期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 28, 期 2, 页码 375-383出版社
INFORMA HEALTHCARE
DOI: 10.3109/14756366.2012.668541
关键词
Antitumor; quinazoline; sulfonamide; synthesis
资金
- King Abdulaziz city for science and technology (KACST) [ARP-29-265]
- King Saud University, Riyadh, Saudi Arabia [10-MED1188-02]
New series of quinazoline containing sulfonamide derivatives were prepared and screened for their antitumor activity. Four human cancer cell lines, namely, hepatoma cancer cell line (HepG2), breast cancer cell line (MCF-7), cervix cancer cell line (HeLa) and colon cancer cell line (HCT-8), were used to measure the cytotoxic activity. Compounds 8 and 21 exhibited remarkable antitumor activity almost similar to that of the standard drug (doxorubicin). Six compounds 16, 22, 23, 29, 30 and 33, showed considerable activity and few compounds were totally inactive.
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