Review
Endocrinology & Metabolism
Noha M. Shawky
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, characterized by reproductive and metabolic abnormalities. Offspring of PCOS women may have increased risk of hypertension and cardiovascular diseases. Limited studies have been conducted on the long-term risks of hypertension and cardiovascular diseases in PCOS offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
K. J. Polinski, S. L. Robinson, D. L. Putnick, R. Sundaram, A. Ghassabian, P. Joseph, V Gomez-Lobo, E. M. Bell, E. H. Yeung
Summary: Children born to mothers with PCOS did not show different cardiometabolic outcomes compared to children without exposure.
HUMAN REPRODUCTION
(2023)
Article
Health Care Sciences & Services
Mardia Lopez-Alarcon, Victor Saul Vital-Reyes, Eduardo Almeida-Gutierrez, Jorge Maldonado-Hernandez, Salvador Flores-Chavez, Juan Manuel Dominguez-Salgado, Jose Vite-Bautista, David Cruz-Martinez, Aly S. Barradas-Vazquez, Ricardo Z'Cruz-Lopez
Summary: Polycystic ovary syndrome (PCOS) is often accompanied by metabolic disturbances related to androgen excess and obesity. This study found that obesity is strongly associated with biomarkers related to glucose and liver metabolism, while free testosterone (FT) is only correlated with glucose and liver-related indicators. Women with obesity are at a higher risk of metabolic disorders compared to lean women, regardless of hyperandrogenemia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Endocrinology & Metabolism
Yue Xu, Zhi-Yang Zhou, Jie-Xue Pan, He-Feng Huang
Summary: A potential correlation between PCOS and asthma has been supported by increasing evidence. Epidemiological studies have shown that women with PCOS are more susceptible to asthma. Both conditions share common pathological conditions, and understanding their internal connection is important for prevention and control strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Pawel Dybciak, Dorota Raczkiewicz, Ewa Humeniuk, Tomasz Powrozek, Mariusz Gujski, Teresa Malecka-Massalska, Artur Wdowiak, Iwona Bojar
Summary: This meta-analysis utilized research utilizing the Hospital Anxiety and Depression Scale (HADS) to determine the prevalence, mean level, standardized mean difference, and probability of depression in patients with PCOS. The results indicate an increased risk of depressive symptoms in women with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Shu Zhou, Yiping Ji, Haimei Wang
Summary: The incidence of hypertensive disorders complicating pregnancy (HDCP) in patients with polycystic ovary syndrome (PCOS) is relatively high, with factors like age, BMI, family history of hypertension, history of adverse pregnancy, history of contraceptive pills use, and family history of HDCP being identified as independent risk factors. Early prevention and intervention measures targeting these risk factors can help reduce the occurrence of HDCP in PCOS patients.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Yidong Xie, Li Xiao, Shangwei Li
Summary: The study found that metformin treatment can improve obesity and insulin resistance in the F1 female offspring of PCOS-IR rats, but the phenotypes of PCOS were not stably inherited in the F2 female offspring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lim Leek Mei, Muhammad Azrai Abu, Kah Teik Chew, Aniza Ismail, Ani Amelia Zainuddin, Abdul Ghani Nur Azurah
Summary: The Polycystic Ovary Syndrome Questionnaire is a reliable tool for measuring health-related quality of life. The Malay version of this questionnaire has been developed and found to be valid for assessing the impact of polycystic ovary syndrome on Malaysian women's health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Rosa Wartena, Mushi Matjila
