Article
Microbiology
Giovanna Ginestra, Teresa Gervasi, Francesca Mancuso, Federica Bucolo, Laura De Luca, Rosaria Gitto, Davide Barreca, Giuseppina Mandalari
Summary: In this study, a series of arylsulfonamide compounds were screened and the structure-activity relationship was established based on a hit compound. The antifungal activity against various Candida species was tested, and cytotoxicity was evaluated. These findings could contribute to the development of novel topical therapeutics for fungal infections.
Article
Engineering, Chemical
Ayodeji Precious Ayanwale, Brenda Lizbeth Estrada-Capetillo, Simon Yobanny Reyes-Lopez
Summary: This study synthesized and characterized ZrO2-Ag2O nanoparticles, demonstrating their effective antifungal activity against Candida spp. with no significant impact on human cell viability.
Article
Microbiology
Gladys Pinilla, Yenifer Tatiana Coronado, Gabriel Chaves, Liliana Munoz, Jeannette Navarrete, Luz Mary Salazar, Carlos Pelleschi Taborda, Julian E. Munoz
Summary: Fungal infections have become a major problem in immunosuppressed or ICU patients, and the resistance of fungi to conventional antifungal treatments is increasing. This study evaluated the in vitro antifungal activity of LL-37 analogue peptides against Candida spp. The results suggest that LL37-1 and AC-2 have the best inhibitory effect on Candida strains.
Article
Pharmacology & Pharmacy
Jisue Lee, Jae-Goo Kim, Haena Lee, Tae Hoon Lee, Ki-Young Kim, Hakwon Kim
Summary: Novel compound NAIMSs, especially NAIMS 7c, exhibit potent antifungal activity against Candida spp. and C. auris, potentially inducing cell apoptosis by increasing ROS production and disrupting mitochondrial function. Further in vivo studies are warranted to explore the potential of NAIMSs as novel antifungal agents.
Article
Infectious Diseases
Clarice Elvira Saggin Sabadin, Soraia Lima Lopes, Olga Fischmamm Gompertz, Gilglecia Novaes Pereira Santana, Analy Salles de Azevedo Melo, Lilian Rigo, Daniel Archimedes Da Matta, Dulce Aparecida Barbosa
Summary: This study investigated oral colonization of Candida species and their susceptibility to antifungals in liver transplant patients. Results showed stable yeast species colonization in some patients over 6 months, but substitution in others. The study highlights the importance of monitoring antifungal resistant strains.
Article
Food Science & Technology
Hao Yu, Zi-Xi Lin, Wen-Liang Xiang, Ming Huang, Jie Tang, Yue Lu, Qiu-Huan Zhao, Qing Zhang, Yu Rao, Lei Liu
Summary: This study demonstrates the antifungal activity of D-limonene against Candida tropicalis by disrupting the cell membrane and intracellular ion homeostasis, suggesting its potential to prevent food contamination.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agricultural Engineering
Rita Ribeiro, Liliana Fernandes, Raquel Costa, Carlos Cavaleiro, Ligia Salgueiro, Mariana Henriques, Maria Elisa Rodrigues
Summary: This study aimed to compare the effects of several essential oils (EOs) from Thymus spp. on Candida auris biofilm. Results showed different antifungal activities among the EOs, and the differences in their chemical compositions could explain these variations. Thymus vulgaris and Thymus zygis oils demonstrated the greatest antifungal effects and could be promising alternatives for the treatment of C. auris infections.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Rabina Kumpakha, Donna M. Gordon
Summary: The study demonstrates that occidiofungin effectively targets hyphae elongation in Candida species by inhibiting the morphological changes associated with yeast-to-hyphae switching. This suggests that occidiofungin could be a promising candidate for the treatment of Candida associated infections, as it may also inhibit the heterogeneous population of cells present in a clinical setting.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Ilaria Maria Saracino, Claudio Foschi, Matteo Pavoni, Renato Spigarelli, Maria Chiara Valerii, Enzo Spisni
Summary: This study aimed to test the antifungal activity and potential synergistic effect of five essential oil components. The results showed that cinnamaldehyde and eugenol had the best inhibitory effects on Candida strains, with a highly additive effect.
