Article
Cardiac & Cardiovascular Systems
Qiongjie Zhou, Xingzhong Zhao, Jinghui Xu, Yu Xiong, Jon F. R. Barrett, Xing-Ming Zhao, Xiaotian Li
Summary: This retrospective study aimed to describe the frequency of preeclampsia and aspirin use in real-world practice among women with twin pregnancies. The results showed that the use of low-dose aspirin was associated with a higher incidence of preeclampsia, possibly due to poor compliance with the medication. Further randomized controlled trials or prospective cohort studies are needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
L. Carolina Martinez-King, Michael Machiorlatti, Tony Ogburn, Jennifer Salcedo
Summary: This study aimed to evaluate physicians' knowledge and practices regarding the use of low-dose aspirin for preeclampsia risk reduction. The survey results showed that although over 90% of physicians recommended low-dose aspirin, there were gaps in knowledge and differences in practices. Enhanced screening tools and tailored medical education are needed to identify patients who may benefit from this intervention.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Manesha Putra, Madagedara Maduka Balasooriya, Alexander L. Boscia, Evrim Dalkiran, Robert J. Sokol
Summary: The ACC/AHA published new guidelines which have expanded the aspirin eligibility by 8% in the USPSTF guidelines. Despite this increase, the USPSTF guidelines remain the most cost-effective approach, with a projected increase in cost savings by $9.4 million. Using the ACC/AHA definition of hypertension still results in an annual cost-saving of $9.4 million in the United States when compared with the JNC7 guidelines.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Medicine, General & Internal
Wen-Yue Chen, Su-Fang Sun
Summary: This systematic review and meta-analysis evaluated the clinical effectiveness of low-dose aspirin combined with calcium supplements for the prevention of preeclampsia. The results showed that compared with the control group, the experimental group had lower incidence rates of preeclampsia with gestational hypertension, preeclampsia, gestational hypertension, preterm birth, postpartum hemorrhage, and fetal growth restriction.
Article
Obstetrics & Gynecology
Alexandra J. D. Phelps, Calla Holmgren
Summary: The study aimed to assess the usage of low-dose aspirin by obstetrician-gynecologists for pregnant women at risk of hypertensive disorders of pregnancy, based on guidelines from the American College of Obstetricians and Gynecologists and the United States Preventive Services Task Force. It also evaluated prescribing practices in relation to specific risk factors to identify the women who are most likely to not receive the recommended therapy.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Cardiac & Cardiovascular Systems
Li Zheng, Binbin Xia, Yuan Yuan, Yuran Wang, Yan Wang
Summary: This systematic review examines the efficacy and safety of combining low-molecular-weight heparin (LMWH) or unfractionated heparin with low-dose aspirin (LDA) in preventing preeclampsia in high-risk women. The meta-analysis of 14 randomized controlled trials found that the addition of LMWH to LDA reduces the risk of preeclampsia, small-for-gestational age, fetal and neonatal death, and gestational hypertension without increasing the risk of bleeding. However, larger studies are needed to further validate these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Piotr Tousty, Magda Fraszczyk-Tousty, Sylwia Dzidek, Hanna Jasiak-Jozwik, Kaja Michalczyk, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: Preeclampsia is a complex disorder of pregnancy with significant fetal and maternal consequences, and aspirin is recommended for high-risk women to reduce the risk. This review compared 14 guidelines and found variations in recommended dose, screening method, and timing for starting aspirin. Many societies now recommend higher doses (>75 mg) of aspirin, with most suggesting initiation before 16 weeks' gestation. The introduction of risk assessment models, such as the one proposed by the Fetal Medicine Foundation, has led to a shift in recommendations towards identifying high-risk populations and implementing aspirin prophylaxis, resulting in reduced morbidity for mothers and infants.
