Article
Pharmacology & Pharmacy
Kamal Sweidan, Ghassan Abu Sheikha, Ghassan Shattat, Tariq Al-qirim, Majdi Bkhaitan
Summary: A series of N-(benzoylphenyl)-carboxamide derivatives were synthesized and compounds 3b, 5a, and 5b showed significant hypolipidemic effects. These compounds have the potential to be lipid-lowering agents, reducing the risk of atherosclerosis and cardiovascular disease.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Basmah Al-Jammal, Buthaina Hussein, Yusuf Al-Hiari, Tareq Al-Qirim, Manal Al-Najdawi, Lama Hamadneh, Mohammad Alwahsh, Balqis Ikhmais
Summary: The hypolipidemic effect of furan carboxamide derivatives was investigated using the Triton WR-1339 rat model. Nineteen compounds were synthesized and tested, and the results showed significant activity in reducing triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, as well as increasing high-density lipoprotein cholesterol levels.
Article
Biochemistry & Molecular Biology
Esra Palabiyik, Ayse Nurseli Sulumer, Handan Uguz, Bahri Avci, Seda Askin, Hakan Askin, Yeliz Demir
Summary: This study aimed to investigate the potential reparative impact of ethanol extract walnut seed coat (E-WSC) on metabolic enzymes activity in hyperlipidemia-induced rats. The results showed that E-WSC improved the effects of hyperlipidemia on balance and prevented alterations in the activity of metabolic enzymes. Therefore, E-WSC powder may be a promising natural compound for the treatment of cognitive disorders and hyperlipidemia as adjuvant therapy.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Integrative & Complementary Medicine
Fidele Ntchapda, Fernand C. Tchatchouang, David Miaffo, Barthelemy Maidadi, Lorella Vecchio, Rodrigue E. Talla, Christian Bonabe, Paul F. Seke Etet, Theophile Dimo
Summary: The study found that the aqueous extract of Ipomoea batatas leaves has hypolipidemic and anti-atherosclerogenic effects on diet-induced hypercholesterolemic rats, and can restore normal blood glucose and lipid levels.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Zoology
Abdullah Abdo Albegali, Tayyaba Aftab, Atiq-ur-Rehman, Amir Rashid, Mayada Mohammad
Summary: This study investigated the lipid-lowering effects of a methanol extract of Citrullus lanatus seeds in hyperlipidemia rats. The results showed that the extract significantly reduced total cholesterol, triglycerides, LDL, VLDL, AST, and ALT levels, while maintaining HDL levels within the normal range. The study suggests that the plant may have potential as a supportive treatment for hyperlipidemia.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Article
Clinical Neurology
Lu Xu, Kai Wang, Shengfeng Wang, Lili Liu, Xiaozhen Lv, Yongfeng Song
Summary: This study revealed that high levels of triglycerides increased the risk of depressive symptoms in men, especially in individuals without hypertension and diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Cell Biology
Yukihito Higashi
Summary: Dyslipidemia is linked to endothelial dysfunction leading to atherosclerosis and cardiovascular complications. Breaking the progression from endothelial dysfunction to cardiovascular complications is clinically important in dyslipidemia patients. Lipid-lowering therapy improves endothelial function in dyslipidemia patients. The relationships of components of a lipid profile with endothelial function, such as LDL cholesterol, HDL cholesterol, and triglycerides, are complex. This review focuses on exploring their roles.
