Article
Biochemistry & Molecular Biology
Tibor Stark, Fabio Arturo Iannotti, Serena Di Martino, Martina Di Bartolomeo, Jana Ruda-Kucerova, Fabiana Piscitelli, Carsten T. Wotjak, Claudio D'Addario, Filippo Drago, Vincenzo Di Marzo, Vincenzo Micale
Summary: According to a study on Sprague-Dawley rats, prenatal exposure to MAM resulted in behavioral alterations in adulthood, including social withdrawal and cognitive impairment, which mimicked schizophrenia-like symptoms. Neonatal reflex delay and increased levels of 2-AG in the brain were observed prior to these abnormalities. Early treatment with the CB1 antagonist/inverse agonist AM251 reversed schizophrenia-like deficits, whereas it affected the behavioral performance of control rats and increased 2-AG content in the prefrontal cortex.
Review
Gastroenterology & Hepatology
Hailey Cuddihey, Wallace K. MacNaughton, Keith A. Sharkey
Summary: This review illustrates the role of the endocannabinoid system in regulating intestinal homeostasis, including the regulation of intestinal permeability, fluid secretion, and immune regulation. It also emphasizes the reciprocal regulation between the endocannabinoid system and the gut microbiome.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurelien Laguerre, Kaya Keutler, Sebastian Hauke, Carsten Schultz
Summary: Pharmacological treatment targeting cannabinoid receptors 1 and 2 in pancreatic beta cells can significantly affect insulin release by modulating intracellular calcium levels. The study demonstrates that CB1 and CB2 receptors have counteracting effects on cytosolic calcium oscillations and act as a compensator/attenuator switch for regulating beta cell excitability.
CELL CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lannie O'Keefe, Teresa Vu, Anna C. Simcocks, Kayte A. Jenkin, Michael L. Mathai, Deanne H. Hryciw, Dana S. Hutchinson, Andrew J. McAinch
Summary: Treatment with the CB1 antagonist/inverse agonist AM251 reduced fat pad weight and altered hormone levels in obese rats, but did not induce browning in white adipose tissue or alter gene expression in skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chih-Hua Chang, Yu-Chen Liu, Chih-Yang Sun, Chun-Lin Su, Po-Wu Gean
Summary: Reactive impulsive aggression is characterized by rage and violence in response to threatening events. Social isolation in early adolescence can lead to hyper-excitatory activity in the ventral hippocampus, promoting impulsive aggression. Activation of cannabinoid type 1 receptors (CB1Rs) has been shown to reduce impulsive aggression, potentially through suppressing neural activity in the vHip -> VMH pathway.
NEUROBIOLOGY OF STRESS
(2021)
Article
Biochemistry & Molecular Biology
Sepideh Khaksar, Mona Salimi, Hadi Zeinoddini, Nima Naderi
Summary: This research investigated the involvement of CB1 and TRPV1 receptors in the protective effects of anandamide in epilepsy. The results showed that anandamide decreased seizure scores, while the TRPV1 and CB1 antagonists had no effect on seizure scores. Co-administration of the antagonists attenuated the protective effect of anandamide. Furthermore, anandamide led to a decrease in the expressions of CREB and p-CREB in hippocampal neurons.
NEUROCHEMICAL RESEARCH
(2022)
Article
Clinical Neurology
Jonathan J. Simone, Matthew R. Green, Cheryl M. McCormick
Summary: As more countries and states legalize the medical use of cannabis, there is a growing interest among health and research professionals in the endocannabinoid system (ECS). This review discusses the maturation of the ECS during adolescence and the consequences of manipulating the ECS during this period, highlighting sex differences and future research directions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Nutrition & Dietetics
Nicholas DiPatrizio
Summary: The gut-brain signaling system, particularly the endocannabinoid system in the upper gastrointestinal tract, plays a crucial role in controlling food intake and the dysregulation of this system is associated with obesity. Direct and indirect interactions between endocannabinoids and vagal afferent neurons are key mechanisms in this control, with a focus on how diet-induced obesity impacts these pathways.
