Article
Pharmacology & Pharmacy
Yun-Ho Choi, Jaeyoon Kim, Jae Young Shin, Nae-Gyu Kang, Sanghwa Lee
Summary: This study investigated the antiandrogenic effects of FMN in prostate cancer cells. FMN inhibited androgen receptor protein expression, decreased PSA level, and downregulated androgen regulated genes. FMN bound to androgen receptor and regulated androgen receptor signaling through the PI3K-AktMDM2 pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Aniko Bertokova, Natalia Svecova, Katarina Kozics, Alena Gabelova, Alica Vikartovska, Eduard Jane, Michal Hires, Tomas Bertok, Jan Tkac
Summary: This article examines the best procedure for isolating exosomes, which are considered to be a rich source of biomarkers. The study compared several isolation procedures and found that magnetic-based kits were the most effective. It also determined that storing isolated exosomes at -20°C is optimal and observed that cancerous prostate cell lines produce more exosomes than non-cancerous cell lines. Additionally, the study explored the response of cell lines to stress and investigated the effect of Triton X-100 on exosome lysis. The article concludes by discussing the advantages of using a self-made 2D biochip for monitoring exosome interactions and the potential of lectin fluorescent microarrays for analyzing glycans in lysed exosomes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Feyza Sen, Gabriel T. Sheikh, Johannes von Hinten, Andreas Schindele, Malte Kircher, Alexander Dierks, Christian H. Pfob, Sebastian E. Serfling, Andreas K. Buck, Theo Pelzer, Takahiro Higuchi, Alexander Weich, Ralph A. Bundschuh, Rudolf A. Werner, Constantin Lapa
Summary: Despite the availability of novel targeted treatment options, small cell lung cancer (SCLC) still has a poor prognosis. This study aimed to evaluate the prognostic value of somatostatin receptor (SSTR) expression assessed by positron emission tomography (PET) and investigate the efficacy of SSTR-targeted radionuclide therapy (PRRT). The results showed that SSTR-targeted PET is not a prognostic tool for outcome in SCLC patients, but it can be an important tool for treatment decision. PRRT may be a promising treatment option for some patients with SCLC as a second or third line treatment.
Article
Multidisciplinary Sciences
Lina A. Dahabiyeh, Wafa Hourani, Wesam Darwish, Farah Hudaib, Bashaer Abu-Irmaileh, Pran Kishore Deb, Katharigatta N. Venugopala, Viresh Mohanlall, Rana Abu-Dahab, Mohammad H. Semreen, Yasser Bustanji
Summary: Prostate cancer is the second most common tumor in males worldwide. This study evaluated the anticancer activity of seven synthesized 2,3-dihydroquinazolin-4(1H)-one analogues against PC3 and DU145 cancer cell lines. The results showed that these compounds exhibited cytotoxicity and inhibited cancer cell migration. Metabolomics analysis revealed that one of the compounds, C5, disrupted essential metabolic pathways involved in cancer cell proliferation and growth. These findings suggest the potential of these compounds, particularly C5, as anticancer agents and highlight the promising role of metabolomics in investigating their activity and identifying therapeutic targets.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Leire Moya, Carina Walpole, Fiona Rae, Srilakshmi Srinivasan, Inge Seim, John Lai, David Nicol, Elizabeth D. Williams, Judith A. Clements, Jyotsna Batra
Summary: This study successfully established four cell lines derived from localized prostate cancer, including two benign and two malignant cell lines. The characteristics and molecular events of these cell lines could help in understanding the development and progression of cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Cell Biology
Rebeca San Martin, Priyojit Das, Renata Dos Reis Marques, Yang Xu, Justin M. Roberts, Jacob T. Sanders, Rosela Golloshi, Rachel Patton McCord
Summary: The study reveals that changes in 3D genome structure play a detrimental role in the progression of prostate cancer, affecting spatial compartment identity, gene expression, and genomic aberrations.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Shanshan Qin, Yuanyou Yang, Jiajia Zhang, Yuzhen Yin, Weihao Liu, Han Zhang, Xin Fan, Mengdie Yang, Fei Yu
Summary: Intravenously administered [At-211]SAB-Oct showed significant efficacy against SSTR2-positive SCLC tumors, suppressing tumor growth and enhancing the efficacy of immunotherapy by up-regulating specific proteins on tumor cell membrane surface.