Article
Microbiology
Henry W. Nabeta, Joseph C. Kouokam, Amanda B. Lasnik, Joshua L. Fuqua, Kenneth E. Palmer
Summary: This study demonstrates the novel antifungal activity of Q-Griffithsin (Q-GRFT) against various Candida strains by binding to alpha-mannan in the cell wall, disrupting cell wall integrity, and inducing ROS formation leading to cell death. Q-GRFT also inhibits the growth of other Candida species and shows potential as a drug candidate for the prevention and treatment of fungal infections.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Dawrin Pech-Puch, Diana Grilo, Susana Eunice Calva-Perez, Andreia Pedras, Harold Villegas-Hernandez, Sergio Guillen-Hernandez, Raul Diaz-Gamboa, Mateo Forero Tunjano, Jaime Rodriguez, Oscar A. Lenis-Rojas, Carlos Jimenez, Catarina Pimentel
Summary: This study screened 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, for antifungal activity and identified nine crude extracts with potent antifungal activity, including four from sponge species. The chemical composition analysis of one of the most active fractions revealed the presence of mirabilin B and penaresidin B. These findings highlight the marine organisms of the Yucatan Peninsula as important sources of natural products with promising fungicidal activity, which could greatly advance the treatment of invasive fungal infections, particularly in immunosuppressed patients.
Article
Microbiology
Maria A. Holanda, Cecilia R. da Silva, Joao B. de A. Neto, Livia G. do A. Sa, Francisca B. S. A. do Nascimento, Daiana D. Barroso, Lisandra J. da Silva, Thiago M. Candido, Amanda C. Leitao, Amanda D. Barbosa, Manoel O. de Moraes, Bruno C. C. Moraes, Helio V. N. J. Moraes
Summary: This study revealed that midazolam has antifungal activity against planktonic Candida cells and can reduce the viability of Candida biofilms. Scanning electron microscopy showed that midazolam can alter the appearance of Candida biofilms.
FUTURE MICROBIOLOGY
(2021)
Article
Microbiology
A. Espinel-Ingroff, M. Sasso, J. Turnidge, M. Arendrup, F. Botterel, N. Bourgeois, B. Bouteille, E. Canton, S. Cassaing, E. Dannaoui, M. Dehais, L. Delhaes, D. Dupont, A. Fekkar, J. Fuller, G. Garcia-Effron, J. Garcia, G. M. Gonzalez, N. P. Govender, H. Guegan, J. Guinea, S. Houze, C. Lass-Florl, T. Pelaez, A. Forastiero, M. Lackner, R. Magobo
Summary: Susceptibility testing for antifungal drugs is crucial in the clinical setting, relying on categorical endpoints and epidemiological cutoff values for different species. Collaborative efforts have led to the development of Etest sensitivity values for various Candida and Aspergillus species, aiding in clinical laboratory testing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Maisa Santos Fonseca, Daniela Meria Rodrigues, Ana Rita Sokolonski, Danijela Stanisic, Luiz Marcelo Tome, Aristoteles Goes-Neto, Vasco Azevedo, Roberto Meyer, Danilo Barral Araujo, Ljubica Tasic, Ricardo Dias Portela
Summary: This study evaluated the activity of Fusarium oxysporum-based silver nanoparticles (AgNPs) on Candida spp. isolated from denture stomatitis lesions and investigated their interference on biofilm formation and mechanisms of action. The results showed that AgNPs were effective against most Candida spp. and could potentially be a new therapeutic agent against oral candidiasis.
Article
Pharmacology & Pharmacy
Maria Laura Meneses, Maite Recalde, Paula Lorena Martin, Alejandro Guillermo Pardo
Summary: The aim of this study was to calculate the Minimum inhibitory concentrations (MICs) of silver nanoparticles and clotrimazole for Candida species and evaluate their interaction. The results showed synergistic activity between clotrimazole and silver nanoparticles for Candida albicans susceptible to fluconazole. However, indifference was observed for the other species tested. It is recommended to incorporate other measurement methodologies for confirming the results.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ulviye Acar Cevik, Ismail Celik, Aysen Isik, Iqrar Ahmad, Harun Patel, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Breast cancer is a common female cancer worldwide. In this study, a series of benzimidazole-1,3,4-oxadiazole derivatives were synthesized and compound 5a exhibited potent anticancer activity against breast cancer cell lines.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Plant Sciences
Fatih Demirci, Kerem Terali, Ayse Esra Karadag, Sevde Nur Biltekin, Ezgi Ak Sakalli, Betul Demirci, Muberra Kosar, K. Husnu Can Baser
Summary: This study evaluated the inhibitory potentials of O. majorana, O. minutiflorum, O. vulgare, and O. onites essential oils and their main constituent carvacrol for angiotensin-converting enzyme 2 and lipoxygenase enzyme. The results showed that these essential oils and carvacrol have the potential to inhibit the enzymes. Protein-ligand docking and interaction profiling provided insights into the inhibitory mechanisms of the major constituents.
