Article
Biochemistry & Molecular Biology
Adel S. El-Azab, Alaa A-M Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy, Claudiu T. Supuran
Summary: New Schiff's bases based on quinazoline scaffold 4-27 were investigated for their inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. Some compounds showed potent inhibitory activity, comparable to the known inhibitor AZ, and demonstrated high selectivity towards different CA isoforms.
Article
Biochemistry & Molecular Biology
Dejan Agic, Maja Karnas, Sanja Tomic, Mario Komar, Zrinka Karacic, Vesna Rastija, Drago Beslo, Domagoj Subaric, Maja Molnar
Summary: This study investigated the inhibitory activity of 27 quinazolinone-Schiff's bases against human DPP III and identified five most potent inhibitors. These compounds were found to bind to the central enzyme cleft and interact with residues of the substrate binding subsites to exert inhibitory effects. Additionally, molecular dynamics simulations provided valuable insights into the mechanism of inhibitor binding and stabilization.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Gopalakrishnan Sasikumar, Annadurai Subramani, Ramalingam Tamilarasan, Punniyamurthy Rajesh, Ponnusamy Sasikumar, Salim Albukhaty, Mustafa K. A. Mohammed, Subramani Karthikeyan, Zaidon T. Al-aqbi, Faris A. J. Al-Doghachi, Yun Hin Taufiq-Yap
Summary: A series of ternary metal complexes (Co(II), Ni(II), Cu(II), and Zn(II)) were synthesized and characterized by elemental analysis and spectroscopic methods. These complexes were synthesized from metal salts with Schiff's-base-containing amino acids, salicylaldehyde derivatives, and heterocyclic bases, and showed promising pharmacological properties. The complexes exhibited a distorted, square pyramidal geometry around metal ions and their molecular structures were optimized by DFT calculations. The complexes were further investigated for their electrochemical behavior, catalytic properties, antibacterial activity, cytotoxic effects, and anticancer applications.
Article
Biochemistry & Molecular Biology
Kiran Meena, Prabhat Kumar Baroliya
Summary: In this study, we synthesized and characterized azines Schiff base ligands and their palladium complexes. The synthesized ligands coordinated with palladium through azomethine nitrogen and heteroatom or aryl carbon. The antimicrobial and antimalarial activities of the ligands and complexes were evaluated. Schiff base L-4 exhibited good antibacterial activity against S. aureus and antimalarial activity against P. falciparum. Complex C-1 showed the best antibacterial activity against S. typhi, while complex C-4 exhibited remarkable antimalarial activity among the tested compounds. Further exploration of azines based ligands and their Pd complexes as antimicrobial and antimalarial agents is recommended.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Chemistry, Physical
Rajesh Kumar, Aditya Abha Singh, Umesh Kumar, Pallavi Jain, Atul Kumar Sharma, Chandra Kant, Md. Serajul Haque Faizi
Summary: This review highlights the recent advances in the synthesis of heterocyclic Schiff base transition metal complexes and their antimicrobial activities, particularly antibacterial and antifungal properties. Schiff base metal complexes have shown great potential in various biological applications and may serve as promising candidates for drug discovery.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Myung Uk Park, Myeongjin Kim, Sung Hyun Kim, ChangJun Lee, Kyo-Seok Lee, Jaehun Jeong, Mann-Ho Cho, Dug Young Kim, Kyung-Hwa Yoo
Summary: The strain applied to TMDs reduces their bandgap and causes a funnel-like band structure with funneled excitons moving towards the most strained region. A funnel device based on asymmetrically strained WS2 and MoS2 is presented, with Raman and photoluminescence shifts indicating the effect of strains. Different devices with symmetric and asymmetric electrodes are constructed to investigate the conversion of funneled excitons into electrical currents. The scanning photocurrent mapping images show a fork-shaped pattern, suggesting the conversion is possible. The effect of strains on the Schottky barrier is dependent on the TMD used, as demonstrated by enhanced short-circuit current for WS2 and suppressed current for MoS2.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Varish Ahmad, Mohammad Omaish Ansari
Summary: Graphene and its nanocomposites have attracted significant interest due to their efficient antimicrobial properties. Graphene has found applications in tissue engineering and has been successfully conjugated with existing drugs to improve therapeutic efficacy. This review discusses the antimicrobial potential, synthesis, and toxicity of graphene-based nanomaterials in biological systems.
