Article
Food Science & Technology
Tingting Song, Xuemei Zhou, Xiangming Ma, Yanping Jiang, Weiren Yang, Faxiao Liu, Mei Liu, Libo Huang, Shuzhen Jiang
Summary: The study found that ZEA can linearly increase nutrient digestibility and availability, promote the expression of estrogen/progesterone receptors in the uterus and endometrial cells.
Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Biochemistry & Molecular Biology
Lin Lu, Yingni Chen, Zhenshan Yang, Shijin Liang, Songqi Zhu, Xiaohuan Liang
Summary: During decidualization in rodents, uterine stromal cells undergo reprogramming to differentiate into different cell types, forming primary and secondary decidual zones. Secondary decidual zones are accompanied by angiogenesis. Estrogen, both ovarian and locally synthesized, is essential for the progress of decidualization. Cystatin B (Cstb) is highly expressed in the decidual tissue of the uterus, but its regulation and mechanism in decidualization are not known.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sohyeon Moon, Ok-Hee Lee, Byeongseok Kim, Jinju Park, Semi Hwang, Siyoung Lee, Giwan Lee, Hyukjung Kim, Hyuk Song, Kwonho Hong, Jaejin Cho, Youngsok Choi
Summary: The expression of YAP in the mouse endometrium is periodic and regulated by hormones. YAP plays an important role in the regulation of uterine endometrium dynamics through Hippo signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mira Park, So Hee Park, Hyunsun Park, Hye-Ryun Kim, Hyunjung J. Lim, Haengseok Song
Summary: In this study, it was demonstrated that Adamts-1 is a novel target gene of E-2-ER-MAPK-EGR1, critical for embryo implantation in the mouse uterus during early pregnancy.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jin Bai, Yao Li, Guofeng Yan, Jing Zhou, Alejandra Garcia Salmeron, Olamide Tolulope Fategbe, Sathish Kumar, Xuejin Chen, Dong-Bao Chen
Summary: This study found that endogenous estrogens selectively stimulate uterine artery CBS expression through specific estrogen receptors in pregnant rats, leading to increased production of hydrogen sulfide and enhanced uterine blood flow during pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Caglar Berkel, Ercan Cacan
Summary: Estrogen, estrogen receptors, and estrogen-related receptors play a role in cisplatin resistance, associated with higher resistance in cancer cells, mainly due to decreased caspase activity.
Review
Medicine, Research & Experimental
Agnieszka Anna Rawluszko-Wieczorek, Kamila Romanowska, Michal Nowicki
Summary: Estrogens, a group of hormones, play pivotal roles in physiological processes and are implicated in pathophysiological changes such as cancer. The two isoforms of estrogen receptor (ER), ER alpha and ER beta, elicit different transcriptional and tissue-specific responses. The expression of ER subtypes and their correlation with clinical outcomes of cancer are influenced by co-regulators, which play a role in modulating transcriptional activity on target gene chromatin. This review provides an overview of ER-driven responses, focusing on the complex interaction between ERs and chromatin modifiers, and discusses how chromatin accessibility and epigenetic modifications contribute to ER recruitment and transactivation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Sohyeon Moon, Semi Hwang, Byeongseok Kim, Siyoung Lee, Hyoukjung Kim, Giwan Lee, Kwonho Hong, Hyuk Song, Youngsok Choi
Summary: In this review, the authors describe the association between the female reproductive system and the Hippo signaling pathway, as well as novel Hippo pathway genes and potential target genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Teresa Tropea, Damiano Rigiracciolo, Milena Esposito, Marcello Maggiolini, Maurizio Mandala
Summary: Increasing levels of estrogens in pregnancy contribute to the physiological adaptations of maternal vasculature. The GPER receptor plays a role in regulating uteroplacental blood flow through vasorelaxation in the uterine arteries. This study found that GPER expression and vasorelaxation are increased in pregnant rats compared to non-pregnant rats, suggesting the involvement of GPER in the regulation of uteroplacental blood flow during pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo, Lin-Ying Cao
Summary: This study revealed the potential endocrine disruption mechanism of Niclosamide by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs) at environmentally-related nanomolar levels. By fluorescence competitive binding assays and luciferase reporter gene assays, it was found that NIC showed higher binding affinity with ERR gamma than other receptors. Additionally, molecular docking simulations indicated that NIC could bind to ERR gamma with the highest binding energy.
Article
Biology
Mitsunori Matsuo, Jia Yuan, Yeon Sun Kim, Amanda Dewar, Hidetoshi Fujita, Sudhansu K. Dey, Xiaofei Sun
Summary: This study reveals that mice with uterine depletion of Foxa2 may enter embryonic diapause, with Msx1 and LIF potentially playing a role in resuming pregnancy.