Article
Biochemistry & Molecular Biology
Tomasz Charytoniuk, Hubert Zywno, Klaudia Berk, Wiktor Bzdega, Adrian Kolakowski, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Summary: The increasing prevalence of obesity and related diseases poses serious threats to global health. Dysregulation of the endocannabinoid system (ECS) can lead to metabolic imbalance and diseases. Physical exercise can alter the ECS and have positive effects on metabolic pathologies. However, there is limited data on the direct correlation between the ECS and physical activity in terms of metabolic health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gabriella Dornyei, Zsolt Vass, Csilla Berta Juhasz, Gyorgy L. Nadasy, Laszlo Hunyady, Maria Szekeres
Summary: Metabolic syndrome is a complex disease state that arises from an unhealthy, sedentary lifestyle. It brings about various metabolic complications and reduces life expectancy. The endocannabinoid system plays a crucial role in signalization processes in both the central nervous system and peripheral tissues, affecting several physiological functions. Understanding cannabinoid receptor functions can offer potential therapeutic effects for the treatment of metabolic diseases like diabetes, insulin resistance, obesity, and hypertension.
Article
Chemistry, Multidisciplinary
Janelle M. Tobias, Gabriela Rajic, Alexander E. G. Viray, David Icka-Araki, James A. Frank
Summary: Fatty acid amides (FAAs) are lipids that target cannabinoid receptors and regulate insulin secretion. The Optically-Cleavable Targeted (OCT)-ligand approach was developed to investigate the mechanisms by which FAAs regulate beta-cell excitability, showing potential for new experimental possibilities in targeted pharmacology.
Review
Neurosciences
Shuangtao Li, Yuanbing Huang, Lijun Yu, Xiaoyu Ji, Jie Wu
Summary: Cannabinoids, isolated from cannabis and present in animal nervous and immune systems, have shown promising clinical medicinal value, particularly in the field of neurodegenerative diseases such as Alzheimer's disease. This review explores the therapeutic potential of cannabinoids in treating Alzheimer's disease, highlighting their interactions with different endocannabinoid receptor subtypes and the role of the endocannabinoid system in this disease. The underlying mechanisms and potential usefulness of cannabinoids in clinical treatment are also discussed.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzi, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano
Summary: Corticosteroid-mediated stress responses involve complex brain circuits and mitochondrial activity, and the endocannabinoid system plays a role in regulating these processes. The study shows that corticosterone impairs novel object recognition (NOR) task performance in mice through the activation of mitochondrial CB1 receptors and the regulation of neuronal mitochondrial calcium levels. Different brain circuits are modulated by this mechanism to mediate the effects of corticosterone during specific phases of the task.
Article
Clinical Neurology
Riikka M. Ajalin, Haidar Al-Abdulrasul, Jouni M. Tuisku, Jussi E. S. Hirvonen, Tero Vahlberg, Salla Lahdenpohja, Juha O. Rinne, Anna E. Bruck
Summary: CB1 receptor availability is lower in patients with Parkinson's disease compared to healthy controls. Dopaminergic medication increases CB1 receptor availability towards normal levels.
MOVEMENT DISORDERS
(2022)
Review
Endocrinology & Metabolism
Melissa L. Kozakiewicz, Chad A. Grotegut, Allyn C. Howlett
Summary: The endocannabinoid system plays a crucial role in early pregnancy success, embryo development, and parturition, influencing uterine activation and maternal-fetal interaction, regulating pregnancy maintenance and timing of labor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Enrrico Bloise, Jair R. S. Braga, Cherley B. V. Andrade, Guinever E. Imperio, Lilian M. Martinelli, Roberto A. Antunes, Karina R. Silva, Cristiana B. Nunes, Luigi Cobellis, Flavia F. Bloise, Stephen G. Matthews, Kristin L. Connor, Tania M. Ortiga-Carvalho
Summary: Following intracytoplasmic sperm injection (ICSI), placental SNAT2 protein expression is downregulated, leading to increased cell turnover and altered levels of specific nutrients in the umbilical vein, without changes in placental morphology. These findings suggest potential mechanisms through which ICSI impacts pregnancy outcomes and modifies disease risk trajectories in offspring.
