Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Chen Zong, Annelies Bronckaers, Guy Willems, Hong He, Maria Cadenas de Llano-Perula
Summary: Bioactive nanomaterials have great potential in periodontal tissue regeneration and have improved oral health in translational and clinical applications. This article reviews recent advancements in nanomaterials for periodontal tissue regeneration and discusses future research directions, focusing on improving oral health. Biomimetic and physiochemical properties of nanomaterials are described, including their effects on alveolar bone, periodontal ligament, cementum, and gingiva regeneration. The safety issues and potential complications of using nanomaterials as regenerative materials are also discussed.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sonntana Seang, Nichakorn Chenboonthai, Natnicha Nisaeh, Araya Teantongdee, Saharat Jamsai, Chanunchida Changgnam, Kanika Yoongkiew, Somchai Yodsanga, Paksinee Kamolratanakul, Sermporn Thaweesapphithak, Thantrira Pornthaveetus, Vincent Everts, Thanaphum Osathanont, Chalida Nakalekha Limjeerajarus
Summary: This study evaluated the effects of iloprost as a root surface treatment agent on periodontal ligament regeneration and mineralization. The results showed that iloprost promoted periodontal ligament regeneration, reduced root resorption, and stimulated acellular cementum deposition. In vitro experiments also demonstrated that iloprost increased hPDLC mineralization through activation of the PGI(2) receptor.
JOURNAL OF ENDODONTICS
(2022)
Review
Engineering, Biomedical
Mafalda S. Santos, Alexandra B. dos Santos, Marta S. Carvalho
Summary: Periodontitis is a destructive inflammatory disease that can lead to the loss of teeth. Tissue engineering approaches using hydrogels have advantages in mimicking tissues and providing sustained drug delivery for periodontal regeneration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Camila Alves Costa, Tatiana Miranda Deliberador, Rodrigo Paolo Flores Abuna, Thaisangela Lopes Rodrigues, Sergio Luis Scombatti de Souza, Daniela Bazan Palioto
Summary: Regenerative approaches using mesenchymal stem cells, specifically cultured BM-MSCs, showed higher levels of early bone formation and more cementum-like tissue formation compared to spontaneous healing and BMAC. This indicates that cultured BM-MSCs are capable of achieving complete periodontal regeneration including the insertion of fibers in new cementum-like tissue.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Serife Buket Bozkurt, Sema Sezgin Hakki, Alpdogan Kantarci
Summary: This study evaluated the effects of RvD1 and RvE1 on cementoblasts and found that they promote cell proliferation and mineralization while regulating gene expression through different pathways, suggesting their potential therapeutic role in periodontal regeneration.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohammed Zayed, Koichiro Iohara
Summary: The study aims to investigate the functional changes of periodontal ligament cells (PDLCs) in aging and found that aged PDLCs exhibited decreased growth rate, increased expression of p16, upregulated chronic inflammation molecules IL-6 and TNF-α, and decreased expression of Bcl-2 in CE. Thus, donor age is a key factor influencing the utilization of PDLCs for tooth regeneration.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Chen Zong, Wannes Van Holm, Annelies Bronckaers, Zuodong Zhao, Stevan Cokic, Merve Kubra Aktan, Ana Belen Castro, Bart Van Meerbeek, Annabel Braem, Guy Willems, Maria Cadenas de Llano-Perula
Summary: The study shows that pretreatment of human periodontal ligament stem cells (hPDLSCs) with gold nanocomplexes (AuNCs) and transplantation in a collagen hydrogel scaffold can effectively protect alveolar bone from resorption and promote bone regeneration, suggesting a promising strategy for bone defect treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Nasim Golafshan, Miguel Castilho, Arwa Daghrery, Morteza Alehosseini, Tom van de Kemp, Konstantinos Krikonis, Mylene de Ruijter, Renan Dal-Fabbro, Alireza Dolatshahi-Pirouz, Sarit B. Bhaduri, Marco C. Bottino, Jos Malda
Summary: Periodontitis is a common chronic inflammatory oral disease that can lead to severe tissue destruction and tooth loss if left untreated. Researchers have developed a compositionally and structurally tailored graded scaffold using melt electrowriting (MEW) for regeneration of the periodontal ligament-to-bone interface. The MEW-fabricated scaffolds have shown excellent regenerative capacity and mimicry of the periodontal complex.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hsiang-Hsi Hong, Ting-An Chou, Adrienne Hong, Yi-Fang Huang, Tzung-Hai Yen, Chao-Hua Liang, Alex Hong, Hui-Yi Hsiao, Chung-Yi Nien
Summary: This study confirms the cemento-inductivity effect of calcitriol and the potential of enamel matrix derivative (EMD) on human periodontal ligament-derived cells (hPDLCs). Calcitriol enhances cementogenic gene expression and mineralization formation, while EMD stimulates protein expression but has weaker mineralization capacity. These findings suggest that calcitriol and EMD can provide differential enhancement of cemento-induction and mineralization at different differentiation stages.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Melis Isik, Ibrahim Vargel, Erdogan Ozgur, Sefa Burak Cam, Petek Korkusuz, Emel Emregul, Sedat Odabas, Burak Derkus
Summary: Advances in bone tissue engineering have been made through the integration of biologically active extracellular nanovesicles with biomaterial platforms. This offers a promising solution for overcoming reduced bone volume and facilitating efficient bone regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Developmental Biology
Mari M. Saito, Kazuo Onuma, Yasuo Yamakoshi
Summary: The cementum is the outermost layer of hard tissue that covers the dentin in the root of teeth and plays a crucial role in periodontal tissue regeneration. This review explores the function and histological structure of cementum, discussing the possibility of using a biochemical approach to promote cementum regeneration in periodontal tissue. The article also examines the limitations of current dental implant treatments in periodontal tissue regeneration and suggests a potential advancement in periodontal tissue regenerative medicine through the combination of material science and biochemical methods.
