Article
Immunology
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria G. Tsokos, Iannis E. Adamopoulos
Summary: Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation and IL-27 also inhibits IL-23-induced inflammation associated with myeloid cell infiltration in the joints and spleen. The IL-27 anti-inflammatory response is associated with reduced levels of myeloid cells in the spleen and bone marrow.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Dongni Huang, Yuxin Ran, Zheng Liu, Jie He, Nanlin Yin, Hongbo Qi
Summary: Preterm labor is a multifactorial syndrome that involves the abnormal expression of IL-27 and its receptors. This study demonstrated that the IL-27/IFN-γ/ERK axis mediates the inflammatory effect in preterm labor, and WSX-1 knockdown can delay birth. The findings suggest a potential therapeutic target in inhibiting the pro-inflammatory effect in preterm labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yuxin Ran, Dongni Huang, Youwen Mei, Zheng Liu, Yunqian Zhou, Jie He, Hanwen Zhang, Nanlin Yin, Hongbo Qi
Summary: This study revealed that elevated IL-27 is associated with the onset of preterm birth (PTB) and the overexpression of IL-27 is related to the activation of immune-inflammatory processes. IL-27 may mediate immune-inflammatory imbalance mainly through monocyte-macrophage and neutrophils, providing a potential novel strategy for the prevention and treatment of PTB.
Article
Microbiology
Gongguan Liu, Osama Abas, Yong Fu, Yanli Chen, Ashley B. Strickland, Donglei Sun, Meiqing Shi
Summary: Tip-DCs are key immune effector cells involved in fighting off various infections, but their excessive development can lead to tissue damage. This study reveals that IL-27 plays a crucial role in inhibiting Tip-DC development during parasitic infections by interfering with the CD4(+) T cell-IFN-gamma axis and preserving the balance between Ly6C(-) and Ly6C(+) monocytes. Targeting IL-27 signaling may offer a promising approach for therapeutic intervention to control Tip-DC development.
Article
Cell Biology
Youwen Mei, Yuxin Ran, Zheng Liu, Yunqian Zhou, Jie He, Nanlin Yin, Hongbo Qi
Summary: This study found that IL-27 may contribute to preterm labor by activating maternal peripheral blood mononuclear cells and inducing inflammatory responses in amniotic epithelial cells.
Article
Microbiology
Jiajia Zeng, Shuaini Yang, Yuqing Tuo, Xiaoyu Zha, Ruoyuan Sun, Tingsha Lu, Hong Zhang, Lu Tan, Sai Qiao, Hong Bai
Summary: IL-27/IL-27R signaling plays a protective role in Chlamydia trachomatis infection by promoting Th1 response and suppressing neutrophilic inflammation. IL-27 expression was observed in dendritic cells (DCs), and its signaling in DCs restricted the production of IL-10, thus supporting the Th1 response against chlamydial infection.
Article
Multidisciplinary Sciences
Kristen N. Morrow, Zhe Liang, Ming Xue, Deena B. Chihade, Yini Sun, Ching-wen Chen, Craig M. Coopersmith, Mandy L. Ford
Summary: Sepsis leads to impairment in memory T cells, with IL-27 potentially affecting co-inhibitory molecules by regulating TIGIT, but not associated with sepsis mortality.
Article
Chemistry, Multidisciplinary
Min Nie, Danqing Huang, Guopu Chen, Yuanjin Zhao, Lingyun Sun
Summary: A bioadhesive microparticle carrying IL-27 MSC-derived extracellular vesicles (MSCIL-27 EVs) was developed using microfluidic technology. The microcarriers exhibited sustained release effect and effective wet adhesion, and demonstrated potential therapeutic efficacy in treating IBD.
