Article
Biochemistry & Molecular Biology
Changhwan Yeo, Chae Ryeong Ahn, Jai-Eun Kim, Young Woo Kim, Jinbong Park, Kwang Seok Ahn, In Jin Ha, Yoon Jae Lee, Seung Ho Baek, In-Hyuk Ha
Summary: This study demonstrates the anti-inflammatory and articular regeneration effects of Chaenomeles Fructus (CF) on rat chondrocytes with osteoarthritis, suggesting it as a promising therapeutic option for the treatment of OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da Yeong Lee, Kyoung Jin Park, Lalita Subedi, Gyu Sung Lee, Ji-Hyeok Lee, Won-Min Lee, Sang Un Choi, Seong-Min Hong, Sun Yeou Kim, Chung Sub Kim
Summary: This study identified four new oxylipins obtained from Chaenomeles sinensis twigs, which have diverse biological activities including anti-inflammatory, antimicrobial, and regulatory effects. Among them, oxylipin D showed potent inhibitory effect on nitric oxide production, neurotrophic activity, and cytotoxicity in human cancer cell lines.
Article
Infectious Diseases
Kalee E. E. Rumfelt, William J. J. Fitzsimmons, Rachel Truscon, Arnold S. S. Monto, Emily T. T. Martin, Adam S. S. Lauring
Summary: A new luciferase microneutralization (LMN) assay was developed, combining the advantages of conventional microneutralization assay with the ease of hemagglutinin inhibition assay. It provides a more feasible, standardized and applicable method for measuring serological responses to influenza vaccination or infection.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Biochemistry & Molecular Biology
Dong Hyun Kim, Lalita Subedi, Hye Ryeong Kim, Sang Un Choi, Sun Yeou Kim, Chung Sub Kim
Summary: Research on Chaenomeles sinensis has discovered new phenolic compounds and known compounds in the twigs of the plant, showing potential anti-neuroinflammatory effects, neurotrophic activity, and cytotoxicity against human cancer cell lines.
Article
Biochemistry & Molecular Biology
Wen-Yue Wang, Jing-Hao Gao, Zhao Qin, Hua-Min Liu
Summary: In this study, LCC preparations were extracted from Chinese quince fruits and analyzed using various chemical and instrumental approaches. The results showed that LCC fractions from October fruits were more stable and homogeneous, and exhibited good antioxidant activity. NMR analysis revealed the presence of different types of lignin linkages and lignin-pectin complexes in the LCC preparations. This study is significant for understanding the chemical bonds of LCC macromolecules in plant cell walls and the industrial applications of Chinese quince fruits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Virology
Nidhi Mittal, Nayanika Sengupta, Sameer Kumar Malladi, Poorvi Reddy, Madhuraj Bhat, Raju S. Rajmani, Koen Sedeyn, Xavier Saelens, Somnath Dutta, Raghavan Varadarajan
Summary: Research indicates that the genetic fusions of H1-H3 hemagglutinin ectodomains can enhance influenza vaccine efficacy while reducing manufacturing complexity and cost. These fusion immunogens induce H1 and H3-specific immune responses and offer protection. Mice immunized with these fusions show higher neutralizing antibody titers against challenging H1N1 and H3N2 viruses.
