Article
Multidisciplinary Sciences
Youzi Dong, Quanlin Zhao, Yuguo Wang
Summary: This study used network pharmacology and molecular docking to explore the mechanism of the Astragalus membranaceous (AM)-Angelica sinensis (AS) compound in the treatment of diabetic nephropathy (DN). The results suggest that the compound may treat DN by regulating various biological processes.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Hailu Yao, Junli Zhao, Lingjia Zhu, Yudan Xie, Nana Zhao, Ruiqi Yao, Huan Sun, Guang Han
Summary: The study revealed the protective effect of Andrographis paniculata against PM2.5-induced lung injury by modulating the NF-kappa B pathway, suggesting a potential therapeutic strategy for respiratory diseases. Compared to andrographolide, AEP exhibited superior efficacy in alleviating pathological damage caused by PM2.5 exposure.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae Sik Yu, Sung Ho Lim, Seoung Rak Lee, Chang-Ik Choi, Ki Hyun Kim
Summary: The ethanol extract of white mulberry fruits and its derived fractions showed strong antioxidant and anti-inflammatory effects by inhibiting ROS generation and lowering iNOS expression, suggesting their potential as natural antioxidant and anti-inflammatory agents.
Review
Cell Biology
Libin Chen, Xintong Jin, Jian Ma, Bo Xiang, Xiayu Li
Summary: YAP is a transcriptional regulator that plays a role in cell proliferation, organ size, and tissue development and regeneration. Recent research has focused on YAP in inflammation and immunology, revealing its involvement in inflammatory disease and tumor immune escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Joao Paulo Loureiro Damasceno, Hemerson Silva da Rosa, Luciana Silva de Araujo, Niege Aracari Jacometti Cardoso Furtado
Summary: This review focuses on the bioavailability of diterpene lactones from Andrographis paniculata, highlighting strategies to enhance their oral bioavailability.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2022)
Article
Geriatrics & Gerontology
Gabriela Kodja Vivian, Renaira Oliveira da Silva, Andressa Cristina Antunes Santos, Araceli Aparecida Hastreiter, Carolina Carvalho Dias, Edson Naoto Makiyama, Primavera Borelli, Claudia de Oliveira Rodrigues, Ricardo Ambrosio Fock
Summary: The immune function of macrophages in elderly individuals with malnutrition is compromised, and this impairment is more pronounced in aged protein-malnourished animals.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jianhua Ye, Shenghui Shen, Xialing Dai, Tianjie Zhang
Summary: The study aimed to evaluate the ameliorative effect of Angelica sinensis polysaccharide (ASP) on Toll-like receptor 4 (TLR4)/Nuclear factor kappa B (NF-kappa B) pathway in myocardial ischemia-reperfusion injury (MIRI) rats. The results showed that ASP reduced inflammation by inhibiting the TLR4/NF-kappa B pathway, suppressed cardiomyocyte apoptosis, and exerted cardioprotective effects.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Environmental Sciences
Trixia Julaton, Aibelou Taclendo, Glenn Oyong, Ofelia Rempillo, Maria Cecilia Galvez, Edgar Vallar
Summary: This study investigates the effects of Polycyclic Aromatic Hydrocarbons (PAHs) and A. paniculata (AP) phytocompounds on inflammation-related proteins using in silico techniques. The results show that PAHs can induce inflammation, while AP phytocompounds have anti-inflammatory properties. The study suggests that AP phytocompounds have the potential to inhibit the inflammatory activity induced by PAHs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Fatemeh Aziz-Aliabadi, Hadi Noruzi, Ahmad Hassanabadi
Summary: This study aimed to determine the appropriate levels of green tea leaf powder (GTP) and mulberry leaf powder (MLP) in the diet, which positively affects broilers' performance. The results showed that the addition of 2% powders significantly increased daily weight gain and reduced feed conversion ratio, while the addition of 1% GTP increased villus height index. Therefore, the addition of appropriate levels of GTP and MLP is beneficial for the growth and immune response of broilers.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dong-Uk Shin, Ji-Eun Eom, Hyeon-Ji Song, Sun Young Jung, Thi Van Nguyen, Kyung Min Lim, Ok Hee Chai, Hyun-Jin Kim, Gun-Dong Kim, Hee Soon Shin, So-Young Lee
Summary: Cigarette smoke is a major factor in the development of chronic obstructive pulmonary disease (COPD). This study investigated the protective effects of Camellia sinensis extract against pulmonary inflammation in a COPD mouse model. The extract suppressed immune cell infiltration, cytokine secretion, mucus hypersecretion, and lung parenchyma injuries. In vitro experiments revealed its inhibitory effect on inflammation-related molecules in various cell types. The results suggest that Camellia sinensis extract could be an effective approach for treating or preventing chronic pulmonary diseases.
