Article
Chemistry, Organic
Justin Dhanaraj Chellaian, S. S. Salin Raj
Summary: A series of metal complexes were synthesized and characterized, showing potential catalytic, biological, and anticancer activities through various analysis methods.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Li Chen, Jin-Mei Qi, Shu Yang, Si-Nuo Sun, Sheng-Jiao Yan
Summary: We have developed a new method to synthesize functionalized chromeno[2,3-c]pyrrol-9(1H)-one derivatives (CMPOs) 3 and 3' from 3-formylchromones by reacting with proline derivatives. This strategy involves a cascade reaction that occurs by simply heating a mixture of substrates 1 with 2 and toluene, followed by oxidation with oxygen and catalysis by CuBr. In a single step, this protocol cleaves two bonds (2 C-C) and forms three bonds (1 C-N and 2 C-C bonds) to produce a range of CMPOs 3 and 3'. This method can be used to synthesize functionalized CMPOs for combinatorial and parallel syntheses in a one-pot reaction.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Drzewiecka-Antonik, Marta Struga, Agnieszka Glogowska, Ewa Augustynowicz-Kopec, Katarzyna Dobrzynska, Alicja Chrzanowska, Anna Wolska, Pawel Rejmak, Marcin T. Klepka, Malgorzata Wrzosek, Anna Bielenica
Summary: Copper complexes with 1,3-disubstituted thiourea derivatives were synthesized and their structures and properties were investigated. The complexes exhibited antimicrobial, antituberculosis, and antitumor activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ioana Maria Carmen Ienascu, Adina Cata, Mariana Nela Stefanut, Iuliana Popescu, Gerlinde Rusu, Paula Sfirloaga, Daniel Ursu, Cristina Mosoarca, Anamaria Dabici, Corina Danciu, Delia Muntean, Raluca Pop
Summary: The goal of this research was to design novel chloro-substituted salicylanilide derivatives and their beta-cyclodextrin complexes in order to obtain efficient antibacterial compounds and to demonstrate the beneficial role of complexation on the efficiency of these compounds.
Article
Chemistry, Inorganic & Nuclear
Soumen Saha, Sha Tamanna Sahil, Md Motiur R. Mazumder, Alexander M. Stephens, Bryan Cronin, Evert C. Duin, Jonah W. Jurss, Byron H. Farnum
Summary: Two NNN pincer complexes of Cu(II) and Ni(II) with BPIMe- ligands were synthesized and characterized structurally, spectroscopically, and electrochemically. The complexes displayed catalytic activity for the reduction of CO2, with the Cu(II) complex showing higher activity than the Ni(II) complex. However, both complexes decomposed into copper and nickel metal on the electrode surface during extended reductive electrolysis, indicating the role of ligand reduction in electrocatalysis and decomposition processes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Physical
Hadi Kargar, Amir Adabi Ardakani, Muhammad Nawaz Tahir, Muhammad Ashfaq, Khurram Shahzad Munawar
Summary: Three new mononuclear metal complexes with Salen-type tetradentate Schiff base ligand have been synthesized and characterized, showing significant antibacterial activities against various bacterial strains. Nickel and copper complexes have monoclinic crystal system, while zinc complex has orthorhombic crystal system, all with specific coordination geometries.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Mosad A. El-ghamry, Fatma M. Elzawawi, Ayman A. Abdel Aziz, Khadija M. Nassir, Samy M. Abu-El-Wafa
Summary: A new Schiff base ligand derived from antiviral valacyclovir and its metal complexes (Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II)) were synthesized. The type of bonding between the ligand and metal ions was clarified and the complexes showed high thermal stability and antimicrobial and antitumor activity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Jia-Rui Jiang, Jian-Duo Zhang, Geng-Yun Yin, Jian-Quan Shi, Bing-Biao Cai, Wen-Wu Yang, Le-Le Deng, Li Xu, Tao Zhou, Qiu-Fen Hu, Min Zhou, Wei-Song Kong
Summary: Two new chromone derivatives (1 and 2) isolated from Cassia auriculata twigs were evaluated for their anti-MRSA activity, showing good inhibition with IZD of 12.8 +/- 2.2 and 13.0 +/- 2.5 mm, respectively. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Himadri Priya Gogoi, Anmol Singh, Pranjit Barman, Diganta Choudhury
Summary: A series of Cu(II), Zn(II), and Cd(II) complexes coordinated with a new Schiff base ligand (L1) were synthesized and characterized. The ligand exhibited strong DNA binding ability, while the Cd(II) complex showed better antibacterial properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Guowei Gu, Tao Zhang, Jianyuan Zhao, Wuli Zhao, Yan Tang, Lu Wang, Shan Cen, Liyan Yu, Dewu Zhang
Summary: Three new chromanone dimer derivatives, paecilins F-H (1-3), were isolated from mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated and their configurations were resolved. Compounds 5 and 11 showed significant anti-influenza A virus activities, compounds 8 and 9 exhibited cytotoxic activities against the MIA-PaCa-2 cell line, and compound 10 showed antibacterial activities against Bacillus cereus.