Article
Immunology
Tong Li, Colleen Hadigan, Jarred M. Whitlock, Jing Qin, Jai Kumar, Princy Kumar, Marta Catalfamo
Summary: In people with HIV, the presence of osteoclasts significantly enhances secretion of cytokines by T cells. IL-27 may regulate this process by inhibiting IL-17 secretion and downregulating surface expression of RANKL in CD4 T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
James A. Harker, Trever T. Greene, Burton E. Barnett, Phuc Bao, Aleksandr Dolgoter, Elina I. Zuniga
Summary: The IL-6 cytokine family signals through gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with LCMV Cl13. IL-6 and IL-27 signaling have distinct and overlapping roles, with IL-6 regulating Tfh differentiation, IL-27 regulating CD4 T cell survival, and both promoting IL-21.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anup Bobhate, Vijay Viswanathan, Vivekanandhan Aravindhan
Summary: Anti-inflammatory cytokines play a dual role in modulating inflammation and immunity, with levels fluctuating in individuals with latent TB infection and varying degrees of glucose intolerance. These cytokines, including IL-27, IL-10, IL-1Ra, and TGF-beta, show distinct patterns in different stages of diabetes and LTBI status, suggesting a complex interplay between immune response and metabolic disorders. Defects in these cytokine levels, particularly in individuals with both LTBI and known diabetes, may exacerbate the synergy between diabetes and TB infection.
Article
Multidisciplinary Sciences
Kristina Schaedlich, Laura-Sophie Beier, Judith Kolbe, Martin Wabitsch, Jana Ernst
Summary: Research suggests that exposure to DEHP leads to an inflammatory state in SGBS-derived adipocytes, but THP-1 macrophages exposed to SGBS-CM did not show DEHP-induced effects. However, medium containing (pre)adipocyte-secreted factors had a significant impact on the expression and secretion of macrophage and inflammatory markers in THP-1 macrophages, leading to significantly increased accumulation of intracellular lipid droplets.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Maria Lourdes Macalinao, Shin-Ichi Inoue, Sanjaadorj Tsogtsaikhan, Hirotaka Matsumoto, Ganchimeg Bayarsaikhan, Jiun-Yu Jian, Kazumi Kimura, Yoshiaki Yasumizu, Tsuyoshi Inoue, Hiroki Yoshida, Julius Hafalla, Daisuke Kimura, Katsuyuki Yui
Summary: This study reveals that IL-27 plays a critical role in inhibiting the development of unique Th1 memory precursor CD4(+) T cells during malaria infection, and neutralization of IL-27 enhances immune responses and protection.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Qi Zuo, Zhikui Cheng, Guoqing Zhang, Yongfang Xia, Gang Xu, Wei Cao, Xiaodan Yang, Yundong Fu, Rui He, Peining Fang, Yifei Guo, Longyu Nie, Yu Huang, Lin Liu, Jianbo Zhan, Shi Liu, Ying Zhu
Summary: The study reveals that the IL-6-IL-27 complex exhibits stronger antiviral effects than individual subunits, mainly mediated by IL-27A subunit and IL-27 receptor alpha. This complex induces phosphorylation of STAT1 and STAT3, showing antiviral activity in host defense against viruses.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Wang, Dehai Li, Guangchao Cao, Qiping Shi, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Xu, Leqing Zhu, Hua Zhang, Rachel J. Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I. Shulman, Vishwa Deep Dixit, Ligong Lu, Hengwen Yang, Richard A. Flavell, Zhinan Yin
Summary: Studies have shown that IL-27 plays a critical role in improving thermogenesis, countering obesity, and ameliorating insulin resistance, making it a promising target for anti-obesity immunotherapy.