MOLECULAR PHARMACEUTICS
(2023)
Article
Genetics & Heredity
Claudia Giambartolomei, Ji-Heui Seo, Tommer Schwarz, Malika Kumar Freund, Ruth Dolly Johnson, Sandor Spisak, Sylvan C. Baca, Alexander Gusev, Nicholas Mancuso, Bogdan Pasaniuc, Matthew L. Freedman
Summary: The study evaluated the use of chromosome conformation capture combined with immunoprecipitation to identify target genes for prostate cancer GWAS risk loci. The results confirmed previously reported PrCa target genes identified through GWAS/eQTL overlap and identified links between GWAS variants and genes known to play a role in prostate cancer biology. HiChIP was also able to predict enhancer elements at prostate cancer risk loci and confirm their regulatory role in gene expression through CRISPR interference.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Oncology
Fatemeh Akbarian, Farid Dadkhah, Arezoo Campbell, Farrokh Asadi, Ghasem Ahangari
Summary: The study revealed a potential pathogenic role of dopamine receptor signaling in prostate cancer and suggested that dopamine receptor modulators could be a novel treatment strategy for prostate cancer.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Prudencio Saez-Martinez, Francisco Porcel-Pastrana, Jesus M. Perez-Gomez, Sergio Pedraza-Arevalo, Enrique Gomez-Gomez, Juan M. Jimenez-Vacas, Manuel D. Gahete, Raul M. Luque
Summary: This study demonstrates the potential therapeutic role of somatostatin (SST) and cortistatin (CORT) in prostate cancer (PCa) treatment. Treatment with SST and CORT inhibits proliferation and aggressiveness of certain PCa cells, through modulation of oncogenic signaling pathways and down-regulation of critical genes. Interestingly, CORT is highly expressed while SST is not detected in PCa cells, suggesting that CORT may act as an autocrine/paracrine regulator of PCa progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mariana Brutt Pacheco, Vania Camilo, Nair Lopes, Filipa Moreira-Silva, Margareta P. Correia, Rui Henrique, Carmen Jeronimo
Summary: The combined treatment of DNA methylation inhibitor hydralazine and histone deacetylase inhibitors panobinostat and valproic acid showed synergistic growth inhibitory effects on prostate cancer cells, particularly in DU145 cells. This suggests that these drugs may be potential therapeutic tools to counteract the progression of prostate cancer.
Article
Endocrinology & Metabolism
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Guillermo Serra, Isabel Salinas, Gemma Xifra, Paula Casano-Sancho, Cristina Carrato, Betina Biagetti, Gemma Sesmilo, Jennifer Marcos-Ruiz, Helena Rodriguez-Lloveras, Anna Rueda-Pujol, Anna Aulinas, Alberto Blanco, Cristina Hostalot, Andreu Simo-Servat, Fernando Munoz, Marta Rico, Javier Ibanez-Dominguez, Esteban Cordero, Susan M. Webb, Mireia Jorda, Manel Puig-Domingo
Summary: This study evaluated the expression of epithelial-mesenchymal transition (EMT)-related markers in non-functioning pituitary neuroendocrine tumors (NF-PitNET) and found that NF-PitNET had an enhanced EMT phenomenon. SSTR3 targeting could be a potential therapeutic option for NF-PitNET, except for silent corticotroph adenomas. PEBP1 could be an informative biomarker for tumor regrowth in NF-PitNET.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Bruno Martinucci, Maira Smaniotto Cucielo, Brenda Carvalho Minatel, Sarah Santiloni Cury, Gabriel Henrique Caxali, Mirian Carolini Esgoti Aal, Sergio Luis Felisbino, Danillo Pinhal, Robson Francisco Carvalho, Flavia Karina Delella
Summary: This study investigated the impact of fibronectin on miRNA expression in prostate cancer cells and found that these miRNAs may be involved in the development of prostate cancer. This is significant in understanding prostate cancer in both men and other animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Vittoria Favero, Arianna Cremaschi, Alberto Falchetti, Agostino Gaudio, Luigi Gennari, Alfredo Scillitani, Fabio Vescini, Valentina Morelli, Carmen Aresta, Iacopo Chiodini
Summary: Mild hypercortisolism (mHC) is characterized by excessive cortisol secretion without the typical symptoms of Cushing's syndrome, increasing the risk of various health issues. Testing cortisol levels after a 1 mg overnight dexamethasone suppression test is the preferred method of diagnosis, with surgery and medical therapy being common treatment options for patients with mHC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Xuanjin Cheng, Yongxing Liu, Jiahe Wang, Yujie Chen, Andrew Gordon Robertson, Xuekui Zhang, Steven J. M. Jones, Stefan Taubert
