期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 24, 期 3, 页码 818-824出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360802399662
关键词
Salsola species; tetrahydroisoquinoline alkaloids; acetylcholinesterase; butyrylcholinesterase; inhibition; antioxidant activity
From the aerial parts of Salsola oppositofolia, S. soda and S. tragus an alkaloid extract was obtained and tested to evaluate antioxidant and anti-cholinesterase activities. The in vitro study of the antioxidant activity by the DPPH method revealed a significant activity of Salsola alkaloid extracts with IC50 values ranging from 16.30 mu g/mL for S. oppositifolia to 26.17 mu g/mL for S. tragus. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities were evaluated. S. tragus alkaloid extract exerted the highest inhibitory activity against AChE (IC50 of 30.2 mu g/mL) and BChE (IC50 of 26.5 mu g/mL). Interestingly, S. soda and S. oppositifolia exhibited a selective inhibitory activity against BChE with IC50 values of 34.3 mu g/mL and 32.7 mu g/mL, respectively. Tetrahydroisoquinoline alkaloids were identified and quantified by GC/MS analysis.
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