期刊
JOURNAL OF ENDODONTICS
卷 36, 期 10, 页码 1638-1642出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.joen.2010.05.005
关键词
Dental pulp; intradental course; myelinated axon; ultrastructure
资金
- Ministry of Education, Science and Technology [R13-2008-009-01001-0]
Introduction: Previous studies have suggested that myelinated axons lose their myelin and become thinner in their peripheral course to the target organ. In this study, we investigated the morphologic changes of pulpal myelinated axons between their root portion (radicular pulp) and their terminal area (peripheral pulp). Methods: Sections of pulp of the rat upper molar teeth were immunostained for the marker of myelinated axons neurofilament (NF) 200. The proportion of NF200+ myelinated and unmyelinated fibers and their sizes were analyzed by using quantitative electron microscopy. Results: The axon area, myelin thickness, and fraction of NF200+ myelinated axons of all NF200+ axons were significantly lower in peripheral than in radicular pulp. In addition, large unmyelinated axons were frequently observed in peripheral pulp. Conclusions: These results suggest that pulpal innervation originates predominantly from myelinated axons, and the myelinated axons undergo extensive morphologic changes during their course from the radicular to ;the peripheral pulp. (J Endod 2010;36:1638-1642)
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