Summary: Survival analysis is a valuable technique in cancer research for identifying prognostic biomarkers and genetic vulnerabilities. cSurvival is a newly developed analytical tool that allows for gene- and GS-level survival analysis, as well as integration of clinical and experimental data, showing great potential for applications in cancer studies.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Endocrinology & Metabolism
S. Cannavo, M. Cappa, D. Ferone, A. M. Isidori, S. Loche, M. Salerno, M. Maghnie
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Frank L. Dini, Nicola Riccardo Pugliese, Pietro Ameri, Umberto Attanasio, Roberto Badagliacca, Michele Correale, Valentina Mercurio, Carlo Gabriele Tocchetti, Piergiuseppe Agostoni, Alberto Palazzuoli
Summary: Right heart failure is a clinical syndrome characterized by symptoms and signs caused by dysfunction and/or overload of the right heart structures, mainly the right ventricle, resulting in systemic venous hypertension, peripheral edema, and decreased tissue perfusion ability of the right heart. RHF can be caused by various cardiac diseases, including coronary artery disease, hypertension, valvular heart disease, cardiomyopathies, and myocarditis. Early recognition and identification of the underlying cause of RHF are crucial for effective treatment and prognosis improvement.
HEART FAILURE REVIEWS
(2023)
Article
Endocrinology & Metabolism
Federico Gatto, Richard A. Feelders, Peter M. van Koetsveld, Fadime Dogan, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lelij, Jessica Amaru, Diego Ferone, Leo J. Hofland
Summary: Cabergoline (CAB) is an off-label medical therapy for acromegaly, but it is overshadowed by first-generation somatostatin receptor ligands like octreotide (OCT). In this study, OCT was found to be slightly more effective than CAB in inhibiting growth hormone (GH) secretion in vitro. Additionally, the response to CAB treatment was shown to be better in GH/prolactin (PRL) co-secreting tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Roberta Gualtierotti, Massimiliano Ruscica
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Elena Cichero, Federica Rapetti, Matteo Lusardi, Naomi Scarano, Silvana Alfei, Paola Altieri, Silvano Garibaldi, Pietro Ameri, Maria Grazia Signorello, Chiara Brullo
Summary: In the past few years, we have developed a large library of new selective phosphodiesterase 4D (PDE4D) inhibitors. These inhibitors retain the catechol portion of the well-known PDE4 inhibitor Rolipram, with different substitutions in place of the lactam group. Through molecular docking studies, we designed and synthesized new compounds that showed potential PDE4 inhibitory activity, especially with the enzyme's flat aromatic residues. In vitro assays confirmed their antioxidant/anti-inflammatory activity, similar to other known PDE4 inhibitors.
Article
Cell Biology
Paolo Magni
Summary: Cardiovascular diseases are the leading cause of morbidity, mortality, and disability across the globe. The interaction between sex/gender and age has been proven to have a significant impact on the pathophysiology and clinical presentation of atherosclerosis. To address the gaps in knowledge in this area, more research involving women as participants in clinical studies is necessary. Age-related discrimination, or ageism, must also be addressed to ensure equal access to healthcare for older individuals of both genders. Diagnostic and prevention protocols for managing cardiovascular diseases should be improved based on these factors, alongside innovative biomedical and communication strategies.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Nutrition & Dietetics
Elisa Mattavelli, Elena Olmastroni, Manuela Casula, Liliana Grigore, Fabio Pellegatta, Andrea Baragetti, Paolo Magni, Alberico L. Catapano
Summary: Recent epidemiological studies have shown a decrease in adherence to the Mediterranean diet (MedDiet). A prospective cohort study was conducted to evaluate changes in individual determinants of MedDiet adherence over time. The study reveals an overall decrease in MedDiet adherence, highlighting the need for better dietary interventions.