Article
Microbiology
Mila W. Reginatto, Klaus Novaes Fontes, Victoria R. S. Monteiro, Natalia L. Silva, Cherley Borba Vieira Andrade, Hanailly Ribeiro Gomes, Guinever E. Imperio, Flavia Fonseca Bloise, George Eduardo Gabriel Kluck, Georgia Correa Atella, Stephen G. Matthews, Enrrico Bloise, Tania M. Ortiga-Carvalho
Summary: The study demonstrated that LPS administration can alter placental transport systems and lipid homeostasis, leading to an increased risk of fetal death and early labor. Changes in placental ABC and lipid transporter expression, as well as disruptions in maternal plasma and placental lipid levels, were observed following LPS treatment. These alterations may impact fetal xenobiotic exposure and placental lipid exchange in cases of bacterial infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Cherley Borba Vieira Andrade, Victoria Regina de Siqueira Monteiro, Sharton Vinicius Antunes Coelho, Hanailly Ribeiro Gomes, Ronny Paiva Campos Sousa, Veronica Muller de Oliveira Nascimento, Flavia Fonseca Bloise, Stephen Giles Matthews, Enrrico Bloise, Luciana Barros Arruda, Tania Maria Ortiga-Carvalho
Summary: Research suggests that gestational ZIKV infection triggers specific proinflammatory responses and affects placental turnover and transporter expression in a manner dependent on virus concentration and maternal immune status. Placental damage may impair proper fetal-maternal exchange function and fetal growth/survival, likely contributing to congenital Zika syndrome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Aline F. P. Souza, Juliana Woyames, Rosiane A. Miranda, Lorraine S. Oliveira, Bruna Caetano, Isabela L. Martins, Manuella S. Souza, Cherley B. Andrade, Thais Bento-Bernardes, Flavia F. Bloise, Rodrigo S. Fortunato, Isis H. Trevenzoli, Luana L. Souza, Carmen C. Pazos-Moura
Summary: This study investigates the effects of maternal high-fat diet on the liver mitochondrial responses to fructose intake in adult offspring. It found that moderate maternal high-fat diet can increase the intensity of liver mitochondrial alterations induced by fructose in offspring. The findings suggest that maternal diet can influence the risk of fructose damage in the liver of adult offspring.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jessika Geisebel Oliveira Neto, Silvia Karl Boechat, Juliana Santos Romao, Lia Rafaella Ballard Kuhnert, Carmen Cabanelas Pazos-Moura, Karen Jesus Oliveira
Summary: Cinnamaldehyde treatment in adolescence has long-term benefits for WAT and BAT metabolism in rat models of obesity, highlighting its potential as a reprogramming nutraceutical in the treatment of childhood obesity.
Article
Biochemistry & Molecular Biology
Juliana Woyames, Aline Fonseca Pereira Souza, Rosiane Aparecida Miranda, Lorraine Soares Oliveira, Bruna Caetano, Cherley Borba Vieira Andrade, Rodrigo Soares Fortunato, Georgia Correa Atella, Isis Hara Trevenzoli, Luana Lopes Souza, Carmen Cabanelas Pazos-Moura
Summary: Maternal high-fat diet and fructose induced alterations in lipid metabolism and mitochondrial function in skeletal muscle of adult offspring. These changes were modified by maternal diet and fiber type, and were associated with higher skeletal muscle fructose-induced mitochondria injury in adult offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Luana L. Souza, Egberto G. Moura, Patricia C. Lisboa
Summary: Overfeeding during lactation can negatively impact the health of the baby, increasing the risk of obesity and metabolic disorders. Using a small litter model, similar metabolic profiles have been observed in rodents, making it an efficient tool to study the adaptive mechanisms involved in obesity. Hormones, such as leptin, insulin, and adrenal hormones, as well as hypothyroidism, play a role in satiety, glucose homeostasis, adipogenesis, and energy metabolism. Other reported effects include behavioral modifications, hepatic metabolism changes, and reproductive dysfunctions. This review highlights the complex adaptive mechanisms involved in the obesity phenotype induced by early overnutrition, emphasizing the importance of proper nutritional habits during lactation.