Article
Cardiac & Cardiovascular Systems
Weston W. Blakeslee, Ying-Hsi Lin, Matthew S. Stratton, Philip D. Tatman, Tianjing Hu, Bradley S. Ferguson, Timothy A. McKinsey
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Review
Pharmacology & Pharmacy
Marie-Louise Ricketts, Bradley S. Ferguson
CURRENT PHARMACEUTICAL DESIGN
(2018)
Review
Nutrition & Dietetics
Levi W. Evans, Bradley S. Ferguson
Article
Cell Biology
Bradley S. Ferguson, Heesun Nam, Ron F. Morrison
CELLULAR SIGNALLING
(2019)
Review
Biochemistry & Molecular Biology
Justine Habibian, Bradley S. Ferguson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rushita Bagchi, Bradley Ferguson, Matthew Stratton, Tianjing Hu, Maria Cavasin, Ying-Hsi Lin, Kunhua Song, Philipp Scherer, Sheila Collins, Edward Seto, Timothy McKinsey
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Levi W. Evans, Maheshi Athukorala, Kristina Martinez-Guryn, Bradley S. Ferguson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Levi Evans, Yiqui Shen, Abigail Bender, Leah E. Burnett, Musheng Li, Justine S. Habibian, Tong Zhou, Bradley S. Ferguson
Summary: The study reveals the beneficial effects of phytochemicals from plant-based foods on heart health by preventing pathological cardiac hypertrophy. These compounds target divergent gene pathways within cardiac myocytes and regulate overlapping signaling and gene pathways to exert anti-hypertrophic actions. Further research in rodent models of heart failure is needed to fully understand their roles in the heart.
Article
Cardiac & Cardiovascular Systems
Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Marcello Rubino, Emma L. Robinson, Maria A. Cavasin, Matthew S. Stratton, Andrew M. Kidger, Tianjing Hu, Stephen M. Keyse, Robert A. McKnight, Robert H. Lane, Eva S. Nozik, Mary C. M. Weiser-Evans, Timothy A. McKinsey
Summary: DUSP5 acts as a negative regulator of smooth muscle cell proliferation in pulmonary arteries, playing a crucial role in pulmonary hypertension and right ventricular hypertrophy. This research reveals the protective mechanism of DUSP5 in the cardiovascular system.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Environmental Sciences
Valentina J. Alaasam, Xu Liu, Ye Niu, Justine S. Habibian, Simon Pieraut, Brad S. Ferguson, Yong Zhang, Jenny Q. Ouyang
Summary: Artificial light at night (ALAN) disrupts natural circadian rhythms, impacting behavior and physiology in both humans and wildlife. Studies have shown that even low levels of ALAN can lead to changes in nighttime activity and cardiovascular health, emphasizing the need for research into the ecological impacts of light pollution.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Justine S. Habibian, Matthew J. Bolino, Bradley S. Ferguson
Summary: Skeletal muscle differentiation requires the activation of satellite cells to proliferate, differentiate, and fuse. This process is regulated by myogenic transcription factors, which are tightly controlled by intracellular signaling pathways, including the protein kinase D (PKD) family. In this study, the researchers found that inhibiting class I histone deacetylases (HDACs), specifically HDAC8, attenuated PKD phosphorylation in skeletal muscle cells, suggesting that HDAC8 may function as a feedback regulator of PKD phosphorylation during muscle differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Levi Evans, Tori Price, Nathaniel Hubert, Julia Moore, Yiqui Shen, Maheshi Athukorala, Steven Frese, Kristina Martinez-Guryn, Bradley S. Ferguson
Summary: This study demonstrates that emodin can attenuate pathological cardiac hypertrophy in female mice, with no significant changes in body weight or blood pressure. Analysis also indicates that hypertension alters the microbiome of mice, while emodin affects the composition of gut microbiota.
Review
Biochemistry & Molecular Biology
Levi W. Evans, Matthew S. Stratton, Bradley S. Ferguson
NATURAL PRODUCT REPORTS
(2020)
Article
Medicine, Research & Experimental
Rushita A. Bagchi, Bradley S. Ferguson, Matthew S. Stratton, Tianjing Hu, Maria A. Cavasin, Lei Sun, Ying-Hsi Lin, Dianxin Liu, Pilar Londono, Kunhua Song, Maria F. Pino, Lauren M. Sparks, Steven R. Smith, Philipp E. Scherer, Sheila Collins, Edward Seto, Timothy A. McKinsey
Review
Food Science & Technology
Levi W. Evans, Samantha S. Romanick, Bradley S. Ferguson
FUNCTIONAL FOODS IN HEALTH AND DISEASE
(2017)