Article
Biochemistry & Molecular Biology
Achille Parfait Nwakiban Atchan, Orissa Charlene Monthe, Armelle Deutou Tchamgoue, Yeshvanthi Singh, Shilpa Talkad Shivashankara, Moorthy Karthika Selvi, Gabriel Agbor Agbor, Paolo Magni, Stefano Piazza, Uma Venkateswaran Manjappara, Jules-Roger Kuiate, Mario Dell'Agli
Summary: This study characterized four Cameroonian spice extracts and investigated their antioxidant and synergistic anti-inflammatory activities in human gastric adenocarcinoma cells. The extracts showed high amounts of phenolic and flavonoid compounds with antioxidant properties, and their combination exerted synergistic effects on inflammatory markers in gastric epithelial cells.
Review
Cardiac & Cardiovascular Systems
Erica Gianazza, Chiara Macchi, Cristina Banfi, Massimiliano Ruscica
Summary: Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a key regulator of low-density lipoprotein receptor (LDLR), can directly contribute to atheroma development. Recent studies have revealed non-cholesterol-related processes mediated by PCSK9, and advancements in proteomics and lipidomics have helped identify novel lipids and proteins associated with PCSK9. These findings have the potential to develop new statistical models for cardiovascular disease (CVD) risk prediction. Furthermore, PCSK9 has been found to impact extracellular vesicles (EVs) composition, which could contribute to a prothrombotic state in CVD patients and may be targeted to counteract atherosclerosis progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Laura Manna, Eleonora Rizzi, Eleonora Bafile, Andrea Cappelleri, Massimiliano Ruscica, Chiara Macchi, Michele Podaliri Vulpiani, Romolo Salini, Emanuela Rossi, Concetta Panebianco, Francesco Perri, Valerio Pazienza, Federica Federici
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that have a significant impact on patients' quality of life. This study aimed to evaluate the effects of oral administration of Lentilactobacillus kefiri SGL 13 and Andrographis paniculata on DSS-treated mice.
FRONTIERS IN NUTRITION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ambra Costa, Pietro Ameri
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Alessandra Ghigo, Pietro Ameri
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Pietro Ameri, Jolanta M. Siller-Matula, Igor Diemberger, Marianne Gwechenberger, Ladislav Pecen, Marius Constantin Manu, Jose Souza, Raffaele De Caterina, Paulus Kirchhof
Summary: Heart failure is a risk factor for adverse events in patients with atrial fibrillation. This study investigates the relationship between heart failure and outcomes in atrial fibrillation patients treated with edoxaban. The results show that patients with heart failure have higher rates of major bleeding and all-cause death, indicating the need for optimized management and novel preventive strategies.
Article
Biochemistry & Molecular Biology
Alyssa J. J. Paganoni, Rossella Cannarella, Roberto Oleari, Federica Amoruso, Renata Antal, Marco Ruzza, Chiara Olivieri, Rosita A. Condorelli, Sandro La Vignera, Fationa Tolaj, Anna Cariboni, Aldo E. Calogero, Paolo Magni
Summary: Gonadotropin-releasing hormone (GnRH) neurons play a crucial role in regulating reproduction. AMH, GH, and IGF1 were found to enhance the migration and function of GnRH neurons in vitro. However, their involvement in the development and function of GnRH neurons in vivo remains unknown. This study evaluated the expression of AMHR2, GHR, and IGF1R during different developmental stages in mice, revealing differential protein expression patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Miron Sopic, Baiba Vilne, Eva Gerdts, Fabio Trindade, Shizuka Uchida, Soliman Khatib, Stephanie Bezzina Wettinger, Yvan Devaux, Paolo Magni
Summary: Multiomics studies offer accurate strategies for ASCVD, and AI and ML can integrate multiple datasets for personalized approaches. Challenges in data quality and privacy need to be addressed.
TRENDS IN MOLECULAR MEDICINE
(2023)