Review
Medicine, General & Internal
Mohamad Swaikat, Ignacio Faus-Matoses, Alvaro Zubizarreta-Macho, Israa Ashkar, Vicente Faus-Matoses, Carlos Bellot-Arcis, Jose Enrique Iranzo-Cortes, Jose Maria Montiel-Company
Summary: A systematic review found that regenerative endodontic treatment (RET) showed high survival and success rates in treating traumatized necrotic immature permanent teeth. However, the impact of trauma on the prognosis of RET remains uncertain. Further research is needed to evaluate root maturation using 3-dimensional radiographic evaluations in traumatized teeth, and high-level clinical studies comparing RET with apexification are necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Mohammad Sabeti, Daniel Ghobrial, Maryam Zanjir, Bruno R. da Costa, Yating Young, Amir Azarpazhooh
Summary: This study aimed to assess the most successful treatment modality for regenerative endodontic treatment (RET) in immature permanent teeth with pulpal necrosis. The results of network meta-analysis showed that blood clot scaffold, platelet-rich plasma (PRP), and platelet-rich fibrin (PRF) exhibited good treatment effects, but their long-term efficacy is limited.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chaehwan Lee, Minju Song
Summary: This study reviewed failed cases after regenerative endodontic procedures (REPs) and proposed a treatment algorithm to assist clinical decision-making. The primary reasons for treatment failure were persistent infection and root resorption. Consideration of the treatability of the tooth, accessibility to the canal, and the presence of an apical seat were identified as key factors in obtaining successful outcomes in clinical decision-making.
JOURNAL OF ENDODONTICS
(2022)
Review
Engineering, Multidisciplinary
Naresh Kumar, Nazrah Maher, Faiza Amin, Hani Ghabbani, Muhammad Sohail Zafar, Francisco Javier Rodriguez-Lozano, Ricardo E. Onate-Sanchez
Summary: This paper thoroughly reviews and discusses various pulp-regenerative approaches and materials used in regenerative endodontics, highlighting current trends and future research prospects in this field.
Article
Medicine, Research & Experimental
Mohamed M. Elashiry, Shereen N. Raafat, Franklin R. Tay, Shehabeldin M. Saber
Summary: The study found that rapamycin has a positive effect on the viability and osteogenic differentiation potential of human periodontal ligament stem cells (hPDLSCs) in the presence of sodium hypochlorite (NaOCl). The hPDLSCs treated with rapamycin showed the highest percentage of viable cells and the best osteogenic differentiation potential. Rapamycin achieves these effects by activating autophagy and inhibiting mTOR gene expression.
Article
Engineering, Biomedical
Zain Siddiqui, Amanda M. Acevedo-Jake, Alexandra Griffith, Nurten Kadincesme, Kinga Dabek, Dana Hindi, Ka Kyung Kim, Yoshifumi Kobayashi, Emi Shimizu, Vivek Kumar
Summary: Pulp capping and dental pulp regeneration are evolving techniques to regenerate pulp tissue and maintain tooth vitality, with various methods and materials being used in regenerative endodontics.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Qian Li, Zhiai Hu, Yongxi Liang, Cancan Xu, Yi Hong, Xiaohua Liu
Summary: The study developed a multifunctional peptide-conjugated, pH-sensitive non-viral gene vector for fast revascularization and pulp regeneration in a full-length human tooth root. This vector significantly increased gene transfection efficiency, reduced cytotoxicity, upregulated VEGF expression in dental pulp stem cells, and accelerated new blood vessel formation and pulp tissue regeneration. The approach proves to be safe and effective for regenerative endodontics.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Sahng G. Kim
Summary: Despite the recent surge in studies on dental pulp regeneration using tissue engineering strategies, the translation of these findings into therapeutic applications remains a challenge. This scoping review systematically reviewed the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration, showing potential for vascularized pulp-like tissue regeneration and successful regeneration of vital tissue in clinical trials. More high-quality studies are needed to further evaluate the safety and efficacy of stem cell transplantation for dental pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Justyna Zbanska, Katarzyna Herman, Piotr Kuropka, Maciej Dobrzynski
Summary: Regenerative endodontic procedure (REP) is an alternative treatment for immature permanent teeth with incomplete root development, aiming to promote angiogenesis, reinnervation, and further root formation. The success of REP depends on the condition of the tooth and the cooperation of the patient.
APPLIED SCIENCES-BASEL
(2021)
Article
Computer Science, Information Systems
Mehmet Emin Kaval, Gozde Kandemir Demirci, Alp Abidin Atesci, Firat Sarsar, Furkan Dindaroglu, Pelin Gueneri, Mehmet Kemal Caliskan
Summary: This study evaluated the quality, content, and demographics of YouTube (TM) videos about regenerative endodontic procedures (REPs). The findings revealed that these videos predominantly provide clinical information about patient chairside practice of REPs and could be considered as a supplementary information source for dental students and practitioners.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Diana B. Sequeira, Ana Rafaela Oliveira, Catarina M. Seabra, Paulo J. Palma, Carlos Ramos, Maria H. Figueiredo, Ana C. Santos, Ana L. Cardoso, Joao Peca, Joao Miguel Santos
Summary: The findings of this study demonstrate that SCAPs combined with PRP scaffold can induce the formation of dentin-like and pulp-like tissues in root segments. The presence of barriers such as ProRoot MTA or Biodentine did not significantly affect the deposition of hard material in the root segments, but the area of newly deposited dentin was significantly greater in segments with a Biodentine barrier compared to a ProRoot MTA barrier.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Martyna Smeda, Kerstin M. Galler, Melanie Woelflick, Andreas Rosendahl, Christoph Moehle, Beate Lenhardt, Wolfgang Buchalla, Matthias Widbiller
Summary: Both dental pulp and apical papilla are potential sources of stem cells for regenerative endodontic treatments. This study compared the molecular characteristics of dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP). The results showed that both cell types expressed similar mesenchymal stem cell markers and had the ability to differentiate into various lineages. However, differences were observed in the profiles of secreted molecules and gene regulation. Overall, both DPSC and SCAP are suitable for dental pulp tissue engineering from a molecular biological perspective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jishnu Krishna Kumar, Padmapriya Surendranath, Rajalakshmanan Eswaramoorthy
Summary: Conventional endodontic treatment of young permanent teeth with necrotic pulp has a poor prognosis. Regenerative endodontics, such as revascularization using platelet-rich fibrin, provides a successful alternative treatment for immature nonvital permanent teeth.
Article
Dentistry, Oral Surgery & Medicine
Zafer C. Cehreli, Gizem Erbas Unverdi, Elif Ballikaya
Summary: This case series demonstrates the clinical and radiographic outcomes of regenerative endodontic treatment (RET) using deciduous pulp autotransplantation in traumatized, necrotic young permanent incisors. Follow-up observations at 12 and 24 months showed radiographic evidence of complete periapical healing, slight increase in dentinal wall thickness, and continued apical closure in all patients.
JOURNAL OF ENDODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yoshi Terauchi, Leif K. Bakiand, George Bogen
Summary: The types of pulpal disease in multirooted teeth can vary from one root canal to the next, allowing for different treatment options based on the disease status of each canal. A combination of procedures tailored to each canal's assumed pulpal status was utilized in this case series, with satisfactory healing responses observed in all cases. This report demonstrates the efficacy of using a combination of treatment procedures to provide specific treatment benefits in various clinical situations.
JOURNAL OF ENDODONTICS
(2021)