Article
Cell Biology
Cheng Luo, Qi Chen, Bowen Liu, Shengpeng Wang, Hualin Yu, Xiaowei Guan, Yonghua Zhao, Yitao Wang
Summary: The study demonstrates that Angelica sinensis and Cinnamomum cassia extracts have effects on the inflammatory and autophagic pathways in the pathology of ischemic stroke. Treatment with AC extract can reduce inflammatory response, enhance autophagy, and protect against neural apoptosis through modulation of various molecules and pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Multidisciplinary Sciences
Josimar Dornelas Moreira, Alexei Iakhiaev, Ramakrishna Vankayalapati, Bock-Gie Jung, Buka Samten
Summary: HDAC1 inhibitor DHOB enhances IL-1β production by increasing NLRP3 expression, promoting cleaved caspase-1, and enhancing ASC oligomerization. DHOB rescues defective IL-1β production and increases NLRP3 expression in dendritic cells infected with Mycobacterium tuberculosis. HDAC2, but not HDAC1, controls IL-1β production through NLRP3 inflammasome activation.
Article
Biochemistry & Molecular Biology
Shashi S. Suman, Akhilesh Kumar, Ashish K. Singh, Ajay Amit, R. K. Topno, K. Pandey, V. N. R. Das, P. Das, Vahab Ali, Sanjiva Bimal
Summary: By activating dendritic cells with cTXN, a potential vaccine prospect for controlling visceral leishmaniasis was demonstrated, resulting in complete protection against the disease in infected mice.
Article
Plant Sciences
Nanjaian Mahadevan, Munish Goyal, Vasudevan Rajalakshimi, Noohu Abdulla Khan, Kumarappan Chidambaram
Summary: A combined extract of Andrographis paniculata, Boerhavia diffusa, Eclipta alba, and Picrorhiza kurroa showed significant hepatoprotective activity against carbon tetrachloride and paracetamol-induced hepatotoxicity in rats. The extract reversed the biochemical parameters reflecting liver function, indicating its potential as a hepatoprotective agent.
INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
(2022)
Article
Integrative & Complementary Medicine
Miaw-Ling Chen, Chia-Chien Hsieh, Bor-Luen Chiang, Bi-Fong Lin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Article
Integrative & Complementary Medicine
Miaw-Ling Chen, Chi-Heng Wu, Li-Shiuan Hung, Bi-Fong Lin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Editorial Material
Integrative & Complementary Medicine
Bi-Fong Lin, Bor-Luen Chiang, Yan Ma, Jin-Yuarn Lin, Miaw-Ling Chen
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Article
Food Science & Technology
Hsueh-Yun Lu, Bi-Fong Lin
JOURNAL OF FUNCTIONAL FOODS
(2016)
Article
Biochemistry & Molecular Biology
Chi-Heng Wu, Tzu-Chien Huang, Bi-Fong Lin
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2017)
Review
Immunology
Chia-Chien Hsieh, Bi-Fong Lin
AUTOIMMUNITY REVIEWS
(2011)
Article
Integrative & Complementary Medicine
Wen-Wan Chao, Yueh-Hsiung Kuo, Shie-Liang Hsieh, Bi-Fong Lin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2011)
Article
Agriculture, Multidisciplinary
Wen-Wan Chao, Yueh-Hsiung Kuo, Bi-Fong Lin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2010)
Article
Agriculture, Multidisciplinary
Yong-Han Hong, Ssu-Ching Wang, Chin Hsu, Bi-Fong Lin, Yueh-Hsiung Kuo, Ching-Jang Huang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2011)
Article
Agriculture, Multidisciplinary
Chung-Huang Wang, Shu-Chen Hsieh, Huei-Ju Wang, Miaw-Ling Chen, Bi-Fong Lin, Been-Huang Chiang, Ting-Jang Lu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Plant Sciences
Wen-Wan Chao, Yong-Han Hong, Miaw-Ling Chen, Bi-Fong Lin
JOURNAL OF ETHNOPHARMACOLOGY
(2010)
Article
Geriatrics & Gerontology
Wen-Harn Pan, Yi-Ping Chang, Wen-Ting Yeh, Yu-Shu Guei, Bi-Fong Lin, Ien-Lan Wei, Feili Lo Yang, Yung-Po Liaw, Kuan-Ju Chen, Wei J. Chen
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2012)
Article
Geriatrics & Gerontology
K. -J. Chen, W. -H. Pan, C. -J. Huang, B. -F. Lin
JOURNAL OF NUTRITION HEALTH & AGING
(2011)
Review
Integrative & Complementary Medicine
Wen-Wan Chao, Bi-Fong Lin
Article
Nutrition & Dietetics
Kuan-Ju Chen, Wen-Harn Pan, Yi-Chin Lin, Bi-Fong Lin
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
(2011)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)