Review
Biochemistry & Molecular Biology
Darina Bacenkova, Marianna Trebunova, Dasa Cizkova, Radovan Hudak, Erik Dosedla, Alena Findrik-Balogova, Jozef Zivcak
Summary: The article discusses the complex process of placental implantation and development, as well as current technologies used to study the behavior of placental cells. Regulation by transcription factors leads to differentiation of trophoblast cells and formation of distinct populations. The 3D in vitro model is crucial for studying placental physiology and modeling placental diseases.
Article
Cell Biology
Jin Seok, Sujin Jun, Jinki Cho, Sohea Park, Jung Ok Lee, Gi Jin Kim
Summary: The study reveals that PD-MSCs regulate the balance between survival and death of trophoblast cells, protect damaged mitochondria, and enhance trophoblast invasion. These findings suggest that PD-MSCs modulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Jiali You, Wei Wang, Hsun-Ming Chang, Yuyin Yi, Hongjin Zhao, Hua Zhu, Yu Sun, Minyue Tang, Chunyan Wang, Yimiao Sang, Guofang Feng, Shaobing Cheng, Peter C. K. Leung, Yi-Min Zhu
Summary: Embryo implantation and trophoblast invasion are critical for establishing pregnancy, with BMP2 playing a significant role in regulating these processes by influencing gene expression and promoting the development and invasion of embryo and trophoblast cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Meiyuan Jin, Shouying Xu, Jiayong Li, Lu Li, Chao Tang
Summary: The study showed that ARID1A regulates trophoblast cell migration and invasion in human placenta by modulating Snail and MMP-9 proteins, suggesting a critical role in supporting healthy placental function.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study reveals that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression, which subsequently contributes to the pathogenesis of preeclampsia.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemical Research Methods
Yong Pu, Jeremy Gingrich, Almudena Veiga-Lopez
Summary: Placental trophoblast cell invasion into the maternal uterus is a crucial and complex event in the formation of the maternal-fetal interface. A 3D PDMS microfluidic platform has been developed to accurately evaluate trophoblast invasion, allowing for real-time monitoring, imaging, and collection of invasive cells. This platform provides insights into pathways regulating trophoblast invasion and is useful for toxicological screening.
Article
Food Science & Technology
Limei Yang, Le Hu, Hongyu Tang, Xuemei Chen, Xueqing Liu, Yue Zhang, Yixian Wen, Yongxiu Yang, Yanqing Geng
Summary: Ti3C2 MXene exposure impairs villus explant extension ability and trophoblast cell functions by inhibiting cell migration and invasion abilities, and enhancing autophagy. Inhibition of autophagy may be a potential therapeutic strategy for alleviating nanoparticle-induced placental toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang
Summary: This study aimed to investigate the effect of GDF-8 on invasion and MMP2 expression in human EVT cells, and found that Snail is a key factor in GDF-8-induced MMP2 expression and cell invasion.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ze Wu, Lanlan Fang, Sizhu Yang, Yibo Gao, Zhen Wang, Qingxue Meng, Xuan Dang, Ying-Pu Sun, Jung-Chien Cheng
Summary: This study discovers a new biological function and underlying molecular mechanisms of GDF-11 in the regulation of human extravillous trophoblast cell invasion.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Reproductive Biology
Tae Yokouchi-Konishi, Yongjie Liu, Liping Feng
Summary: Proper extravillous trophoblast invasion is important for normal placenta development and pregnancy. This study reveals that attenuation of progesterone receptor membrane component 2 promotes cell proliferation, invasion, and angiogenesis in extravillous trophoblasts by activating hypoxia-inducible factor 1 alpha signaling. This discovery provides new insights into the mechanisms of trophoblast invasion.
BIOLOGY OF REPRODUCTION
(2023)
Article
Developmental Biology
Andreanna Burman, Rolando Garcia-Milian, Madeleine Wood, Natalie A. DeWitt, Vasilis Vasiliou, Seth Guller, Vikki M. Abrahams, Shannon Whirledge
Summary: The use of acetaminophen may interfere with critical trophoblast functions, potentially impacting fetal development.