Article
Plant Sciences
Ayse Esra Karadag, Aysegul Caskurlu, Betul Demirci, Fatih Demirci
Summary: Microbial resistance is a significant issue in modern healthcare systems, and this study evaluated the efficacy of combining amoxicillin with lavender and fennel essential oils against human pathogenic strains. The results showed a synergistic effect with potential future applications.
Article
Biochemistry & Molecular Biology
Derya Osmaniye, Iqrar Ahmad, Begum Nurpelin Saglik, Serkan Levent, Harun M. Patel, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Alzheimer's disease is a progressive and fatal neurodegenerative disease that affects the elderly and is characterized by memory and cognitive impairments. In this study, new compounds were synthesized and their inhibitory potentials against AChE and BChE were evaluated. Two compounds showed significant activity against AChE. Further analysis revealed their interactions with the enzyme active site similar to a reference drug.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Ulviye Acar Cevik, Ismail Celik, Aysen Isik, Ulkuye Dudu Gul, Gizem Bayazit, Hayrani Eren Bostanci, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal and antibacterial activities. Two compounds showed significant antifungal activity against multiple strains and one of them also exhibited higher antibacterial activity against a specific strain, comparable to reference drugs.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Biochemistry & Molecular Biology
Mehlika Dilek Altintop, Gulsen Akalin Ciftci, Nalan Yilmaz Savas, Ipek Ertorun, Betul Can, Belgin Sever, Halide Edip Temel, Ozkan Alatas, Ahmet Ozdemir
Summary: Indole-based small molecules were synthesized and subjected to in vitro colorimetric assay to evaluate their COX inhibitory profiles. Compound 3b showed selective cytotoxic activity against NSCLC cells through apoptosis induction and Akt inhibition, while also exhibiting anti-inflammatory action. Based on in vitro and in vivo experimental data, compound 3b stands out as a lead anti-NSCLC agent endowed with in vivo anti-inflammatory action, acting as a dual COX-1 and Akt inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Derya Osmaniye, Asaf Evrim Evren, Sevval Karaca, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Selective COX-2 inhibitors are commonly used for pain management due to their reduced adverse effects compared to non-selective COX inhibitors. This study synthesized 16 new thiadiazole derivatives and evaluated their COX-1 and COX-2 inhibitory potential. The results showed that compounds 3c and 3d exhibited significant activity against COX-2, with compound 3d being similar to the reference drug celecoxib. Molecular dynamics studies further elucidated the binding mode of compound 3d on COX-2.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Mehlika Dilek Altintop, Halide Edip Temel, Ahmet Ozdemir
Summary: This paper describes the synthesis and biological activity study of 2-pyrazoline compounds endowed with selective COX-1 inhibitory potency. Through chemical synthesis and experimental testing, two compounds with selective COX-1 inhibitory activity were discovered. Based on molecular simulation data, these compounds are estimated to have favorable oral bioavailability and drug-likeness. This research provides a rational guideline for further modifications at different sites on the 2-pyrazoline motif to bring out a new class of selective COX-1 inhibitors.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Emir Guzel, Ulviye Acar Cevik, Asaf Evrim Evren, Hayrani Eren Bostanci, Ulkuye Dudu Gul, Ugur Kayis, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: In this study, a series of benzimidazole-1,2,4-triazole derivatives were synthesized and evaluated for their antifungal activity. The compounds showed significant antifungal potential, especially against C. glabrata. Three compounds demonstrated higher antifungal activity compared to voriconazole and fluconazole. Molecular docking studies provided insights into the possible binding mode of these compounds.
