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Biochemistry & Molecular Biology
Kanokwan Somwong, Pattawika Lertpatipanpong, Wutigri Nimlamool, Aussara Panya, Yingmanee Tragoolpua, Rujipas Yongsawas, Wandee Gritsanapan, Hataichanok Pandith, Seung Joon Baek
Summary: In this study, the stem bark of Holoptelea integrifolia was investigated for its potential wound healing properties. The major bioactive compounds, friedelin and lupeol, were identified and their effects on wound healing were studied. It was found that these compounds significantly reduced wound area and increased keratinocyte migration. Furthermore, they exhibited anti-inflammatory properties by regulating gene expression involved in skin re-epithelialization.
Article
Agronomy
Magdalena Lacko-Bartosova, Amandeep Kaur, Lucia Lacko-Bartosova, L'ubomir Kobida, Matej Hudec, Jan Moudry
Summary: This study evaluated and compared the radical scavenging activities, phenolic concentrations, and concentrations of phenolic acids of different wheat varieties under organic farming conditions. The results showed that an extremely dry and warm ripening period negatively affected the synthesis of phenolic compounds, and common wheat had higher phenolic concentrations compared to spelt cultivars.
Article
Biotechnology & Applied Microbiology
Sumita Mondal, Abhijit Bandyopadhyay
Summary: The methanolic leaf extract (MLE) of Holoptelea integrifolia has significant photoprotective and antioxidant activity due to a high concentration of phenols, flavonoids, and tannins. MLE was found to effectively block 93% of UV-B radiation, with the highest concentration providing the lowest transmission erythema and pigmentation values. The antioxidant potential of MLE was evaluated through various assays, and it was also shown to provide protection against UV-induced DNA damage. Phenolic acids, including tannic acid, gallic acid, and p-coumaric acid, were identified and quantified in different fractions of MLE. These findings suggest that MLE contains valuable phytocompounds with UV-blocking and antioxidant properties, offering promising pharmaceutical prospects.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Cell Biology
Dinesh Thummuri, Lalita Guntuku, Veerabhadra Swamy Challa, Ravinder Naik Ramavat, Vegi Ganga Modi Naidu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Neurosciences
Kaipuzha Venu Athira, Sikta Bandopadhyay, Pavan Kumar Samudrala, V. G. M. Naidu, Mangala Lahkar, Sumana Chakravarty
CURRENT NEUROPHARMACOLOGY
(2020)
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Nanoscience & Nanotechnology
Ankit Gangrade, Basveshwar Gawali, Praveen Kumar Jadi, Vegi G. M. Naidu, Biman B. Mandal
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Biochemistry & Molecular Biology
Sahu Henamayee, Kishore Banik, Bethsebie Lalduhsaki Sailo, Bano Shabnam, Choudhary Harsha, Satti Srilakshmi, V. G. M. Naidu, Seung Ho Baek, Kwang Seok Ahn, Ajaikumar B. Kunnumakkara
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Immunology
Manish Kumar Jeengar, Sudeep Chenna Narendra, Dinesh Thummuri, Mattias Magnusson, V. G. M. Naidu, Srinivas Uppugunduri
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Mukta Agrawal, Shailendra Saraf, Swarnlata Saraf, Sunil K. Dubey, Anu Puri, Umesh Gupta, Prashant Kesharwani, V Ravichandiran, Pramod Kumar, V. G. M. Naidu, Upadhyayula Suryanarayana Murty, Ajazuddin, Amit Alexander
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
Sahabuddin Ahmed, Samir Ranjan Panda, Mohit Kwatra, Bidya Dhar Sahu, V. G. M. Naidu
Summary: Activation of NLRP3 inflammasome plays a crucial role in neurodegenerative diseases, and understanding the bidirectional signaling involved in this process is key for treatment. This study investigated the role of LPS, H2O2, and PA in NLRP3 inflammasome-driven neurodegeneration and found that targeting damaged mitochondria and scavenging free radicals could potentially limit microglial activation and support neuronal survival in PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Materials Science, Biomaterials
Sushma Venkata Mudigunda, Deepak B. Pemmaraju, Shivangi Paradkar, Eswara Rao Puppala, Basveshwar Gawali, Suryanarayana Murty Upadhyayula, Naidu Vegi Gangamodi, Aravind Kumar Rengan
Summary: Retinoblastoma is a critical intraocular malignancy in children, and chemo/photothermal therapy with multifunctional polymeric nanoparticles (PNPs) entrapped with anticancer drug and near-infrared dye showed significant cytotoxic effect on retinoblastoma cells. In vivo studies in a mice model demonstrated optimal photoacoustic signals, suggesting the potential of this combined approach for retinoblastoma therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Medicinal
Md Jahangir Alam, Ozair Alam, Ahmad Perwez, Moshahid Alam Rizvi, Mohd Javed Naim, Vegi Naidu, Mohd Imran, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel
Summary: In this study, a series of compounds were designed, synthesized, and evaluated for their anti-cancer activity and cytotoxicity. Compound 5o showed excellent cytotoxicity and most of the compounds exhibited drug-like properties.
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Prasanna A. Yakkala, Samir R. Panda, Syed Shafi, V. G. M. Naidu, M. Shahar Yar, Philemon N. Ubanako, Samson A. Adeyemi, Pradeep Kumar, Yahya E. Choonara, Eugene Radchenko, Vladimir A. Palyulin, Ahmed Kamal
Summary: Newly synthesized 1,2,4-triazolo-linked bis-indolyl conjugates exhibit enhanced cytotoxic activity against colon and breast cancer cells. These compounds induce cell cycle arrest, apoptosis, and lower the expression levels of markers involved in the beta-catenin pathway of colorectal cancer.
Article
Chemistry, Medicinal
Prasanna A. Yakkala, Samir R. Panda, Vegi G. M. Naidu, Syed Shafi, Ahmed Kamal
Summary: A library of pyridine-based 1,2,4-triazolo-tethered indole conjugates were synthesized and evaluated for anti-proliferative activity against six human cancer cell lines. The synthesized conjugates showed effective activity against the HT-29 cell line, with compounds 14a, 14n, and 14q exhibiting promising cytotoxicity. These compounds induced cell cycle arrest, disrupted mitochondrial membrane potential, and increased ROS production. They also inhibited the expression of markers involved in S-catenin and PI3K pathways.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Nishant Kumar Jain, Shalini Dimri, Rajendra Prasad, Gayathri Ravichandran, Vegi Naidu, Abhijit De, Rohit Srivastava
ACS APPLIED BIO MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Poulomi Dey, Eswara Rao Puppala, Vegi Ganga Modi Naidu, Gopal Das, Aiyagari Ramesh
ACS APPLIED BIO MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Nishant Kumar Jain, R. S. Prabhuraj, M. C. Bavya, Rajendra Prasad, Rajdip Bandyopadhyaya, V. G. M. Naidu, Rohit Srivastava
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)