Article
Psychiatry
Karim Abdel Aziz, Fadwa Al-Mugaddam, Subi Sugathan, Prashanth Saseedharan, Tarek Jouini, Mohamed Elhassan Elamin, Hamdy Moselhy, Dina Aly El-Gabry, Danilo Arnone, Sherif M. Karam
Summary: This study found that both acylated and total ghrelin levels were significantly reduced in bipolar disorder patients compared to healthy controls, and were positively correlated with markers of illness severity but negatively correlated with prescribed mood stabilizers, weight, and body mass index.
Article
Biochemistry & Molecular Biology
Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Sun
Summary: This study demonstrates that GHS-R regulates energy homeostasis by altering feeding patterns, and differentially modulates feeding patterns in a site- and diet-dependent manner.
Article
Multidisciplinary Sciences
Camilla O. D. Araujo, Renan M. Montenegro, Amanda P. Pedroso, Virginia O. Fernandes, Ana Paula D. R. Montenegro, Annelise B. de Carvalho, Lila M. Oyama, Carla S. C. Maia, Eliane B. Ribeiro
Summary: This study found that patients with congenital generalized lipodystrophy (CGL) have appetite disturbances compared to eutrophic individuals, with lower fasting acylated ghrelin levels and no physiological drop after meal intake. These disturbances seem to play a role in hunger attenuation and satiety, but not in acute satiation.
Article
Multidisciplinary Sciences
Eleni Rebelos, Giuseppe Daniele, Beatrice Campi, Alessandro Saba, Kalle Koskensalo, Jukka Ihalainen, Ekaterina Saukko, Pirjo Nuutila, Walter H. Backes, Jacobus F. A. Jansen, Pieter C. Dagnelie, Sebastian Koehler, Bastiaan E. de Galan, Thomas T. van Sloten, Coen D. A. Stehouwer, Ele Ferrannini
Summary: This study found no correlation between circulating NAA levels, central NAA levels, cognitive function, or cerebral small vessel disease. These results indicate that circulating NAA levels do not reflect the related features in the brain.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Li, Xue-Jun Jiang, Qun-Hui Wang, Xing-Liang Wu, Zhe Qu, Tao Song, Wei-Guo Wan, Xiao-Xin Zheng, Xin Yi
Summary: This study investigated potential plasma biomarkers associated with the pathophysiologic progression of coronary chronic total occlusion (CTO) and identified protein dynamics in plasma after successful revascularization of CTO vessels. The results revealed that proteins were mainly related to negative regulation of proteolysis, regulation of peptidase activity, negative regulation of hydrolase activity, humoral immune response, and lipid location.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shana O. Warner, Yufei Dai, Nicole Sheanon, Michael V. Yao, Rebecca L. Cason, Shahriar Arbabi, Shailendra B. Patel, Diana Lindquist, Jason J. Winnick
Summary: Fasting increases the risk of hypoglycemia in individuals with type 1 diabetes, and it also negatively affects insulin-induced hypoglycemia responses in healthy individuals.
Article
Multidisciplinary Sciences
Yanmei Wang, Qianxian Wu, Qian Zhou, Yuyu Chen, Xingxing Lei, Yiding Chen, Qiu Chen
Summary: This meta-analysis found that obese individuals have lower baseline levels of circulating acyl ghrelin (AG) and des-acyl ghrelin (DAG), as well as a faster decline in postprandial AG levels. These findings provide important clinical evidence for further investigations into the role of various forms of ghrelin in energy homeostasis.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Christine Sommer, Kjersti G. Vangberg, Gunn-Helen Moen, David M. Evans, Sindre Lee-Odegard, Ingvild K. Blom-Hogestol, Line Sletner, Anne K. Jenum, Christian A. Drevon, Hanne L. Gulseth, Kare Birkeland
Summary: This study investigates the influence of glucose, insulin, body fat, BMI, food intake, and physical activity on serum sOb-R levels. The researchers found that BMI and insulin were causally linked to decreased sOb-R levels, while intensive exercise and food intake acutely increased sOb-R levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ge Li, Yusei Tataka, Kayoko Kamemoto, Haixin Wen, Kazuna Yamanaka, Chihiro Nagayama, Masashi Miyashita
Summary: This study found that the concentration of acylated ghrelin is suppressed after exercise and meal consumption, and butyrylcholinesterase (BChE) may not be involved in this process.
Article
Endocrinology & Metabolism
Ge Li, Yusei Tataka, Kayoko Kamemoto, Haixin Wen, Kazuna Yamanaka, Chihiro Nagayama, Masashi Miyashita
Summary: This study aimed to investigate the effects of exercise and meal consumption on the concentration of butyrylcholinesterase (BChE) and acylated ghrelin in young healthy men. The findings suggest that BChE may not be involved in suppressing acylated ghrelin after exercise and meal consumption.
