating the sensitivity of basal forebrain cholinergic neurons to oxidative stress which may contribute to early cognitive decline in Alzheimer's disease.
CURRENT ALZHEIMER RESEARCH
(2021)
Article
Neurosciences
Laura Martinez Gonzalez, Adam Bourissai, Melissa Lessard-Beaudoin, Rejean Lebel, Luc Tremblay, Martin Lepage, Rona K. Graham
Summary: Olfactory dysfunction and atrophy of olfactory brain regions are early indicators of cognitive impairment and Alzheimer's disease. This study investigated the effects of docosahexaenoic acid (DHA) on olfactory deficits in APOE4 mice. The results showed that APOE4 mice on a control diet exhibited memory deficits and abnormal olfactory behavior, while those on a DHA diet did not. These findings suggest that a diet rich in DHA may have some benefits for individuals with the APOE4 gene, but may not alleviate all symptoms.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aseel El Hajj, Ameziane Herzine, Gaetano Calcagno, Frederic Desor, Fathia Djelti, Vincent Bombail, Isabelle Denis, Thierry Oster, Catherine Malaplate, Maxime Vigier, Sandra Kaminski, Lynn Pauron, Catherine Corbier, Frances T. Yen, Marie-Claire Lanhers, Thomas Claudepierre
Summary: Perturbations in cholesterol metabolism are linked to neurodegenerative diseases. The interaction between glial cells and neurons is essential for regulating brain cholesterol trafficking. The lipolysis-stimulated lipoprotein receptor (LSR) plays a crucial role in maintaining brain cholesterol homeostasis. Deficiency of astroglial LSR may result in cognitive defects and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Ethan Schonfeld, Elan Schonfeld, Casey Aman, Navroop Gill, Dami Kim, Sydney Rabin, Bushraa Shamshuddin, Lloyd Sealey, Ricardo Gabriel Senno
Summary: Sensory and olfactory deficits tend to lateralize to the left side of the body, while motor deficits lateralize to the right side. Clinical correlates of motor lateralization include female gender, depression, MMSE<15, and diabetes, while clinical correlates of sensory lateralization include use of psychotherapeutic agent, age, MMSE<15, and male gender. Clinical correlates of olfactory lateralization include age, number of medications, and male gender.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Jaewon Kim, Dong Keon Yon, Kyu Yeong Choi, Jang Jae Lee, Namwoo Kim, Kun Ho Lee, Jae Gwan Kim
Summary: The study suggests that olfactory-stimulated fNIRS could be a potential diagnostic tool for early detection of mild cognitive impairment (MCI) and/or Alzheimer's disease (AD).
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Liliana Ramirez-Gomez, Mark W. Albers, Ana Baena, Clara Vila-Castelar, Joshua T. Fox-Fuller, Justin Sanchez, Felipe Jain, Alefiya D. Albers, Francisco Lopera, Yakeel T. Quiroz
Summary: The study aimed to investigate olfactory function and its association with AD brain pathology markers among ADAD mutation carriers. The findings showed that worse olfactory identification performance was linked to older age, decreased cognitive scores, and increased amyloid-beta and tau pathology burden.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Victoria Campos-Pena, Pavel Pichardo-Rojas, Talia Sanchez-Barbosa, Emma Ortiz-Islas, Citlali Ekaterina Rodriguez-Perez, Pedro Montes, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Rafael Valencia-Quintana, Jorge Francisco Cerna-Cortes, Danira Toral-Rios
Summary: The presence of insoluble aggregates of amyloid beta (A beta) in the brain is a hallmark of Alzheimer's disease, and it has been shown to contribute to extensive neuronal loss. The distribution and content of cholesterol in the membrane play an important role in the production and accumulation of A beta peptides, leading to dysfunction and neuronal death. The monomeric forms of A beta peptides can trigger changes in Tau phosphorylation and cognitive function through their internalization by specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Melissa Lessard-Beaudoin, Laura M. Gonzales, Majed AlOtaibi, Raphael Chouinard-Watkins, Melanie Plourde, Frederic Calon, Rona K. Graham
Summary: The study found a significant decrease in OB weight in APOE4 transgenic mice at 12 months of age, accompanied by inflammation and decreased NeuN expression. These phenotypes were alleviated on a DHA diet, suggesting potential benefits for APOE4 carriers.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Lulin Nie, Kaiwu He, Fengzhu Xie, Shifeng Xiao, Shupeng Li, Jia Xu, Kaiqin Zhang, Chen Yang, Li Zhou, Jianjun Liu, Liangyu Zou, Xifei Yang
Summary: The study demonstrated that loganin could improve cognitive function and alleviate anxiety behavior and memory deficits in 3xTg-AD mice. It effectively reduced Aβ deposition, altered APP expression and processing, and decreased phosphorylated tau levels. Loganin also modulated energy metabolism, synaptic proteins, and inflammatory response, suggesting its potential as a candidate drug for ameliorating molecular deficits, pathologies, and cognitive impairment in Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Ivan Emmanuel Ramos-Martinez, Maria Carmen Rodriguez, Marco Cerbon, Juan Carlos Ramos-Martinez, Edgar Gustavo Ramos-Martinez
Summary: In various central nervous system diseases, inflammation has been linked to the etiologic process, prompting research on using cholinergic agonists and vagus nerve stimulation for treatment and inflammation control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zhi-Ru Chen, Jia-Bao Huang, Shu-Long Yang, Fen-Fang Hong
Summary: This article reviews the role of cholinergic signaling in AD and its correlation with other risk factors. Due to the complex and unclear pathogenesis of AD, effective methods to prevent and treat AD are currently unavailable, making research to discover novel therapeutic drugs crucial.
Article
Biochemistry & Molecular Biology
Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Lim
Summary: This study found that olfactory dysfunction is associated with beta-amyloid deposition in the brain and is related to cognitive impairments in the trajectory of Alzheimer's disease. Olfactory deficits may serve as an additional marker for disease progression and contribute to understanding the underlying mechanisms of AD.
Article
Behavioral Sciences
Giulia Giacomucci, Giulia Galdo, Cristina Polito, Valentina Berti, Sonia Padiglioni, Salvatore Mazzeo, Eleonora Chiaro, Maria Teresa De Cristofaro, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
Summary: This study aims to assess empathy deficits and their neural correlates in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia. The study found that impairment of cognitive empathy starts at the MCI stage and extends to dementia. Increased emotional contagion may be related to dysfunction in specific brain regions.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)