Article
Endocrinology & Metabolism
Guizhi Deng, Yunjie Li, Wenke Cheng
Summary: The study aimed to investigate the relationship between lipid profile and prevalence of hypertension in Chinese adult women. The results showed that TC, LDL-c, and non-HDL-c were positively associated with hypertension prevalence, while HDL-c was negatively associated with hypertension prevalence but became nonsignificant after full adjustment for variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Siwei Chen, Wenke Cheng
Summary: The study found that elevated total cholesterol, LDL-c, and non-HDL-c were related to the incidence of hypertension in Chinese adult males. Triglycerides, however, were not significantly associated. After adjusting for BMI, the relationship between HDL-c and hypertension shifted from no association to a positive correlation. The BN model showed that age, BMI, fasting plasma glucose (FPG), and total cholesterol were strongly associated with hypertension incidence.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Mehran Nouri, Mohammad Ali Mohsenpour, Niki Katsiki, Saeed Ghobadi, Alireza Jafari, Shiva Faghih, Maciej Banach, Mohsen Mazidi
Summary: In this meta-analysis, the relationship between serum lipid profile and breast cancer risk was investigated. The results showed a negative association between high-density lipoprotein cholesterol (HDL-C) level and breast cancer risk, while other indicators such as TG, TC, ApoA and LDL-C were not associated with breast cancer development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Article
Medicine, General & Internal
Kounseok Lee, Sunhae Kim, Jung Ki Jo
Summary: This study aimed to examine the effects of various socio-demographic characteristics, abnormal cholesterol levels, and BMI indicators on depressive symptoms and suicidal ideation in the Korean population. The results showed that high triglyceride levels were a risk factor for depression in men, while blood lipid factors did not significantly affect suicidal ideation in males.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Anas Shamsi
Summary: This study investigates the binding between donepezil and ferritin using molecular docking and molecular dynamics simulation, revealing that the binding of donepezil stabilizes ferritin structure and leads to fewer conformational changes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Otorhinolaryngology
Sa'ed H. Zyoud, Muna Shakhshir, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Samah W. Al-Jabi
Summary: This study is a bibliometric analysis of publications related to COVID-19 and olfactory and/or gustatory dysfunction, and it reveals that the United States, Italy, and the United Kingdom are the countries with the highest number of relevant publications.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dima A. Sabbah, Hla H. Samarat, Eveen Al-Shalabi, Sanaa K. Bardaweel, Rima Hajjo, Kamal Sweidan, Reema Abu Khalaf, Aya M. Al-Zuheiri, Ghassan Abushaikha
Summary: In this study, a series of compounds targeting PI3K alpha were developed, and they exhibited distinct anticancer activity against cancer cells. Computational modeling studies revealed the interaction between these compounds and key amino acids, as well as their drug-like properties. These findings provide important biological insights for further development of anticancer drugs.
Article
Health Policy & Services
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Faris El-Dahiyat, Maimona Jairoun, Moyad Shahwan, Mena Al Ani, Mustafa Habeb, Zaheer-Ud-Din Babar
Summary: This study aimed to evaluate the knowledge, attitude, and determinants of acceptance of a third COVID-19 vaccine booster dose in the UAE. The findings showed variations in knowledge and attitude among the population, indicating the need for government and public health authorities to take steps to increase vaccine acceptance and enhance vaccine education and communication.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Badrah S. Alghamdi, Saleh Baeesa, Haythum O. Tayeb, Ghulam Md Ashraf, Anas Shamsi
Summary: Neuronal damage in iron-sensitive brain regions is associated with iron dyshomeostasis and neurodegenerative diseases, particularly Alzheimer's disease (AD). Ferritin plays a key role in iron homeostasis. Natural compound bryostatin may have therapeutic implications for AD. This study explores the binding mechanism of bryostatin 1 with ferritin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Muhammed Alzweiri, Kamal Sweidan, Obada abu Saleh, Tamam Al-Helo
Summary: A group of new 2-oxo-1,2-dihydroquinoline-3-carboxamides have been synthesized and shown to have strong potency in inhibiting acetylcholinesterase enzyme. One compound (compound 7) exhibited better recovery from scopolamine-induced dementia compared to donepezil in the zebra fish model.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Munazza Ahmed, Ahlam M. Semreen, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Ahmed Alhusban, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares, Mohammad H. Semreen, Karem H. Alzoubi
Summary: Glioblastoma (GB) is a type of aggressive brain tumor with unclear biology and challenges in diagnosis and prognosis due to its heterogeneity. Omics techniques, including proteomics and metabolomics, have shown promise in understanding the regulatory network of enzymes and metabolites in GB. This review highlights the significant contributions of these tools in GB research and treatment, emphasizing the impact of integrative omics approaches in overcoming therapeutic challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yousra A. A. Hagyousif, Basma M. M. Sharaf, Ruba A. A. Zenati, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Alexander D. D. Giddey, Ahmad Y. Y. Abuhelwa, Karem H. H. Alzoubi, Nelson C. C. Soares, Mohammad H. H. Semreen
Summary: Skin cancer is the most common type of cancer among the white skin population, and metabolomics technology can be used to evaluate the metabolic profile of human skin cancer, which can be applied in diagnosis and treatment. Different analytical platforms, including GC-MS, LC-MS, and NMR, can be used in metabolomics analysis of skin cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ruba A. Zenati, Alexander D. Giddey, Hamza M. Al-Hroub, Yousra A. Hagyousif, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares, Mohammad H. Semreen
Summary: Untargeted multi-omics analysis of plasma is used for identifying novel biomarkers and understanding molecular mechanisms of human diseases. This study compares the results of metabolomic and proteomic analyses using two solvent systems for analyte extraction from plasma samples. It finds that methanol-only extraction shows greater reproducibility for quantification, while methanol/chloroform extraction provides greater coverage of extracted metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Razan I. I. Nassar, Muna Barakat, Samar Thiab, Feras El-Hajji, Hiba Barqawi, Waseem El-Huneidi, Iman A. A. Basheti, Eman Abu-Gharbieh
Summary: To address vaccine hesitancy, providing accurate data on COVID-19 vaccines is necessary. A cross-sectional study was conducted to collect data on side effects experienced by individuals who received the inactivated COVID-19 vaccine, and the majority of participants reported experiencing side effects.