Article
Nutrition & Dietetics
Zahide Karaca, Recep C. Yuksel, Gulsah Gunes Sahin, Neslihan Sungur, Sahin Temel, Gulden Baskol, Bahadir T. Arikan, Murat Sungur, Kursat Gundogan
Summary: This study aimed to determine serum total and acylated ghrelin levels serially in critically ill patients and investigate their relationship with clinical outcomes in the intensive care unit. The findings showed that ghrelin levels slightly decreased while acylated ghrelin levels substantially increased over time in critically ill patients. There was no significant difference between serum total ghrelin/acylated ghrelin levels and ICU mortality.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Nutrition & Dietetics
Rocco Barazzoni, Gianluca Gortan Cappellari, Michela Zanetti, Katherine A. Klaus, Annamaria Semolic, Matthew L. Johnson, K. Sreekumaran Nair
Summary: Moderate caloric restriction can improve insulin sensitivity in obese individuals, potentially due to increased levels of unacylated ghrelin (UnAG). The study found that caloric restriction led to an increase in UnAG levels and was positively associated with improvements in insulin sensitivity.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jamie van Son, Mireille J. Serlie, Marcus Stahlman, Fredrik Backhed, Max Nieuwdorp, Judith Aron-Wisnewsky
Summary: In overweight and obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.
Article
Biology
Deetje Iggena, Sein Jeung, Patrizia Maier, Christoph Ploner, Klaus Gramann, Carsten Finke
Summary: This study investigates the role of multisensory information in memory-guided spatial navigation. The results show that the availability of multisensory input improves spatial navigation in both individuals with hippocampal lesions and those without. It has a significant impact on navigational behavior, with greater improvement in spatial memory performance observed in patients. The study concludes that congruent multisensory information shifts computations to extrahippocampal areas that support spatial navigation and compensates for spatial navigation deficits.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Becky J. Proskocil, Gina N. Calco, Zhenying Nie
Summary: This study found that hyperinsulinemia increases bronchoconstriction induced by the vagus nerve in obese rats, as well as significantly increases methacholine-induced airway smooth muscle contraction. Insulin enhances intracellular calcium and smooth muscle contraction, providing insights into potential asthma treatment targets.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angelos Dimas, Anastasia Politi, George Papaioannou, Thomas M. Barber, Martin O. Weickert, Dimitris K. Grammatopoulos, Sudhesh Kumar, Sophia Kalantaridou, Georgios Valsamakis
Summary: Increased maternal food intake affects fetal development and metabolism, with gut-hormone molecules playing a crucial role. However, the correlation between maternal appetite axis hormones and birth weight is not consistent, suggesting their role in regulating fetal energy deposition mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Harpal S. Randeva, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Resveratrol, a polyphenol chemical found in many plant-based dietary products, has potential health benefits. After ingestion, it undergoes extensive metabolism, inhibits adipogenesis and fat accumulation, possesses anti-inflammatory effects, and may improve insulin sensitivity and inflammatory status. However, optimal dosage and benefits within the general population need further research.
Article
Nutrition & Dietetics
Charlotte Wernicke, Anne Pohrt, Laura Pletsch-Borba, Konstantina Apostolopoulou, Silke Hornemann, Nina Meyer, Jurgen Machann, Christiana Gerbracht, Frank Tacke, Andreas F. H. Pfeiffer, Joachim Spranger, Knut Mai
Summary: This study aimed to assess the long-term effects of a dietary intervention high in protein and unsaturated fatty acids on intrahepatic lipids and metabolism. The study found that in adherent older individuals following dietary recommendations, a high-protein and unsaturated fatty acids diet can have beneficial long-term effects on liver fat and lipid metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Robert Wagner, Martin Heni, Konstantinos Kantartzis, Arvid Sandforth, Juergen Machann, Fritz Schick, Andreas Peter, Louise Fritsche, Julia Szendroedi, Andreas F. H. Pfeiffer, Annette Schuermann, Matthias Blueher, Hans Hauner, Jochen Seissler, Stefan Bornstein, Michael Roden, Norbert Stefan, Andreas L. Birkenfeld, Morris F. White, Hans-Ulrich Haering, Andreas Fritsche
Summary: The objective of this study was to examine the effects of lifestyle intervention on impaired insulin secretion in specific subphenotypes of prediabetes. Participants from the Prediabetes Lifestyle Intervention Study were divided into six prediabetes clusters and assessed for insulin secretion, glycemia, insulin sensitivity, and liver fat changes during a 1-year intervention. The lifestyle intervention improved glycemic traits in all high-risk clusters, while insulin secretion increased only in clusters 3 and 5. However, high liver fat in cluster 5 hindered the improvement of insulin secretion.
