Article
Orthopedics
Guo-Shuang Zheng, Xing Qiu, Ben-Jie Wang, De-Wei Zhao
Summary: This study investigated the collapse mechanism in osteonecrosis of the femoral head (ONFH) by studying the relationship between changes in femoral head blood circulation and histomorphometry characteristics of the collapse area. The results showed that the collapse in ONFH always involved the margin of the necrotic lesion of the lateral column and started at the lateral column, which was ischemic. Preserving a portion of the blood supply to the lateral column improved the prognosis and delayed collapse. Measurement of blood flow in the lateral area of the femoral head can predict collapse and guide clinical therapy.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Qiu-Shi Wei, Zi-Qi Li, Zhi-Nan Hong, Guo-Ju Hong, Feng-Xiang Pang, Peng Yang, Fan Yang, Ying-Jia Yuan, Zhi-Kun Zhuang, Wei He
Summary: In this retrospective study of ONFH patients, the CPA was found to be a stronger predictor of femoral head collapse compared to other factors, with a higher accuracy and sensitivity.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Biotechnology & Applied Microbiology
Sumit Murab, Teresa Hawk, Alexander Snyder, Sydney Herold, Meghana Totapally, Patrick W. Whitlock
Summary: Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. While hip replacement is a viable option for older patients, it poses significant challenges for pediatric, adolescent, and young adult patients. Early detection is vital, but current diagnostic techniques are not sensitive enough. Various surgical techniques exist to prevent disease progression, but their effectiveness is limited, and more research is needed in tissue engineering for a potential long-term solution.
BIOENGINEERING-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Fei Sun, Jian Lin Zhou, Zi Lin Liu, Ze Wen Jiang, Hao Peng
Summary: In this study, the researchers used bioinformatic analysis and in vitro experiments to investigate the effect of ferroptosis on osteocytes in steroid-induced osteonecrosis of the femoral head. They found that glucocorticoids can induce ferroptosis in MC3T3-E1 cells by down-regulating the expression of SLC7A11. Furthermore, overexpression of SLC7A11 and the use of a ferroptosis inhibitor can reverse the ferroptosis induced by glucocorticoids. These findings provide new insights into the molecular mechanisms of glucocorticoid-induced osteonecrosis and suggest a potential treatment option for this condition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoo Sung Song, Won Woo Lee, Moon Seok Park, Nak Tscheol Kim, Ki Hyuk Sung
Summary: Quantitative bone SPECT/CT is useful in predicting the occurrence of AVN in pediatric patients with SCFE or femoral neck fracture, especially in patients with a decreased mean SUV ratio.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lan Tang, Bin Li, Qiuming Su, Xi Chen, Rongxin He
Summary: This study identified 10 hub genes and 85 therapeutic drugs for osteonecrosis of the femoral head (ONFH) through integrated bioinformatics analysis and literature mining. The findings have significant implications for future genetic and related research in ONFH.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shan Shi, Ping Luo, Li Sun, Limin Xie, Tong Yu, Zhenchang Wang, Xuedong Yang
Summary: The study found that the initial bone resorption lesion in ARCO Stage 2-3A ONFH can predict femoral head collapse progression. A threshold MAC of 49 mm(2) was identified for predicting rapid progression, with higher areas in specific regions indicating a higher likelihood of collapse.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Crim, Lester J. Layfield, James Derek Stensby, Robert L. Schmidt
Summary: Radiography is useful in depicting osteonecrosis in most patients undergoing femoral head resection, but there are false-positive and false-negative findings. Diagnostic difficulty increases in patients with advanced osteoarthritis or subchondral fractures, leading to increased uncertainty for both radiologic and pathologic evaluations. The accuracy of MRI for osteonecrosis evaluation requires further study due to limited patient numbers.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Review
Medicine, General & Internal
Jeremy T. Hines, Woo Lam Jo, Quanjun Cui, Michael A. Mont, Kyung Hoi Koo, Edward Y. Cheng, Stuart B. Goodman, Yong Chan Ha, Phillippe Hernigou, Lynne C. Jones, Shin Yoon Kim, Takashi Sakai, Nobuhiko Sugano, Takuaki Yamamoto, Mel S. Lee, Dewei Zhao, Wolf Drescher, Tae Young Kim, Young Kyun Lee, Byung Ho Yoon, Seung Hoon Baek, Wataru Ando, Hong Seok Kim, Jung Wee Park
Summary: Non-traumatic osteonecrosis of the femoral head (ONFH) predominantly affects adults younger than 50 years, leading to femoral head collapse and hip arthritis. The use of corticosteroids for leukemia and organ transplantation has contributed to the increasing prevalence of ONFH.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Orthopedics
Kyung-Hoi Koo, Michael A. Mont, Quanjun Cui, Jeremy T. Hines, Byung-Ho Yoon, Wendy M. Novicoff, Yun Jong Lee, Edward Y. Cheng, Wolf Drescher, Philippe Hernigou, Shin-Yoon Kim, Nobuhiko Sugano, De-Wei Zhao, Yong-Chan Ha, Stuart B. Goodman, Takashi Sakai, Lynne C. Jones, Mel S. Lee, Takuaki Yamamoto, Young-Kyun Lee, Yusuhn Kang, James Burgess, Dennis Chen, Nicole Quinlan, Jian Zhong Xu, Jung-Wee Park, Hong-Seok Kim
Summary: A novel classification for early stage osteonecrosis of the femoral head (ONFH) was developed and compared to three previous classifications. The results demonstrate that the novel classification is more reliable and valid, and has better predictive ability for future femoral head collapse.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Medicine, General & Internal
Adrian Cardin-Pereda, Daniel Garcia-Sanchez, Nuria Teran-Villagra, Ana Alfonso-Fernandez, Michel Fakkas, Carlos Garces-Zarzalejo, Flor Maria Perez-Campo
Summary: Osteonecrosis of the Femoral Head (ONFH) is a disabling disease with challenging diagnosis and staging, relying on imaging studies and anatomopathological analysis. Disagreements between different healthcare specialists are common. The study found a high degree of histological confirmation for clinico-radiological diagnosis of ONFH, but only moderate agreement between radiologists and orthopedic surgeons.