Article
Biotechnology & Applied Microbiology
Suad Yousif Aldorkee, Ali Abdul, Hussein S. Al-Janabi
Summary: Schiff bases are important in synthesizing new chemical ligands and have diverse biological activities. In this study, oxime derivatives were synthesized and their antimicrobial activities were investigated. The m-AAOX ligands showed stronger antimicrobial effects compared to the o-AAOX ligands, with L2 being the most effective against bacteria and other m-AAOX derivatives inhibiting fungi. The m-AAOX derivatives of Schiff bases have the potential to be promising antimicrobial agents.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Aly Abdou, Hassan M. Mostafa, Abdel-Mawgoud M. Abdel-Mawgoud
Summary: In this study, a series of metal complexes based on azocoumarin ligand were synthesized and characterized. The metal complexes showed high antibacterial and antifungal activity and complied with drug-likeness rules. These findings suggest their potential applications in drug development.
INORGANICA CHIMICA ACTA
(2022)
Review
Chemistry, Inorganic & Nuclear
Julia Helena Bormio Nunes, Douglas Hideki Nakahata, Pedro Paulo Corbi, Raphael Enoque Ferraz de Paiva
Summary: Sulfonamides are revolutionary drugs for the treatment and management of bacterial infections, with additional activities against tumors, fungi, and viruses. Silver sulfadiazine, a widely used sulfonamide, has been applied topically for the prevention and treatment of burn patients' infections. However, there is ongoing debate regarding the true efficacy of silver sulfadiazine as a topical treatment for burn wounds compared to other dressings loaded or not with silver-containing agents.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
S. N. Dandekar, O. A. Lotlikar, M. M. Ramana, S. Rathod
Summary: In this study, a series of isatin-based oxo-spiro chromene Schiff's bases were synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile with aromatic aldehydes using silica sulfuric acid (SSA) as an efficient acid catalyst. Spectroscopic techniques confirmed the formation of the desired products, which were then screened in vitro for antibacterial and anticancer activities. Molecular docking was also conducted to predict the potential mode of action of these derivatives.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
M. Ali, Essam Nageh Sholkamy, Ahmed S. Alobaidi, Muhanna K. Al-Muhanna, Assem Barakat
Summary: Schiff bases of chitosan were prepared using thermal and ultrasound approaches and confirmed by FT-IR, XRD, and TGA. The CS Schiff bases showed better thermal stability than pure CS and exhibited high antimicrobial activity against +ve Gram bacteria and -ve Gram bacteria.
Review
Chemistry, Multidisciplinary
Noufal Kandoth, Subhadip Barman, Atin Chatterjee, Sandip Sarkar, Anik Kumar Dey, Sumit Kumar Pramanik, Amitava Das
Summary: This review focuses on the development of upconverting nanoparticles based on core-shell lanthanide-doped nanoclusters for photoactive nanosystems against microbial infection and its therapeutic application. Utilizing NIR photoirradiation generated by lanthanum doped UCNPs, antimicrobial photodynamic therapy and multimodal therapy are achieved. The study highlights the efficacy of UCNPs against antibiotic-resistant bacterial colonies, drug-resistant fungi, and viruses, along with presenting their biosafety and biocompatibility at both in vitro and in vivo levels.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Education, Scientific Disciplines
Monika Shirke, Monali Gangthade, Pratip Chaskar, Rakesh Somani
Summary: Compounds containing electron withdrawing groups (-NO2, -CI, -Br) on the aromatic ring showed improved antimicrobial activity, with particular efficacy against fungal and bacterial strains.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Review
Engineering, Chemical
Khalida Naseem, Mudassir Hussain Tahir, Fatima Farooqi, Suryyia Manzoor, Saba Urooge Khan
Summary: Alginate extracted from marine brown algae is a widely used biopolymer for the fabrication of metal nanoparticle composites, which find applications in catalysis and biological treatment.
REVIEWS IN CHEMICAL ENGINEERING
(2023)
