期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 26, 期 3, 页码 404-411出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2010.519336
关键词
Antioxidant activity; Lamiaceae; aromatic plant; inhibition of NO production; Origanum heracleoticum; radical-scavenging activity; terpenes
The present study shows the chemical profile and the in vitro properties (antioxidant and inhibition of nitric oxide production) of the Origanum heracleoticum L. (Lamiaceae). The ethanolic extract of the aerial parts is characterized by terpenes and fatty acids. The extract, with high total phenol and flavonoid content, showed a significant radical-scavenging activity (IC50 value of 12.8 mu mu g/mL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test and an interesting antioxidant activity with the beta beta-carotene bleaching test (IC50 values of 12.9 and 14.1 mu mu g/mL at 30 and 60 min of incubation, respectively). The test for the inhibition of NO production, performed using the murine monocytic macrophage RAW 264.7 cell line, showed that the extract had significant activity with an IC50 value of 108.5 mu mu g/mL. The cytotoxic effect of O. heracleoticum extract in presence of lipopolysaccharide (LPS) (1 mu mu g/mL) was evaluated but found to be negligible.
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