Summary: The relationship between polycystic ovarian syndrome (PCOS) and recurrent pregnancy loss (RPL) is still poorly understood and requires further research. Factors that should be further investigated include the contribution of PCOS phenotypes, BMI, obesity, insulin resistance, hyperandrogenemia, SHBG, hs-CRP, CTRP6, adiponectin, plasma leptin, homocysteine, AMH, and thrombophilia to the risk of miscarriage. Other factors that need to be explored in relation to the risk of miscarriage in PCOS patients with RPL include sOB-R, PAI-Fx, and Factor-V-Leiden mutations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Sushila Arya, Karl R. Hansen, Jennifer D. Peck, Robert A. Wild
Summary: This study aimed to investigate the impact of metabolic syndrome on fertility success and pregnancy complications in obese women with polycystic ovary syndrome undergoing ovulation induction. The results showed that metabolic syndrome was associated with lower rates of live birth and clinical pregnancy, as well as an increased risk of pregnancy complications, particularly gestational diabetes and macrosomia. Additionally, the type of medication used for ovulation induction also affected outcomes, with letrozole showing higher live birth rates compared to clomiphene in the presence of metabolic syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Endocrinology & Metabolism
Fang Yang, Jin-Chun Lu, Tao Shen, Yi-Han Jin, Yuan-Jiao Liang
Summary: Hyperlipidemia may have adverse effects on the outcome of IVF in PCOS patients, increasing the dosage of gonadotropin and affecting embryo quality and endometrial receptivity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhirong Zhang, Yue Liu, Jiali Lv, Di Zhang, Kuona Hu, Jingyu Li, Jinlong Ma, Linlin Cui, Han Zhao
Summary: This study described lipidomic characteristics of offspring born to polycystic ovary syndrome (PCOS) women (PCOS-off) and identified significant alterations in lipid profiles, especially among girls (PCOS-g) and boys (PCOS-b) born to PCOS women. Abnormal lipid levels in PCOS-off indicated risks for glucose metabolism and cardiovascular diseases. Some lipids, such as phosphatidylcholines, lysophosphatidylcholine, and sphingomyelin, may serve as potential markers in this population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhiyan Chen, Jichun Tan, Huichun Wang, Beihong Zheng, Jian Liu, Guimin Hao, Zaixin Guo, Zhengyi Sun, Qi Yu
Summary: The use of combined oral contraceptives (COCs) as antiandrogenic pretreatment before ovulation induction in PCOS patients with hyperandrogenism did not show superior results in terms of ovulation and pregnancy outcomes compared to direct letrozole-induced ovulation therapy. Performing antiandrogenic therapy before ovulation induction in patients with PCOS does not provide any benefit in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Jamie L. Benham, Jane E. Booth, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. Sigal
Summary: The most effective and cost-efficient ways to recruit women with polycystic ovary syndrome were through unpaid advertisements and Facebook advertisements, with no participants reporting learning about the trial through multiple methods. Traditional media was also more successful in attracting participants compared to Facebook and unpaid advertisements.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Obstetrics & Gynecology
M. W. Kemp, J. P. Newnham, J. G. Challis, A. H. Jobe, S. J. Stock
HUMAN REPRODUCTION UPDATE
(2016)
Article
Obstetrics & Gynecology
Scott W. White, Julie A. Marsh, Stephen J. Lye, Laurent Briollais, John P. Newnham, Craig E. Pennell
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2016)
Article
Medicine, Research & Experimental
Maria Nikiforou, Matthew W. Kemp, Rick H. van Gorp, Masatoshi Saito, John P. Newnham, Niki L. Reynaert, Leon E. W. Janssen, Alan H. Jobe, Suhas G. Kallapur, Boris W. Kramer, Tim G. A. M. Wolfs
LABORATORY INVESTIGATION
(2016)
Article
Immunology