Article
Nutrition & Dietetics
Jiudan Zhang, Sylva Mareike Schaefer, Stefan Kabisch, Marta Csanalosi, Bettina Schuppelius, Margrit Kemper, Mariya Markova, Nina Marie Tosca Meyer, Olga Pivovarova-Ramich, Farnaz Keyhani-Nejad, Sascha Rohn, Andreas F. H. Pfeiffer
Summary: This study investigates the contribution of amino acids to postprandial hyper-glucagonemia in type 2 diabetes patients. The research shows that type 2 diabetes patients have excessive glucagon responses after mixed meals, while the obese control group only shows small initial and delayed greater glucagon responses. The role of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in mixed meals is unclear.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Simon I. I. Dreher, Martin Irmler, Olga Pivovarova-Ramich, Katharina Kessler, Karsten Juerchott, Carsten Sticht, Louise Fritsche, Patrick Schneeweiss, Juergen Machann, Andreas F. H. Pfeiffer, Martin Hrabe de Angelis, Johannes Beckers, Andreas L. L. Birkenfeld, Andreas Peter, Andreas M. M. Niess, Cora Weigert, Anja Moller
Summary: This study examined the response of subcutaneous adipose tissue (SAT) to exercise and compared it with skeletal muscle. The results showed that SAT responds differently to exercise, with reductions in transcripts related to lipid storage and lipogenesis, as well as modulation of the circadian rhythm, which can potentially prevent metabolic syndrome progression towards diabetes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Marina Tsoli, Kosmas Daskalakis, Maria Wedin, Anna Angelousi, Sebastian Povlsen, Raj Srirajaskanthan, George Giovos, Martin O. Weickert, Angelika Kogut, Beata Kos-Kudla, Kira Oleinikov, Simona Grozinsky-Glasberg, Gregory Kaltsas
Summary: Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but can be detected using new diagnostic tools. A retrospective analysis was performed to study the characteristics and prognostic significance of PMs in NEN patients. The presence of PMs did not have a significant negative impact on overall survival (OS) in this study.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Michael Kruse, Silke Hornemann, Anne-Cathrin Ost, Turid Frahnow, Daniela Hoffmann, Andreas Busjahn, Martin A. Osterhoff, Bettina Schuppelius, Andreas F. H. Pfeiffer
Summary: This study investigated the gene expression changes in white adipose tissue after an isocaloric high-fat diet in healthy human twins. The results showed that fatty acid transport was reduced, while fructose transport was increased, potentially leading to increased de novo lipogenesis. These gene expression changes were partially inherited.
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: The Mediterranean Diet is a plant-based diet rich in vegetables, fruit, cereals, and olive oil. It has numerous health benefits, including improved longevity, reduced risk of chronic diseases such as diabetes and obesity, and improved cognitive function. The diet also influences the gut microbiota, promoting the growth of beneficial bacteria and reducing the growth of harmful bacteria. The adoption of the Mediterranean Diet is beneficial for both health and the environment, and should be encouraged globally.
Review
Biochemistry & Molecular Biology
Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Metabolic-associated fatty liver disease (MAFLD) has become the most common cause of chronic liver disease globally, affecting one in four people. Despite only a small proportion of MAFLD patients progressing to cirrhosis, it still plays a significant role in its development. However, MAFLD faces challenges such as insidious and asymptomatic onset, lack of accurate diagnostic tests, and absence of specific therapies.
Review
Gastroenterology & Hepatology
Mona Reinshagen, Stefan Kabisch, Andreas F. H. Pfeiffer, Joachim Spranger
Summary: Nonalcoholic fatty liver disease (NAFLD) is strongly associated with metabolic syndrome and type 2 diabetes, and can independently lead to long-term complications. Direct diagnostics for NAFLD are either invasive, costly, or dependent on the examiner's expertise. Biomarkers, specifically liver fat indices, provide a cheap diagnostic alternative for NAFLD prediction, but have limited accuracy for liver fat quantification. Currently, they lack precision for individual patient monitoring but can serve as compound biomarkers in large cohorts.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Thomas Skurk, Anja Bosy-Westphal, Arthur Gruenerbel, Stefan Kabisch, Winfried Keuthage, Peter Kronsbein, Karsten Muessig, Helmut Nussbaumer, Andreas F. H. Pfeiffer, Marie-Christine Simon, Astrid Tombek, Katharina S. S. Weber, Diana Rubin
Article
Endocrinology & Metabolism
Thomas Skurk, Anja Bosy-Westphal, Arthur Gruenerbel, Stefan Kabisch, Winfried Keuthage, Peter Kronsbein, Karsten Muessig, Andreas F. H. Pfeiffer, Marie-Christine Simon, Astrid Tombek, Katharina S. Weber, Diana Rubin
Meeting Abstract
Endocrinology & Metabolism
B. Schuppelius, R. Schueler, O. Pivovarova-Ramich, S. Hornemann, A. Busjahn, J. Machann, M. Kruse, A. F. H. Pfeiffer