Article
Cell Biology
Monique Fatmous, Alin Rai, Qi Hui Poh, Lois A. Salamonsen, David W. Greening
Summary: This study investigated the impact of sEVs released by endometrial epithelial cells on trophoblast invasion, revealing their ability to promote invasion and induce proteome and surfaceome changes in trophoblast cells to support embryo implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Huimin Shi, Renyu Kong, Xu Miao, Lingshan Gou, Xin Yin, Yuning Ding, Xiliang Cao, Qingyong Meng, Maosheng Gu, Feng Suo
Summary: Reduced levels of PPP1R3G may contribute to the progression of pre-eclampsia by suppressing trophoblast invasion and migration and targeting the Akt/MMP-9 signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Genetics & Heredity
Roland Abi Nahed, Deborah Reynaud, Nicolas Lemaitre, Solene Lartigue, Caroline Roelants, Daniel Vaiman, Mohamed Benharouga, Claude Cochet, Odile Filhol, Nadia Alfaidy
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Otorhinolaryngology
Si Mohamed Bouzoubaa, Mohammed Benlahfid, Mustapha Sidqui, Touria Aboussaouira, Chouaib Rifki, Sophie Brouillet, Wael Traboulsi, Nadia Alfaidy, Mohamed Benharouga
CLINICAL OTOLARYNGOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Amal Kouadri, Johanna Cormenier, Kevin Gemy, Laurence Macari, Peggy Charbonnier, Pierre Richaud, Isabelle Michaud-Soret, Nadia Alfaidy, Mohamed Benharouga
Summary: Cystic fibrosis (CF) is caused by mutations in the CFTR gene, leading to an apical chloride channel dysfunction. In CF patients, early inflammation (EI) in the lung is associated with oxidative stress (OX-S) generated by imbalances in oxidant/antioxidant status. Copper (Cu) has been identified as a key factor in CF-associated OX-S, with an increase in Cu concentration being linked to inflammatory responses. These findings suggest new avenues for investigating CF-associated early inflammation.
Article
Biochemistry & Molecular Biology
Deborah Reynaud, Frederic Sergent, Roland Abi Nahed, Wael Traboulsi, Constance Collet, Christel Marquette, Pascale Hoffmann, Gianfranco Balboni, Qun-Yong Zhou, Padma Murthi, Mohamed Benharouga, Nadia Alfaidy
Summary: The study highlights the association between EG-VEGF and pregnancy pathologies, suggesting antagonization of its receptors as a potential therapeutic approach. Through independent or combined treatments with antagonists PC7 and PKRA in normal pregnancy outcomes, the study uncovers the biological significance of EG-VEGF and its potential for safe use in improving pregnancy outcomes.
Article
Oncology
Deborah Reynaud, Roland Abi Nahed, Nicolas Lemaitre, Pierre-Adrien Bolze, Wael Traboulsi, Frederic Sergent, Christophe Battail, Odile Filhol, Vincent Sapin, Houssine Boufettal, Pascale Hoffmann, Touria Aboussaouira, Padma Murthi, Rima Slim, Mohamed Benharouga, Nadia Alfaidy
Summary: NLRP7 plays a critical role in the development of gestational choriocarcinoma (CC), promoting tumor growth and suppressing maternal immune response. This discovery highlights the therapeutic potential of targeting NLRP7 in this rare female reproductive cancer.
Article
Multidisciplinary Sciences
Tiphaine Raia-Barjat, Camille Sarkis, Florence Rancon, Lise Thibaudin, Jean-Christophe Gris, Nadia Alfaidy, Celine Chauleur
Summary: Maternal vitamin D insufficiency during pregnancy may increase the risk of preeclampsia, and lower vitamin D levels at 32 weeks are associated with a higher risk of placenta-mediated complications. Maintaining adequate levels of vitamin D in pregnant women can help prevent the onset of late PMC.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Roland Abi Nahed, Maya Elkhoury Mikhael, Deborah Reynaud, Constance Collet, Nicolas Lemaitre, Thierry Michy, Pascale Hoffmann, Frederic Sergent, Christel Marquette, Padma Murthi, Tiphaine Raia-Barjat, Nadia Alfaidy, Mohamed Benharouga
Summary: NLRP7 gene is overexpressed in gestational choriocarcinoma (CC) and may contribute to cancer cells' tolerance to the maternal immune system through regulating immune tolerance-related factors and promoting cell proliferation while inhibiting differentiation.
