期刊
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
卷 63, 期 2, 页码 121-127出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jech.2008.077602
关键词
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资金
- University of Hong Kong Foundation for Development and Research
- University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
- Guangzhou Public Health Bureau
- Guangzhou Science and Technology Bureau, Guangzhou, China
- University of Birmingham, UK
Background: In observational studies, mainly from Western Caucasian populations, moderate alcohol use has been shown to be associated with a lower risk of diabetes. However, whether the protection is due to the attributes of alcohol or to those of moderate alcohol users is difficult to disentangle. A population with a different distribution of alcohol consumption and diabetes prevalence from Western populations was studied as a counterfactual comparison. Methods: Baseline data from the Guangzhou Biobank Cohort Study phases 1 and 2 (2003-6) were used to examine the adjusted associations, using multivariable censored linear regression, of alcohol use with fasting blood glucose in older (>= 50 years) men (n = 5740) and women (n = 14 274) from southern China. Moderate alcohol use was defined as weekly drinking of (210 g alcohol in men and (140 g in women. The expected associations of alcohol with high-density lipoprotein (HDL) cholesterol and blood pressure were also checked. Results: Moderate alcohol users had very similar fasting glucose levels to never users, adjusted for age, sex, socioeconomic status, smoking and physical activity. In contrast, moderate alcohol users had higher HDL-cholesterol by 0.05 mmol/litre (95% CI 0.02 to 0.07). Excessive (more than moderate) alcohol users had higher fasting glucose. Conclusions: In an understudied population with a different pattern of alcohol use from the populations usually studied, the biologically expected effects of moderate alcohol use were seen, but there was little effect on fasting glucose. Although cross-sectional studies cannot be conclusive, this pattern of findings, if confirmed, suggests that moderate alcohol use may not affect fasting glucose, although excessive use may be a risk factor.
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