Simplified Finite-Element Model for Tissue Regeneration with Angiogenesis

A simplified finite-element model for tissue regeneration is proposed. The model takes into account the sequential steps of angiogenesis (neo-vascularization) and wound closure (the actual healing of a wound). An innovation in the present study is the combination of both partially overlapping processes, yielding novel insights into the process of wound healing, such as geometry related influences, and could be used to investigate the influence of local injection of hormones that stimulate partial processes occurring during wound healing. These insights can be used to improve wound healing treatments. The models consist of nonlinearly coupled diffusion-reaction equations, in which transport of oxygen, growth factors, and epidermal cells and mitosis are taken into account.