Article
Medicine, Research & Experimental
Mohammad G. Mohammad, Rania Saeed, Abdul Khader Mohammed, Anila Khalique, Mohamad Hamad, Waseem El-Huneidi, Mawieh Hamad, Jalal Taneera
Summary: Mounting evidence suggests a link between GDF15 expression and diabetes mellitus. The role of GDF15 in pancreatic beta-cell function was investigated through bioinformatics analysis and functional experiments. Silencing Gdf15 reduced insulin release, glucose uptake, increased ROS production, and apoptosis levels, while its overexpression in human islets was associated with increased insulin secretion. These findings highlight the significant role of GDF15 in pancreatic beta-cell function.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Noor Mazin, Ammar Jairoun, Sahab Al Khoja, Monzer Shahwan, Osama Najjar, Tariq Al-Qirim
Summary: The aim of this study was to determine the prevalence of vitamin D deficiency in elderly patients with type 2 diabetes mellitus and its association with diabetic nephropathy. The study found a high prevalence of vitamin D deficiency in this population, and a significant association between low vitamin D levels and diabetic nephropathy, as well as other biochemical factors such as e-GFR and Alb: Cr ratio.
Review
Chemistry, Medicinal
Neel Parekh, Ashish Garg, Renuka Choudhary, Madhu Gupta, Ginpreet Kaur, Seema Ramniwas, Moyad Shahwan, Hardeep Singh Tuli, Gautam Sethi
Summary: Cancer is a complex disease characterized by uncontrolled growth and spread of abnormal cells. Telomerase, an enzyme overexpressed in cancer cells, plays a critical role in cell proliferation and survival. Naturally occurring flavonoids can inhibit telomerase expression through various mechanisms, making them potential therapeutic agents for cancer. Numerous studies support the anti-cancer activity of flavonoids and their ability to deactivate telomerase in different cancer types.
Article
Agriculture, Dairy & Animal Science
Yasser Bustanji, Katia H. Abu Shihab, Waseem El-Huneidi, Mohammad H. Semreen, Eman Abu-Gharbieh, Karem H. Alzoubi, Mohammad A. Y. Alqudah, Ahmad Y. Abuhelwa, Eman Y. Abu-Rish, Hana Bajes, Khaled Obaideen, Islam Hamad, Nelson C. Soares, MoezAlIslam E. Faris
Summary: This study used the Scopus database to analyze and evaluate the bibliometric indicators of global monkeypox research. The results showed that the United States was the most active in terms of researchers and institutions, but there was less global cooperation than anticipated. Fostering international collaboration is crucial for addressing this global threat.
Article
Multidisciplinary Sciences
Waseem El-Huneidi, Shabana Anjum, Abdul Khader Mohammed, Shuhd Bin Eshaq, Sham Abdrabh, Yasser Bustanji, Nelson C. Soares, Mohammad H. Semreen, Karem H. Alzoubi, Eman Abu-Gharbieh, Jalal Taneera
Summary: Rosmarinic acid (RA) exerts a protective effect against streptozotocin-induced beta-cell damage by modulating the NF-kappa B and Bcl-2 pathways.