Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

(2012) Jean-Philippe Cosse et al.   Anti-Cancer Agents in Medicinal Chemistry

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Inhibition of 4E-BP1 Sensitizes U87 Glioblastoma Xenograft Tumors to Irradiation by Decreasing Hypoxia Tolerance

(2009) Ludwig Dubois et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

(2008) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Carbonic anhydrase IX: historical and future perspectives

(2008) Egbert Oosterwijk   BJU INTERNATIONAL

Development of small molecule carbonic anhydrase IX inhibitors

(2008) Claudiu T. Supuran   BJU INTERNATIONAL

Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia

(2008) Silvia Pastorekova et al.   BJU INTERNATIONAL

Reactive species: A cell damaging rout assisting to chemical carcinogens

(2008) Mario E. Goetz et al.   CANCER LETTERS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy

(2008) Mayumi Ono   CANCER SCIENCE

Hypoxia in prostate cancer: A powerful shield against tumour destruction?

(2008) L. Marignol et al.   CANCER TREATMENT REVIEWS

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study

(2008) M. R. Albertella et al.   CLINICAL CANCER RESEARCH

Hypoxic Regulation of Metastasis via Hypoxia-Inducible Factors

(2008) Marc Vooijs et al.   CURRENT MOLECULAR MEDICINE

Fluorescence- and Spin-Labeled Carbonic Anhydrase Inhibitors

(2008) Alessandro Cecchi et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer-Associated Carbonic Anhydrases and Their Inhibition

(2008) J. Pastorek et al.   CURRENT PHARMACEUTICAL DESIGN

[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model

(2008) Ludwig Dubois et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET imaging with hypoxia tracers: a must in radiation therapy

(2008) Giovanni Lucignani   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

(2008) S. Toffoli et al.   FEBS Journal

Reactive oxygen species in phagocytic leukocytes

(2008) John M. Robinson   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

(2008) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductive Heme-Dependent Activation of theN-Oxide Prodrug AQ4N by Nitric Oxide Synthase

(2008) Clinton R. Nishida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments of Carbonic Anhydrase Inhibitors as Potential Anticancer Drugs

(2008) Anne Thiry et al.   JOURNAL OF MEDICINAL CHEMISTRY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Safety and Side Effects of Immediate Instillation of Apaziquone Following Transurethral Resection in Patients With Nonmuscle Invasive Bladder Cancer

(2008) K. Hendricksen et al.   JOURNAL OF UROLOGY

Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin

(2008) Sarah K. Harten et al.   MOLECULAR BIOLOGY OF THE CELL

Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

(2008) Audrey Sermeus et al.   Molecular Cancer

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Dissecting the Role of Multiple Reductases in Bioactivation and Cytotoxicity of the Antitumor Agent 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1)

(2008) C. Yan et al.   MOLECULAR PHARMACOLOGY

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

iNOS as a therapeutic target for treatment of human tumors

(2008) Brian Fitzpatrick et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

(2008) Michaël G. Magagnin et al.   PROTEOMICS

Transcriptional responses to intermittent hypoxia

(2008) Jayasri Nanduri et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology

Carbonic anhydrase IX: A new druggable target for the design of antitumor agents

(2007) Jean-Yves Winum et al.   MEDICINAL RESEARCH REVIEWS

Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

(2007) Elisabeth L. Pagé et al.   MOLECULAR BIOLOGY OF THE CELL