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Chemistry, Medicinal
Thitikan Summat, Sutee Wangtueai, Sangguan You, Weerawan Rod-in, Woo Jung Park, Supatra Karnjanapratum, Phisit Seesuriyachan, Utoomporn Surayot, Elena Talero, Javier avila-Roman, Kazuo Umezawa
Summary: Crude polysaccharides extracted from white jellyfish showed good anti-inflammatory activity, especially JF3. JF3 was able to inhibit NF-kappa B and MAPK-related inflammatory pathways, and also had an impact on the expression of CD11b and CD40.
Article
Biochemistry & Molecular Biology
Alexander L. Rusanov, Peter M. Kozhin, Olga Tikhonova, Victor G. Zgoda, Dmitry S. Loginov, Adela Chlastakova, Martin Selinger, Jan Sterba, Libor Grubhoffer, Nataliya G. Luzgina
Summary: The study compared the proteomic profiles of immortalized cell lines and primary cells, finding significant differences in the abundances of various proteins associated with phagocytosis. This suggests that validation of results using PMJ2-R cells as a model for peritoneal macrophages should be carefully conducted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Shumin Yan, Yufei Huang, Le Xu, Xiaoyu Dong, Shuang Wang, Xue Jiao, Ming Yuan, Guoyun Wang
Summary: The development of endometriosis is closely associated with macrophages, particularly the M1 type, which is believed to inhibit its progression. Escherichia coli induces macrophage polarization towards M1 in various diseases and shows differences in the reproductive tract of patients with and without endometriosis; however, its specific role in endometriosis development remains unknown.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Immunology
Qiuyuan Shao, Cheng Sun, Qingyan Zhang, Jin Liu, Yangyang Xia, Bo Jin, Xiaoping Qian
Summary: The study found that macrophages can regulate the transition of pericytes to peritoneal fibrosis through the GSDMD/IL-1 beta axis, suggesting a potential new therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xue Chen, Qiong Jiang, Laibin Ren, Hongyu Ren, Haizhao Xu, Jinyong Wang, Pengbo Wang, Shanze Chen, Yuanqi Hua, Sichong Ren, Ning Huang, Lanlan Zhang, Lijia Xiao
Summary: This study elucidated the importance of self-renewal and polarization of macrophages in maintaining the population homeostasis and function of peritoneal macrophages. It identified the molecular mechanism that regulates these processes and provided new insights for further research.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Fernanda Tomiotto-Pellissier, Virginia Marcia Contato, Taylon Felipe Silva, Ricardo Luis Nascimento de Matos, Mariana Barbosa Detoni, Ana Carolina Jacob Rodrigues, Amanda Cristina Carloto, Danielle Bidoia Lazarin, Nilton Syogo Arakawa, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Pryscilla Fanini Wowk, Wander Rogerio Pavanelli
Summary: SOL demonstrates in vitro leishmanicidal effects against promastigotes through an apoptosis-like mechanism, while also reducing TNF-alpha and increasing IL-12p70, reactive oxygen species (ROS), and nitric oxide (NO) levels against amastigotes.
Article
Medicine, Research & Experimental
Jonathan R. Baker, Peter S. Fenwick, Carolin K. Koss, Harriet B. Owles, Sarah L. Elkin, Jay Fine, Matthew Thomas, Karim C. El Kasmi, Peter J. Barnes, Louise E. Donnelly
Summary: Current treatments for chronic obstructive pulmonary disease (COPD) are unable to modify the underlying pathophysiology and disease progression, necessitating the search for alternative therapies. This study reveals that COPD patients have increased levels of IL-36α and decreased levels of IL-36 receptor antagonist (IL-36Ra) in bronchoalveolar and nasal fluid. IL-36α stimulates the release of CXCL1, which can be inhibited by exogenous IL-36Ra, suggesting that blocking IL-36R could attenuate COPD-induced inflammation.
Article
Biotechnology & Applied Microbiology
JeongUn Choi, Ju Hyun Nam, Weerawan Rod-in, Chaiwat Monmai, A-yeong Jang, SangGuan You, Woo Jung Park
Summary: The study aimed to investigate the immune effects of crude polysaccharide (GBPC) extracted from Korean ginseng berry on peritoneal macrophages in mice with cyclophosphamide-induced immunosuppression. The results showed that oral administration of 500 mg/kg BW/day GBPC could promote the proliferation, NO production, and phagocytosis of peritoneal macrophages, similar to the normal group. GBPC of 50-500 mg/kg BW/day also dose-dependently stimulated the immune function of macrophages in immunosuppressed mice.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Chenyang Liu, Yan Xu, Yichi Lu, Pan Du, Xiaoxiao Li, Chengchun Wang, Peng Guo, Ling Diao, Guozhong Lu
Summary: The study demonstrates that S-IT MSCs can effectively induce M2 polarization of macrophages via IL-6 dependent signaling pathways and accelerate wound healing. Results show that S-IT MSCs significantly enhance the ability of M2 phenotype to promote vascularization and collagen deposition, ultimately improving wound healing quality.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Weihua Xu, Keyin Tian, Shaowen Hu, Mingxiao Chen, Meng Zhang
Summary: In MRSA infection, Il9 deletion promotes M2 polarization and phagocytosis of macrophages, inhibits macrophage apoptosis, and exhibits a protective role. The regulation of Il9 expression may be dependent on the activation of TLR2/PI3K pathway.
INFECTION AND IMMUNITY
(2023)
Article
Cell Biology
Ryota Hashimoto, Hiroshi Koide, Youichi Katoh
Summary: Lipopolysaccharide (LPS) is an endotoxin that induces acute inflammatory response by activating macrophages to produce nitric oxide (NO) through the RAS-RAF-MEK-ERK signaling cascade. This study showed that the combination of LPS and MEK inhibitors enhanced NO production and mortality in mice with LPS-induced inflammation. The MEK inhibitor enhanced IL-12 expression and synergistically induced NO production with TNF-alpha, contributing to the increased mortality rate.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Isidora Protic-Rosic, Andrijana Nesic, Ivana Lukic, Radmila Miljkovic, Dragan M. Popovic, Marina Atanaskovic-Markovic, Marijana Stojanovic, Marija Gavrovic-Jankulovic
Summary: The study introduces a newly designed recombinant chimera with potential immunomodulatory effects for the treatment of allergic diseases, showing promising implications for allergen-specific immunotherapy.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Masayoshi Yamaguchi, Kazunori Hashimoto, Mayumi Jijiwa, Tomiyasu Murata
Summary: This study reveals that inflammatory macrophages regulate the proliferation and death of prostate cancer cells through the signaling processes of NF-kappa B, STAT3, or regucalcin.
CELLULAR SIGNALLING
(2023)
Article
Microbiology
Yanxi Liu, Zhiqian Li, Shuo Wang, Changjian Zhang, Li Han, Qun Sun, Xuelin Han
Summary: The study demonstrates that swollen conidia of Aspergillus fumigatus induce the release of pro-inflammatory factors IL-8 and MCP-1 through activation of decrin-1 and CR3 receptors in lung epithelial A549 cells.
CURRENT MICROBIOLOGY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)