Article
Endocrinology & Metabolism
Jie Yu, Sarah L. Berga, Qingying Meng, Mingjing Xia, Trudy A. Kohout, Marcel van Duin, Robert N. Taylor
Summary: The study demonstrated the important regulatory role of dopamine receptor type 2 in endometrial tissue and cells, showing that dopamine agonists like cabergoline can promote decidualization in vitro, potentially serving as therapeutic agents for infertility due to inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Gisela Soledad Bracho, Gabriela Anahi Altamirano, Laura Kass, Enrique Hugo Luque, Veronica Lis Bosquiazzo
REPRODUCTIVE SCIENCES
(2019)
Meeting Abstract
Developmental Biology
Ramiro Alarcon, Guillermina Pacini, Virginia Lorenz, Dalma Belen Cadaviz Fernandez, Jorgelina Varayoud, Enrique Hugo Luque, Maria Mercedes Milesi
Article
Cell Biology
Cora Stoker, M. Florencia Andreoli, Laura Kass, Veronica L. Bosquiazzo, M. Florencia Rossetti, G. Canesini, Enrique H. Luque, Jorge G. Ramos
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Correction
Toxicology
Maria M. Milesi, Virginia Lorenz, Pablo M. Beldomenico, Stella Vaira, Jorgelina Varayoud, Enrique H. Luque
ARCHIVES OF TOXICOLOGY
(2020)
Article
Environmental Sciences
German Hugo Galoppo, Yamil Ezequiel Tavalieri, Gonzalo Schierano-Marotti, Mario Raul Osti, Enrique Hugo Luque, Monica Milagros Munoz-de-Toro
ENVIRONMENTAL RESEARCH
(2020)
Review
Cell Biology
Paola Ingaramo, Ramiro Alarcon, Monica Munoz-de-Toro, Enrique H. Luque
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Review
Cell Biology
Y. E. Tavalieri, G. H. Galoppo, G. Canesini, E. H. Luque, M. M. Munoz-de-Toro
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Editorial Material
Cell Biology
Enrique H. Luque, Monica Mufioz-de-Toro
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Environmental Sciences
Ramiro Alarcon, Oscar E. Rivera, Paola I. Ingaramo, Maria Tschopp, Gisela H. Dioguardi, Mercedes M. Milesi, Monica Munoz-de-Toro, Enrique H. Luque
ENVIRONMENTAL POLLUTION
(2020)
Article
Food Science & Technology
Virginia Lorenz, Guillermina Pacini, Enrique H. Luque, Jorgelina Varayoud, Maria M. Milesi
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Marine & Freshwater Biology
Y. E. Tavalieri, R. Alarcon, M. V. Tschopp, G. Canesini, E. H. Luque, M. Munoz-de-Toro, G. H. Galoppo
Summary: Endocrine disrupting compounds (EDCs) can alter the oviduct differentiation in Caiman latirostris, potentially leading to impaired reproduction. Exposure to BPA and E2 during early postnatal stages affects the levels of Wnt-7a, Wnt-5a, β-catenin, and FoxA2, contributing to altered histological features and protein expressions in the oviduct.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Paola I. Ingaramo, Ramiro Alarcon, Maria L. Caglieris, Jorgelina Varayoud, Enrique H. Luque, Monica Munoz-de-Toro
Summary: This study demonstrates that neonatal exposure to glyphosate-based herbicides can result in adverse effects on uterine angiogenesis in rats, potentially leading to increased post-implantation losses.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Gabriela A. Altamirano, Eduardo Masat, Oscar Rivera, Ramiro Alarcon, Gisela Dioguardi, Monica Munoz-de-Toro, Enrique H. Luque, Laura Kass
Summary: The aim of this study was to assess the effects of early postnatal exposure to a glyphosate-based herbicide (GBH) on pre-pubertal mammary development in Friesian lambs. GBH-exposed lambs exhibited larger mammary ducts and decreased area occupied by terminal duct lobular units, accompanied by an increase in adipocyte area in the mammary stroma. The expression of estrogen receptor alpha and progesterone receptor was altered in the GBH-exposed lambs, as well as decreased epithelial cell proliferation and changes in the IGF-1 system.
Article
Environmental Sciences
Guillermina Canesini, German H. Galoppo, Yamil E. Tavalieri, Gisela P. Lazzarino, Cora Stoker, Enrique H. Luque, Jorge G. Ramos, Monica Munoz-de-Toro
Summary: Environmental exposure to agrochemicals during early development can lead to permanent alterations in normal physiology. This study investigated the effects of atrazine exposure on gonadal development in caiman embryos, and found that it disrupts the expression of biomarkers and genes involved in sex determination and gonadal differentiation. The results suggest that atrazine can interfere with gonadal developmental programming and the observed effects may be present in other vertebrate species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Meeting Abstract
Developmental Biology
Dalma Belen Cadaviz Fernandez, Virginia Lorenz, Guillermina Pacini, Maria Paula Gastiazoro, Milena Durando, Enrique Hugo Luque, Jorgelina Varayoud, Maria Mercedes Milesi