Article
Multidisciplinary Sciences
Seyed Mohammad Ghafoori, Gayle F. Petersen, Deborah G. Conrady, Brandy M. Calhoun, Matthew Z. Z. Stigliano, Ruth O. Baydo, Rena Grice, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Jade K. Forwood
Summary: Influenza virus causes annual outbreaks of flu, resulting in a significant economic burden on the healthcare system. It has caused several pandemics with millions of deaths in the past century. This study characterizes the structures of seven influenza A virus hemagglutinins (HAs) and identifies conserved residues involved in receptor binding. The study also shows that modifications in a certain region disrupt the binding of a specific antibody, providing new insights for anti-influenza vaccine development.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Shuang Cai, Yan-Yan Ning, Zhao Qin, Hua -Min Liu, Xue-De Wang, Li-Xia Hou
Summary: Chinese quince seed gum (CQSG) has shown great potential as a cryoprotectant in frozen foods, as it exhibits improved rheological, textural, emulsifying, and foaming properties after freeze-thaw treatment.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Virology
Fan Yang, Linwei Zhu, Fumin Liu, Linfang Cheng, Hangping Yao, Nanping Wu, Haibo Wu, Lanjuan Li
Summary: This study generated a panel of neutralizing monoclonal antibodies against influenza A virus (H3N2) and identified relevant epitopes that influence antigenicity. The epitopes were mainly in antigenic site A, B, and C, with site B being the most immunodominant. Amino acid substitutions at site B resulted in decreased antibody capability for blocking receptor binding. The study also discovered a novel substitution at site C, which showed neutralizing activity against multiple H3N2 strains, suggesting a potential epitope for inducing broad neutralizing antibody responses.
Article
Chemistry, Applied
Yan-Yan Ning, Wen-Bo Miao, Hua-Min Liu, Zhao Qin, Xue-De Wang, Li-Xia Hou
Summary: The study found that Chinese quince seed gum extracted under different conditions exhibited differences in properties, with alkaline treatment promoting xylose conversion, and acid treatment affecting thermal and emulsifying stability.
CARBOHYDRATE POLYMERS
(2021)
Article
Immunology
Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Hae-Ahm Lee, Eun-Kyung Moon, Beom-Ku Han, Fu-Shi Quan
Summary: This study developed virus-like particles containing different proteins of SARS-CoV-2 and showed that they could induce mice to produce spike protein-specific antibodies. S full and S1 immune sera elicited virus-neutralizing activities, suggesting the potential of these VLPs as effective vaccines.
Article
Food Science & Technology
Jin-Ok Kim, Gami An, Jung-Hye Choi
Summary: This study investigates the potential of Acanthopanax sessiliflorum and Chaenomeles sinensis extracts in mitigating UVB-induced skin photoaging. The extracts inhibited MMP-1/-3 expression in vitro, with the mixture of the two extracts showing the strongest inhibitory effect. Oral administration of the mixture in UVB-irradiated hairless mice reduced wrinkle formation, skin roughness, and epidermal thickness while promoting collagen fiber deposition. These findings suggest the therapeutic potential of this extract mixture in protecting against skin photoaging.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Meng Li, Zhi-guang Zhang, Jing-ya Shi, Ya-ge Li, Jing-ke Zhang, Yang Ying, Xiao-yan Deng, Xiao-ke Zheng, Wei-sheng Feng
Summary: Two new compounds, chaenomelesterpenoid A and chaenomelesterpenoid B, isolated from Chaenomeles sinensis fruits, showed protective effects against corticosterone-induced damage in PC-12 cells, improving cell viability significantly.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hongli Cai, Zhuoheng Zhong, Yiran Chen, Shuyao Zhang, Hao Ling, Hongwei Fu, Lin Zhang
Summary: Two PPO isozymes, HjyPPO1 and HjyPPO3, were cloned from Huangjinya tea. Both isozymes efficiently oxidized catechin substrates to produce four theaflavins, with HjyPPO3 exhibiting higher oxidation efficiency. The optimal pH and temperature for HjyPPO3 were 5.5 and 30℃, respectively.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Sarah M. Valencia, Eric Rochat, Melissa J. Harnois, Maria Dennis, Helen S. Webster, Bhavna Hora, Amit Kumar, Hsuan-Yuan (Sherry) Wang, Leike Li, Daniel Freed, Ningyan Zhang, Zhiqiang An, Dai Wang, Sallie R. Permar
Summary: The study shows that vaccination with V160 can result in a similar breadth of gB-specific antibodies compared to natural infection, but their binding characteristics and antigenic specificity are different. Antibodies isolated from V160 vaccinees have weaker neutralizing ability against gB compared to those from natural infection.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)