期刊
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
卷 68, 期 6, 页码 565-570出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jech-2013-203503
关键词
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资金
- State Key Project Specialized for Infectious Diseases of China [2008ZX10002-015, 2012ZX10002008-002]
- United States National Institutes of Health [R37 CA070867, R01 CA082729]
- Fogarty International Clinical Research Scholars and Fellows Program at Vanderbilt University [R24 TW007988-5]
- Cancer Prevention and Control Training Program at the University of Alabama at Birmingham - National Institutes of Health [5R25 CA047888]
Background Cholelithiasis and cholecystectomy have been proposed as risk factors for liver cancer, but findings have been inconsistent. We assessed this association using data from the Shanghai Women's and Men's Health Studies. Methods History of cholelithiasis and cholecystectomy were reported at baseline and follow-up interviews, and liver cancer diagnoses were ascertained from the Shanghai Cancer Registry and Vital Statistics Unit. Adjusted hazard ratios (aHRs) and 95% CIs were calculated after adjustment for potential confounders. Results A history of cholelithiasis and cholecystectomy was reported by 9.5% and 3.6% of participants at baseline, respectively. After a total of 859 882 person-years of follow-up for women and 391 093 for men, incident liver cancer was detected in 160 women and 252 men. A positive association was observed between a history of cholelithiasis or cholecystectomy and liver cancer in men (aHR 1.46; 95% CI 1.02 to 2.07) and women (aHR 1.55; 95% CI 1.06 to 2.26). Similar results were observed for cholelithiasis only, but cholecystectomy did not reach statistical significance. There was no strong evidence for detection bias of liver cancer due to cholelithiasis or cholecystectomy. Conclusions Our study suggests that cholelithiasis and possibly cholecystectomy may increase the risk of liver cancer.
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