Article
Pharmacology & Pharmacy
Anita Yovas, Shervin Prince Stanely, Reya Issac, Stanely Mainzen Prince Ponnian
Summary: Beta-caryophyllene was found to have anti-hyperlipidemic and antioxidant effects, which could inhibit the risk of isoproterenol-induced myocardial infarction in rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Silvia Di Giacomo, Marco Gulli, Roberta Facchinetti, Marco Minacori, Romina Mancinelli, Ester Percaccio, Caterina Scuderi, Margherita Eufemi, Antonella Di Sotto
Summary: The combination of anticancer drugs and chemosensitizing agents has potential in potentiate chemotherapy and reduce toxicity in aggressive and chemoresistant cancers. This study found that caryophyllane sesquiterpenes can enhance the efficacy of sorafenib in HCC, CCA, and PDAC cell models. The synergistic effects were associated with the modulation of STAT3 signaling and ABC transporters.
Article
Biochemistry & Molecular Biology
Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, Jose Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli, Natasha Irrera
Summary: The present study evaluated the effects of beta-Caryophyllene (BCP) on Cd-induced neurotoxicity. The results showed that BCP treatment reduced ROS production, increased Nrf2 expression, and protected cells from death. BCP also regulated the apoptosis pathway and reduced the increase of pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Uriel Ulises Rodriguez-Mejia, Juan Manuel Viveros-Paredes, Adelaida Sara Minia Zepeda-Morales, Lucrecia Carrera-Quintanar, Jose Sergio Zepeda-Nuno, Gilberto Velazquez-Juarez, Vidal Delgado-Rizo, Trinidad Garcia-Iglesias, Luisa Guadalupe Camacho-Padilla, Elizabeth Varela-Navarro, Luis Alberto Anguiano-Sevilla, Esmeralda Marisol Franco-Torres, Rocio Ivette Lopez-Roa
Summary: This study found that β-Caryophyllene (BCP) has the potential to reduce endotoxemia and serum leptin levels in obesity and regulate the abundance of intestinal microbiota, thus suggesting a potential therapeutic role in obesity.
Article
Multidisciplinary Sciences
Valtcho D. Zheljazkov, Filippo Maggi
Summary: The study showed that distillation can improve the compositional profile of cannabinoids in hemp biomass, converting cannabinoid acids into cannabinoids like CBD and CBC. Distilled hemp biomass had higher cannabinoid content compared to non-distilled, with the addition of CBN in the distilled biomass.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Patricia Weimer, Taina Kreutz, Renata P. Limberger, Rochele C. Rossi, Adley A. N. de Lima, Valdir F. Veiga, Bibiana Verlindo de Araujo, Leticia S. Koester
Summary: This study investigated the correlation between the skin permeation and in vivo antiedematogenic activity of beta-caryophyllene and caryophyllene oxide from Copaifera multijuga oleoresin in topical nanoemulgels. The results indicate that the presence of similar compounds affects the permeation profile, and beta-caryophyllene is an essential compound for the pharmacological activity of the oleoresin.
Article
Plant Sciences
Erik Nunes Gomes, Harna Patel, Bo Yuan, Weiting Lyu, H. Rodolfo Juliani, Qingli Wu, James E. Simon
Summary: This study assessed the biomass productivity, chemical composition of essential oil, and polyphenol accumulation of two new catnip cultivars (CR3 and CR9) and their hybrid (CR9xCR3) across four successive harvests. The results showed that the aromatic profile and polyphenol accumulation had a genotype-dependent response to successive harvests. This study highlights the potential of these catnip genotypes for the supply of natural products for pest control and other industries.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Applied
Renato Fernando Menegazzo, Wanessa de Campos Bortolucci, Herika Line Marko de Oliveira, Andre Werlang Menegazzo, Jose Eduardo Goncalves, Carla Maria Mariano Fernandez, Zilda Cristiani Gazim, Ana Daniela Lopes
Summary: This study extracted and analyzed the essential oil components of Tradescantia pallida, and identified the presence of various oxygenated sesquiterpene compounds. This contributes to the understanding of the biological activities exhibited by this plant.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Valquiria Bruna Guimaraes Silva, Beatriz Meyruze Barros da Fonseca, Julio Cesar Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Alisson Macario de Oliveira, Thiago Henrique Napolea, Maria Tereza dos Santos Correia, Vera Lucia de Menezes Lima, Wendeo Kennedy Costa, Marcia Vanusa da Silva
Summary: The aim of this study was to evaluate the antinociceptive and anti-inflammatory potential of Psidium cattleyanum leaves essential oil. Gas chromatography-mass spectrometry (GC/MS) was used to analyze the oil. The results showed that the essential oil has significant antinociceptive and anti-inflammatory effects, and has potential for application in the pharmaceutical and food industry.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N. Goyal, Bassem Sadek, Niraj Kumar Jha, Juma Al Kaabi, Shreesh Ojha
Summary: BCP is a natural compound with selective agonist properties that activate CB2R and have various pharmacological effects. BCP shows protective effects in the heart, liver, nervous system, kidneys, gastrointestinal tract, cancer, with antioxidant, anti-inflammatory, and immunomodulatory actions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Marija Nazlic, Karla Akrap, Dario Kremer, Valerija Dunkic
Summary: This study isolated free volatile compounds from Croatian Veronica species using different extraction techniques, and analyzed their composition. The study identified several common compounds and observed differences in composition among different Veronica species. The antioxidant activity of the extracts was also tested.
Article
Pharmacology & Pharmacy
Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Recent research indicates that BCP, through its action on CB2 receptors and other mechanisms, can effectively reduce METH reward and intake, as well as motivation to seek and take METH. Additionally, BCP also inhibits METH-enhanced electrical BSR, and blocks METH-primed and cue-induced reinstatement of drug-seeking behavior.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Yan Wang, Qinsong Yang, Yifan Zhu, Lan Zhao, Pengju Ju, Guoyun Wang, Chaochao Zhou, Changqing Zhu, Huijuan Jia, Yun Jiao, Huimin Jia, Zhongshan Gao
Summary: This study identified candidate genes regulating the production of volatile organic compounds (VOCs) in red bayberry through transcriptome analysis. The gene MrTPS3 was found to regulate the synthesis of β-caryophyllene, while MrTPS20 was found to regulate the synthesis of α-pinene. A single amino acid substitution between different cultivars resulted in the loss of function of MrTPS3 and led to differences in β-caryophyllene production.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Mazen M. El-Hammadi, Andrea L. Small-Howard, Mercedes Fernandez-Arevalo, Lucia Martin-Banderas
Summary: Terpenes derived from Cannabis sativa, including beta-myrcene, beta-caryophyllene, and nerolidol, were successfully encapsulated in PLGA-based nanoparticles in this study. These nanoparticles may serve as promising therapeutic tools for the enhanced delivery of cannabis-derived terpenes.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Saad S. Dahham, Yasser Tabana, Muhammad Asif, Marawan Ahmed, Dinesh Babu, Loiy E. Hassan, Mohamed B. Khadeer Ahamed, Doblin Sandai, Khaled Barakat, Arno Siraki, Amin M. S. A. Majid
Summary: The study demonstrated that BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of VEGF secretion, and sprouting of microvessels. BCP also deformed the vascularization architecture in a chick embryo chorioallantoic membrane assay and showed a significant reduction in tumor growth in xenograft models by inducing apoptosis and modulating gene expressions related to cell survival and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
