Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sara Csiha, Balazs Ratku, Sandor Somodi, Ferenc Sztanek, Ildiko Seres, Gyorgy Paragh, Mariann Harangi
Summary: This study investigates the association between betatrophin and lipoprotein subfractions. The results show that betatrophin concentrations are significantly higher in obese patients with type 2 diabetes (T2D) and nondiabetic obese (NDO) subjects compared to healthy controls, particularly in females. The findings highlight the importance of measuring serum betatrophin for cardiovascular risk assessment in obese patients, with consideration of gender differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lovro Ziberna, Zala Jenko-Praznikar, Ana Petelin
Summary: This review paper discusses the relationship between obesity and bilirubin, highlighting that obese patients typically have lower serum bilirubin levels as bilirubin is a potent antioxidant molecule that helps alleviate inflammation. The study also proposes potential strategies to increase serum bilirubin levels in obese patients.
Article
Medical Laboratory Technology
Jennifer Powers Carson, Jyoti Arora
Summary: Previous studies have shown a negative correlation between body mass index (BMI) and glycated albumin (GA). However, many of these studies were limited to populations with a narrow range of BMI. This study aimed to investigate if this correlation still exists when a wider range of BMI is considered. The results showed no significant negative correlation between BMI and GA, but weak negative correlations were observed between BMI and individual components such as glycated serum proteins and albumin.
CLINICAL BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Chia-Ho Lin, Yu-Hsuan Li, Ya-Yu Wang, Wen-Dau Chang
Summary: The study found that higher NLR was associated with an increased CKD risk in overweight/obese individuals, but not in normal-weight men and women. NLR may have a role in predicting CKD in overweight/obese individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Marina Berbegal, Mario Tome-Fernandez, Miriam Sanchez-SanSegundo, Ana Zaragoza-Marti, Jose Antonio Hurtado-Sanchez
Summary: The study found that obese individuals performed poorer in short-term phonological memory and working memory, with weight, BMI, waist-hip ratio index, body fat, and visceral fat showing inverse correlations with memory function. Muscle mass was not a significant predictor of memory function, while higher systolic blood pressure was associated with worse memory function.
FRONTIERS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Shengyu Guo, Feiyue Liu, Qinghua Wu
Summary: The disease burden caused by obesity has increased significantly in China, and less than 30% of obese individuals meet the weekly physical activity standards recommended by the WHO. Our survey found that there is an association between subjective health status and exercise behavior in obese people, and individuals with higher education and income are more likely to participate in sports.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Nutrition & Dietetics
Karla Arnotti, Mandy D. Bamber, Veronica Brewer
Summary: This study aimed to examine the effects of increased fruit and vegetable consumption on blood pressure in overweight and obese individuals. The results showed that increased fruit and vegetable consumption can decrease systolic and diastolic blood pressure in this population, potentially reducing the risk of cardiovascular events. However, the limited number of studies, significant heterogeneity, possible publication bias, and quality concerns should be taken into consideration when interpreting the findings.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Jiaxin Liao, Yuting Li, Xiaoting Gui, Yong Zhang, Xu Hu, Liang Cheng, Wen Hu, Feng Bai
Summary: This study found a relationship between serum ISM1 and T2DM and observed alterations in serum ISM1 levels in DSPN and diabetic adults with obesity.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Nutrition & Dietetics
Hanshu Gao, Qianlong Zhang, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Cuiying Gu, Wenjing Feng, Yanan Ma, Zhaoqing Sun, Liqiang Zheng
Summary: This study found a positive association between serum spermidine levels and the odds of obesity in a cross-sectional study, but a negative association between spermidine levels and the risk of increased BMI in a follow-up study among Chinese adults. Further research is needed to determine the exact mechanism underlying the association between spermidine and obesity, as well as the potential for interventions.