Article
Obstetrics & Gynecology
Manaphat Suksai, Alan Geater, Thitima Suntharasaj, Chitkasaem Suwanrath, Kla Charernjiratragul, Noppasin Khwankaew
Summary: This study evaluated the effectiveness of a preeclampsia (PE) screening program in pregnant Thai women using the NICE guideline. The results suggest that screening with the NICE guideline followed by low-dose aspirin prophylaxis may not be an effective strategy for preventing PE in this population.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Immunology
C. Stern, K. Mayer-Pickel, E. -C. Weiss, K. Kutllovci-Hasani, M. Nanda, K. Eberhard, M. Cervar-Zivkovic, F. Prueller
Summary: Preeclampsia remains a life-threatening pregnancy complication with severe morbidity and mortality. Low-dose Aspirin is globally recommended to prevent preeclampsia in high-risk pregnancies, but there are still questions around optimal dosing and effectiveness. This study found that around one third of women did not have sufficient platelet inhibition even with a daily dosage of 150 mg Aspirin, suggesting a need for further personalized research to maximize preventive benefits for both mother and child.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Guanlin Li, Wei Wei, Lingge Suo, Chun Zhang, Haiyan Yu, Hui Liu, Qing Guo, Xiumei Zhen, Yang Yu
Summary: The study demonstrated that aspirin treatment can effectively improve renal failure and pathological changes induced by preeclampsia, attenuating tubular injury and reducing kidney inflammation. It also suppresses renal cell apoptosis and oxidative stress. The mechanism involves inhibition of the WNT5A/NF-kappa B signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Li Lin, Jing Huai, Boya Li, Yuchun Zhu, Juan Juan, Meihua Zhang, Shihong Cui, Xianlan Zhao, Yuyan Ma, Yangyu Zhao, Yang Mi, Hongjuan Ding, Dunjin Chen, Weishe Zhang, Hongbo Qi, Xiaotian Li, Guanlin Li, Jiahui Chen, Huijing Zhang, Mengting Yu, Xiaotong Sun, Huixia Yang
Summary: The use of 100 mg aspirin for prevention of preeclampsia in high-risk pregnant women in China did not show significant efficacy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jeremy R. Van't Hof, Sue Duval, Niki C. Oldenburg, Jeffrey R. Misialek, Milton Mickey Eder, Clarence Jones, John R. Finnegan, Russell Luepker
Summary: Despite major changes in national guidelines, overall primary prevention aspirin use did not significantly change among African American samples from 2015 to 2019. The adjusted aspirin use rate for women remained around 37% and slightly increased to 30% for men. Participants who had discussed aspirin with a healthcare practitioner were more likely to use aspirin.
PREVENTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ka Cheuk Yip, Ziyin Luo, Xiaman Huang, Weijen Lee, Layla Li, Chenyang Dai, Weiyu Zeng, Tsz Ngai Mok, Qiyu He, Ruiman Li
Summary: The meta-analysis suggests that high-risk pregnant women can prevent preeclampsia or preterm delivery by taking low-dose aspirin; the most efficient period is <= 16 weeks of gestation, and the best dose is >= 100 mg.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Ellen Kupka, Susanne Hesselman, Roxanne Hastie, Riccardo Lomartire, Anna Karin Wikstrom, Lina Bergman
Summary: This study aimed to investigate the association between low-dose aspirin use and preterm birth among women with a previous preterm birth. A Swedish register-based cohort study found that low-dose aspirin use was associated with a reduced risk of preterm birth, particularly in spontaneous preterm births.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Norman C. Wang, Carlita Shen, Terence J. McLaughlin, Jack Z. Li, Alisse Hauspurg, Kathryn L. Berlacher, Aditya Bhonsale, Sandeep K. Jain, Krishna Kancharla, Samir Saba
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2020)
Editorial Material
Obstetrics & Gynecology
Alisse Hauspurg
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Alisse Hauspurg, Lara Lemon, Camila Cabrera, Amal Javaid, Anna Binstock, Beth Quinn, Jacob Larkin, Andrew R. Watson, Richard H. Beigi, Hyagriv Simhan
Review
Obstetrics & Gynecology
Alisse Hauspurg, Arun Jeyabalan
Summary: High blood pressure in the postpartum period can occur in women with antenatal hypertensive disorders or develop de novo. The distinction between postpartum preeclampsia or eclampsia and those with antepartum onset is unclear. The diagnosis of postpartum preeclampsia should be considered in women with new-onset hypertension 48 hours to 6 weeks after delivery. There are limited evidence-based guidelines for the diagnosis and management of this condition. Risk factors for postpartum preeclampsia include older maternal age, black race, maternal obesity, and cesarean delivery. Prompt recognition and treatment are important, as delayed-onset postpartum preeclampsia can lead to maternal morbidity. Further research is needed to better understand the pathophysiology and specific risk factors. Improved understanding of postpartum preeclampsia is crucial for patient care, counseling, and reducing maternal morbidity and mortality in the postpartum period.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Nina W. Ragunanthan, Jordan Lamb, Alisse Hauspurg, Stacy Beck
Summary: This study investigated the relationship between race and counseling/prescription and uptake of aspirin among women with chronic hypertension. The findings suggest that black women are equally likely to receive counseling about aspirin as women of other races, but their rates of uptake are lower.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Christina J. Megli, Alisse Hauspurg, Raman Venkataramanan, Steve N. Caritis
Summary: Through clinical samples and in vitro studies, the research found a correlation between plasma 17-OHPC concentration and LPS-stimulated IL-10 production in women receiving 17-OHPC for preventing preterm birth, supporting an immunomodulatory mechanism of action of 17-OHPC in the prevention of recurrent preterm birth.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Peripheral Vascular Disease
J. M. Catov, M. F. Muldoon, R. E. Gandley, J. Brands, A. Hauspurg, C. A. Hubel, M. Tuft, M. Schmella, G. Tang, W. T. Parks
Summary: Women with adverse pregnancy outcomes, such as preeclampsia and preterm birth, may have placental vascular lesions that are associated with an adverse cardiovascular profile a decade after delivery. These lesions are characterized by microvascular rarefaction, higher blood pressure, and more atherogenic lipids.
