期刊
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
卷 68, 期 3, 页码 275-279出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jech-2013-203159
关键词
Socio-Economic; Inequalities; Mortality; Smoking; Cohort studies
资金
- British Heart Foundation
- UK Medical Research Council [MC_UU_12019/01]
- ESRC [ES/F02679X/1] Funding Source: UKRI
- MRC [MC_UU_12019/1, G0902037, G0601647, G1000616, G0701830, MR/K013351/1] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Economic and Social Research Council [ES/F02679X/1] Funding Source: researchfish
- Medical Research Council [MR/K013351/1, G8802774, G0601647, MC_UU_12019/1, G0902037, G19/35, G1000616, G0100222, G0701830] Funding Source: researchfish
Background A large part of the socioeconomic mortality gradient can be statistically accounted for by social patterning of adult health behaviours. However, this statistical explanation does not consider the early life origins of unhealthy behaviours and increased mortality risk. Methods Analysis is based on 2132 members of the MRC National Survey of Health and Development with mortality follow-up and complete data. Smoking behaviour was summarised by pack-years of exposure. Socioeconomic circumstances were measured in childhood (father's social class (age 4), maternal education (age 6)) and age 26 (education attainment, home ownership, head of household social class). We estimated the direct effect of early circumstances, the indirect effect through smoking and the independent direct effect of smoking on inequality in all-cause mortality from age 26 to 66. Results Mortality risk was higher in those with lower socioeconomic position at age 26, with a sex-adjusted HR (relative index of inequality) of 1.97 (95% CI 1.18 to 3.28). Smoking and early life socioeconomic indicators together explained 74% of the socioeconomic gradient in mortality (the gradient). Early life circumstances explained 47% of the gradient, 23.5% directly and 23.0% indirectly through smoking. The explanatory power of smoking behaviour for the gradient was reduced from 50.8% to 28% when early life circumstances were added to the model. Conclusions Early life socioeconomic circumstances contributed importantly to social inequality in adult mortality. Our life-course model focusing on smoking provides evidence that social inequalities in health will persist unless prevention strategies tackle the intergenerational transmission of disadvantage and risk.
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