Article
Nutrition & Dietetics
Qinqiu Wang, Xiaoying Shi, Jinghua Wang, Juanwen Zhang, Chengfu Xu
Summary: This study found that a low serum vitamin D level is associated with NAFLD in obese participants but not in lean participants. Obese individuals with NAFLD had lower levels of serum vitamin D compared to obese individuals without NAFLD. Serum vitamin D level was negatively correlated with NAFLD prevalence in obese participants, and independently associated with NAFLD risk in this group.
Article
Medical Laboratory Technology
Yakup Dulgeroglu, Mujgan Ercan
Summary: This study determined the biological variation data for serum neopterin, an indicator of cell-mediated immune response. The asymmetric RCV values indicate significant change between consecutive measurements, and the high degree of individuality suggests the use of personal reference data and significance of change for the evaluation of neopterin serum concentrations.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Nutrition & Dietetics
Miguel Huang, Claudia dos Santos Cople-Rodrigues, Dan L. Waitzberg, Ilanna Marques Gomes da Rocha, Cintia Chaves Curioni
Summary: This study conducted a systematic review on the effects of herbal medicine on gut microbiota in obese individuals and found that certain herbs can modulate the gut microbiota and are associated with weight loss.
Article
Medicine, General & Internal
Nazli Haciagaoglu, Huseyin Cetin, Ozlem Hurmeydan, Engin Ersin Simsek
Summary: The study revealed a significant relationship between betatrophin and risk groups determined by the Framingham scoring system and triglyceride levels, indicating its potential as a new biomarker for predicting CVD risk.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Nutrition & Dietetics
Wei-Yi Cheng, Wan-Ju Yeh, Jung Ko, Ya-Ling Huang, Hsin-Yi Yang
Summary: This study found that incorporating 60g of dehulled adlay into the diet may have beneficial effects on lipid profiles and inflammatory markers in overweight and obese individuals.
Meeting Abstract
Endocrinology & Metabolism
Jian Zhou, Si Chen, Jie Cheng, Li Shen, Jiankun Zhu, Ying Lou, Yuqian Bao, Weiping Jia
Meeting Abstract
Endocrinology & Metabolism
Chen Si, Jingyi Lu, Yuqian Bao, Jian Zhou, Weiping Jia
Article
Endocrinology & Metabolism
Junxian Li, Lei Xu, Weijing Zhao, Jiemin Pan, Junxi Lu, Huijuan Lu, Jinhua Yan, Jianping Weng, Fang Liu
Summary: This study found that increased serum IL-17A is a risk factor for autoimmune type 1 diabetes (T1D) in Chinese population, while IL-17F is not independently associated with T1D. The GG genotype of IL17RA rs4819554 may decrease the risk of autoimmune T1D.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Cardiac & Cardiovascular Systems
Shiyun Wang, Zixuan Deng, Hong Zhang, Rong Zhang, Dandan Yan, Xiaojiao Zheng, Weiping Jia, Cheng Hu
Summary: Hp genotype affects the association between DDAH 1 rs233109 and diabetic macroangiopathy in Chinese patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Si Chen, Jingyi Lu, Danfeng Peng, Fengjing Liu, Wei Lu, Wei Zhu, Jian Zhou, Weiping Jia
Article
Pharmacology & Pharmacy
Peng Dong, Hongshuai Lv, Weiping Jia, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi
Summary: Polysaccharide-based dual-drug conjugates represent an effective way to improve chemotherapeutic agents by enhancing drug solubility and increasing drug accumulation in tumor tissues.
