Article
Endocrinology & Metabolism
Marco Castellana, Filippo Procino, Elisa Biacchi, Roberta Zupo, Luisa Lampignano, Fabio Castellana, Rodolfo Sardone, Andrea Palermo, Roberto Cesareo, Pierpaolo Trimboli, Gianluigi Giannelli
Summary: This study compared the efficacy of RYGB and SG for T2D remission and found that RYGB had a higher chance of achieving remission at 1 year compared to SG, while only showing a significant difference in achieving broad criteria for remission at 5 years. No other differences were found between the two procedures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Ji Yeon Park, Oh Kyoung Kwon, Jae-Han Jeon, Yeon-Kyung Choi, Ki Bum Park
Summary: The study investigated glucose metabolism and incretin hormone response post-DG in low BMI patients with gastric cancer and type 2 diabetes. BII reconstruction achieved better diabetes control with increased GLP-1 secretion and reduced hyperglucagonemia and GIP compared to BI or RY reconstruction at 6 months postoperatively.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Review
Nutrition & Dietetics
Jessica Lewgood, Barbara Oliveira, Marie Korzepa, Scott C. Forbes, Jonathan P. Little, Leigh Breen, Robert Bailie, Darren G. Candow
Summary: The prevalence of Type 2 diabetes (T2D) is increasing and creating a large economic burden. This review critically evaluates the effects of various dietary strategies on diabetes management as well as examines several purported supplements aiming to improve glucose control and body composition.
Article
Biochemistry & Molecular Biology
Marzieh Salehi, Ralph DeFronzo, Amalia Gastaldelli
Summary: This study investigated the effect of weight loss surgery on insulin kinetics. The results showed that the altered insulin clearance rate after surgery is mainly attributed to the liver rather than other organs. In addition, the endogenous insulin clearance rate is more sensitive to the increase in circulating insulin levels, while peripheral insulin sensitivity is similar among the three groups. After a meal, the weight loss surgery group had higher insulin secretion, independent of glycemic levels. Compared to sleeve gastrectomy, gastric bypass surgery resulted in greater post-meal insulin secretion and a reduction in post-meal insulin clearance rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yeongkeun Kwon, Jin-Won Kwon, Jane Ha, Dohyang Kim, Jaehyeong Cho, Soo Min Jeon, Shin-Hoo Park, Jinseub Hwang, Nam Hoon Kim, Sungsoo Park
Summary: The developed diabetes prediction (DP) score is a useful tool for predicting T2D remission after gastric cancer surgery, showing comparable performance with machine-learning models. The DP score incorporates five parameters and demonstrates predictive abilities for T2D remission at 3, 6, and 9 years post-surgery.
Article
Multidisciplinary Sciences
Yun Suk Choi, Jin Wook Yi, Woo Young Shin, Yoonseok Heo
Summary: The rates of early gastric cancer and type 2 diabetes mellitus (T2DM) are increasing in Korea. Oncometabolic surgery, which combines metabolic surgery and cancer surgery into one procedure, has shown promising results in treating gastric cancer and T2DM simultaneously. A study conducted in Inha University Hospital analyzed the outcomes of 48 patients who underwent long-limb Roux-en-Y gastrectomy (LRYG) and found that remnant beta cell function is a significant predictor of successful glycemic control in T2DM patients.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Chunjie Su, Qian Cheng, Liyun Wang
Summary: Roux-en-Y gastric bypass (RYGB) significantly improves hepatic glucose metabolism and increases the expression of Sirt1 in T2DM rats. Furthermore, RYGB improves glucose metabolism by activating the IRS1/mTOR2/PKB pathway through regulating Sirt1.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo
Summary: Roux-en Y gastric bypass surgery and sleeve gastrectomy alter postprandial glucose metabolism, increasing the risk of hypoglycemia. After surgery, there is a reduced hepatic glucose production response during insulin-induced hypoglycemia. However, the counterregulatory response to hypoglycemia is similar among individuals with surgery and without surgery.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Surgery
Kristina H. Lewis, David E. Arterburn, Fang Zhang, Katherine Callaway, Jamie Wallace, Adolfo Fernandez, Dennis Ross-Degnan, James F. Wharam
Summary: This study compared diabetes outcomes following vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The results showed that RYGB patients were more likely to discontinue all diabetes medications, but VSG patients had lower total diabetes medication dose by the second year postoperatively.
Article
Endocrinology & Metabolism
Shihao Hu, Yuzhi Lu, Andrea Tura, Giovanni Pacini, David Z. D'Argenio
Summary: Glucose effectiveness, the ability of glucose to regulate glucose utilization and production in the body, plays a significant role in maintaining normal blood sugar levels. Hierarchical statistical analysis revealed that individuals with type 2 diabetes had a decreased glucose effectiveness compared to non-diabetic individuals. This finding suggests that glucose effectiveness could be a potential marker for glucose metabolism disorders and a target for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mohamed A. Marie, Ahmed Rabiee, Mona Youssry Helmy, Mohamed Sabry Tourky, Mohamed Gamal Qassem, Hossam El-Din Shaaban, Mohamed D. Sarhan
Summary: Independent predictors of complete remission of T2DM after LSG were younger age, shorter duration, single oral antidiabetic, lower HOMA-IR, and higher C-peptide. The combined marker of young age, short duration of DM, and low HOMA-IR had a sensitivity of 93% and specificity of 82% in predicting complete remission.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kamil Demircan, Sandra Hybsier, Thilo Samson Chillon, Valentin Max Vetter, Eddy Rijntjes, Ilja Demuth, Lutz Schomburg
Summary: This study investigates the associations of serum selenium and selenoprotein P concentrations with type 2 diabetes (T2D) and hypertension in a cohort of older individuals. The results suggest a sex-specific interrelationship between selenium status and T2D and hypertension, with apparent biomarker-specific associations.
Article
Physiology
Ping Luo, Yaoquan Cao, Pengzhou Li, Guohui Wang, Zhi Song, Weizheng Li, Zhihong Su, Hui Zhou, Xianhao Yi, Zhibing Fu, Xulong Sun, Haibo Tang, Beibei Cui, Qianqian Yu, Liyong Zhu, Shaihong Zhu
Summary: Both LRYGB and LSG effectively induced remission of insulin resistance in patients with T2DM and a BMI of 27.5-32.5 kg/m(2). LRYGB group had a higher percentage of patients achieving the target composite endpoint compared to LSG group.
FRONTIERS IN PHYSIOLOGY
(2021)
