期刊
出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03601230903163863
关键词
Veterinary pharmaceuticals; liquid chromatography-tandem mass spectrometry LC-MS-MS; poultry litter; antimicrobials
资金
- Environment Canada
Pharmaceuticals are emerging contaminants with potential risks to the environment and human health. A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed for determination of the antimicrobials virginiamycin, monensin, salinomycin, narasin and nicarbazin in poultry litter and soil. This method involves methanol extraction and clean-up of extracts through glass microfibre filters, introduction of the extracts and separation of compounds on a Zorbax Eclipse XDB C8 column, and compound detection in a Quattro Micro Micromass spectrometer. For litter samples, Method Detection Limits ranged from 0.1-0.6 mu g Kg(-1), while Limits of Quantitation (LOQs) were 2, 1, 0.4, 1 and 2 mu g Kg(-1) for virginiamycin, monensin, salinomycin, narasin and nicarbazin, respectively. For soil samples calculated LOQs were 2, 3, 1, 1, and 1 mu g Kg(-1) for virginiamycin, monensin, salinomycin, narasin and nicarbazin, respectively. Application of the LC-MS-MS method for detection of veterinary pharmaceuticals in litter collected from commercial poultry farms showed that compounds were present at concentrations ranging from 10-11,000 mu g Kg(-1).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据