Article
Biochemistry & Molecular Biology
Constance Collet, Jonathan Lopez, Christophe Battail, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Sophie Patrier, Nicolas Lemaitre, Touria Hajri, Jerome Massardier, Benoit You, Francois Mallet, Francois Golfier, Nadia Alfaidy, Pierre-Adrien Bolze
Summary: The TGF-beta pathway appears to play a crucial role in the progression of placental malignancies, potentially being a key step in their evolution. SALL4 was found to be strongly expressed in postmolar choriocarcinoma, as an upstream regulator of TGF-beta. Further studies should investigate the value of TGF-beta family members as biomarkers and new therapeutic targets.
Article
Cell Biology
Irvan Alfian, Amlan Chakraborty, Hannah E. J. Yong, Sheetal Saini, Ricky W. K. Lau, Bill Kalionis, Evdokia Dimitriadis, Nadia Alfaidy, Sharon D. Ricardo, Chrishan S. Samuel, Padma Murthi
Summary: This study found that the gene expression of placental inflammasomes is different in FGR pregnancies, which may contribute to abnormal trophoblast function.
Review
Biochemistry & Molecular Biology
Tiphaine Raia-Barjat, Margaux Digonnet, Antoine Giraud, Taghreed Ayash, Seline Vancolen, Mohamed Benharouga, Celine Chauleur, Nadia Alfaidy, Guillaume Sebire
Summary: Preterm birth and chorioamnionitis have significant impacts on both infant and maternal health. Effective treatments and diagnostic methods are still lacking. Animal models can provide insights into the underlying mechanisms and aid in the development of novel therapies.
Article
Cell Biology
Deborah Reynaud, Nadia Alfaidy, Constance Collet, Nicolas Lemaitre, Frederic Sergent, Celine Miege, Emmanuelle Soleilhac, Alaa Al Assi, Padma Murthi, Gilles Courtois, Marie-Odile Fauvarque, Rima Slim, Mohamed Benharouga, Roland Abi Nahed
Summary: This study reveals for the first time the mechanism by which NLRP7 contributes to the growth and tumorigenesis of gestational choriocarcinoma (GC) through multiple mechanisms. The study found that NLRP7 is highly expressed in GC tumor cells and affects tumor development by regulating the activity of NF-κB, increasing malignant cell survival, dedifferentiation, camouflage, and facilitating lung metastasis. These findings provide potential molecular targets for the treatment of GC.
Article
Biochemistry & Molecular Biology
Hadi Younes, Ioanna Kyritsi, Zineb Mahrougui, Mohamed Benharouga, Nadia Alfaidy, Christel Marquette
Summary: The effects of PROK1 and PROK2 on murine cerebral cell lines were investigated in this study. It was found that PROK1 decreased neural cell proliferation, while PROK2 reduced the proliferation of all tested cell lines and increased their migration ability. Blocking PROKR1 and PROKR2 with antagonists inhibited PROK2-mediated astrocyte migration, and PROKs increased BBB permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Martina Vincenzi, Amin Kremic, Appoline Jouve, Roberta Lattanzi, Rossella Miele, Mohamed Benharouga, Nadia Alfaidy, Stephanie Migrenne-Li, Anumantha G. Kanthasamy, Marimelia Porcionatto, Napoleone Ferrara, Igor V. Tetko, Laurent Desaubry, Canan G. Nebigil
Summary: This article introduces a type of small peptides called prokineticins (PKs) that were discovered 20 years ago. They play roles in various physiological and pathological processes and have the potential to be biomarkers. PKR1 and PKR2, their G-protein coupled receptors, can be therapeutic targets for cardiovascular, metabolic, and neural diseases. The article summarizes the current knowledge of PK family functions and emphasizes the future perspectives for research on PKs.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Tiphaine Raia-Barjat, Celine Chauleur, Constance Collet, Florence Rancon, Pascale Hoffmann, Morgane Desseux, Nicolas Lemaitre, Mohamed Benharouga, Antoine Giraud, Nadia Alfaidy
Summary: Serum EG-VEGF concentrations could be considered as a reliable biomarker for predicting spontaneous preterm birth in high-risk pregnant women with placenta-mediated complications.
SCIENTIFIC REPORTS
(2023)
Review
Physiology
Nadia Alfaidy, Sophie Brouillet, Gayathri Rajaraman, Bill Kalionis, Pascale Hoffmann, Tiphaine Barjat, Mohamed Benharouga, Padma Murthi
FRONTIERS IN PHYSIOLOGY
(2020)
