Article
Multidisciplinary Sciences
Ji Kent Kwah, Aimee Jaramillo-Lambert
Summary: The article describes a method to determine embryonic viability and brood size in Caenorhabditis elegans. This technique can be used to assess errors in meiosis, fertilization, and embryogenesis and is easily adoptable for new researchers. It is an excellent model organism for studying these processes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Environmental Sciences
Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Summary: The study revealed that oxidative stress induced by MC-LR can activate the DNA damage-mediated ATM/p53 signaling pathway to induce autophagy in male germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Huanliang Liu, Lijie Tian, Shuting Wang, Dayong Wang
Summary: The study compared the transgenerational toxicity of 20 nm and 100 nm polystyrene nanoparticles using Caenorhabditis elegans as a model, finding that exposure to 20 nm particles resulted in more severe toxicity than 100 nm particles due to differences in transgenerational activation of oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Huixia Zhang, Xu Zhao, Yehao Li, Ping Xie
Summary: This study systematically verifies the adverse effects of MC-LR exposure on oxidative stress markers, health, functional traits, and performance traits in fish and mammals, and identifies MDA and LPO activities as indicators of oxidative stress. The study also highlights the impact of MC-LR exposure concentration on LPO, MDA, and growth.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Jiaqian Hong, Yiming Song, Jiayan Xie, Jianhua Xie, Yi Chen, Ping Li, Danyang Liu, Xiaobo Hu, Qiang Yu
Summary: This study used Caenorhabditis elegans as a model organism to investigate the toxic effects and mechanisms of acrolein (ACR) exposure. The results showed that ACR exposure shortened the lifespan of C. elegans, reduced reproductive capacity and locomotive behavior, and increased oxidative stress levels. ACR also affected the expression of antioxidant-related genes. The findings suggest that ACR exposure induces aging and oxidative stress in C. elegans, activating the DAF-16/FOXO pathway.
Article
Environmental Sciences
Rong Zhou, Yue Yu, Huan Miao, Na Zhao, Yuanqing Bu, Houhu Zhang
Summary: In this study, the toxicity of the herbicide atrazine and its main metabolites, deethylatrazine (DEA) and deisopropylatrazine (DIA), was compared using the in vivo model Caenorhabditis elegans. The results showed that DEA and DIA had lower toxicity on locomotion and reproduction compared to atrazine. Additionally, DEA and DIA induced less transgenerational toxicity on locomotion than atrazine and caused less oxidative stress and alteration in gene expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Carolin L. Schultz, Sylvain Bart, Elma Lahive, David J. Spurgeon
Summary: Surface functionalization and eco-corona formation can modulate the toxicity of nanoplastics, altering the potency and order of toxicity. The effects of surface charges on nanoplastic toxicity are primarily linked to differences in effect thresholds and dose-associated damage parameters, rather than toxicokinetic parameters. Eco-corona interactions between particles can reduce toxicity, but the order of potency of charged forms remains consistent.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Environmental Sciences
Shiyu Zhang, Xingde Du, Haohao Liu, Michael D. Losiewic, Xinghai Chen, Ya Ma, Rui Wang, Zhihui Tian, Linjia Shi, Hongxiang Guo, Huizhen Zhang
Summary: MC-LR is an emerging environmental pollutant produced by cyanobacteria that poses a threat to wildlife and human health by damaging reproductive organs and causing trans-generational and developmental toxicity. The mechanisms of MC-LR-induced reproductive toxicity mainly include the inhibition of protein phosphatase activity and the induction of oxidative stress, with potential involvement of epigenetic modifications. Additional research is needed to further understand the estrogenic effects of MC-LR and its impact on reproductive health.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Huimin Liu, Guanghan Fu, Wenjing Li, Bingjie Liu, Xiaoxue Ji, Shouan Zhang, Kang Qiao
Summary: In this study, the toxic effects of fluopimomide on Caenorhabditis elegans and the possible mechanisms were evaluated. Results indicated that fluopimomide had negative effects on the growth, pharyngeal pumping, and antioxidant systems of C. elegans. Furthermore, it was found that oxidative stress and mitochondrial damage may be involved in the toxicity of fluopimomide.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Yang Liu, Chun -Li Qi, Da -Wei Li, Hong-Ye Li, Rui-Man Li, Wei-Dong Yang
Summary: This study reveals that MCLR exposure weakens the colonic epithelial barrier by interfering with cytoskeletal stability, exacerbating homeostasis maintenance in the intestinal microenvironment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Toxicology
Ying Ma, Xiaomeng Ding, Qing Liu, Yanting Pang, Yuna Cao, Ting Zhang
Summary: The complex formed by the adsorption of classic toxins onto nanomaterials may exhibit stronger toxic effects than the individual materials. The surface adsorption effects mediated by nanomaterials can impact the bioavailability, toxicokinetics, distribution, and biological effects of classic toxins. This discovery is of great significance for the assessment of nanotoxicity.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Environmental Sciences
Xu Zhao, Kan Fu, Kai-ping Xiang, Lan-ying Wang, Yun-fei Zhang, Yan-ping Luo
Summary: In this study, the toxicities of glufosinate-ammonium on Caeno-rhabditis elegans were investigated. It was found that glufosinate-ammonium hindered the development, neurotoxicity and reproductive function of C. elegans, and caused oxidative damage and apoptosis.
Article
Environmental Sciences
Xiang Wan, Chen Cheng, Yurong Gu, Xiubo Shu, Liqiang Xie, Yanyan Zhao
Summary: The study investigated the single and mixture toxic effects of MC-LR and Phe mixtures on aquatic organisms, with results showing that the mixture toxicity was concentration-dependent and exhibited synergistic effects at low concentrations. The protective effects of high concentrations of MC-LR may lead to antagonistic effects. Furthermore, exposure to low concentrations of the mixture had a greater toxic effect on D. magna than either chemical alone.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Yue Yang, Shuilin Zheng, Hanyu Chu, Can Du, Mengshi Chen, Mohammed Y. Emran, Jihua Chen, Fei Yang, Li Tian
Summary: The objective of this study was to determine the effect and the mechanism of subchronic MC-LR toxicity on preexisting diet-induced colorectal damage. The results showed that MC-LR may cause colorectal inflammation and barrier disruption by stimulating the Raf/ERK signaling pathway. The study suggests that MC-LR treatment may exacerbate the colorectal toxicity caused by an HFD.
Article
Environmental Sciences
Xiaodong Ling, Junli Zuo, Meiqi Pan, Hongyan Nie, Jianzhong Shen, Qing Yang, Tien-Chieh Hung, Guangyu Li
Summary: The accumulation of nanoplastics exacerbates the toxic effects of microcystin on the liver of zebrafish, leading to cellular damage and oxidative stress. The presence of nanoplastics enhances the bioavailability of microcystin in the liver and alters the levels of reactive oxygen species, malondialdehyde, glutathione, and catalase, exacerbating the oxidative stress response.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