Article
Orthopedics
Antonin Chochola, Jan Bartonicek, Pavel Dousa, Michal Tucek
Summary: The study evaluates the long-term results of valgus intertrochanteric osteotomy (VITO) in adolescents with avascular necrosis of the femoral head (ANFH) after femoral neck fracture. VITO can improve the function of the hip joint, but cannot completely restore the original shape and structure of the femoral head.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Satoshi Ikemura, Goro Motomura, Koichiro Kawano, Satoshi Hamai, Masanori Fujii, Yasuharu Nakashima
Summary: This study compared the assessment of anteroposterior osteonecrotic lesion of the femoral head using axial and oblique axial MRI slices. The results showed significant differences in the posterior intact ratio between the two slices, with the oblique axial slice being more suitable for predicting the prognosis of the femoral head.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Paul Hoogervorst, Joshua C. Campbell, Natalie Scholz, Edward Y. Cheng
Summary: This study evaluated the outcomes of core decompression (CD) with bone marrow aspiration concentrate (BMAC) in osteonecrosis of the femoral head (ONFH). The results showed no significant differences in radiographic progression or conversion to total hip arthroplasty (THA) between the CD with BMAC group and the control groups. Obesity and the extent of ONFH were identified as predictive factors for progression. Further research is needed with a larger randomized controlled trial.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Biochemistry & Molecular Biology
Jin Huang, Fei Hu, Raphael N. Alolga, Xiaojian Yin
Summary: This study characterized the cartilage protein profiles of patients with AVNFH and identified potential proteins involved in the progression of AVNFH using proteomics technique. The significantly changed proteins were mainly involved in ECM-receptor interaction, focal adhesion, and glycolysis pathways. The marker proteins could help us understand the pathogenesis of AVNFH.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Instruments & Instrumentation
Linna Zhang, Meixiu Sun, Zhennan Wang, Hongxiao Li, Yingxin Li, Gang Li, Ling Lin
INFRARED PHYSICS & TECHNOLOGY
(2017)
Article
Instruments & Instrumentation
Wenting Dai, Ling Lin, Gang Li
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Instruments & Instrumentation
Gang Li, Yue Yu, Cui Zhang, Ling Lin
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Correction
Instruments & Instrumentation
Wenting Dai, Ling Lin, Gang Li
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Instruments & Instrumentation
Xiaoqing Yi, Gang Li, Ling Lin
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Instruments & Instrumentation
Xiaoqing Yi, Liling Hao, Fangfang Jiang, Lisheng Xu, Shaoxiu Song, Gang Li, Ling Lin
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Instruments & Instrumentation
Shengzhao Zhang, Linna Zhang, Gang Li, Ling Lin
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Spectroscopy
Gang Li, Sijia Xu, Mei Zhou, Qirui Zhang, Ling Lin
SPECTROSCOPY LETTERS
(2017)
Article
Chemistry, Multidisciplinary
Shengzhao Zhang, Gang Li, Jiexi Wang, Donggen Wang, Ying Han, Minxia Liu, Ling Lin
Article
Chemistry, Multidisciplinary
Yao Peng, Gang Li, Mei Zhou, Huaile Wang, Ling Lin
Article
Chemistry, Analytical
Qiwen Bao, Gang Li, Zhengchun Yang, Jun Wei, Wenbo Cheng, Zilian Qu, Ling Lin
Summary: In this study, a workstation with high-throughput detection requirements was developed, which supports parallel signal stimulation and online electrochemical analysis functions. The platform utilizes a highly integrated Bluetooth chip for wireless data transmission and can be visualized on a smartphone. By using a carbon-graphene oxide/screen-printed carbon electrodes (CB-GO/SPCE), the electrochemical performance of the electrodes was examined for the online analysis of L-tyrosine (Tyr) using differential pulse voltammetry (DPV). The multi-channel electrochemical platform with CB-GO-based screen-printed array electrodes showed low detection limit, good interference immunity, and stability for Tyr detection.
Article
Chemistry, Analytical
Ximeng Feng, Haixia Yu, Xiaoqing Yi, Shaohui Wang, Gang Li, Ling Lin
ANALYTICAL METHODS
(2017)
Article
Spectroscopy
Zhu Xian-feng, Jiao Bin, Zhao Jing, Li Gang, Lin Ling
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2017)
Proceedings Paper
Optics
Shengzhao Zhang, Linna Zhang, Zhe Li, Gang Li, Ling Lin
OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS VII
(2017)
Article
Spectroscopy
Liu Ming, Zhao Jing, Li Gang, Zhang Hong-ming, Wu Tai-xia
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2017)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)