Article
Cardiac & Cardiovascular Systems
Alisse Hauspurg, Derek J. Marsh, Rebecca B. McNeil, C. Noel Bairey Merz, Philip Greenland, Adam C. Straub, Caroline E. Rouse, William A. Grobman, Victoria L. Pemberton, Robert M. Silver, Yii-Der Ida Chen, Brian M. Mercer, Lisa D. Levine, Afshan Hameed, Matthew K. Hoffman, Hyagriv N. Simhan, Janet M. Catov
Summary: Hypertensive disorders of pregnancy are linked to future cardiovascular disease, potentially due to pre-pregnancy subclinical cardiac dysfunction. This study examined the association between higher NT-proBNP concentrations in early pregnancy and hypertensive disorders of pregnancy and hypertension 2 to 7 years postpartum. The findings suggest that higher NT-proBNP concentrations are associated with a lower risk of these conditions.
Letter
Obstetrics & Gynecology
Alisse Hauspurg, Arun Jeyabalan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Rachel Bennett, Zuber D. Mulla, Pavan Parikh, Alisse Hauspurg, Talayeh Razzaghi
Summary: This study predicts preeclampsia using a new method that considers the imbalanced and sparse nature of the data, as well as racial disparities. The researchers validated their model using diverse data sources and identified influential factors for the general population and minority groups. Their models outperformed existing techniques and provided evidence of the predictive power of clinical databases for preeclampsia prediction among minority populations.
Article
Obstetrics & Gynecology
Malamo E. Countouris, Amy L. Marino, Megan Raymond, Alisse Hauspurg, Kathryn L. Berlacher
Summary: Intravenous drug abuse is an increasing risk factor for peripartum infective endocarditis. Peripartum IE carries a high risk of complications, including maternal mortality, and requires multidisciplinary management at a tertiary care center.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Alisse Hauspurg, Derek Marsh, Janet Catov
Article
Chemistry, Analytical
Simion Kreimer, Ali Haghani, Aleksandra Binek, Alisse Hauspurg, Saeed Seyedmohammad, Alejandro Rivas, Amanda Momenzadeh, Jesse G. Meyer, Koen Raedschelders, Jennifer E. Van Eyk
Summary: Proteomic analysis requires rapid mass spectrometry methods to capture population and biological heterogeneity. This study used a short liquid chromatography gradient and rapid mass spectrometry data acquisition to reproducibly quantify a set of moderate analytes. By using the dual-trap single-column configuration, the study achieved high IU in rapid analysis and enables high-throughput epidemiological research and cell-based perturbation screening.
ANALYTICAL CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Francis M. Hacker, Arun Jeyabalan, Beth Quinn, Alisse Hauspurg
Summary: This study explored the feasibility of a patient-driven universal postpartum home blood pressure monitoring program, which was found to be feasible and may require closer monitoring in women, especially those with risk factors or limited medical resources.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Review
Psychiatry
Nina E. Ross, Tinsley G. Webster, Camille A. Tastenhoye, Alisse K. Hauspurg, Jill E. Foust, Priya R. Gopalan, Susan Hatters Friedman
Summary: This article provides a systematic review of existing literature on capacity evaluations in women with psychiatric illness making reproductive decisions. The results show that decisions about termination of pregnancy were most common, and schizophrenia was the most common psychiatric diagnosis. Psychiatric illness adds complexity to obstetrical medical decision-making, requiring multidisciplinary collaboration and advanced care planning.
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)