Article
Biochemistry & Molecular Biology
Thamires Siqueira de Oliveira, Marilia Kimie Shimabukuro, Victoria Regina Siqueira Monteiro, Cherley Borba Vieira Andrade, Anita Boelen, Simone Magagnin Wajner, Ana Luiza Maia, Tania Maria Ortiga-Carvalho, Flavia Fonseca Bloise
Summary: This study investigates the impact of inflammation on thyroid hormone signaling during myogenesis. The results show that inflammation can reduce the myogenic stimulus and alter intracellular metabolism of thyroid hormones. However, late differentiation is not affected by the inflammatory milieu.
Article
Multidisciplinary Sciences
V. R. S. Monteiro, C. B. V. Andrade, H. R. Gomes, M. W. Reginatto, G. E. Imperio, K. N. Fontes, D. A. Spiess, W. S. Rangel-Junior, V. M. O. Nascimento, C. O. S. Lima, R. P. C. Sousa, F. F. Bloise, S. G. Matthews, E. Bloise, P. M. Pimentel-Coelho, T. M. Ortiga-Carvalho
Summary: Limited information is available about the effect of mid-pregnancy viral infections on placental expression and offspring behavior. This study found that maternal exposure to a synthetic double-stranded RNA viral mimic disrupted placental cell turnover and impaired offspring behavior in adult life.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Thaiane G. Gaique, Silvia K. Boechat, Jessika Geisebel O. Neto, Thais Bento-Bernardes, Renata F. Medeiros, Carmen C. Pazos-Moura, Karen J. Oliveira
Summary: Cinnamaldehyde supplementation has a significant impact on glycemic metabolism in healthy adolescent rats, leading to weight loss, improved glucose tolerance, and increased insulin signaling in the liver of adolescent rats. However, the treatment with cinnamaldehyde does not show significant effects on adult rats.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ricardo H. Costa-e-Sousa, Rodrigo Rorato, Anthony N. Hollenberg, Kristen R. Vella
Summary: This study reveals that thyrotropin-releasing hormone (TRH) neurons in the paraventricular nucleus of the hypothalamus play a direct role in regulating thyroid hormone levels and have significant functions in negative feedback and fasting. Activation of TRH neurons increases thyrotropin (TSH) and thyroid hormone (TH) levels and prevents the decrease of TH levels during fasting. Activation of AgRP/NPY neurons leads to a decrease in TH levels despite increased feeding, while inhibition of these neurons prevents the decrease in TH levels during fasting.
Article
Biology
J. G. O. Neto, J. S. Romao, C. C. Pazos-Moura, K. J. Oliveira
Summary: This study found that short-term fructose consumption induced molecular changes in the thyroid and increased the expression of thyroid hormone-related signaling genes in brown adipose tissue (BAT), potentially leading to increased BAT activity.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Rhayanna B. Gaglianone, Flavia Fonseca Bloise, Jussara Lagrota-Candido, Claudia Mermelstein, Thereza Quirico-Santos
Summary: The mdx mouse model of Duchenne Muscular Dystrophy (DMD) exhibits sarcolemma instability and a mild multi-stage dystrophinopathy. The study found increased calcium deposits and high activity of calcium related proteases in mdx diaphragm at 12 weeks, along with decreased expression of muscle-specific proteins. These results suggest that calcium deposits and persistent activity of calcium dependent proteases are involved in the degeneration and regeneration processes in the mdx diaphragm.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Physiology
Thamires Siqueira Oliveira, Anderson Teixeira Santos, Cherley Borba Vieira Andrade, Johnatas Dutra Silva, Natalia Blanco, Nazareth de Novaes Roche, Juliana Woyames, Pedro Leme Silva, Patricia Rieken Macedo Rocco, Wagner Seixas da-Silva, Tania Maria Ortiga-Carvalho, Flavia Fonseca Bloise
Summary: This study found that sepsis can lead to morphological changes in the diaphragm, increased mitochondrial damage, and impaired function, suggesting that diaphragm damage during sepsis is associated with mitochondrial dysfunction.
FRONTIERS IN PHYSIOLOGY
(2021)