Article
Multidisciplinary Sciences
Jing Yan, Yuemei Zhang, Hairong Yu, Yicen Zong, Daixi Wang, Jiangfei Zheng, Li Jin, Xiangtian Yu, Caizhi Liu, Yi Zhang, Feng Jiang, Rong Zhang, Xiangnan Fang, Ting Xu, Mingyu Li, Jianzhong Di, Yan Lu, Xinran Ma, Jian Zhang, Weiping Jia, Cheng Hu
Summary: This study reveals that GPSM1 is genetically associated with T2D and obesity. The authors demonstrate that myeloid GPSM1 promotes metabolic inflammation and accelerates T2D and obesity development. They also identify a small molecule compound that inhibits GPSM1 function, potentially making it a candidate for metabolic therapy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Cheng Li, Xiaojing Ma, Jingyi Lu, Rui Tao, Xia Yu, Yifei Mo, Wei Lu, Yuqian Bao, Jian Zhou, Weiping Jia
Summary: Continuous glucose monitoring (CGM) can assess diabetic statuses continuously, and the complexity of glucose time series index (CGI) derived from CGM data is significantly associated with various glucose metabolism-related parameters, making it a novel marker for evaluating glucose homeostasis.
FRONTIERS OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jing Wang, Hua Liang, You Wang, Xueying Zheng, Fei Chen, Jian Shao, Zhaoxu Geng, Li Zheng, Wenying Yang, Jianping Weng, Tao Xu, Kaixin Zhou
Summary: Using data from Chinese patients with newly diagnosed type 2 diabetes, the study found that mitochondrial DNA copy number (mtDNA-CN) can serve as a biomarker to guide the choice between metformin and acarbose.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Rong Yu, Xiaoqi Ye, Xiangning Wang, Qiang Wu, Lili Jia, Keqing Dong, Zhijun Zhu, Yuqian Bao, Xuhong Hou, Weiping Jia
Summary: This study found a positive association between serum cholinesterase (ChE) and the incidence of diabetic retinopathy (DR). High levels of ChE were associated with an increased risk of DR. ChE may serve as a potential biomarker for predicting the occurrence of DR.
NUTRITION & METABOLISM
(2023)
Article
Chemistry, Multidisciplinary
Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu
Summary: Nrg4 is an adipose tissue-enriched factor that regulates glucose and lipid metabolism and is closely associated with obesity. It acts on ErbB4 in the hypothalamus, excites PVN neurons, and influences energy balance. Its effects on reducing obesity are mediated through ErbB4-mediated excitation of Oxt release from Oxt neurons.
Article
Endocrinology & Metabolism
Yanping Yuan, Xianghai Zhou, Weiping Jia, Jian Zhou, Fan Zhang, Jianling Du, Linong Ji
Summary: The study aimed to develop an HbA1c prediction model with both fasting and postprandial capillary blood glucose to estimate HbA1c in type 2 diabetes. The new HbA1c prediction model using ridge regression showed better prediction ability and good agreement.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychology, Multidisciplinary
Ruoting Liu, Xueying Zheng, Ziyu Wang, Mingjie Zhou, Jianping Weng, Yan-mei Li, Xuefeng Chen
Summary: This study investigates the social motives underlying compliance among individuals with infectious diseases. The results show that individuals with COVID-19 symptoms have lower levels of compliance, which is attributed to a decrease in disease avoidance and familial motives. The study also suggests that exclusion concern weakens the effects of COVID-19 symptoms on compliance. Therefore, enhancing disease avoidance and familial motives may serve as effective intervention strategies to promote compliance among potentially infected individuals.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Lee-Ling Lim, Eric S. H. Lau, Alice P. S. Kong, Amy W. C. Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia, Aravind Sosale, Banshi D. Saboo, Jothydev Kesavadev, Su-Yen Goh, Thy Khue Nguyen, Yotsapon Thewjitcharoen, Raymond Suwita, Ronald C. W. Ma, Elaine Y. K. Chow, Andrea O. Y. Luk, Juliana C. N. Chan
Summary: Diabetes-related death due to cardiorenal diseases is higher in women than men in Asia, possibly due to gender disparity in quality of care and health habits. A study assessed adults with type 2 diabetes from 11 Asian countries/areas and compared treatment target attainment, use of cardiorenal-protective drugs, and health habits by gender. The findings showed that in most countries/areas, men had higher rates of achieving treatment targets than women.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