Article
Biochemistry & Molecular Biology
Dariusz Karcz, Karolina Starzak, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta, Daniel Kaminski, Bernadette Creaven, Hollie Jenkins, Piotr Radomski, Anna Milos, Lidia Slusarczyk, Arkadiusz Matwijczuk
Summary: A series of coumarin-thiadiazole hybrids and their Cu(II) and Zn(II) complexes were synthesized and characterized, showing bidentate chelation properties. The Zn(II) complexes had a 1:1 ligand:metal ratio, while the Cu(II) complexes had a 2:1 ratio. All compounds exhibited lower antibacterial activity compared to commercial antibiotics, but showed moderate acetylcholinesterase inhibition activity in neurodegenerative assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Shunmugasundaram Gurusamy, Kumar Krishnaveni, Murugesan Sankarganesh, Radhakrishnan Nandini Asha, Alagarsamy Mathavan
Summary: In this study, Schiff base metal complexes of VO(IV), Cu(II), and Zn(II) were synthesized and characterized. The metal complexes exhibited good antibacterial activity against Staphylococcus aureus and strong antioxidant activity against DPPH radicals. Spectroscopic studies confirmed the binding of the metal complexes with DNA and protein molecules. Molecular docking studies provided insights into the interactions between the metal complexes and biomolecules.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Medicinal
Ilona Bereczki, Zsolt Szucs, Gyula Batta, Tamas Milan Nagy, Eszter Ostorhazi, Katalin E. Kover, Aniko Borbas, Pal Herczegh
Summary: In order to enhance the antibacterial activity of teicoplanin against vancomycin-resistant enterococci, various dimeric derivatives were prepared. A cobalt coordination complex of a dimeric derivative showed high activity against VanA teicoplanin-resistant enterococci. Both covalent and complex dimeric derivatives exhibited significant activity against the resistant strain, but had no remarkable effect on other bacterial strains.
Article
Chemistry, Inorganic & Nuclear
Hany M. Abd El-Lateef, Mai M. Khalaf, Mahmoud Kandeel, Aly Abdou
Summary: In this study, three new complexes based on Ciprofloxacin (CPFX) and 2-(1H-benzimidazol-2-yl)phenol (2-Bip) were prepared and characterized. The structures were determined using various analytical techniques, and the ligands exhibited mono-negatively bi-dentate behavior. Quantum chemistry simulations were performed to optimize the structures and investigate the frontier orbitals. The prepared complexes showed enhanced antibacterial activity and antioxidant characteristics compared to the free ligand CPFX.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Melaine Gonzalez-Garcia, Fidel Morales-Vicente, Erbio Diaz Pico, Hilda Garay, Daniel G. Rivera, Mark Grieshober, Lia Raluca Olari, Rudiger Gross, Carina Conzelmann, Franziska Krueger, Fabian Zech, Caterina Prelli Bozzo, Janis A. Mueller, Alexander Zelikin, Heinz Raber, Dennis Kubiczek, Frank Rosenau, Jan Muench, Steffen Stenger, Barbara Spellerberg, Octavio L. Franco, Armando A. Rodriguez Alfonso, Ludger Staendker, Anselmo J. Otero-Gonzalez
Summary: Cm-p5 and its derivatives showed moderate antimicrobial activity against certain bacteria and viruses, indicating potential applications but requiring further structural optimization.
Review
Chemistry, Medicinal
Md. Mominur Rahman, Sheikh Shohag, Md. Rezaul Islam, Shomaya Akhter, Sadia Afsana Mim, Rohit Sharma, Abdur Rauf
Summary: SARS-CoV-2 was discovered in Wuhan in late 2019 and has spread worldwide, leading to the current pandemic. With the absence of targeted therapeutics, scientists are exploring synthetic bioactive compounds for potential drugs or vaccines against COVID-19. Medicinal herbs have long been used as traditional healing medications due to their broad therapeutic range and minimal side effects. Due to the lack of synthetic antiviral medications, pharmaceutical and alternative therapies have utilized herbal compositions. The widespread availability of herbal and dietary products globally has resulted in their frequent usage. This review article discusses the immunomodulatory and antiviral effects of certain herbs in Bangladesh, and how their active ingredients have been collected. Despite the availability of FDA-approved medications and vaccines for treating COVID-19, there is a push to use herbal medicine as immunomodulators and vaccine adjuvants for prevention.
MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Md. Mominur Rahman, Limon Ahmed, Fazilatunnesa Anika, Anha Akter Riya, Sumaiya Khatun Kali, Abdur Rauf, Rohit Sharma
Summary: Nowadays, environmental pollution is a critical issue due to excessive industrialization, burning of fossil fuels, mining, agriculture, and plastics. Various approaches for treating environmental toxins are available, but effective, long-lasting, and less harmful solutions are in high demand. Modern research focuses on polymer-based nanoparticles, which are used in drug design, environmental remediation, and other fields. This article discusses the synthesis, characterization, and photocatalytic process of bioinorganic nanomaterials and their contributions to environmental remediation.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2023)
Review
Food Science & Technology
Anees Ahmed Khalil, Md. Mominur Rahman, Abdur Rauf, Md. Rezaul Islam, Sultana Juhara Manna, Ammar Ahmed Khan, Samee Ullah, Muhammad Nadeem Akhtar, Abdullah S. M. Aljohani, Waleed Abdulmonem, Jesus Simal-Gandara
Summary: The olive family, particularly Olea europaea L., is widely used for olive oil production. Different parts of the olive tree contain bioactive compounds such as oleuropein, apigenin, hydroxytyrosol, etc. Researchers have utilized various extraction methods to increase oleuropein yield, including maceration, soxhlet, microwave-assisted, ultrasonication, and supercritical fluid methods. This review focuses on in vitro and in vivo studies exploring the nutraceutical properties of oleuropein, revealing its potential in treating obesity, diabetes, cardiovascular complications, neurodegenerative diseases, cancer, inflammation, microbial infections, and oxidation. The comprehensive literature provided in this review contributes to the scientific community's understanding of oleuropein's absorption, metabolism, bioavailability, extraction techniques, and nutraceutical perspectives.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Md. Rezaul Islam, Md. Mominur Rahman, Puja Sutro Dhar, Feana Tasmim Nowrin, Nasrin Sultana, Muniya Akter, Abdur Rauf, Anees Ahmed Khalil, Alessandra Gianoncelli, Giovanni Ribaudo
Summary: Ovarian cancer is a major health concern for women with no obvious cause, frequent misdiagnosis, and poor prognosis. Natural compounds have advantages in treating the disease due to their multi-target actions, long application history, and widespread availability. They are perceived to have limited adverse effects on healthy cells or tissues and show potential as valid treatment alternatives. This review discusses the mechanistic insights and possible targets of natural compounds against ovarian cancer from a medicinal chemist's perspective and provides an overview of the pharmacology of natural products studied for their potential application in treating ovarian cancer models.
Review
Multidisciplinary Sciences
Muhammad Arif, Ayesha Fazal Nawaz, Shahid Ullah Khan, Hasnat Mueen, Fizza Rashid, Hassan A. Hemeg, Abdur Rauf
Summary: Radiation therapy against cancer often fails due to various restrictions, such as its lack of targeting and potential harm to normal tissues. Nanoparticles have the ability to enhance the efficacy of radiation treatment by increasing radiation sensitivity. However, there are challenges in the production and application of nanoparticles for cancer radiation therapy.
Article
Multidisciplinary Sciences
Adil Mujawah, Abdur Rauf, Sami Bawazeer, Abdul Wadood, Hassan A. Hemeg, Saud Bawazeer
Summary: This study isolated a bioactive compound from chloroform extract of Diospyros kaki (Japanese persimmon), which exhibited promising antioxidant, lipoxygenase inhibitory, and muscle relaxant activities. The results support the traditional usage of D. kaki in treating various diseases.
Article
Education & Educational Research
Aliya Khalid
Summary: This paper explores the portrayal of mothers as either educated and beneficial for their daughters' education or lacking education and detrimental to their daughters' future prospects, through a comparative analysis of policy texts and scholarly work. The findings are then supplemented with semi-structured interviews with rural Pakistani mothers, highlighting how mothers' aspirations contribute to their daughters' educational opportunities. The paper argues that understanding mothers' perspectives is crucial in informing global policy discourses and investigating the potential of mothers in contexts of material and social constraint.