Article
Chemistry, Medicinal
Cevik Ulviye Acar, Ismail Celik, Leyla Pasayeva, Hanifa Fatullayev, Hayrani E. Bostanci, Yusuf Ozkay, Zafer A. Kaplancikli
Summary: Benzimidazole-1,3,4-oxadiazole derivatives (5a-z) were synthesized and characterized using spectroscopic techniques. The synthesized compounds were evaluated for their antidiabetic potential against alpha-glucosidase and alpha-amylase enzymes. Compounds 5g and 5q exhibited the highest activity against alpha-glucosidase, while compounds 5g, 5o, 5s, and 5x showed excellent potential against alpha-amylase. The antioxidant activities of these compounds were also evaluated, and molecular docking and dynamics simulations were performed to investigate their binding mode and mechanism.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Mohamad Fawzi Mahomoodally, Gokhan Zengin, Seebaluck-Sandoram Roumita, Giovanni Caprioli, Ahmed M. Mustafa, Diletta Piatti, Evren Yildiztugay, Gunes Ak, Ayse Esra Karadag, Asaad Khalid, Ashraf N. Abdalla, Abdullahi Ibrahim Uba, Fatih Demirci
Summary: This study investigated the antioxidant and enzyme inhibitory activities of four extracts from Arum elongatum, and identified 28 compounds in the extracts. The extracts showed high antioxidant and enzyme inhibitory activities, which could be attributed to the presence of compounds such as chlorogenic acids, caffeic acid, and kaempferol. Further investigations are needed to explore the potential of Arum elongatum extracts in developing biopharmaceuticals.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Ulviye Acar cevik, Ismail Celik, Ufuk Ince, Zahra Maryam, Iqrar Ahmad, Harun Patel, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: In this study, a new series of 1,3,4-thiadiazole derivatives were synthesized, characterized, and evaluated for their biological activities. The structures of the final compounds were determined using various analytical techniques. The synthesized compounds were tested for their antimicrobial activity against bacteria and fungi, and compounds 3f and 3g showed remarkable antifungal activity. Docking experiments and molecular dynamics simulations were used to understand the binding forms and validate the theoretical studies of selected compounds. Density functional theory (DFT) calculations were performed to predict the reactivity and chemical characteristics of the compounds, and the results were correlated with experimental data. Additionally, computational estimation was carried out to predict the ADME properties of the most active compound 3f.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Environmental Sciences
Gamze Goger, Deniz Yuksel, Fatih Goger, Yavuz Bulent Kose, Fatih Demirci
Summary: Tripleurospermum callosum has been found to have therapeutic potential against urinary system ailments. In vitro and in vivo experiments were conducted using different extracts of the plant, and the results showed that the extracts were relatively non-toxic and exhibited anti-infective effects against urinary system pathogens, indicating their potential in infection control.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Derya Osmaniye, Begum Nurpelin Saglik, Narmin Khalilova, Serkan Levent, Gizem Bayazit, Ulkuye Dudu Gul, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Cancer is a prevalent and progressive disease, and its incidence is increasing globally. The development of novel drugs is necessary due to the side effects and resistance of existing drugs. Additionally, cancer patients are susceptible to bacterial and fungal infections. In this study, new naphthalene-chalcone derivatives were synthesized and their anticancer-antibacterial-antifungal properties were evaluated. Compound 2j exhibited anticancer activity against the A549 cell line with IC50 = 7.835 +/- 0.598 mu M, as well as antibacterial and antifungal activities. It also demonstrated apoptotic potential and inhibited VEGFR-2 enzyme.
Article
Biochemistry & Molecular Biology
Kemal Husnu Can Baser, Ayse Esra Karadag, Sevde Nur Biltekin, Murat Erturk, Fatih Demirci
Summary: The antiviral potential of Coldmix(R) and its major constituents 1,8-cineole and alpha-pinene was evaluated in vitro. Coldmix(R), 1,8-cineole, and alpha-pinene showed ACE2 enzyme inhibitory activity of 72%, 88%, and 80% respectively. In the direct contact test, the virus was destroyed by 79.9% within 5 minutes and 93.2% in the 30th minute. The in vitro cytotoxicity cell assay showed that E6 VERO healthy cells were not affected by toxicity. Further in vivo evaluation using different virus classes is suggested based on the promising initial antiviral results.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