Matthew W. Kemp, Shatha Ahmed, Michael L. Beeton, Matthew S. Payne, Masatoshi Saito, Yuichiro Miura, Haruo Usuda, Suhas G. Kallapur, Boris W. Kramer, Sarah J. Stock, Alan H. Jobe, John P. Newnham, Owen B. Spiller
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Demelza J. Ireland, Elizabeth A. Nathan, Shaofu Li, Adrian K. Charles, Lisa F. Stinson, Matthew W. Kemp, John P. Newnham, Jeffrey A. Keelan
Article
Obstetrics & Gynecology
Sarah J. Stock, Olga Patey, Basky Thilaganathan, Scott White, Lucy L. Furfaro, Matthew S. Payne, Owen B. Spiller, Andres Noe, Rory Watts, Sean Carter, Demelza J. Ireland, Alan H. Jobe, John P. Newnham, Matthew W. Kemp
REPRODUCTIVE SCIENCES
(2017)
Article
Obstetrics & Gynecology
Matthew S. Payne, Demelza J. Ireland, Rory Watts, Elizabeth A. Nathan, Lucy L. Furfaro, Matthew W. Kemp, Jeffrey A. Keelan, John P. Newnham
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Multidisciplinary Sciences
Maria Nikiforou, Esmee M. R. Jacobs, Matthew W. Kemp, Mathias W. Hornef, Matthew S. Payne, Masatoshi Saito, John P. Newnham, Leon E. W. Janssen, Alan H. Jobe, Suhas G. Kallapur, Boris W. Kramer, Tim G. A. M. Wolfs
SCIENTIFIC REPORTS
(2016)
Article
Cardiac & Cardiovascular Systems
Priyakumari Ganesh Parmar, H. Rob Taal, Nicholas J. Timpson, Elisabeth Thiering, Terho Lehtimaki, Marcella Marinelli, Penelope A. Lind, Laura D. Howe, Germaine Verwoert, Ville Aalto, Andre G. Uitterlinden, Laurent Briollais, Dave M. Evans, Margie J. Wright, John P. Newnham, John B. Whitfield, Leo-Pekka Lyytikainen, Fernando Rivadeneira, Dorrett I. Boomsma, Jorma Viikari, Matthew W. Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W. Montgomery, Albert Hofman, Mika Kahonen, Nicholas G. Martin, Martin D. Tobin, Ollie Raitakari, Jesus Vioque, Vincent W. V. Jaddoe, Marjo-Riita Jarvelin, Lawrence J. Beilin, Joachim Heinrich, Cornelia M. van Duijn, Craig E. Pennell, Debbie A. Lawlor, Lyle J. Palmer
CIRCULATION-CARDIOVASCULAR GENETICS
(2016)
Editorial Material
Immunology
Jeffrey A. Keelan, John P. Newnham
FRONTIERS IN IMMUNOLOGY
(2016)
Editorial Material
Obstetrics & Gynecology
Jonathan Morris, Kiarna Brown, John Newnham
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2020)
Article
Obstetrics & Gynecology
John P. Newnham, Chris Schilling, Stavros Petrou, Jonathan M. Morris, Euan M. Wallace, Kiarna Brown, Lindsay Edwards, Monika M. Skubisz, Scott W. White, Brendan Rynne, Catherine A. Arrese, Dorota A. Doherty
Summary: Preterm birth poses a significant economic burden to the Australian government, with costs mainly attributed to healthcare services and educational needs. Economic evaluations of interventions for preterm birth prevention or treatment should take into account these costs.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Haruo Usuda, Erin L. Fee, Sean Carter, Lucy Furfaro, Tsukasa Takahashi, Yuki Takahashi, John P. Newnham, Mark A. Milad, Masatoshi Saito, Alan H. Jobe, Matthew W. Kemp
Summary: This study evaluated the efficacy of a low-dose betamethasone regimen in achieving preterm lung maturation equivalent to the current dexamethasone treatment, but with reduced risk. The results showed that the low-dose betamethasone treatment achieved significant improvements in lung function and equivalent lung maturation compared to dexamethasone treatment, with fewer disturbances to the maternofetal hypothalamic-pituitary-adrenal axis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Tatiana Ninkov, Elizabeth A. Nathan, Cathryn N. Belcher, Scott W. White, John P. Newnham
Summary: Serial measurement of cervical length at 16 and 19 weeks improves the ability to predict preterm birth in high-risk women prescribed vaginal progesterone therapy.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
John P. Newnham, Scott W. White, Suzanne Meharry, Han-Shin Lee, Michelle K. Pedretti, Catherine A. Arrese, Jeffrey A. Keelan, Matthew W. Kemp, Jan E. Dickinson, Dorota A. Doherty
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)