COMPARATIVE EDUCATION
(2023)
Review
Pharmacology & Pharmacy
Saima Akhter, Farhin Montaha Tasnin, Mohammad Nazmul Islam, Abdur Rauf, Saikat Mitra, Talha Bin Emran, Fahad A. Alhumaydhi, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Muthu Thiruvengadam
Summary: The IL-17 cytokine family plays a critical role in inflammatory and autoimmune diseases, and dysregulation may lead to the development of various conditions. Understanding the role of IL-17 in these diseases is crucial for developing targeted therapeutic strategies.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Medicine, General & Internal
Wajeeha Waseem, Rehman Zafar, Muhammad Saeed Jan, Taghrid S. Alomar, Najla Almasoud, Abdur Rauf, Humayoon Khattak
Summary: In this research, computational docking studies were used to screen 16 FDA-approved antiviral drugs, and it was found that Delavirdine, Fosamprenavir, Imiquimod, Stavudine, and Zanamivir showed excellent inhibition against COVID-19. These findings provide a basis for further development of drugs to treat coronavirus.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Taghrid S. AlOmar, Abdur Rauf, Umer Rashid, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Najla Almasoud, Abdulaziz S. AlOmar, Gauhar Rehman, Zubair Ahmad, Naveed Muhammad, Zafar Ali Shah
Summary: This study evaluates the anti-inflammatory potential of peshawaraquinone, a compound isolated from Fernandoa adenophylla, and investigates its mode of action. The results demonstrate significant anti-inflammatory activity of peshawaraquinone in both in vitro and in vivo models, supported by computational analyses. These findings provide a solid foundation for further exploration and therapeutic applications of peshawaraquinone.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Abid Ali Ahmad, Kashif Hussain, Muhammad Raza Shah, Syed Muhammad Ashhad Halimi, Fazle Rabbi, Zahoor Ahmad, Inamullah Khan, Abdur Rauf, Abdulrahman Alshammari, Metab Alharbi, Hafiz Ansar Rasul Suleria
Summary: The aim of this study was to discover and explore highly potent and efficacious cyclooxygenase inhibitors using indole acetic acid drugs as a starting point. Derivatives of indomethacin, the selected lead compound, were synthesized and their structure and analogues were determined through spectroscopic procedures. The synthesized analogues were then screened for acute toxicity, anti-nociceptive and anti-inflammatory activity, and protein-ligand interaction. The results showed that the derivatives exhibited significant analgesic and anti-inflammatory activities, suggesting their potential as new drug candidates for pain and inflammation.
Article
Multidisciplinary Sciences
Naveed Muhammad, Ihtesham Ul Haq, Muhammad Saeed Jan, Taghrid S. Alomar, Abdur Rauf, Abdul Wadood, Najla Almasoud, Sulaiman Shams
Summary: In this research, an amide based metal carboxylate compound was identified as an anti-diabetic analgesic and anti-inflammatory agent. The compound showed inhibition against diabetic enzymes and demonstrated analgesic and anti-inflammatory effects in vivo. The molecular docking study suggested its potential inhibitory effect on the COX-2 receptor.
Review
Chemistry, Medicinal
Md. Rezaul Islam, Puja Sutro Dhar, Shopnil Akash, Sabeena Hussain Syed, Jeetendra Kumar Gupta, Kumaraswamy Gandla, Muniya Akter, Abdur Rauf, Hassan A. Hemeg, Yasir Anwar, Bassam Oudh Aljohny, Polrat Wilairatana
Summary: This review article provides an up-to-date and thorough summary of modern therapeutic techniques for treating hypertension (HTN), focusing on the molecular mechanisms of action found in substances from plants, herbs, and seafood. Bioactive molecules and seafood components have shown promising effects in regulating vascular tone, reducing oxidative stress and inflammation, and improving endothelial function, making them potential treatments for HTN.
NATURAL PRODUCTS AND BIOPROSPECTING
(2023)
Article
Biochemistry & Molecular Biology
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Ajoy Kumer, Md Sadique Hussain, Smrity Akter, Jeetendra Kumar Gupta, L. H. Thameemul Ansari, Mir Md. Mahfoj Islam Raj, Talha Bin Emran, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Rekha Thiruvengadam, Muthu Thiruvengadam
Summary: Gastric cancer is a serious global health concern. This study investigates the potential role of plant-derived compounds in preventing and treating gastric cancer, providing new perspectives for its treatment.
PROCESS BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Abdur Rauf, Taghrid S. Alomar, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Umer Rashid, Najla Almasoud, Abdulaziz S. Alomar, Gauhar Rehman, Zubair Ahmad, Naveed Muhammad, Zafar Ali Shah, Dorota Formanowicz
Summary: Medicinal plants are an important source of potential drugs for curing diseases. In this research, lapachol was isolated from Fernandoa adenophylla and evaluated for its anti-inflammatory effects. The results showed that lapachol has anti-inflammatory and anti-edematous effects, and it may act as a COX inhibitor by binding to COX-1 and COX-2 enzymes.