Article
Biotechnology & Applied Microbiology
Xiongcheng Xu, Ziqin Chen, Long Xiao, Yanmei Xu, Nianqi Xiao, Weiqiu Jin, Yuling Chen, Yanfen Li, Kai Luo
Summary: This study aimed to investigate the effects of nanosilicate-incorporated PCL (PCL/LAP) nanofibrous membranes on periodontal ligament cells (PDLCs) in vitro and periodontal regeneration in vivo. The results showed that the PCL/LAP nanofibrous membrane exhibited good biocompatibility and bioactivity, enhanced the proliferation and osteogenic differentiation of PDLCs, and promoted periodontal regeneration by orchestrating the immunomodulatory effects of PDLCs. Therefore, the PCL/LAP nanofibrous membrane has the potential to be a promising biomaterial for periodontal regeneration therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Chemistry, Multidisciplinary
Stefano Guizzardi, Giuseppe Pedrazzi, Carlo Galli
Summary: Periodontal regeneration is a complex process that can be enhanced by using enamel matrix derivative (EMD) and low frequency electromagnetic fields (EMFs), which may increase cell sensitivity to EMD and improve its effectiveness.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell & Tissue Engineering
Xiaojing Wang, Guowei Wang, Sarah Zingales, Baodong Zhao
TISSUE ENGINEERING PART B-REVIEWS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Guo-Wei Wang, Mei-Qing Wang, Xiao-Jing Wang, Shi-Bin Yu, Xiao-Dong Liu, Kai Jiao
ARCHIVES OF ORAL BIOLOGY
(2010)
Article
Engineering, Biomedical
Fa-Ming Chen, Rong Chen, Xiao-Jing Wang, Hai-Hua Sun, Zhi-Fen Wu
Article
Engineering, Biomedical
Xiaojing Wang, Faming Chen, Guowei Wang, Wei Ma, Yimin Zhao
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2008)
Article
Dentistry, Oral Surgery & Medicine
Guowei Wang, Xiaojing Wang, Yimin Zhao, Tianwen Guo
JOURNAL OF PROSTHETIC DENTISTRY
(2013)
Article
Materials Science, Coatings & Films
Xiaojing Wang, Guowei Wang, Jun Liang, Jingtao Cheng, Wei Ma, Yimin Zhao
SURFACE & COATINGS TECHNOLOGY
(2009)
Article
Materials Science, Biomaterials
Xiaojing Wang, Guowei Wang, ShouQin Shan, Guangyan Hui, Tingkai Guo, Guangyan Liu, Yimin Zhao
JOURNAL OF MATERIALS CHEMISTRY B
(2014)
Article
Medicine, General & Internal
Guowei Wang, Baodong Zhao, Yujia Kong, DeXun Ma, Lin Yang, Yingliang Song, Xiaojing Wang
Article
Medicine, Research & Experimental
Yupeng Wu, Qi Zhang, Baodong Zhao, Xiaojing Wang
Summary: The study demonstrated that the beta-receptor blocker propranolol promoted early osseointegration of pure titanium implants by enhancing osteogenic differentiation of osteoblasts and mesenchymal stem cells. Propranolol also increased cell proliferation, calcium content, ALP activity, and mRNA/protein expression levels of osteogenic markers while decreasing the expression of beta 2-adrenergic receptor.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Zheng Wang, Xiaojing Wang, Yingruo Wang, Yanli Zhu, Xinqiang Liu, Qihui Zhou
Summary: This review summarizes recent research progress on nano-ZnO modified Ti-implants, introducing their preparation methods and properties, and proposes challenges and future opportunities for these implants.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)